DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcr and c5

DIOPT Version :9

Sequence 1:	NP_524688.1	Gene:	Mcr / 44071	FlyBaseID:	FBgn0267488	Length:	1760	Species:	Drosophila melanogaster
Sequence 2:	XP_001919226.4	Gene:	c5 / 565774	ZFINID:	ZDB-GENE-120510-2	Length:	1704	Species:	Danio rerio

Alignment Length:	1785	Identity:	365/1785 - (20%)
Similarity:	640/1785 - (35%)	Gaps:	447/1785 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   128 REPTYFIVASRMVRPGLIYQVSVSILQAQYPITVHASI-------------------ACDGVQIS 173
            :|..|.|.|.:::|......|.|.:.......|||..:                   |.:..|.|
Zfish    19 QENVYLITAPKVLRLDASETVVVQLFGFDQETTVHLHLKNTLAVGNKEYDYQSLKLNAANNYQAS 83

  Fly   174 GDSKDVKEGIPETLLMRIPPTSVTGSYKLRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTDK 238
            ...:.:.:..|:      ..|||          :.|.:  ..||.:..::..:..:..:|:||||
Zfish    84 ATLRILAKDFPK------EDTSV----------YLQTI--SSAFTDNVKIPVTTVNGFLFIQTDK 130

  Fly   239 PLYMQGETVRFRTIPITTELKGFDNPVDVYMLDPNRHILKRWLSRQSNLGSVSL--EYKLSDQPT 301
            |||...:.|:.|...:..||:.....|.:...|| |.:....:......|:..|  .:|:..:|.
Zfish   131 PLYTPEQEVQVRVYSLNEELRKSARTVTLTFQDP-RGVKVEIIDMTDINGAKPLLPPFKIPLKPI 194

  Fly   302 FGEWTIRVIAQGQQEE----SHFTVEEYYQTRFEVNVTMPAYFFTTDPF--IYGRVMANFTSGLP 360
            :|.|.| |.......|    :.|.|:||......|.:.....:.:.:.|  ...::.|.:..|:|
Zfish   195 YGIWKI-VATYADNFETTATAEFEVKEYVLPSISVQIEPETNYISEENFDTFKLKISAKYVQGMP 258

  Fly   361 VR-GNLTIK--------ATIRPIGYFSNQVLNEKYRLG---RSPL--------------EQTNLY 399
            |: .|:.:|        ..|.|..|.|..:.|.|..:.   ||.|              |.|.||
Zfish   259 VKSANILLKFGYSTPEETVIIPSTYRSYMLYNGKMEVDLDIRSALSSKPDAPQFLNAMKENTFLY 323

  Fly   400 NERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSS 464
                              |...|.:....|||:       .|..|.:| .|.||.:        |
Zfish   324 ------------------VEVLLQESTGGLSQE-------AVLSHVKF-VETPFTL--------S 354

  Fly   465 YEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEVLITATVGEKFYDEIISGYSVA- 528
            ..|.....:..|||.                         ..||:...:||...|..::..:.|
Zfish   355 IIATPPFIKPGLPYA-------------------------MRVLVKDPLGEPVKDVSVTMRATAT 394

  Fly   529 RVYNSSLRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRRDW 593
            .|.|.|..:.|||....|..|:
Zfish   395 TVDNLSDNLKFLGHQDSVTVPS------------------------------------------- 416

  Fly   594 PAQRLPMSQQSDGIWEVKIDIRNDLNLDDRPQARDFLNGVQNMRLQANFVDPRGERIQTELLLVS 658
                     ..||:.....:|..:               |:|........|....:....|...|
Zfish   417 ---------SKDGVAYFTCNIPAN---------------VKNAEFTFETEDASWSQGPLTLKAES 457

  Fly   659 HYSPRNQHIKVTTSTEKPV--VGEY----IIFHIRTNFYLEEFNYLIMSKGVILVNDR-ETITEG 716
            :.|..::::.:....|..|  ||:|    ::|..|....|:.|:|.|:|||.::..|. :.::|.
Zfish   458 YVSVNHRYLYIDLPPESSVFEVGQYVDISVVFSYRDYLSLDTFSYQIISKGKVVKYDTVKRVSEK 522

