DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcr and c3b.2

DIOPT Version :9

Sequence 1:NP_524688.1 Gene:Mcr / 44071 FlyBaseID:FBgn0267488 Length:1760 Species:Drosophila melanogaster
Sequence 2:XP_009294666.1 Gene:c3b.2 / 566347 ZFINID:ZDB-GENE-030131-3063 Length:1769 Species:Danio rerio


Alignment Length:1854 Identity:387/1854 - (20%)
Similarity:681/1854 - (36%) Gaps:545/1854 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   122 LESLHSREPTYFIVASRMVRPG-----------LIYQVSVSILQAQYPITVHASIACDGVQISGD 175
            :|.:....|::.::|...:|||           |...|.|:::...|| ....:::...|.::.|
Zfish    37 IEPVKDPSPSFSLLAPAKIRPGTKQNILVEGHNLAKVVKVTVVVYDYP-NSQTALSRGSVSLNSD 100

  Fly   176 SKDVKEGIPETLLMRIPPTSVTGSYK---LRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTD 237
            :   ...:.:||  .|.|..:....|   :::...:.|::..     |..:..|.||..||:|||
Zfish   101 N---NYSVLQTL--EINPNLLLPDGKKKYVKLVAQFSNIYRA-----EKVMAVSFRSGHIFIQTD 155

  Fly   238 KPLYMQGETVRFRTIPITTELKGFDNPVDVYMLDPNRHILKRWLSRQSNLGSVSLE-YKLSDQPT 301
            ||:|..|:.||||......|.:..:..:.:.:.:|: .|....:.|...:..|..: :.||....
Zfish   156 KPIYNPGDKVRFRAFVSDLEFRSSERTISLEIQNPD-GIAVHGIGRVKAIDGVFSDIFSLSTVVK 219

  Fly   302 FGEWTIRVIA---QGQQE--ESHFTVEEYYQTRFEVNVTMPAYFFTTD-PFIYGRVMANFTSGLP 360
            .|.|  :|:|   ||::.  ...|.|::|....|.|.:|......:.| ..:...:.|.:..|..
Zfish   220 EGRW--KVVAKFDQGKENVFSREFEVKKYVLPAFNVTLTPKTSHLSLDAEKLEVEITARYLYGAQ 282

  Fly   361 VRGNLTIKATIRPIGY--FSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLP 423
            |:|          :.|  |..::..||.||  :.::|.:                          
Zfish   283 VKG----------VAYVLFGIEINGEKKRL--TSMKQID-------------------------- 309

  Fly   424 QDGADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDF 488
                ||:...:......::|.|            |:                             
Zfish   310 ----DLNGGSVSLTMEEIKRAY------------PD----------------------------- 329

  Fly   489 KWPLRELELLVPNLANSEVLITATVGEKFYDEIISGYSVARVYNSSLRVV------FLGDSPQVF 547
                      :.:|..|.|.:.|:|...      ||..:.....|.:::|      .:.|:|:.:
Zfish   330 ----------INSLLGSTVYVKASVLTS------SGSDLVEAEKSGIKIVNSPYMLTIKDTPKYY 378

  Fly   548 KPAMPFTTYLAVEYHDGSPIDPNL------LRQGLMEVSGFVESRNGGRRDWPAQRLPMSQQSDG 606
            ||.:|....:.|..||||| .||:      |::.:...||.:..    ..:.|.:|:|..     
Zfish   379 KPGLPLAMTVIVSNHDGSP-TPNIPVKVTFLKRPISVHSGTINI----HINMPKKRIPYG----- 433

  Fly   607 IWEVKIDIRNDLNLDDRPQARDFLNGVQNMRLQANFVDP--RGERIQTELLLVSHYSPRNQH--- 666
                                       .:..|:...|||  :.|:...:.:.|..||....|   
Zfish   434 ---------------------------NSQMLKVETVDPSLKPEQQAIQEVYVKPYSTFRSHGNY 471

  Fly   667 IKVTTSTEKPVVGEYII--FHIRTNF-----YLEEFNYLIMSKGVILVNDRETIT-EGIKTIAVV 723
            :.|:....:.|||..|.  .:|:::.     .:|...|::::||.|:...|..:. :.:.::.::
Zfish   472 LHVSVGASRVVVGGSISVQVYIKSSLPNHRALVEHLTYIVLNKGKIIQAGRVNVKGQDVTSVHLL 536

