DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcr and C3

DIOPT Version :9

Sequence 1:	NP_524688.1	Gene:	Mcr / 44071	FlyBaseID:	FBgn0267488	Length:	1760	Species:	Drosophila melanogaster
Sequence 2:	NP_000055.2	Gene:	C3 / 718	HGNCID:	1318	Length:	1663	Species:	Homo sapiens

Alignment Length:	1622	Identity:	372/1622 - (22%)
Similarity:	612/1622 - (37%)	Gaps:	421/1622 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   226 SQRSMTIFVQTDKPLYMQGETVRFRTIPITTELKGFDNPVDVYMLDPNRHILKR-WLSRQSNLGS 289
            |.:|..:|:||||.:|..|.||.:|...:..:|......|.|.:.:|....:|: .||.|:.||.
Human   124 SLQSGYLFIQTDKTIYTPGSTVLYRIFTVNHKLLPVGRTVMVNIENPEGIPVKQDSLSSQNQLGV 188

  Fly   290 VSLEYKLSDQPTFGEWTIRVIAQGQQEE---SHFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGR- 350
            :.|.:.:.:....|:|.||...:...::   :.|.|:||....|||.|.....|:    :||..
Human   189 LPLSWDIPELVNMGQWKIRAYYENSPQQVFSTEFEVKEYVLPSFEVIVEPTEKFY----YIYNEK 249

  Fly   351 -----VMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQ 410
                 :.|.|..|..|.|...:...|:.    ..|.::....|.|.|:|
Human   250 GLEVTITARFLYGKKVEGTAFVIFGIQD----GEQRISLPESLKRIPIE---------------- 294

  Fly   411 NPQVQYNVPGQLPQDGADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKT 475
                          ||:         .:.|:.|....|     .|:.|..:|
Human   295 --------------DGS---------GEVVLSRKVLLD-----GVQNPRAED------------- 318

  Fly   476 LPYLRYFNGTFDFKWPLRELELLVPNLANSEVLITATVGEKFYDEIISGYSVARVYNSSLRVV-- 538
                                      |....:.::|||      .:.||..:.:...|.:.:|
Human   319 --------------------------LVGKSLYVSATV------ILHSGSDMVQAERSGIPIVTS 351

  Fly   539 ----FLGDSPQVFKPAMPFTTYLAVEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLP 599
                ....:|:.|||.|||...:.|...|||                            ||.|:|
Human   352 PYQIHFTKTPKYFKPGMPFDLMVFVTNPDGS----------------------------PAYRVP 388

  Fly   600 MS----------QQSDGIWEVKIDI---RNDLNLDDRPQARDFLNGVQNMR-LQANFVDPRGERI 650
            ::          .|.||:.::.|:.   :..|::..|.:.::.....|..| :||
Human   389 VAVQGEDTVQSLTQGDGVAKLSINTHPSQKPLSITVRTKKQELSEAEQATRTMQA---------- 443

  Fly   651 QTELLLVSHYSPRNQ--HIKVTTSTEKPVVGEYIIFHIRTNFYL----------EEFNYLIMSKG 703
                |..|.....|.  |:.|..:..:|  ||    .:..||.|          ..:.||||:||
Human   444 ----LPYSTVGNSNNYLHLSVLRTELRP--GE----TLNVNFLLRMDRAHEAKIRYYTYLIMNKG 498

  Fly   704 VILVNDRETITEGIKTIAVVLS--SEMAPVATIVVW--KINQQGQ--VVADSLTFPVNGISRNNF 762
            .:|...|:....|...:.:.||  ::..|...:|.:  .|...||  |||||:...|......:.
Human   499 RLLKAGRQVREPGQDLVVLPLSITTDFIPSFRLVAYYTLIGASGQREVVADSVWVDVKDSCVGSL 563

  Fly   763 TV---YINNRKARTGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFD-EQT 823
            .|   ...:|:...|:::.:.|.|:.|:.|.|..:|...:.:...|:||.:||...:...| ..|
Human   564 VVKSGQSEDRQPVPGQQMTLKIEGDHGARVVLVAVDKGVFVLNKKNKLTQSKIWDVVEKADIGCT 628

  Fly   824 NGTYKHIWYSHEGNPDELVYFPASSFGVDANRTFEYSG---------------------LIVFTD 867
            .|:.|..               |..|. ||..||..|.                     .:..|:
Human   629 PGSGKDY---------------AGVFS-DAGLTFTSSSGQQTAQRAELQCPQPAARRRRSVQLTE 677

  Fly   868 ------GYVPRRQDTCNRTLGFGECLSG--------RCYR------LEKQCDGLF-DCDDGTDEI 911
                  |..|:....|        |..|        .|.|      |.:.|..:| ||.:...|:
Human   678 KRMDKVGKYPKELRKC--------CEDGMRENPMRFSCQRRTRFISLGEACKKVFLDCCNYITEL 734

  Fly   912 -NCHARNDTELLNYRKYRFNRVLRHYENV---------WLW--KDVNIGPH---GRYIFNVEVPD 961
             ..|||  ...|...:...:..:...||:         |||  :|:...|.   ...:.|:.:.|
Human   735 RRQHAR--ASHLGLARSNLDEDIIAEENIVSRSEFPESWLWNVEDLKEPPKNGISTKLMNIFLKD 797

  Fly   962 RPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEA 1026
            ....|.:.|.|:|..||..:.: ..|...:|.|||::.:|.:..:.|||.||..::||
Human   798 SITTWEILAVSMSDKKGICVAD-PFEVTVMQDFFIDLRLPYSVVRNEQVEIRAVLYNY------- 854

