DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcr and c4

DIOPT Version :9

Sequence 1:NP_524688.1 Gene:Mcr / 44071 FlyBaseID:FBgn0267488 Length:1760 Species:Drosophila melanogaster
Sequence 2:XP_005157429.1 Gene:c4 / 566261 ZFINID:ZDB-GENE-030131-5697 Length:1700 Species:Danio rerio


Alignment Length:1884 Identity:385/1884 - (20%)
Similarity:697/1884 - (36%) Gaps:551/1884 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   127 SREPTYFIVASRMVRPGLIYQVSVSILQAQYPITVHASIACDGVQISGDSKDV-------KEGIP 184
            :::||..|||..::..|:...|                    |||:.|.:|::       |:...
Zfish    17 AQKPTCLIVAPNVIHLGVEETV--------------------GVQLHGATKEIRMKLYFEKQKES 61

  Fly   185 ETLL-MRIPPTSVTGSY----KLRVEG-FY----QNVFGGLAFLN----------ETRLDFSQRS 229
            |.|. :|....:...:|    ||:|:. .|    :|.:..||.::          :..:..|.:.
Zfish    62 EILSEIRSIILNENNNYQAVVKLKVDATMYGDVEKNSYVQLAAISNDIFEKQDARKANIYLSTKR 126

  Fly   230 MTIFVQTDKPLYMQGETVRFR-------TIPITTEL-------KGFDNPVDVYMLDPNR-HILKR 279
            ..||||||||:|..||.|::|       .:||..||       ||    :.||    || .|:.:
Zfish   127 GYIFVQTDKPIYNPGENVKYRIFILDNYMLPIQDELHVQITNSKG----LIVY----NRVLIINQ 183

  Fly   280 WLSRQSNLGSVSLEYKLSDQPTFGEWTIRVIAQGQQEES----HFTVEEYYQTRFEVNV--TMPA 338
            .|.:...:..|.         ..|:|.| :.:..:..||    .|.|:||....|||.:  :.|.
Zfish   184 ILDKTITIPEVE---------QTGKWKI-ITSFHKFPESTTTVEFEVKEYVLPTFEVKIEASQPY 238

  Fly   339 YFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERW 403
            :...::.|.: .:.|.:|.|..|.|          |.|....:::||:         ..:|    
Zfish   239 HILMSESFPF-NISARYTYGKGVNG----------IAYVRFGLVDEKH---------NKIY---- 279

  Fly   404 RYNNPNQNPQVQYNVPGQLPQDG----ADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSS 464
               .|....|:..       :||    |.|::|:...:|.:.:                      
Zfish   280 ---LPGTEKQITV-------EDGTAGTAVLTKDLKTASQNITQ---------------------- 312

  Fly   465 YEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEVLITATVGEKFYDEIISGYSVAR 529
                           .|..|.:                    :.|..:|.:|     .|| .:..
Zfish   313 ---------------GYIEGYY--------------------IYIAVSVLDK-----ASG-MLEE 336

  Fly   530 VYNSSLRVVFLGDSPQV---------FKPAMPFTTYLAVEYHDGSPIDPNLLRQGLMEVSGFVES 585
            ..:||:::|   .||.|         |.|...|:......|.||:.. |||.....:.:.|..|.
Zfish   337 AESSSVKIV---TSPYVVDLSKTKTYFTPGGVFSVLATATYPDGNRA-PNLKFTATITIDGSSEQ 397

  Fly   586 --RNGGRRDW---------------PAQRLPMSQQSDGIWEVKIDIRND---------------L 618
              :|   ..|               .|:.|.::..::|  ..::.||:|               |
Zfish   398 ILQN---ESWGNEMGDVAMSFQIPPQAKNLAITVFAEG--GDQVVIRSDNKMTASAITAEEQSYL 457

  Fly   619 NLDDRPQARDFLNGVQNMRLQANFVDPRGERIQTELLLVSHYSPRNQHIKVTTSTEKPVVGEYII 683
            :|:...|   ||...::::.:...:.|.|                         ..||       
Zfish   458 SLEVEKQ---FLQAGEDLKARLRDITPEG-------------------------AAKP------- 487

