Protein Alignment Mcr and Cd109

DIOPT Version :10

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: NP_001102241.2
• Gene: Cd109 / 363104
• RGDID: 1311287
• Length: 1442
• Species: Rattus norvegicus
• Alignment Length: 1668
• Identity: 427/1668 - (25%)
• Similarity: 724/1668 - (43%)
• Gaps: 306/1668 - (18%)

  Fly   132 YFIVASRMVRPGLIYQVSVSILQAQYP-ITVHASIACDGVQI-SGDSKDVKE----------GIP 184
            :.:....::|||....:.|.:||...| :.|.|.:    ::| |..|..|.|          ||
  Rat    27 FLVTVPGIIRPGANMTIGVELLQNSPPQVLVKARV----LKIASNRSTTVLEAEGVFNRGHFGI- 86

  Fly   185 ETLLMRIPPTSVTGSYKLRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTDKPLYMQGETVRF 249
             .:|..:|.......|:|.:.|..:.   .:.|.|.|||.|..:.:::|:||||.:|...:.|:|
  Rat    87 -LVLPALPLHKANKIYELHISGKSET---EIVFSNRTRLTFDSKRISVFIQTDKVIYKPKQEVKF 147

  Fly   250 RTIPITTELKGFDNPVDVYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFGEWTIRVIAQGQ 314
            |.:.:.::||.:..|||:|:.||..:::::|||::..||.||..::||..|..|:|:|:|....|
  Rat   148 RVLTLFSDLKPYKTPVDIYIKDPKSNLIQQWLSQEGELGVVSKTFQLSSHPILGDWSIQVQVIDQ 212

  Fly   315 QEESHFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFSN 379
            .....|.|.:|...:|||.:..|.|......::.|.|.|.:|.|.||:|:|::  |..|:.::..
  Rat   213 LYYQSFQVLDYVLPKFEVTLQTPLYCSLKAKYLRGNVTAKYTYGKPVKGSLSL--TFIPLSFWGK 275

  Fly   380 QVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRNQYVVERH 444
            :                         .|..:|.::                      |.:.   :
  Rat   276 K-------------------------KNITKNFEI----------------------NGFT---N 290

  Fly   445 YQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEVLI 509
            :.||.:   .::|......:.|...|.|.:..|.         |..|:..:..:..:|..:....
  Rat   291 FAFDAD---EMKKVMNLKKATEISDGNYDQVDPV---------FPGPVEIVATVTESLTGTSRKA 343

  Fly   510 TATVGEKFYDEIISGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSPIDPNLLRQ 574
            :..|..|.:|.:|.              :|  |...|.||.:.||..:.:...||..:.|..:..
  Rat   344 STNVFFKQHDYVIE--------------IF--DYTTVLKPTLNFTATVKISRSDGKQLTPEEMEN 392

  Fly   575 GLMEVSGFVESRNGGRRDWPAQ---RLPMSQQS---DGIWEVKIDIRNDLNLDDRPQARDFLNGV 633
            .|:.|  ..:.:|.......||   .:.|::.|   :|:.:|:..|.:|.:
  Rat   393 DLVTV--VTQKKNDNPTREKAQGTDYIQMTEYSVPHNGVVKVEFPIMSDSS-------------- 441

  Fly   634 QNMRLQANFVDPRGERIQTELLLVSH---YSPRNQHIKVTTSTEKPVVGEYIIFHIRTNFYLEEF 695
             .::|:|:|:|....       :..|   .||.|.:|::.|..|...||......:..|...:|.
  Rat   442 -ELQLKASFLDSASS-------VAVHSVFTSPSNTYIQLKTRDEHITVGSPFNLTVSGNQKFKEI 498

  Fly   696 NYLIMSKGVILVNDRETITEGIKTIAVVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNGISRN 760
            :|:::|||.::...:::    .:|.::...:..||.|.|:|:.|.|.|:|::|.|..||....:|
  Rat   499 SYMVISKGQLVAVGKQS----SRTFSLTPEASWAPKACIIVYYIEQDGEVISDILKIPVQLDFKN 559

  Fly   761 NFTVYINNRKARTGEKVEVAI-FGEPGSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQTN 824
            ...:..:..:.:..:||.:.| ..:..|.||:..:|.:...:...|::|...::.::..:
  Rat   560 KIKLSWSKPRVKPSDKVSLRISVTQSYSLVGIVAVDKSVKLIGNSNDITMENVVHELELY----- 619

  Fly   825 GTYKHIWYSHEGNPDELVYFPASSFGVDANRTFEYSGLIVFTDGYVPRRQ-----DTCNRTLGFG 884
                        |.:..:....:||.|     |:..||.|.||..:.|..     ||...:..|.
  Rat   620 ------------NTEYYLGMFLNSFAV-----FQECGLWVLTDANLVRDNIDEVYDTQEYSERFA 667

  Fly   885 ECLSGRCYRLEKQCDGLFDCDDGTDEINCHARNDTELLNYRKYRFNRVLRHYENVWLWKDVNIGP 949
            |         |.:.: |.|.:|.:...|.|.|                 :|:...|:|.|..:|.
  Rat   668 E---------ENEAN-LVDFEDTSSASNSHVR-----------------KHFPESWIWLDFYMGS 705

  Fly   950 HGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRV 1014
            .....:.|.|||....|:.|||.:|...|||:.....|....|||||::.:|.:..:||:..:.|
  Rat   706 KNHEEYEVTVPDSITSWVASAFVISEDLGFGLTATPAELHAFQPFFISLNLPYSVIRGEEFALEV 770

