DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcr and c3a.6

DIOPT Version :9

Sequence 1:NP_524688.1 Gene:Mcr / 44071 FlyBaseID:FBgn0267488 Length:1760 Species:Drosophila melanogaster
Sequence 2:NP_001008582.4 Gene:c3a.6 / 494039 ZFINID:ZDB-GENE-041212-2 Length:1642 Species:Danio rerio


Alignment Length:1747 Identity:381/1747 - (21%)
Similarity:665/1747 - (38%) Gaps:455/1747 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   117 IKATFLES-------LHSREPTYFIVASRMVRPGLIYQVSVSILQAQYPITVHASIACDGVQISG 174
            :|..||.:       |...:|.|.:.|..::|.|....|.|   :||              ..||
Zfish     3 VKLLFLSAVLLSSALLTLCDPLYVLSAPNLLRVGSSENVFV---EAQ--------------DYSG 50

  Fly   175 DSKDVKEGIP-------ETLLMRIPPT-----SVTGSYKLRVEGFY--------QNVFGGLAFLN 219
            .|..||..:.       |.|...:..|     .:....|:..:..|        |.|:....|..
Zfish    51 GSLIVKISVKNHPRKNLEILSKTVTLTDENNFQILADIKIPSDRDYFSDDPLEKQYVYLQAQFPT 115

  Fly   220 ET-----RLDFSQRSMTIFVQTDKPLYMQGETVRFRTIPITTELKGFDNP-VDVYMLDPNRHILK 278
            .|     .|.|  :|..||||||||:|..|..|::|...:|:.||..:|. |.|.::||......
Zfish   116 HTLEKVVMLSF--QSGYIFVQTDKPIYTPGSNVQYRIFSLTSGLKPLENAGVSVEIMDPQGITTM 178

  Fly   279 R--WLSRQSNLGSVSLEYKLSDQPTFGEWTIRVIAQGQQEESH---FTVEEYYQTRFEVNVTMPA 338
            |  ...:|   |..|.:|.:....:.|.|.:........::::   |.|::|....:||.::...
Zfish   179 RETIFPKQ---GIRSGKYMVPQPASPGIWKVVTRFTNTPQKNYTADFEVKDYVLPTYEVTLSPSK 240

  Fly   339 YFFTT-DPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNER 402
            .||:. |..:...:.|.:..|..|.|:..:     ..|...:.             .:|::    
Zfish   241 SFFSVKDDSLTVSIEARYLHGNNVNGHAFV-----VFGVMEDD-------------RKTSI---- 283

  Fly   403 WRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEA 467
                 |:...:||.:       ||                                   :.:.:.
Zfish   284 -----PSSLQRVQIS-------DG-----------------------------------EGNAKL 301

  Fly   468 WSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEVLITATVGEKFYDEIISGYSVARVYN 532
            ...|..:|.|.:....|        |.:.:.|..|.:|        |.:..:....|..:.    
Zfish   302 TKQTILQTFPDISQLVG--------RSIYISVSVLTDS--------GSELVEAQRRGIQIV---- 346

  Fly   533 SSLRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSPIDPNLLRQGLMEV---SGFVESRNGGRRDWP 594
            :|...:....:||.|||.|||:..:.:       .|||.:....:||   .|.|:.:.       
Zfish   347 TSPYTINFQKTPQFFKPGMPFSVSVYI-------TDPNQMPAENVEVLVNPGGVKGQT------- 397

  Fly   595 AQRLPMSQQSDGIWEVKIDIRNDLNLDDRPQARDFLNGVQNMRLQANFVDPRGERIQTEL--LLV 657
                    :|:||  .|:.:.:             :.|...:.:.....||:.:..|..|  ::.
Zfish   398 --------KSNGI--AKLTVNS-------------IEGSSALEITVQTKDPKFDDDQQALKKMVP 439

