Protein Alignment Mcr and a2m3e

DIOPT Version :10

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: NP_001188334.2
• Gene: a2m3e / 562067
• ZFINID: ZDB-GENE-030131-9306
• Length: 1482
• Species: Danio rerio
• Alignment Length: 1698
• Identity: 363/1698 - (21%)
• Similarity: 639/1698 - (37%)
• Gaps: 406/1698 - (23%)

  Fly   104 EEPSLTRGKSSYNIKATFLESLHSREPTYFIVASRMVRPGLIYQVSVSILQAQYPITVHASIACD 168
            :||.:..|                  |.:.::...::..|...::.||:|:.:..:|:..|:..|
Zfish    63 DEPVIVNG------------------PIFMVMFPSLIESGSDAKLCVSLLKPEGSLTMTISLVDD 109

  Fly   169 -----------------------GVQISGDSKDVKEGIPETLLMRIPPTSVTGSYKLRVEGFYQN 210
                                   ..|:||||       .:|:.:.:...|:|
Zfish   110 KNTETQLVQQTSQRKLHRCFNFQAPQVSGDS-------VQTVRVVVQGPSIT------------- 154

  Fly   211 VFGGLAFLNETRLDFSQRSMTIFVQTDKPLYMQGETVRFRTIPITTELKGFDNPVDVYMLDPNRH 275
                  ...|.::.|.......|:|||||||..|:||.||.:.::.:|...|...::.:|:..|:
Zfish   155 ------MTEERKVMFRSYLPLTFIQTDKPLYNPGQTVNFRVVTMSDKLVPLDQMYNLVVLEDFRN 213

  Fly   276 I-LKRWLSRQSNLGSVSLEYKLSDQPTFGEWTIRVIAQGQQEESHFTVEEYYQTRFEVNVTMPAY 339
            | :.:|.:..|....:.|.:.|..:...|::|:|.....:.....|.|::|...:|:|.:..|..
Zfish   214 IRINQWTNVSSTNWILELSHDLIPESPVGKYTLRAYIGDRIISQSFDVKKYVLPKFDVTLNTPQT 278

  Fly   340 FFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWR 404
            :...|..:.......:|.|.||.|.:.::...:|:.|.
Zfish   279 YSVADVGLKVEACGKYTFGQPVPGQVFVEVCRQPVTYV--------------------------- 316

  Fly   405 YNNPNQNPQVQYNVPGQLPQDGADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWS 469
                 |:|:|.                                    ...::|     |:....:
Zfish   317 -----QDPKVT------------------------------------SVCLKK-----STKTTDT 335

  Fly   470 GTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEVLITATVGEKFYDEIISGYSVARVYNSS 534
            |.....|....:|..:|:            .||.||.| |...:.|:....::|..:...:....
Zfish   336 GCASLALSTSVFFGTSFE------------NNLQNSFV-INVNITEEGTGVVMSKSTTVSITFEV 387

  Fly   535 LRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQRL- 598
            .:|.|: |.|:.:.........::....:|:||:..::.  |::.|           .||.:.|
Zfish   388 GKVKFV-DLPKFYNYGSTVNGKISASDFNGNPINNKVVY--LLDSS-----------QWPHKMLF 438

  Fly   599 PMSQQSDG-----IWEVKIDIRNDLNL--DDRPQ------ARDFLNGVQNMRLQ-------ANFV 643
            .::...:|     :|..... :.||||  ...||      :..|....|.:||.       ..|.
Zfish   439 NLTTNKNGFAEFSLWTTSFP-KADLNLVASATPQSYYGYNSPYFTTDSQVVRLSRTAAPDTPTFS 502

  Fly   644 DPRGERIQTELLLVSHYSPRNQHIKVTTSTEKPVVGEYIIFHIRTNFYLEEFNYLIMSKGVILVN 708
            |....:::..|...:.|.     :.||.|    .|||       |..|..:..|::||:|||:::
Zfish   503 DLSIVKLEQPLKCGTTYP-----VTVTYS----FVGE-------TGDYSADIIYMVMSRGVIILH 551

  Fly   709 D--------RETITEGIKTIAVVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVY 765
            .        .:|:|:|..|..:.:.::||||..|:|:.:.....||..|.:|.......|..::.
Zfish   552 GFISVQALASDTLTKGTVTFDLSIVAKMAPVVQILVYSVLPSQTVVTGSASFDTEKCFSNQVSLQ 616

  Fly   766 INNRKARTGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKI-----ITKMSNF----DE 821
            .:...|..||...:.:..:.||..|||.||.:...||:|..|:...:     :..:||:    ::
Zfish   617 FSPATAVPGEGSILTVSAQAGSLCGLSAIDQSVLIMQSGGRLSAEAVFNLLPLQSLSNYPPGAED 681

  Fly   822 QTNGTYKHIWYSHEGNPDELVYFPASSFG--------VDANRTFEYSGLIVFTD--GYVPRRQDT 876
            |.|..|..   |....|....|....|.|        |.|.....|..:|.|.:  |.||
Zfish   682 QQNCFYVR---SRRAVPTNQAYNTFKSVGIKIATNLPVRAPPCMTYKDVIYFPNFRGVVP----- 738

  Fly   877 CNRTLGFGECLSGRCYRLEKQCDGLFDCDDGTDEINCHARNDTELLNYRKYRFNRVLRHYENVWL 941
                      |....:.:.::.....    ...|:...:..|..:..|           :...|:
Zfish   739 ----------LQEAVFAMAREAPAPI----AKAEVAGSSSVDVTIRTY-----------FPETWI 778