  Fly   684 FHIRTNFYLEEFNYLIMSKGVILVNDRETITEGIKTIAVVLSSEMAPVATIVVWKIN---QQGQV 745
                |.||     :::.|||.|:...|...| ...|:.|.::.:|.|...:|.:...   .:..|
Zfish   488 ----TFFY-----FMVWSKGQIVQMGRVPRT-AFTTVNVKVNVDMVPSFRLVAYYFTGSASKESV 542

  Fly   746 VADSLTFPVNGISRNNFTVYINN-RKARTGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTY 809
            ||||:...|..:.:..  :.||. .:.:...:.||.:...|.:.|.|..:|||.|.:.. |:|:.
Zfish   543 VADSVWVDVKDVCKGK--IEINPLAEIKPATQFEVTVETNPKTKVALVAVDSAVYILNK-NKLSL 604

  Fly   810 AKIITKMSNFD--------EQTNGTYKHIWYS--------------HEGN----------PDELV 842
            .|:...|:::|        |.::...:....:              |:.|          ||.:.
Zfish   605 QKMFDYMNSYDLACSVGGGEDSSAVLQRAGLTFICNCALKTPTALEHKCNKKTTNRVRRAPDYVA 669

  Fly   843 YFPASSFGVDANRTFEYSGLIVFTDGYVPRRQDTCNRTLGFGECLSGRCYRLE--KQCDGLF-DC 904
            .:.|      ...:|:........||..|.:..|        .|:. |..|::  :.|...| :|
Zfish   670 KYNA------VVNSFKNQDRKCCLDGVRPSKMQT--------SCVD-RLKRVKESESCRKAFKEC 719

  Fly   905 DDGTDEINCHARNDTELLNYRKYRFNRVL-----------------RHYENVWLWKDVNIGPHGR 952
            .:..||     |...|....||....||:                 .::...|:|..:.....|.
Zfish   720 CEAADE-----RRKREKFEKRKTSLGRVVGDSFDEIVINEDLIYIRNYFPQSWMWTVIESDNKGL 779

  Fly   953 YIFNVEVPDRPAYWMVSAFSVSPSKGFGMMN-KALEYVGVQPFFINVEMPEACRQGEQVGIRVTV 1016
            ....|..||....|.|.|..:||:|||.:.. |.|..  .:.||::|.:|.:.::.||:.::..|
Zfish   780 IRHEVVAPDSITTWEVQAVGISPTKGFCIAEPKPLTV--FKDFFLSVNLPYSVKRNEQLQVKAVV 842

  Fly  1017 FNYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSYNPRTSFG-EHQFFIYLEAQGTTVVYVPVVPQ 1080
            :||....::.||.|:          :.:|:.      |:.| :.:..:.:.......||..|||.
Zfish   843 YNYKQESLKVIVKLN----------KVEGLC------TAGGNDVKEEVTVSGNSAVTVYFTVVPL 891

  Fly  1081 RLGN--VDVTLHVATLLGTDTITRTLHVESDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQ-TPE 1142
            .:||  :||..:.:.:: .|.:.:.|.||.:|......:...:|.:     |:.:..|::. ..|
Zfish   892 IIGNLHIDVLAYASEII-HDRVEKKLRVEGEGELTSIDREFNIDPN-----LKKIEFNISSPVDE 950

  Fly  1143 IPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVN---ASSLLSLPMESGEQNAFSFAANLYTIM 1204
            :|...|       ::..:...|.|:|...... :|   ...|:.||....||.....:..::.:.
Zfish   951 VPAGSD-------SETSLGFKGGVMGESIDNC-LNLEGIDKLIQLPTGCAEQTMVKMSPAIHAMR 1007

  Fly  1205 YMRLINQ---RNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQ 1266
            |:...||   ........|...:..||...|:..:.|||:..|.    .:.||:|||::..:...
Zfish  1008 YLDATNQWLSLKAERRDEARSMIQTGYNTVLTHKKDDGSYGAFL----RTPSSIWLTAFIAKELT 1068

  Fly  1267 EASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPDRKMNR--TNFDKNITLTSHVLI 1329
            .:     ::.:.::...|::.|.:|:..|...|::.:...|.|:.|..  .....::.||:.|||
Zfish  1069 GS-----QDIVNVNKLYIQEAMSYLISKQKSNGAWDDPNRLFDQGMKGGVEQATDDVPLTAFVLI 1128

