DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcr and PZP

DIOPT Version :9

Sequence 1:NP_524688.1 Gene:Mcr / 44071 FlyBaseID:FBgn0267488 Length:1760 Species:Drosophila melanogaster
Sequence 2:XP_011519106.1 Gene:PZP / 5858 HGNCID:9750 Length:1500 Species:Homo sapiens


Alignment Length:1700 Identity:383/1700 - (22%)
Similarity:668/1700 - (39%) Gaps:401/1700 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   126 HSREPTYFIVASRMVRPGLIYQVSVSILQAQYPITVHASIACDGVQISG-----------DSKDV 179
            :|.||.|.::...::......:..|.:......:||.||:.      ||           ..||:
Human    24 NSTEPQYMVLVPSLLHTEAPKKGCVLLSHLNETVTVSASLE------SGRENRSLFTDLVAEKDL 82

  Fly   180 KEGIPETLLMRIPPTSVTGSYKLRVEGFYQNVFGGLAFLNETRLDFSQRSMT--------IFVQT 236
            ...:..| |.||..:|......::::|..|              ||.:|:..        :||||
Human    83 FHCVSFT-LPRISASSEVAFLSIQIKGPTQ--------------DFRKRNTVLVLNTQSLVFVQT 132

  Fly   237 DKPLYMQGETVRFRTIPITTELKGFDNPVD-VYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQP 300
            |||:|..|:|||||.:.:....:..:..:. :|:.:|.|:.:.:|.|.:...|...|.:.||.:|
Human   133 DKPMYKPGQTVRFRVVSVDENFRPRNELIPLIYLENPRRNRIAQWQSLKLEAGINQLSFPLSSEP 197

  Fly   301 TFGEWTIRVIAQ---GQQEESHFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVR 362
            ..|.:  ||:.|   |.:.:..|||||:...:|||.|.:|......|..:...|...:|.|.||.
Human   198 IQGSY--RVVVQTESGGRIQHPFTVEEFVLPKFEVKVQVPKIISIMDEKVNITVCGEYTYGKPVP 260

  Fly   363 GNLTIKATIRPIGYFSNQVLN-EKYRLGRSPLEQTN--------LYNERWRYNNPNQNPQVQYNV 418
            |..|: :..|.:    ::||| :|..:.....:|.|        ::.:..:..|...  :::..|
Human   261 GLATV-SLCRKL----SRVLNCDKQEVCEEFSQQLNSNGCITQQVHTKMLQITNTGF--EMKLRV 318

  Fly   419 PGQLPQDGADLS---------QDILYRNQYV-VERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYR 473
            ..::.::|.||.         .:|:.:.::| |:.|                           :|
Human   319 EARIREEGTDLEVTANRISEITNIVSKLKFVKVDSH---------------------------FR 356

  Fly   474 KTLPYLRYFNGTFDFKWPLRELELLV-------PN------LANSEVLITATVGEKFYDEIISGY 525
            :.:|:....              |||       ||      :.::.....||..|:       |.
Human   357 QGIPFFAQV--------------LLVDGKGVPIPNKLFFISVNDANYYSNATTNEQ-------GL 400

  Fly   526 SVARVYNSSLRV--VFLGDSPQVFKPAMPFTTYLAVEYHDGSPIDPNLLRQGLMEVSGFVESRNG 588
            :...:..:|:.|  :|:    :||                  .:.|||.         |..|   
Human   401 AQFSINTTSISVNKLFV----RVF------------------TVHPNLC---------FHYS--- 431

  Fly   589 GRRDWPAQRLPMSQQSDGIWEVKIDIRNDLNLDDRPQARDFLNGVQNMRLQANFVD--------P 645
                |.|                         :|...|:...|.|  ..|..:::.        |
Human   432 ----WVA-------------------------EDHQGAQHTANRV--FSLSGSYIHLEPVAGTLP 465