  Fly   658 SHYSPRNQ-----HIKVTTSTEKPVVGEYIIFHIRTNFYL--------EEFNYLIMSKGVILVND 709
            ..|..:..     ||.:..:..:  :|:    .::.|..|        ::|.|:|:|||.|:..|
Zfish   440 QAYKTKGSSQNYLHIGIDAAEFE--IGD----QMKVNLNLGKSPGVRDQDFTYMILSKGQIVQAD 498

  Fly   710 R-ETITEGIKTIAVVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYINNRKA-- 771
            | :...:.:.|:::.::.||.|....|.:......:||:||:...|.........|.:...:.  
Zfish   499 RFKRQGQALVTLSLPVTKEMVPSFRFVAYYHVGSSEVVSDSVWVDVKDTCMGTLKVQVKEPRPIY 563

  Fly   772 RTGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQ-TNGTYKHIWYSHE 835
            :.||:..:.|.|:||:.|||..:|.|.:.:.. |.||..||...:...|.. |.|          
Zfish   564 QPGEEFSLLITGDPGAKVGLVAVDKAVHGLNQ-NRLTQTKIWDIVEKHDTGCTAG---------- 617

  Fly   836 GNPDELVYFPASSFGVDANRTFEYSGLIVFTDGYVPRRQDTCNRTLGFGECL--SGRCYRLE--- 895
            |..|.:..|      :||...||     ..|.|      .|.:||:  .||:  |.|..|.|   
Zfish   618 GGRDSMGVF------IDAGLMFE-----SHTAG------GTESRTV--PECVIPSKRRRRAESLQ 663

  Fly   896 --------------KQC--DGLFDCDDG----------TDEINC-----HARNDT---------- 919
                          ::|  ||:.|...|          :|.:.|     |..||.          
Zfish   664 KITTILAGQYSGDLRKCCVDGMRDNKLGYTCERRATYVSDGVECVRAFLHCCNDVVSRSLEAGEE 728

  Fly   920 ELLNYRKYRFNRVLRHYENV------------WLWKDVNIGPHGRYIFNVE-----VPDRPAYWM 967
            |::..|....:    :||:.            |||.: .|.|......:|.     :.:....|.
Zfish   729 EMILARSEESD----YYESFEEITSRTQFPESWLWSE-EILPVCSATTSVTKSRIYLKESITTWQ 788

  Fly   968 VSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHD 1032
            :.|.|:|.:.|..:.:.. |.:..:.|||::::|.:..:.||:.:|..:.||....|:|.:    
Zfish   789 IFAVSLSKTHGICVADPH-EMIVYKMFFIDLKVPFSAVRNEQLQVRAILHNYTKKKIKARL---- 848

  Fly  1033 SPDYKFVHVEEDGIVRSYNPRTSFGEHQFFIYLEAQGTTVVYVPVVPQRLGN--VDVTLHVATLL 1095
              ::|    |...|..|.:.:   |.:|..:.:|:..:..:...::|..|||  ::|.......:
Zfish   849 --EFK----ETKHICSSASNK---GSYQTEVEVESMSSRTIPHVIIPLELGNHWIEVKAAAFDSV 904

  Fly  1096 GTDTITRTLHVESDG-LPQYRHQSVLLDLSNRAYVLEYMHVNV------TQTPEIPYQVDRYFVY 1153
            .:|.:.:.|.|.|:| |...:..:|.|   |.|.:.....|:|      |:.|..|  .:.|   
Zfish   905 YSDGVKKILKVVSEGVLTMVQETNVEL---NPAKIGGLQEVSVRSGKPDTRVPNTP--ANTY--- 961

  Fly  1154 GSNKARISVVG-DVVGPIFPTMPVNA---SSLLSLPMESGEQNAFSFAANLYTIMYMRLINQ--- 1211
                  |||.| |....|  ..|:..   ...:..|..:||:|.......:....|:.:.||   
Zfish   962 ------ISVTGKDFSKTI--EQPIGGEVMKQFIVQPRGTGEENMIYMTFPVIATHYLDITNQWDT 1018

  Fly  1212 -----RNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQEASFY 1271
                 ||:     |..|:..||||||:|.:|||||:...:    :.||.|||:|..:|...||  
Zfish  1019 VGMNRRNE-----AINHIKTGYQRQLTFRKPDGSFAALMT----TPSSTWLTAYVAKVLTIAS-- 1072

