DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcr and c3b.1

DIOPT Version :9

Sequence 1:NP_524688.1 Gene:Mcr / 44071 FlyBaseID:FBgn0267488 Length:1760 Species:Drosophila melanogaster
Sequence 2:XP_009294664.1 Gene:c3b.1 / 563665 ZFINID:ZDB-GENE-030131-2211 Length:1768 Species:Danio rerio


Alignment Length:1844 Identity:387/1844 - (20%)
Similarity:692/1844 - (37%) Gaps:525/1844 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   122 LESLHSREPTYFIVASRMVRPG-----------LIYQVSVSILQAQYPITVHASIACDGVQISGD 175
            :|.:....|::.::|...:|||           |...|.|:::...|| ....:::...|.::.|
Zfish    36 IEPVKDPSPSFSLLAPAKIRPGTKQNILVEGHNLAQVVEVTVVVYDYP-NSQTALSRGSVFLNSD 99

  Fly   176 SKDVKEGIPETLLMRIPPTSVTGSYK---LRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTD 237
            :   ...:.:||  .|.|..:....|   :::...:.|::..     |..:..|.||..||:|||
Zfish   100 N---NYSVLQTL--EINPNLLLPDGKKKYVKLVAQFSNIYRA-----EKVMAVSFRSGHIFIQTD 154

  Fly   238 KPLYMQGETVRFRTIPITTELKGFDNPVDVYMLDPNRHILKRWLSRQSNLGSVSLE-YKLSDQPT 301
            ||:|..|:.||||......|.:..:..:.:.:.:|: .|....:.|...:..|..: :.||....
Zfish   155 KPIYNPGDKVRFRAFVSDLEFRSSERTISLEIQNPD-GIAVHGIGRVKAIDGVFSDIFSLSTVVK 218

  Fly   302 FGEWTIRVIA---QGQQE--ESHFTVEEYYQTRFEVNVTMPAYFFTTD-PFIYGRVMANFTSGLP 360
            .|.|  :|:|   ||::.  ...|.|::|....|.|.:|......:.| ..:...:.|.:..|..
Zfish   219 EGRW--KVVAKFDQGKENVFSREFEVKKYVLPAFNVTLTPKTSHLSLDAEKLEVEITARYLYGAQ 281

  Fly   361 VRGNLTIKATIRPIGY--FSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLP 423
            |:|          :.|  |..::..||.||  :.::|.:                          
Zfish   282 VKG----------VAYVLFGIEINGEKKRL--TSMKQID-------------------------- 308

  Fly   424 QDGADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDF 488
                ||:...:......::|.|            |:                             
Zfish   309 ----DLNGGSVSLTMEEIKRAY------------PD----------------------------- 328

  Fly   489 KWPLRELELLVPNLANSEVLITATVGEKFYDEIISGYSVARVYNSSLRVV------FLGDSPQVF 547
                      :.:|..|.:.:.|:|...      ||..:.....|.:::|      .:.|:|:.:
Zfish   329 ----------INSLLGSTLYVKASVLTS------SGSDLVEAEKSGIKIVKSPYMLTIKDTPKYY 377

  Fly   548 KPAMPFTTYLAVEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLPMSQQSDGIWEVKI 612
            ||.:|....:.|..||||| .||:    .::|: |:||             |:|..| |...:.|
Zfish   378 KPGLPLAMTVIVSNHDGSP-TPNI----PVKVT-FLES-------------PISVHS-GTINIHI 422

  Fly   613 DIRNDLNLDDRPQARDFLNGVQNMRLQANFVDP--RGERIQTELLLVSHYSPRNQH---IKVTTS 672
            ::         |:........|.::::.  |||  :.|:...:.:.|..||..:.|   :.|:..
Zfish   423 NM---------PKTHILYGNSQILKVET--VDPSLKPEQQAIQEVYVKPYSTFSGHDNFLHVSVG 476

  Fly   673 TEKPVVGEYII--FHIRTNF-----YLEEFNYLIMSKGVILVNDRETIT-EGIKTIAVVLSSEMA 729
            ..:.|||..:.  .:|:::.     .:|...|::::||.|:...|..:. :.:.::.:::::||.
Zfish   477 ASRVVVGGSVSVQMYIKSSLPNHRALVEHLTYIVLNKGKIIQAGRVNVKGQDVTSVHLLITTEML 541