  Fly   646 RGERIQTELLLVSHYSPRNQHIKVTTSTEKPVVGEYIIFHIRTNFYLEE--FNYLIMSKGVILVN 708
            .|   .|| .:.:||:...|           .:||           |.|  |:||||:||||:.:
Human   466 CG---HTE-TITAHYTLNRQ-----------AMGE-----------LSELSFHYLIMAKGVIVRS 504

  Fly   709 DRETI------TEGIKTIAVVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYIN 767
            ...|:      .:|...::..:.|::||:|.:.::.|...|:||.||..|.:.....|...:..:
Human   505 GTHTLPVESGDMKGSFALSFPVESDVAPIARMFIFAILPDGEVVGDSEKFEIENCLANKVDLSFS 569

  Fly   768 NRKARTGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKI-----ITKMSNF------DE 821
            ..::.......:.:...|.|...|..:|.:...|:...||:.:.:     :..::||      .|
Human   570 PAQSPPASHAHLQVAAAPQSLCALRAVDQSVLLMKPEAELSVSSVYNLLTVKDLTNFPDNVDQQE 634

  Fly   822 QTNGTYKHIWYSHEGNPDELVYFPASSFGVDANRTFEYSGLIVFTDGYVPRRQDTCNRTLGFGEC 886
            :..|.....::.|.|    .:|.|.||...|.....:..||.|||:..: |:..:|:........
Human   635 EEQGHCPRPFFIHNG----AIYVPLSSNEADIYSFLKGMGLKVFTNSKI-RKPKSCSVIPSVSAG 694

  Fly   887 LSGRCYRLEKQCDGLFDCDDGTDEINCHARNDTELLNYRKYRFNR----------VLRHYENVWL 941
            ..|:         |.:....|..|    .....:|..|.....|.          |..::...|:
Human   695 AVGQ---------GYYGAGLGVVE----RPYVPQLGTYNVIPLNNEQSSGPVPETVRSYFPETWI 746

  Fly   942 WKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQ 1006
            |:.|.:...|.....|.|||....|...||.:|...|.|:.:.| .....||||:.:.||.:..:
Human   747 WELVAVNSSGVAEVGVTVPDTITEWKAGAFCLSEDAGLGISSTA-SLRAFQPFFVELTMPYSVIR 810

  Fly  1007 GEQVGIRVTVFNYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSYNPRTSFGEHQFFIYLEAQGTT 1071
            ||...::.||.||:...|...|.|..||.:          :.|.|.:   ||..:.|....:.| 
Human   811 GEVFTLKATVLNYLPKCIRVSVQLKASPAF----------LASQNTK---GEESYCICGNERQT- 861

  Fly  1072 VVYVPVVPQRLGNVDVT----------------LHVATLLGTDTITRTLHVESDGLPQYRHQSVL 1120
             :...|.|:.||||:.:                :.|..:...||:.:||.||::|:.|.:..|.:
Human   862 -LSWTVTPKTLGNVNFSVSAEAMQSLELCGNEVVEVPEIKRKDTVIKTLLVEAEGIEQEKTFSSM 925

  Fly  1121 LDLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNASSLLSLP 1185
            ...|. |.|.|.:.:      ::|..|    |..|.:|..||:||::|....    |..:||.:|
Human   926 TCASG-ANVSEQLSL------KLPSNV----VKESARASFSVLGDILGSAMQ----NIQNLLQMP 975

  Fly  1186 MESGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNN 1250
            ...||||...||.|:|.:.|:....|..:.::..|..::..||||||::...|||:|.|...:..
Human   976 YGCGEQNMVLFAPNIYVLNYLNETQQLTQEIKAKAVGYLITGYQRQLNYKHQDGSYSTFGERYGR 1040