  Fly  1272 EWENFIWIDATIIEKNMRWLLQH-QTPQGSFFEVTWLPDRKMNRT--NFDKNITLTSHVLITLAT 1333
               :...:|.::|...::||..: |...|.|.|.:.:...:|...  ..|.:.:||:.|||.:..
Zfish  1073 ---DLTVVDESVICSALQWLAANKQLSDGMFKEDSHILHEEMQGAVRGKDADASLTAFVLIAMQE 1134

  Fly  1334 VKDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDVAITAYALQLCNSPIAEEVFAILRRQA 1398
            ...|.......:..:..:|:.|:...:..|   ..|:.|||::||  |.::...|:  .||:|.:
Zfish  1135 GSQICAKSVQNLQSSMNKAVGYLTLRIHTL---TSPYAVAISSYA--LAHAGKLEK--GILKRHS 1192

  Fly  1399 RTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVARREF-FVDPIVR 1462
            .......:|                     |:|... .|::|.|.||:|..|..::| .....||
Zfish  1193 TQNDAGSFW---------------------RVPGAL-HLSLEATGYAVLALVKEQDFQSAGSAVR 1235

  Fly  1463 WLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQGGKTQ---TLYIDDTN 1524
            ||.:||...|...:||.:....:|:.||...::.::|:   ::|:.|.:|.|||   |....:::
Zfish  1236 WLRAQRAAYGAHGTTQASLIVFQAVAEYRTGAKKQDVN---LDIQLSVEGRKTQNKWTFSRSNSH 1297

  Fly  1525 LAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNVDIEKFQTKPPVPAFGLHTK-----AIFH- 1583
            :.:...:::...:   .|.|.|.|.|.|.::..|....|:.:....|  |.|..:     .:.| 
Zfish  1298 VTRSDKVQLAQGF---NVTAHGNGLATLSVYSLYYALPEERENDCKV--FELSVQMDKQLEVSHP 1357

  Fly  1584 GRNQSHISYVACQNWINQNESER-SGMAVLDVAIPTGYWIQQQKLDTYVLSNRVRNLRRARYLER 1647
            |..:|::..:.    .:...||| :.|:||||.:.||:     |:|...||...:.  :.||::|
Zfish  1358 GAIESYLLTIE----THFRSSERDAAMSVLDVGLLTGF-----KVDDGDLSKLAKG--KDRYIDR 1411

  Fly  1648 -----------KIVFYFDYLDHE--DICVNFTIERWYPVANMSRYLPVRIYDYYAPE 1691
                       .:|...:.:.|:  | .|.|.:.:...| .|.:...|.:|:|..|:
Zfish  1412 FEMNKELSDRESLVIILNKVSHKVRD-RVAFRVHKVNEV-GMLQPAGVTVYEYNTPD 1466

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
McrNP_524688.1 A2M_N 232..332 CDD:280081 30/105 (29%)
A2M_N_2 669..799 CDD:285005 34/140 (24%)
LDLa 886..913 CDD:238060 11/57 (19%)
A2M 940..1030 CDD:278630 23/94 (24%)
ISOPREN_C2_like 1177..1490 CDD:298658 83/327 (25%)
A2M_comp 1226..1492 CDD:284982 74/269 (28%)
A2M_recep 1607..1695 CDD:284981 25/98 (26%)
c3a.6NP_001008582.4 A2M_N 130..224 CDD:280081 28/96 (29%)
A2M_N_2 454..590 CDD:285005 34/141 (24%)
ANATO 669..733 CDD:237984 11/63 (17%)
A2M 756..849 CDD:278630 23/100 (23%)
complement_C3_C4_C5 979..1263 CDD:239226 83/326 (25%)
A2M_comp 1033..1263 CDD:284982 72/267 (27%)
A2M_recep 1380..1473 CDD:284981 25/96 (26%)
NTR_complement_C3 1493..1640 CDD:239638
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
22.010

Return to query results.
Submit another query.