DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcr and c3a.3

DIOPT Version :9

Sequence 1:NP_524688.1 Gene:Mcr / 44071 FlyBaseID:FBgn0267488 Length:1760 Species:Drosophila melanogaster
Sequence 2:NP_001032313.2 Gene:c3a.3 / 565074 ZFINID:ZDB-GENE-990415-37 Length:1651 Species:Danio rerio


Alignment Length:1787 Identity:389/1787 - (21%)
Similarity:690/1787 - (38%) Gaps:464/1787 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   117 IKATFLES-------LHSREPTYFIVASRMVRPGLIYQVSVSILQAQ-Y---PITVHASI----- 165
            :|..||.:       |...:|.|.:.|..::|.|....|.|   :|| |   |:.|..|:     
Zfish     3 VKLLFLSAVLLSSALLTLCDPLYVLSAPNLLRVGSSENVFV---EAQDYSGGPLNVRISVKNFPA 64

  Fly   166 ------------------ACDGVQISGD----SKDVKE-------GIPETLLMRIPPTSVTGSYK 201
                              :...:||.||    |.|.|:       ..|...|.::...|....| 
Zfish    65 KNVEMMQKTVTLTGAKYQSLTDIQIPGDRNYFSDDEKKQYVYLQAHFPSVTLEKVVMVSFQSGY- 128

  Fly   202 LRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTDKPLYMQGETVRFRTIPITTELKGFDNP-V 265
                                          :|||||||:|..|..|.:|...:|..||.|..| :
Zfish   129 ------------------------------LFVQTDKPIYTPGSNVHYRIFSMTPNLKPFSKPGI 163

  Fly   266 DVYMLDPNRHILKRWLSRQSNL-----GSVSLEYKLSDQPTFGEWTIRVIAQGQQEESHFT---- 321
            .|.:.:|      :.::..|:.     |..|..|.:.:..:.|.|.: |.......:..||    
Zfish   164 TVDITNP------QGITVASDTIFAEKGVKSSIYNIPEVTSLGMWKV-VTRYANTPQKTFTAEFE 221

  Fly   322 VEEYYQTRFEVNV-TMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNEK 385
            |:||....|||.: |..::::..|    .:...|....|.|.                   :..|
Zfish   222 VKEYVLPTFEVKLKTSKSFYYVGD----SKPKNNEDDSLTVD-------------------MEAK 263

  Fly   386 YRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRNQYVVERHYQFDEE 450
            |..|:.                                .||          |.:||         
Zfish   264 YLFGKK--------------------------------MDG----------NAFVV--------- 277

  Fly   451 WPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLREL--ELLVPNLANSEVLITATV 513
              |.|.....:.|..        .:|..::.|||.     ...||  |::.....|    |...|
Zfish   278 --FGVMDGAMKTSIV--------NSLQKVQVFNGV-----GTAELTREMITKTFKN----IKDLV 323

  Fly   514 GEKFYDEI----ISGYSVARVYNSSLRVVFLGDSP---------QVFKPAMPFTTYLAVEYHDGS 565
            |:..|..:    .||..:.......:::|   .||         |.|||.||....:.|...|.:
Zfish   324 GKSIYVSVNLLTESGSEMVEAEKRGIQIV---TSPYTIHYKRTSQFFKPGMPLGVSVYVTNPDET 385

  Fly   566 PIDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLPMSQQSDGIWEVKIDIRNDLNLDDRPQARDFL 630
            |.:.       :||...|:...|         :....:::||.:|.::.:               
Zfish   386 PAED-------VEVEVLVDGVGG---------VNSKTKANGIAKVTVNTK--------------- 419

  Fly   631 NGVQNMRLQANFVDPR--GERIQTELLLVSHY-----SPRNQHIKVTTSTEKPVVGEYIIFHIRT 688
            .||..:::.|...||.  .|:...:.::...|     |....||.:.::..:  :|:.:..::.|
Zfish   420 AGVSTLKITATTRDPELANEQQADKTMIAQAYKTNLGSKNYLHINIESAEFE--IGDQMTVYLNT 482