  Fly  1251 SDSSVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPDRKMNRT 1315
            :..:.|||::.|:.|.:|     .::|:||...|.:::.||.|.|...|.|.....|.:..: :.
Human  1041 NQGNTWLTAFVLKTFAQA-----RSYIFIDEAHITQSLTWLSQMQKDNGCFRSSGSLLNNAI-KG 1099

  Fly  1316 NFDKNITLTSHVLITLATVK-DISGTLGSRVALATQRALAYIERNMDFLR---HQAQPFDVAITA 1376
            ..:...||:::|.|.|..:. .::..:       .:.||..:|...:..:   |.:..:..|:.|
Human  1100 GVEDEATLSAYVTIALLEIPLPVTNPI-------VRNALFCLESAWNVAKEGTHGSHVYTKALLA 1157

  Fly  1377 YALQLCNSPIA-EEVFAILRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIE 1440
            ||..|...... .|:...|.::|....:.::|   |.||.|:......:.:      :..|..:|
Human  1158 YAFSLLGKQNQNREILNSLDKEAVKEDNLVHW---ERPQRPKAPVGHLYQT------QAPSAEVE 1213

  Fly  1441 TTAYALLVYVARREFFVDP------------IVRWLNSQRLNDGGWASTQDTSAALKALVEY--T 1491
            .|:|.||.|:.     ..|            ||:|:..|:...||::|||||..||.||..|  .
Human  1214 MTSYVLLAYLT-----AQPAPTSGDLTSATNIVKWIMKQQNAQGGFSSTQDTVVALHALSRYGAA 1273

  Fly  1492 VRSRLREVSSLTVEIEASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHV 1556
            ..:|..:.:.:||:   .||...| ...:|:.||..||.|.:|:..|...:...|.....||..:
Human  1274 TFTRTEKTAQVTVQ---DSQTFST-NFQVDNNNLLLLQQISLPELPGEYVITVTGERCVYLQTSM 1334

  Fly  1557 QYNVDIEKFQTKPPVPAFGLHTKAIFH--GRNQSHISYVACQNWINQNESERSGMAVLDVAIPTG 1619
            :||:..|| :..|    |.|..:.:..  ..:::|.|:..............|.|.::||.:.:|
Human  1335 KYNILPEK-EDSP----FALKVQTVPQTCDGHKAHTSFQISLTISYTGNRPASNMVIVDVKMVSG 1394

  Fly  1620 YWIQQQKLDTYVLSNRVRNLRRARYLER------KIVFYFDYLDHEDICVNFTIERWYPVANMSR 1678
            :         ..|...|:.|.|:..:.|      .::.|.:.:.::.:..:|.:.:..||.::..
Human  1395 F---------IPLKPTVKMLERSSSVSRTEVSNNHVLIYVEQVTNQTLSFSFMVLQDIPVGDLKP 1450

  Fly  1679 YLPVRIYDYY 1688
            .: |::||||
Human  1451 AI-VKVYDYY 1459

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
McrNP_524688.1 A2M_N 232..332 CDD:280081 35/103 (34%)
A2M_N_2 669..799 CDD:285005 31/137 (23%)
LDLa 886..913 CDD:238060 4/26 (15%)
A2M 940..1030 CDD:278630 29/89 (33%)
ISOPREN_C2_like 1177..1490 CDD:298658 88/329 (27%)
A2M_comp 1226..1492 CDD:284982 74/284 (26%)
A2M_recep 1607..1695 CDD:284981 18/87 (21%)
PZPXP_011519106.1 A2M_N 128..220 CDD:280081 30/93 (32%)
A2M_N_2 457..602 CDD:285005 38/170 (22%)
A2M 744..834 CDD:278630 29/90 (32%)
SVA <796..891 CDD:283081 29/109 (27%)
A2M_2 964..1270 CDD:239227 88/336 (26%)
A2M_comp 1016..1272 CDD:284982 74/282 (26%)
A2M_recep 1382..1464 CDD:284981 18/87 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

Return to query results.
Submit another query.