  Fly  1015 TVFNYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSYNPRTSFGEHQFFIYLEAQGTTVVYVPVVP 1079
            ::.||:....:.:|::.:|..:..:....| |..:...:|:....:       ...|:|: |:.|
  Rat   771 SIVNYLKDTTKVVVLIEESDSFDILMFSND-INNTIYRKTALVPRE-------NSVTLVF-PIKP 826

  Fly  1080 QRLGNVDVTLHVATLLGTDTITRTLHVESDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQTPEIP 1144
            ..||||.:|:..|:...:|.:|||:.|:.:|:.:...|||||:|.::....|...::.:..|:.
  Rat   827 THLGNVPITVTAASPTSSDVVTRTIVVKPEGVAKSYSQSVLLELIDKKQQTEPKSLSFSFPPDT- 890

  Fly  1145 YQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNA-SSLLSLPMESGEQNAFSFAANLYTIMYMRL 1208
                   :.||.:.:|:.:||::|     ..:|. |||:.||...||||....|.|:|.:.|:..
  Rat   891 -------ISGSERIQITAIGDILG-----SSINGLSSLIRLPYGCGEQNMVYLAPNVYILDYLTK 943

  Fly  1209 INQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDS--SVWLTSYCLRVFQEASFY 1271
            ..|....|::.|...|..||||:|.:.|.|||||.|    .||||  |.||:::.||.|.||:.|
  Rat   944 QKQLTVNLKEKALSFMRQGYQRELLYQREDGSFSAF----GNSDSSGSTWLSAFVLRCFMEAAQY 1004

  Fly  1272 EWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPDRKMN---RTNFDKNITLTSHVLITLAT 1333
                 |.||..::.:...||..|:...|.|    |.|.|.::   :......||||::|:.:|..
  Rat  1005 -----IDIDQDVLHRTYSWLEAHKKTNGEF----WEPGRVIHIELQGGNKSPITLTAYVVTSLLG 1060

  Fly  1334 VKDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDVAITAYALQLCNSPIAEEVFAILRRQA 1398
            .|.....      :..|.::.::|.  :|.|..:..:.:|:..|||....||.|||...:|.:||
  Rat  1061 YKKYQPN------IEIQDSIKFLEN--EFNRGISDNYTLALVTYALSAVGSPKAEEALTMLTQQA 1117

  Fly  1399 RTIGDFMYW--GNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVARREFFVDPIV 1461
            ...||..:|  ...|        .::.|.||        |..||..|||||.:.........||:
  Rat  1118 EKEGDTQFWLSSTSE--------SSESWQSL--------SAQIEIAAYALLAHTQHHVPEGIPIM 1166

  Fly  1462 RWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQGGKTQTLYIDDTNLA 1526
            :||..||.:.||:.|||||..|||||.|::... .:|...:.|.|:..:. .|....:||..||.
  Rat  1167 KWLIKQRNSLGGFVSTQDTVMALKALSEFSALV-YKENRDMQVTIKGPNV-PKPIRFWIDSQNLF 1229

  Fly  1527 KLQSIEI----PDAWGTIKVQAKGAGYAILQMHVQYNVDI-----EKFQTKPPVPAFGLHTKAIF 1582
            ||...|:    |.|   :.|.|.|:|:||.|::|.|||..     .:...:.|: .|.|....
  Rat  1230 KLHKEELAPLDPIA---VNVSAHGSGFAICQLNVDYNVKASSSFKRRRSMENPI-GFDLDVDV-- 1288

  Fly  1583 HGRNQSH-ISYV---ACQNWINQNESERSGMAVLDVAIPTGYWIQQQKLDTYVLSNRVRNLRRAR 1643
               |..| :.|:   .|.:.:...   |:|||:|:|.:.:|:....   |:..||   ..|::..
  Rat  1289 ---NDEHDLRYMKLNVCTSHLGPG---RTGMALLEVNLLSGFTATS---DSIPLS---EILKKVE 1341

  Fly  1644 YLERKIVFYFDYLDHEDICVNFTIERWYPVANMSRYLPVRIYDYYAPERFNESIFDALPTY---- 1704
            |...|:..|.|:::....||.....|.:.|:|:...| |.|.|||.|.|      .|:.:|
  Rat  1342 YEPGKLNLYLDHVNETQFCVKIPTVRDFKVSNIRDGL-VSIVDYYEPSR------QAVRSYNTQM 1399

  Fly  1705 LLNICEVCGSSQC-PYCSIYNMGWRASMSMSLLFFSVFIYLLR 1746
            .|:.|.:.....| .|........|.|.|: |:..|..:|.::
  Rat  1400 KLSSCYLSADPNCRSYMDRATDSLRHSSSL-LVLCSTLLYFVQ 1441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	YfaS	<226..1575	CDD:441940	354/1380 (26%)
		A2M_BRD	667..801	CDD:462235	33/134 (25%)
		A2M	939..1030	CDD:459711	29/90 (32%)
		TED_complement	1160..1490	CDD:462227	114/337 (34%)
		A2M_recep	1605..1699	CDD:462226	28/93 (30%)
Cd109	NP_001102241.2	YfaS	<124..1210	CDD:441940	331/1302 (25%)
		A2M_2	909..1195	CDD:239227	110/322 (34%)
		A2M_recep	1309..1396	CDD:462226	29/102 (28%)