  Fly   717 IKTIAVVLSSEMAPVATIVVWKI---NQQGQVVADSLTFPVNGISRNNFTVYINNRKA----RTG 774
            .:::.:.::.:|.|.|.::|:.:   .::.::||||....|......|..:.::..|.    :..
Zfish   523 SQSLNIKITPDMVPSARLLVYYVLYGEEKAELVADSTWIDVKAKCVKNLNLELSTLKLQDDYKPK 587

  Fly   775 EKVEVAIF----GEPGSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQTNGTYKHIWYSHE 835
            :|:|:.:.    ||  |.|..|.:|:|.:.::...:....||:              :|:..|..
Zfish   588 DKLEIKVSSRSKGE--SLVAFSAVDTALFNLRTNKKDPLKKIL--------------QHVEKSDL 636

  Fly   836 G--------NPDELVYFPASSFGVDANRTFEYSGLIVFT--------------DGYVPRR----- 873
            |        |.|                .|:.:||:..|              |...|:|
Zfish   637 GCGKGGGKNNAD----------------VFDRAGLMFITNANAKASSAGGTCSDTLRPKRSVDLK 685

  Fly   874 ---QDTCNRTLGFGE-CLSG-------------------------RCYRLEKQCDGLFD--CDDG 907
               :|...:...|.| ||||                         |.|..||.|...|:  |...
Zfish   686 KKFEDKAQKYGAFREYCLSGTRSSPTLETCKDRANRVTLPNKKTRRDYEKEKYCRLAFEQCCVFA 750

  Fly   908 TDEINCHARN------------DTELLNYRKYRFNRVLRHYENVWLWKDVNIGPHGRYIFNVEVP 960
            .|....:|.|            |..|...|.|        :...|||:: ::...|....:..:|
Zfish   751 KDLRKENAENIILSRAAIDFLMDAPLSQVRSY--------FPESWLWEE-HLSKSGSVSISKTLP 806

  Fly   961 DRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITPIE 1025
            |....|.:.|..|. ::|..:.:|.:..  .|..:::|.:|.:..:|||:.::.:|:|...:.|:
Zfish   807 DSITTWELKAVGVF-NEGICVSDKRIPV--SQDIWVDVPLPYSMVRGEQILLKGSVYNQRSSGIK 868

  Fly  1026 AIVVLHDSPDYKFVHVEEDGIVRSYNPRTSFGEHQFFIYLEAQGTTVVYVP--VVPQRLGNVDVT 1088
            ..|.|..|......|..:.|.....|..:.          :..|.:|..|.  ::....|...:|
Zfish   869 FTVTLTASSAVCVFHGAQQGKPDKTNENSG----------QVAGGSVAMVSFYIMALEAGTHTLT 923

  Fly  1089 LHVATLLGTDTITRTLHVESDGLPQYRHQSVLLDLSNRAY-----VLEYMHVNVTQTPEIP-YQV 1147
            ..:.|...|:::.:.|.|..:|:....:....:| .|..:     .||:.  ||.....:| ..|
Zfish   924 FTLTTDWITESVVKKLRVVPEGIRMEEYIGKRID-PNGVFGTPMRKLEFK--NVIPPKIVPKSSV 985

  Fly  1148 DRYFVYGSNKARISVVGDVVGPIFPTM--PVNASSLLSLPMESGEQNAFSFAANLYTIMYM---- 1206
            ||.         |:|.|:|:|.|...:  |.....|.:||..|.|....|.....|...|:
Zfish   986 DRI---------ITVNGEVLGDILSILNNPEGIKMLTNLPRGSAELELMSLLPVYYVYHYLDKTE 1041

  Fly  1207 --RLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDG-SFSLFRSDWNNSDS--SVWLTSYCLRVFQ 1266
              .::.:.....||.....|..|....:||...:| :||:    |...|.  |.|:|:..::...
Zfish  1042 KWNILGKEAAASEKELKRKMQAGITSIMSFQLKNGEAFSM----WAQKDKTPSTWVTALIIKTLS 1102