  Fly   730 PVATIVVWKI---NQQGQVVADSL-------------TFPVNGISRNNFTVYINNRKARTGEKVE 778
            |....|.:.:   ..:.:|||||:             ..||:|...::::         .|...:
Zfish   542 PAFRFVAYYVLPWQHRAEVVADSVFVDVEDRCVGSLNVGPVDGEIVSSYS---------PGSSFK 597

  Fly   779 VAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQ-TNGTYKHIWYSHEGNPDELV 842
            ..:.|:.|:.|.|..:|:|.:.: :.|.||..|:...:...|.. |.|          |..|.:.
Zfish   598 FQVKGDVGAKVSLVAVDNAIFLL-SKNRLTQKKVWEVVDQADMGCTAG----------GGKDNMG 651

  Fly   843 YFPASSFGVDANRTFEYSGLIVFTDGYVPRRQDTCNRT-----------------LGFGECLSGR 890
            .|.      ||...|..|     |.|....::|..::|                 ..:.:.|..|
Zfish   652 VFS------DAGLMFHSS-----TGGSTDSKEDCSSKTKRRRRSAAKLQLRDQLEKAYSDELLQR 705

  Fly   891 CYRLEKQCDGLFDCDDGTDEI----NCHARN--DTE----------------------------- 920
            |            |.||..||    :|:.|:  .||                             
Zfish   706 C------------CVDGMKEIPMPYSCYRRSLYITEDWSCVLAFLRCCAEYRGEELGVITRPPPT 758

  Fly   921 -----------------LLNYRKYRF---------NRVLR-----HYE-NV-------------- 939
                             |:.:.:|.|         :|||:     |.| ||              
Zfish   759 TAPPTIAPPTTSPPTLFLVPHLEYHFPEQPVFFVRDRVLQSMPKLHAEANVVGVRQDSYREVVVE 823

  Fly   940 -----------------------------WLWKDVNI----GPHGRYIFNVE--VPDRPAYWMVS 969
                                         |||.|:.:    ...|..:|.|:  :||....|...
Zfish   824 EEEEAASVFEEDDLSDLEDIYVRSKFFESWLWTDIRLPSTAKSDGLAVFPVDTVLPDSITQWGFL 888

  Fly   970 AFSVSPSKGFGMMNKALEY-VGV-QPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHD 1032
            |.|.||.||..:   |..| |.| :||||::.:|.:..:.|||.|:..:.||..:.:|.:|:|..
Zfish   889 AVSASPEKGVCV---AEPYNVRVWKPFFIDLRLPHSVSRNEQVEIKAVIHNYKNSTLEVMVILEK 950

  Fly  1033 SPDYKFVHVEEDGIVRSYNPRTSFGEHQFFIYLEAQGTTVVYVPVVPQRLGN--VDVTLHVATLL 1095
            :.|...|         :|.     |:|:..:.:.|..:.::...::|.:.|.  :.||...|:.:
Zfish   951 TEDMCSV---------AYT-----GQHRQQVTVAAGSSKLITYTIIPLKTGELPLQVTAVAASFM 1001

  Fly  1096 GTDTITRTLHVESDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQ---TPEIPYQVDRYFVYGSNK 1157
            |.|.:.:.|.|..:|:...:.:|.:|:.|.:........:.|.:   ...:|..|...||     
Zfish  1002 GQDAVKKNLRVVVEGIQTLKVRSFVLNPSEKGGSAGQQLIQVKKMQLDAVVPKSVPETFV----- 1061

  Fly  1158 ARISVVGDVVGPIFPT--MPVNASSLLSLPMESGEQNAFSFAANLYTIMYMRLINQRNKTLE--- 1217
               :|.||::......  ...:.::|:.:|....|||.......|....|:    .|:...|   
Zfish  1062 ---NVRGDLLADSIDNSIKEDSLAALIRMPGGCVEQNLARITLPLIAAHYL----DRSADWEIVG 1119

  Fly  1218 ----KNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQEASFYEWENFIW 1278
                :.|..::..||:.||::.:.|.|:    ..:.|..:|.|:|:|.::||..|     .:||.
Zfish  1120 ISRREEAIKYIQRGYENQLNYKKSDDSY----PPYANEGTSTWITAYVVKVFSMA-----HSFIN 1175