  Fly  1027 IVVLHDSPDYKFVHVEEDGIVRSYNP-----RTSFGEHQFFIYLEAQGTTVVYVPVVPQRLG--N 1084
                ..:.:.| |.||     ..:||     .|:...||..:.:..:.:..|...:||.:.|  .
Human   855 ----RQNQELK-VRVE-----LLHNPAFCSLATTKRRHQQTVTIPPKSSLSVPYVIVPLKTGLQE 909

  Fly  1085 VDVTLHVATLLGTDTITRTLHVESDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQTPEI-PYQVD 1148
            |:|...|.....:|.:.::|.|..:|:...:..:|      |....|.:.....|..:| |..:.
Human   910 VEVKAAVYHHFISDGVRKSLKVVPEGIRMNKTVAV------RTLDPERLGREGVQKEDIPPADLS 968

  Fly  1149 RYFVYGSNKARISVVGDVVGPIFPTMPVNASSLLSL---PMESGEQNAFSFAANLYTIMYMRLIN 1210
            .......::.||.:.|..|..:... .|:|..|..|   |...||||.......:..:.|:....
Human   969 DQVPDTESETRILLQGTPVAQMTED-AVDAERLKHLIVTPSGCGEQNMIGMTPTVIAVHYLDETE 1032

  Fly  1211 QRNK-TLEK--NAFYHMNIGYQRQLSFMRPDGSFSLF--RSDWNNSDSSVWLTSYCLRVFQEASF 1270
            |..| .|||  .|...:..||.:||:|.:|..:|:.|  |:      .|.|||:|.::||..|
Human  1033 QWEKFGLEKRQGALELIKKGYTQQLAFRQPSSAFAAFVKRA------PSTWLTAYVVKVFSLA-- 1089

  Fly  1271 YEWENFIWIDATIIEKNMRWL-LQHQTPQGSFFEVTWLPDRKM---NRTNFDKNITLTSHVLITL 1331
               .|.|.||:.::...::|| |:.|.|.|.|.|...:..::|   .|.|.:|::.||:.|||:|
Human  1090 ---VNLIAIDSQVLCGAVKWLILEKQKPDGVFQEDAPVIHQEMIGGLRNNNEKDMALTAFVLISL 1151

  Fly  1332 ATVKDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDVAITAYALQLCNSPIAEEVFAILRR 1396
            ...|||.....:.:..:..:|..::|.|...|:   :.:.|||..|||    :.:......:|.:
Human  1152 QEAKDICEEQVNSLPGSITKAGDFLEANYMNLQ---RSYTVAIAGYAL----AQMGRLKGPLLNK 1209

  Fly  1397 QARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVARREF-FVDPI 1460
            ...|..|...|     ..|.::|                 .|:|.|:||||..:..::| ||.|:
Human  1210 FLTTAKDKNRW-----EDPGKQL-----------------YNVEATSYALLALLQLKDFDFVPPV 1252

  Fly  1461 VRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQGGK-TQTLYIDDTN 1524
            |||||.||...||:.|||.|....:||.:|...:...:..:|.|.::..|:..| |..::.:..:
Human  1253 VRWLNEQRYYGGGYGSTQATFMVFQALAQYQKDAPDHQELNLDVSLQLPSRSSKITHRIHWESAS 1317

  Fly  1525 LAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYN------VDIEKFQTK---PPVPAFGLHTKA 1580
            |  |:|.|..:..| ..|.|:|.|...|.:...|:      :...||..|   .|.|    .|:.
Human  1318 L--LRSEETKENEG-FTVTAEGKGQGTLSVVTMYHAKAKDQLTCNKFDLKVTIKPAP----ETEK 1375

  Fly  1581 IFHGRNQSHISYVACQNWINQNESERSGMAVLDVAIPTGY----------------WIQQQKLDT 1629
                |.|...:.:..:........:.:.|::||:::.||:                :|.:.:||.
Human  1376 ----RPQDAKNTMILEICTRYRGDQDATMSILDISMMTGFAPDTDDLKQLANGVDRYISKYELDK 1436

  Fly  1630 YVLSNRVRNLRRARYLERKIVFYFDYLDH-EDICVNFTIERWYPVANMSRYLP--VRIYDYY 1688
             ..|:|           ..::.|.|.:.| ||.|:.|.:.:::   |:....|  |::|.||
Human  1437 -AFSDR-----------NTLIIYLDKVSHSEDDCLAFKVHQYF---NVELIQPGAVKVYAYY 1483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	A2M_N	232..332	CDD:280081	30/103 (29%)
		A2M_N_2	669..799	CDD:285005	38/148 (26%)
		LDLa	886..913	CDD:238060	10/42 (24%)
		A2M	940..1030	CDD:278630	26/94 (28%)
		ISOPREN_C2_like	1177..1490	CDD:298658	99/325 (30%)
		A2M_comp	1226..1492	CDD:284982	85/272 (31%)
		A2M_recep	1607..1695	CDD:284981	23/101 (23%)
C3	NP_000055.2	A2M_N	129..224	CDD:280081	26/94 (28%)
		A2M_N_2	458..604	CDD:285005	38/151 (25%)
		ANATO	678..747	CDD:237984	17/78 (22%)
		A2M	770..866	CDD:278630	30/113 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	954..973		3/18 (17%)
		complement_C3_C4_C5	996..1282	CDD:239226	99/325 (30%)
		A2M_comp	1051..1282	CDD:284982	84/270 (31%)
		A2M_recep	1398..1493	CDD:284981	23/101 (23%)
		NTR_complement_C3	1513..1661	CDD:239638
		Interaction with CFP/properdin. /evidence=ECO:0000269\|PubMed:28264884, ECO:0000269\|PubMed:31507604	1634..1659
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	4	3.870