  Fly  1267 EASFYEWENFIWIDATIIEKNMRWLLQH-QTPQGSFFEVTWLPDRKMNRTNF---DKNITLTSHV 1327
            :.     ..::::|..::...:.||::: |...|||.|:......|:.....   :|::.|||:|
Zfish  1103 DI-----HEYVYVDTDVLANAIHWLIKNCQNEDGSFSELAKTNPHKLMGAGVGVTEKSVYLTSYV 1162

  Fly  1328 LITLATVKDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDV-AITAYALQLC--NSPIAEE 1389
            :|.:.....|..........|..|.:.|:........|:.:...| ||.:||:.:.  :...|..
Zfish  1163 MIGIKNALKIPNLKLQVFKDALDRGMQYLISRFRKSSHKIESLYVRAIASYAMTVADIDDGTAVN 1227

  Fly  1390 VFAILRRQARTIGD---FMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVA 1451
            |:..::::|:..|:   ..:|...:....|.|            |....:.::|||.|.||..:.
Zfish  1228 VYENIKKKAKIDGNPPRVCFWQESDTNIDPLK------------PSSVTAKSVETTVYVLLNTLT 1280

  Fly  1452 RREF-FVDPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQGGKT 1515
            |.|. :..||:.||...:...||..|||||...|:||..|::::|...: ::.|:||..::|.:.
Zfish  1281 RGETEYAKPILNWLTQDQRYGGGVYSTQDTILTLEALTMYSIKAREANL-NMVVDIEYKTRGERI 1344

  Fly  1516 QTLYIDDTN-LAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNVDIEK-----FQTKPPVPAF 1574
            ..:.:.... :||  .||:......|...|...|.:.:::...|.|..|.     |.|...:
Zfish  1345 SRIQLTQQKPVAK--PIEVTQNDDVIVKTAMSTGVSFVKLKTVYYVMTESNKSCLFDTTIDI--- 1404

  Fly  1575 GLHTKAIFHGRNQSHIS-------YVACQNW---INQNESERSGMAVLDVAIPTGYWIQQQKLDT 1629
                    |..:|:...       .|||..:   .|..|:| |.:.|:::.:|||.....:.||.
Zfish  1405 --------HDSDQNSDDPMLLSQRIVACAKFKPPENSLETE-SALTVMEINLPTGVTPVLEDLDE 1460

  Fly  1630 YV--LSNRVRNLRRARYLERKIVFYFDYLDHEDI-CVNFTIERWYPVANMSRYLPVRIYDYYAPE 1691
            |.  |.:|:.|.   ..:..|:|...|.:..::. ||.|.|...:. ..|::.....:|:|.||.
Zfish  1461 YQNGLESRISNY---EVIGDKVVLQIDSIPSDNFYCVGFRILEEFE-TGMTKASEFTVYEYQAPA 1521

  Fly  1692 RFNESIFDALPTYLLNICE----VCGSSQC 1717
            .....::......||.:||    .|.:::|
Zfish  1522 FKCTKLYQKQTRKLLRLCEEDHCQCMAAEC 1551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	A2M_N	232..332	CDD:280081	29/105 (28%)
		A2M_N_2	669..799	CDD:285005	36/147 (24%)
		LDLa	886..913	CDD:238060	12/53 (23%)
		A2M	940..1030	CDD:278630	21/89 (24%)
		ISOPREN_C2_like	1177..1490	CDD:298658	77/332 (23%)
		A2M_comp	1226..1492	CDD:284982	67/279 (24%)
		A2M_recep	1607..1695	CDD:284981	23/90 (26%)
c5	XP_001919226.4	A2M_N	124..218	CDD:280081	26/95 (27%)
		A2M_N_2	472..615	CDD:285005	36/144 (25%)
		ANATO	687..756	CDD:237984	15/68 (22%)
		A2M	786..873	CDD:278630	21/90 (23%)
		ISOPREN_C2_like	1005..1320	CDD:298658	78/335 (23%)
		A2M_comp	1064..1322	CDD:284982	67/278 (24%)
		A2M_recep	1438..1528	CDD:284981	23/93 (25%)
		NTR_like	1546..1698	CDD:295338	2/6 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	5	4.880