  Fly  1330 TL---ATVKDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDVAITAYALQLCNSPIAEEVF 1391
            ::   ..|.|:......|||:  .:|.:|:|..:|.:|   .|:.:|:|||:..|.:...||   
Zfish  1129 SMHHALKVYDLGSDTELRVAM--DKAKSYLEAQLDAVR---SPYSLAVTAYSFSLHDHRSAE--- 1185

  Fly  1392 AILRRQARTIGD-------FMYW---GNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYAL 1446
              .|:..:.:.|       ..:|   |.:..|:.                 :.|:.::|||||||
Zfish  1186 --ARKAQQKLQDIANCDDKMCFWKAKGGRGEPKD-----------------KADARSVETTAYAL 1231

  Fly  1447 LVYV-----ARREFFVDPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEI 1506
            |..:     ::.:.    |..||..||.:.||:.|||||..||:||.:|::::  .:|..|.:.:
Zfish  1232 LTTLIVGDKSKSKL----IANWLTEQRRHGGGFRSTQDTVLALEALTKYSIQN--NDVDDLNLRV 1290

  Fly  1507 EASSQGGKTQTLYIDDTNLAKLQSIEIPDAWG-TIKVQAKGAG-YAILQMH-------------- 1555
            |...:.|:.:.|::...|...|.::::.|... |:.:|..|.| .|::|.:              
Zfish  1291 EMCLENGQKKDLHLTKNNALTLSAVKVRDVGKVTLNIQGTGRGTLAVVQTYRTMKKDESFCDLFH 1355

  Fly  1556 --------VQYNVD---------IEKFQTKPPVPAFGLHTKAIFHGRN------------QSHIS 1591
                    ::|..|         .|.:.|........:.....|..|:            :|.:.
Zfish  1356 LTVTVKGELEYKTDNSQDLLEDYYESYDTSEAQNDEPMSNMQWFDLRSRRKRQISEEPIKESSLI 1420

  Fly  1592 YVACQNWINQNESERSGMAVLDVAIPTGYWIQQQKLDTYVLSNRVRNLRRARYLE------RKIV 1650
            |..|   :...:....||.::|:::.:|.....:.|:..|....       :|::      .|:.
Zfish  1421 YTVC---VGLKKKNSEGMIIVDISLLSGLIPNSKDLEHNVKGTE-------KYIDHYEIHHNKVY 1475

  Fly  1651 FYFDYLDHEDICVNFTIERWYPVANMSRYLPVRIYDYYAPERFNESIFDALPTYLLNICEVCGSS 1715
            .||..:...:.|:.|..::..|:..:.....| |||||:||: ...||...|.....|.::|...
Zfish  1476 LYFAKITETEECLQFGADQAVPMGLVQPASAV-IYDYYSPEK-RCGIFYTAPQKSPMISKLCQGD 1538

  Fly  1716 QCPY----CSIYNMGWRASM-SMSLLFFSVF---------IYLLRSR--------THLVLNMMQ 1757
            .|..    |:...:.:..:| |.|...|:.:         |.:|.||        |.|:.:::|
Zfish  1539 VCTCAEGGCAKLKVTFSKNMESNSRSSFACYDPSVDYVYVIKILSSRSDDVFMYYTTLITDVLQ 1602

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
McrNP_524688.1 A2M_N 232..332 CDD:280081 36/118 (31%)
A2M_N_2 669..799 CDD:285005 32/133 (24%)
LDLa 886..913 CDD:238060 8/29 (28%)
A2M 940..1030 CDD:278630 27/90 (30%)
ISOPREN_C2_like 1177..1490 CDD:298658 83/338 (25%)
A2M_comp 1226..1492 CDD:284982 74/285 (26%)
A2M_recep 1607..1695 CDD:284981 21/93 (23%)
c4XP_005157429.1 A2M_N 128..220 CDD:280081 32/109 (29%)
A2M_N_2 459..595 CDD:285005 38/182 (21%)
ANATO 675..731 CDD:237984 14/69 (20%)
A2M 766..856 CDD:278630 27/91 (30%)
complement_C3_C4_C5 977..1276 CDD:239226 83/338 (25%)
A2M_comp 1032..1278 CDD:284982 74/285 (26%)
A2M_recep 1434..1522 CDD:284981 22/96 (23%)
NTR_complement_C4 1540..1698 CDD:239639 13/63 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
54.880

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