  Fly  1279 IDATIIEKNMRWLLQH-QTPQGSFFEVTWLPDRKMN--RTNFDKNITLTSHVLITLATVKDISGT 1340
            ::...:...:.:||:: |...|:|.|...:.|..|.  ....:...:||:.|||.||..:|....
Zfish  1176 VNEKHLCGPLLYLLKNKQGYDGTFQEDNPVYDTSMTGAMRGSEYKASLTAFVLIALAEAQDKVTC 1240

  Fly  1341 LGSRVAL--ATQRALAYIERNMDFLRHQAQPFDVAITAYALQLCNSPIAEEVFAILRRQARTIGD 1403
            ....|.:  .:::|..|:..:...|   .:|:..||..|||.:.|:..   |.::|.:.|..  |
Zfish  1241 QDQEVNIRDKSRQAAGYLTEHFSRL---TRPYTAAIACYALAVSNNAC---VKSMLLKFASP--D 1297

  Fly  1404 FMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYV-------ARREFFVDPIV 1461
            ..:|.:          .|..:|:|            |.|.||||..:       |...|      
Zfish  1298 HSHWPD----------SNNYFFTL------------EATGYALLALIKSGHMEEAEAPF------ 1334

  Fly  1462 RWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQGGKTQTLYIDDTNLA 1526
            ||||..|...||:.|||.|...|:||.||.|:.......:|.|::   |..|::...:..:.|||
Zfish  1335 RWLNEHRGIGGGYGSTQSTMVVLQALSEYLVKRPPPSDLNLLVQL---SVPGRSDVRWTFNPNLA 1396

  Fly  1527 KL-QSIEIP-DAWGTIKVQAKGAGYAILQMHVQYN--VDIEKFQTKPPVPAFGLHTKAIFHGRNQ 1587
            .: :|..:| |.  ...|.|.|.|..:|::...|:  .|:.:..|     ..|..........|:
Zfish  1397 YVARSSRVPLDQ--EFSVAASGNGKGVLEVVTVYHQLPDVYENST-----CNGFQLDVSIAETNE 1454

  Fly  1588 SHISYVACQNWINQN----ESERSGMAVLDVAIPTGYWIQQQKLDTYVLSNRVRNLRRARYLER- 1647
            ...|.|.....:|.|    |..:..|.:||:.:|||:  :.:..|..:|:|.|     .||:.. 
Zfish  1455 KTSSDVEKSFRLNVNVRALEERQVRMVILDIGLPTGF--EPENSDLELLTNSV-----DRYINNF 1512

  Fly  1648 -----------KIVFYFDYLDHEDICVNFTIERWYPVANMSRYLPVRIYDYYAPERFNESIFDAL 1701
                       .|:..|...:.|...::|.:.:.:.| .:.:...|::|.||..:: :.|.|.:.
Zfish  1513 QVVDNLSDRGSLIIHLFKVSNKEAEMISFRLNQKFKV-GLLQPSTVKVYQYYNKDK-SCSRFYSP 1575

  Fly  1702 P---TYLLNICE--VCGSSQCPYC 1720
            |   ..|..|||  ||..||...|
Zfish  1576 PEDKQQLDQICEGDVCRCSQGDCC 1599

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
McrNP_524688.1 A2M_N 232..332 CDD:280081 30/105 (29%)
A2M_N_2 669..799 CDD:285005 30/153 (20%)
LDLa 886..913 CDD:238060 8/30 (27%)
A2M 940..1030 CDD:278630 33/97 (34%)
ISOPREN_C2_like 1177..1490 CDD:298658 83/331 (25%)
A2M_comp 1226..1492 CDD:284982 75/277 (27%)
A2M_recep 1607..1695 CDD:284981 21/99 (21%)
c3b.1XP_009294664.1 A2M_N 149..242 CDD:280081 27/95 (28%)
A2M_N_2 500..619 CDD:285005 25/127 (20%)
ANATO 691..747 CDD:237984 12/67 (18%)
A2M 852..948 CDD:278630 33/98 (34%)
TRAPPC10 <939..>991 CDD:289361 11/65 (17%)
complement_C3_C4_C5 1079..1363 CDD:239226 83/332 (25%)
A2M_comp 1133..1363 CDD:284982 73/274 (27%)
A2M_recep 1480..1573 CDD:284981 22/101 (22%)
NTR_like 1593..1766 CDD:295338 3/7 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
43.870

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