  Fly   942 WKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQ 1006
            |:..::|..|.....:.|||....|...||.:| |.|||:....| ....||||:.:.:|.:..:
Zfish   779 WQLAHVGDSGSSSVPLTVPDTITTWDTEAFCLS-SSGFGLALPVL-LTSFQPFFLELTLPYSIIR 841

  Fly  1007 GEQVGIRVTVFNYMITPIEAIVVLHDSPDYKFVHV-EEDGIVRSYNPRTSFGEHQFFIYLEAQGT 1070
            ||...::.|||||:...|:..|....|.::....: ::|....|.|.|.:|   ::.:.....||
Zfish   842 GEFFELKATVFNYLSQCIKVQVTPTPSSNFTLKSLDDQDSSTISANGRKTF---KWALTASVIGT 903

  Fly  1071 TVVYV--PVVPQR--LGNVDVTLHVATLLGTDTITRTLHVESDGLPQYRHQSVLLDLSNRAYVLE 1131
            ..|.|  ...|.:  .||.|||  |.:....|.:||:|.|.::|:             .|.::..
Zfish   904 LNVTVSGEASPSQELCGNQDVT--VPSRGRIDIVTRSLLVLAEGV-------------ERTFIRS 953

  Fly  1132 YM----HVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNASSLLSLPMESGEQN 1192
            ::    ...:::..:|.:..:  .:.||.|..:||:||::|....    |..:||.:|...||||
Zfish   954 WLLCPKGTTLSEVVKITFPTN--VIQGSAKCSVSVIGDIMGRALK----NLDNLLRMPSGCGEQN 1012

  Fly  1193 AFSFAANLYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWL 1257
            ....|.|:|.:.|:.:..|....:...|..::.||||.:|::...|||||.|..|    .|:.||
Zfish  1013 MIILAPNIYILRYLTVTAQLTPVIRDTATGYLQIGYQGELNYRHTDGSFSTFGYD----PSNTWL 1073

  Fly  1258 TSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPDRKMNRTNFDKNIT 1322
            |::.:|.|..|     .:|.:||..:::....||:..|...|.|.:...|..:.| :.....|:|
Zfish  1074 TAFVMRTFGLA-----RSFTYIDPNVLKSAKDWLISTQGSDGGFVQQGTLYHKDM-KGGVGDNVT 1132

  Fly  1323 LTSHVLITL----ATVKDISGTLGSRVALATQRALAYIERNMDFLR----HQAQPFDVAITAYAL 1379
            :|.:::::|    ..|.|                 ..|.:.:.|||    :....:..|:.||..
Zfish  1133 MTGYIVLSLLEIGVPVTD-----------------PVITKALSFLRPLVGNLGNTYVTALLAYTF 1180

  Fly  1380 QLC-NSPIAEEVFAILRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTA 1443
            .|. .:....::...||..|.:.|..::|....                     ..|:|.:|.:|
Zfish  1181 SLAGETSTRAQLLHSLRNTAISEGTTLHWSQTT---------------------SGDTLAVEISA 1224

  Fly  1444 YALLVYVARREF------FVDPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSL 1502
            |.||..:.....      :.:.||.||.:|:...||:.|||||..||:||..|..:. .....|.
Zfish  1225 YVLLAVLTVHPVTTANLGYANRIVNWLVAQQNPYGGFTSTQDTVVALQALALYAAQV-FSPGGSS 1288

  Fly  1503 TVEIEASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNVDIEKFQT 1567
            ||.:::|...|......:...|....|...:.:..||..|.|:|:..|.:|:...||:
Zfish  1289 TVTVQSSVPAGDVFNFAVTPNNRLLYQRNSLNNVPGTYSVVARGSACASVQVSCFYNI------- 1346

  Fly  1568 KPPVPAFGLHTKAIFHGRNQSHISYVA--CQNW-IN---------QNESERSGMAVLDVAIPTGY 1620
              |.|        |...:..|.::.|.  ||.. :|         ......:.|.::|:.:.:|:
Zfish  1347 --PTP--------ITVSKTLSVVAKVTGNCQAAPVNLMLTFTVKYTGPKPTTNMVLVDIKVLSGF 1401

  Fly  1621 WIQQQKLDTYVLS---NRVRNLRRARYLERKIVFYFDYLDHEDICVNFTIERWYPVANMSRYLP- 1681
                 ..||.:|.   |....::|.......::.|...:. :.:.|.|:|:....|| :....|
Zfish  1402 -----TADTSLLGSPPNFTPFVQRVESDGDHVLVYLQEVP-KGVPVTFSIQLTQAVA-VQNLKPA 1459

  Fly  1682 -VRIYDYY 1688
             :.|||||
Zfish  1460 VIYIYDYY 1467

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	YfaS	<226..1575	CDD:441940	316/1421 (22%)
		A2M_BRD	667..801	CDD:462235	39/141 (28%)
		A2M	939..1030	CDD:459711	30/90 (33%)
		TED_complement	1160..1490	CDD:462227	90/344 (26%)
		A2M_recep	1605..1699	CDD:462226	20/89 (22%)
a2m3e	NP_001188334.2	YfaS	<171..1268	CDD:441940	292/1320 (22%)
		A2M_2	994..1269	CDD:239227	81/326 (25%)
		A2M_recep	1386..1477	CDD:462226	20/89 (22%)