  Fly   689 ----NFYLEEFNYLIMSKGVILVNDR-----ETITEGIKTIAVVLSSEMAPVATIVVWKINQQGQ 744
                ....::|.|:|:|||.|::.:|     :|:.    ::::.::.:|.|....|.:....:.:
Zfish   483 GESPGVKDQDFTYMILSKGQIVLAERFKRQGQTLV----SLSLPVTKDMVPSFRFVAYYHVGKDE 543

  Fly   745 VVADSLTFPVNGISRNNFTVYINNRKA--RTGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNEL 807
            ||:||:...|.........|.:..::.  .||.:|.:.|.|:.|:.|||..:|.|...:.. |.|
Zfish   544 VVSDSVWVDVKDTCMGKLKVEVTEKQKFYETGNEVNLQISGDFGARVGLVVVDKAVQVLNK-NRL 607

  Fly   808 TYAKIITKMSNFDEQTNGTYKHIWYSHEGNPDELVYFPASSFGVDANRTFE---YSGLIVFTDGY 869
            |.:||...:...|....|         .|..|.:..|.      ||...||   ..|....|:..
Zfish   608 TQSKIWDVIEKHDTGCTG---------GGGKDSMGVFS------DAGLMFESDPAGGTNTRTEPK 657

  Fly   870 VP------RRQD---TCNRTLG--FGECLSGRCYRLEKQCDGL------FDCD-------DGTD- 909
            .|      ||.:   |...||.  :.|.:...||      ||:      :.|:       ||.: 
Zfish   658 CPAPPKRKRRSESLQTITTTLAGQYTEKIRPCCY------DGMRNNRIGYTCERRASYVIDGEEC 716

  Fly   910 ---------EINCHARNDTELL-------------NYRKYRFNRVLRHYENVWLWKDVNI----- 947
                     |:..|...:.|.|             :|..|......:.:...|||::.::     
Zfish   717 VKAFLHCCKEVKNHKETEEEELILARKDDEETYEEDYEDYDDITSRKQFPESWLWEEFDLCDKCS 781

  Fly   948 GPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGI 1012
            .|....:  ..:.|....|.:.|.|:||:.|. .:.:..|.|..:.|||::::|.:..:||||.|
Zfish   782 KPSKNKV--TYLKDSITTWQILAISLSPTHGI-CVAEPEEIVVFKSFFIDLKVPYSAVRGEQVEI 843

  Fly  1013 RVTVFNYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSYNPRTSFGEHQFFIYLEAQGTTVVYVPV 1077
            :..:.||....::.:.|       :|  :|..|:..:.:.:   |:::..:.::...:..|...:
Zfish   844 KAIIHNYTPKHLKKVRV-------EF--LETAGVCSAASKK---GKYRATVNVDKDSSIAVSFVI 896

  Fly  1078 VPQRLGNVDVTLHVATLLGTDTITRTLHVESDG-LPQYRHQSVLLDLSNRAYVLEYMHVNV--TQ 1139
            ||..|.:..:.:..:.|..||.:.:||.|.|:| |.:::.|.:.|:.:.:......:...:  .|
Zfish   897 VPMTLESQHIEVKASILDYTDGVRKTLKVVSEGVLTKFQSQKLELNPAKKGEQPLLLRAGIPGDQ 961

  Fly  1140 TPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNAS---SLLSLPMESGEQNAFSFAANLY 1201
            .|..|  |..|         |:|.|:.:.... ...:|.|   .|:..|...||||.......:.
Zfish   962 VPGTP--VHSY---------ITVTGEEISQSI-EHAINGSFMGELIKRPGGCGEQNMAKMTLPVV 1014

  Fly  1202 TIMYMRLINQRNKT---LEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLR 1263
            ...|:...||....   ..|.|..|:..||..||.:.:||||:::    |.|:.||.|||:|..:
Zfish  1015 ATHYLDNTNQWESVGIDRRKVAINHIKTGYDGQLKYRKPDGSYAI----WINTPSSTWLTAYVAK 1075