  Fly   724 LSSEMAPVATIVVWKI---NQQGQVVADSL-------------TFPVNGISRNNFTVYINNRKAR 772
            ::|||.|....|.:.:   ..:.:|||||:             ..||:|...::::         
Zfish   537 ITSEMLPAFRFVAYYVLPWQHRAEVVADSVFVDVEDRCVGSLNVGPVDGEIVSSYS--------- 592

  Fly   773 TGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQ-TNGTYKHIWYSHEG 836
            .|...:..:.|:.|:.|.|..:|:|.:.: :.|.||..|:...:...|.. |.|          |
Zfish   593 PGSSFKFQVKGDVGAKVSLVAVDNAIFLL-SKNRLTQKKVWEVVDQADMGCTAG----------G 646

  Fly   837 NPDELVYFPASSFGVDANRTFEYSGLIVFTDGYVPRRQDTCNRT-----------------LGFG 884
            ..|.:..|.      ||...|..|     |.|....::|..::|                 ..:.
Zfish   647 GKDNMGVFS------DAGLMFHSS-----TGGSTDSKEDCSSKTKRRRRSAAKLQLRDQLEKAYS 700

  Fly   885 ECLSGRCYRLEKQCDGLFDCDDGTDEI----NCHARN---------------------------- 917
            :.|..||            |.||..||    :|:.|:                            
Zfish   701 DELLQRC------------CVDGMKEIPMPYSCYRRSLYITEDWSCVLAFLRCCAEYRGEELGVI 753

  Fly   918 ---------------DTEL-----LNYRKY----------------------RFNRV-------- 932
                           .|.|     |.|.:|                      |.|.|        
Zfish   754 TRPPTTTAPPTTAPPTTSLPTLFDLPYLEYDYMEEKVILRARMIEPMPKLYARANDVGVRQDSYR 818

  Fly   933 -------------------LRHYENV---------WLWKDVNI----GPHGRYIFNVE--VPDRP 963
                               |...|::         |||.|:.:    ...|..:|.|:  :||..
Zfish   819 EVVVEEEEEEAASVFEEDDLSDLEDIYVRSKFFESWLWTDIRLPSTAKSDGLAVFPVDTVLPDSI 883

  Fly   964 AYWMVSAFSVSPSKGFGMMNKALEY-VGV-QPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEA 1026
            ..|...|.|.||.||..:   |..| |.| :||||::.:|.:..:.|||.|:..:.||..:.:|.
Zfish   884 TQWGFLAVSASPEKGVCV---AEPYNVRVWKPFFIDLRLPHSVSRNEQVEIKAVIHNYKNSTLEV 945

  Fly  1027 IVVLHDSPDYKFVHVEEDGIVRSYNPRTSFGEHQFFIYLEAQGTTVVYVPVVPQRLGN--VDVTL 1089
            :|:|..:.|...|         :|.     |:|:..:.:.|..:.::...::|.:.|.  :.||.
Zfish   946 MVILEKTEDMCSV---------AYT-----GQHRQQVTVAAGSSKLITYTIIPLKTGELPLQVTA 996

  Fly  1090 HVATLLGTDTITRTLHVESDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQ---TPEIPYQVDRYF 1151
            ..|:.:|.|.:.:.|.|..:|:...:.:|.:|:.|.:........:.|.:   ...:|..|...|
Zfish   997 VAASFMGQDAVKKNLRVVVEGIQTLKVRSFVLNPSEKGGSAGQQLIQVKKLQLDAVVPKSVPETF 1061

  Fly  1152 VYGSNKARISVVGDVVGPIFPT--MPVNASSLLSLPMESGEQNAFSFAANLYTIMYMRLINQRNK 1214
            |        :|.||::......  ...:.::|:.:|....|||.......|....|:    .|:.
Zfish  1062 V--------NVRGDLLADSIDNSIKEDSLAALIRMPGGCVEQNLARITLPLIAAHYL----DRSA 1114

  Fly  1215 TLE-------KNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQEASFYE 1272
            ..|       :.|..::..||:.||::.:.|.|:    ..:.|..:|.|:|:|.::||..|    
Zfish  1115 DWEIVGISRREEAIKYIQKGYENQLNYKKSDDSY----PPYANEGTSTWITAYVVKVFSMA---- 1171

  Fly  1273 WENFIWIDATIIEKN----MRWLLQH-QTPQGSFFEVTWLPDRKMN--RTNFDKNITLTSHVLIT 1330
             .:||    |:.||:    :.:||:: |...|:|.|...:.|..|.  ....:...:||:.|||.
Zfish  1172 -HSFI----TVNEKHLCGPLLYLLKNKQGYDGTFQEDNPVYDTSMTGAMRGSEYKASLTAFVLIA 1231

  Fly  1331 LATVKDISGTLGSRVAL--ATQRALAYIERNMDFLRHQAQPFDVAITAYALQLCNSPIAEEVFAI 1393
            ||..:|........|.:  .:::|..|:..:...|   .:|:..||..|||.:.|:..   |.::
Zfish  1232 LAEAQDKVTCQDQEVNIRDKSRQAAGYLTEHFSRL---TRPYTAAIACYALAVSNNAC---VKSM 1290

  Fly  1394 LRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYV-------A 1451
            |.:.|..  |..:|.:          .|..:|:|            |.|.||||..:       |
Zfish  1291 LLKFASP--DHSHWPD----------SNNYFFTL------------EATGYALLALIKSGHMEEA 1331

  Fly  1452 RREFFVDPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQGGKTQ 1516
            ...|      ||||..|...||:.|||.|...|:||.||.|:.......:|.|::   |..|::.
Zfish  1332 EAPF------RWLNEHRGIGGGYGSTQSTMVVLQALSEYLVKRPPPSDLNLLVQL---SVPGRSD 1387

  Fly  1517 TLYIDDTNLAKL-QSIEIP-DAWGTIKVQAKGAGYAILQMHVQYN--VDIEKFQTKPPVPAFGLH 1577
            ..:..:.|||.: :|..:| |.  ...|.|.|.|..:|::...|:  .|:.:..|     ..|..
Zfish  1388 VRWTFNPNLAYVARSSRVPLDQ--EFSVAASGNGKGVLEVVTVYHQLPDVYENST-----CNGFQ 1445

  Fly  1578 TKAIFHGRNQSHISYVACQNWINQN----ESERSGMAVLDVAIPTGYWIQQQKLDTYVLSNRVRN 1638
            ........|:...|.|.....:|.|    |..:..|.:||:.:|||:  :.:..|..:|:|.|  
Zfish  1446 LDVSIAETNEKTSSDVEKSFRLNVNVRALEERQVRMVILDIGLPTGF--EPENSDLELLTNSV-- 1506

  Fly  1639 LRRARYLER------------KIVFYFDYLDHEDICVNFTIERWYPVANMSRYLPVRIYDYYAPE 1691
               .||:..            .|:..|...:.|...::|.:.:.:.| .:.:...|::|.||..:
Zfish  1507 ---DRYINNFQVVDNLSDRGSLIIHLFKVSNKEAEIISFRLNQRFKV-GLLQPSTVKVYQYYNKD 1567

  Fly  1692 RFNESIFDALP---TYLLNICE--VCGSSQCPYC 1720
            : :.|.|.:.|   ..|..|||  ||..||...|
Zfish  1568 K-SCSRFYSPPEDKQQLDQICEGDVCRCSQGDCC 1600

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
McrNP_524688.1 A2M_N 232..332 CDD:280081 30/105 (29%)
A2M_N_2 669..799 CDD:285005 32/153 (21%)
LDLa 886..913 CDD:238060 8/30 (27%)
A2M 940..1030 CDD:278630 33/97 (34%)
ISOPREN_C2_like 1177..1490 CDD:298658 86/335 (26%)
A2M_comp 1226..1492 CDD:284982 78/281 (28%)
A2M_recep 1607..1695 CDD:284981 21/99 (21%)
c3b.2XP_009294666.1 A2M_N 150..243 CDD:280081 27/95 (28%)
A2M_N_2 489..620 CDD:285005 27/139 (19%)
ANATO 692..748 CDD:237984 10/67 (15%)
A2M 853..949 CDD:278630 33/98 (34%)
TRAPPC10 <940..>992 CDD:289361 11/65 (17%)
complement_C3_C4_C5 1080..1364 CDD:239226 86/336 (26%)
A2M_comp 1133..1364 CDD:284982 76/279 (27%)
A2M_recep 1481..1574 CDD:284981 22/101 (22%)
NTR_like 1594..1767 CDD:295338 3/7 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
43.870

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