  Fly  1264 VFQEASFYEWENFIWIDATIIEKNMRWLLQH-QTPQGSFFEVTWLPDRK----MNRTNFDKNITL 1323
            ||..|:     :|..|:..:|...::||:.| |.|.|||.|...:.|:.    :...|.|  ::|
Zfish  1076 VFAMAN-----DFFAIEENVICSALKWLVMHKQLPDGSFKEDAPVYDKSIMGGIEGQNTD--VSL 1133

  Fly  1324 TSHVLITLATVKDI-SGTLGSRVALATQRALAYIERNMDFLRHQAQPFDVAITAYALQLCNSPIA 1387
            |:.|||.:...|:| .||:|| :..:.::|:|:::   |.|.....|:.||:|:||  |.|:...
Zfish  1134 TAFVLIAMQEGKEICGGTVGS-LHESMRKAVAFLK---DQLPKLTNPYAVALTSYA--LANADSL 1192

  Fly  1388 EEVFAILRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVAR 1452
            .:  |||...:..:.|..:|   .:|:       ::::|            ||.||||:|..|..
Zfish  1193 NK--AILMMHSTKVNDERFW---NVPE-------RQYYS------------IEATAYAVLALVKA 1233

  Fly  1453 REF-FVDPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQG-GKT 1515
            ::: .....|.||..|:.:.||:.:||.|....:|:.||  .::.:::::..:.:|....| .||
Zfish  1234 KDYDTAGEAVHWLAKQKSSHGGYDTTQVTIMVFQAVAEY--HAQTQDLNNFDLNVELVVPGRRKT 1296

  Fly  1516 Q--TLYIDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNVDIEKFQTKPPVPAFGLHT 1578
            .  |:...:.:||:..::::...:..|   |||.|.|||.:...|..  ..|:.|.....|.|..
Zfish  1297 DRWTIQRSNVHLARSGNVDLNKDFTVI---AKGTGSAILSVLTLYYA--RPFEKKTDCTFFDLSV 1356

  Fly  1579 K--AIFHGRNQSHISYVACQNWINQNESERSGMAVLDVAIPTGYWIQQQKLDTYVLSNRVRNLRR 1641
            |  .|...:..::.:|....::..:|:...:.|.:||:.:|||:.|.:..|       :..:..:
Zfish  1357 KLDKIPETKPGTNGTYNFILDFFYKNKKNDATMTILDIGLPTGFDIDEADL-------KQLSTGK 1414

  Fly  1642 ARYLER-----------KIVFYFDYLDHEDICVNFTIERWYPVANMSRYLP--VRIYDYYAPERF 1693
            .||:::           .::.|.:.:.||  .....:.|.:...|::...|  |.||:||:|:..
Zfish  1415 ERYIQKYEKNKVLSERGSLIIYLNKVSHE--VSEKLVFRMHKTFNVALLQPASVTIYEYYSPDAR 1477

  Fly  1694 NESIF--DALPTYLLNICE----VCGSSQCPY 1719
            .:..:  :...:.|..:|:    ||....|.|
Zfish  1478 CKKYYHPEREDSALYRLCKGDLCVCAEENCSY 1509

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
McrNP_524688.1 A2M_N 232..332 CDD:280081 31/109 (28%)
A2M_N_2 669..799 CDD:285005 31/140 (22%)
LDLa 886..913 CDD:238060 8/49 (16%)
A2M 940..1030 CDD:278630 24/94 (26%)
ISOPREN_C2_like 1177..1490 CDD:298658 96/325 (30%)
A2M_comp 1226..1492 CDD:284982 84/272 (31%)
A2M_recep 1607..1695 CDD:284981 22/100 (22%)
c3a.3NP_001032313.2 A2M_N 128..222 CDD:280081 28/131 (21%)
A2M_N_2 463..599 CDD:285005 31/141 (22%)
ANATO 674..737 CDD:237984 12/68 (18%)
A2M 768..861 CDD:278630 25/102 (25%)
complement_C3_C4_C5 987..1272 CDD:239226 96/325 (30%)
A2M_comp 1042..1272 CDD:284982 82/270 (30%)
A2M_recep 1387..1482 CDD:284981 22/103 (21%)
NTR_complement_C3 1502..1649 CDD:239638 3/8 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
43.870

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