DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcr and C5

DIOPT Version :9

Sequence 1:	NP_524688.1	Gene:	Mcr / 44071	FlyBaseID:	FBgn0267488	Length:	1760	Species:	Drosophila melanogaster
Sequence 2:	NP_444179.1	Gene:	C5 / 362119	RGDID:	2237	Length:	1688	Species:	Rattus norvegicus

Alignment Length:	1822	Identity:	382/1822 - (20%)
Similarity:	677/1822 - (37%)	Gaps:	522/1822 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 FLESLHSREPTYFIVASRMVRPGLIYQVSVSILQAQ-YPITVHASIACDG------------VQI 172
            ||:....:|.||.|.|.::.|.|....|   ::||. |.....|:|:...            |.:
  Rat    17 FLDKTWGQEQTYVISAPKIFRVGSSENV---VIQAHGYTEAFDATISLKSYPDKKVTYSSGYVNL 78

  Fly   173 SGDSKDVKEGIPETLLMRIPPTSVTGSYKLRVEGFYQNVF---GGLAFLNETRLDFSQRSMTIFV 234
            |.::|     ...:.|:.:||....     |.|....:|:   ..:.|....::..:..:..:|:
  Rat    79 SPENK-----FQNSALLTLPPKQFP-----RDENPVSHVYLEVVSMHFSKSKKIPITYDNGFLFI 133

  Fly   235 QTDKPLYMQGETVRFRTIPITTELKGFDNPVDVYMLDPNRHILKRWLSRQSNLGSVSL-EYKLSD 298
            .||||:|...::|:.|...::.:||.......:..:||....:. .:......|.:|. ::|:..
  Rat   134 HTDKPVYTPDQSVKIRVYSLSDDLKPAKRETVLTFVDPEGTEVD-IVEENDYTGIISFPDFKIPS 197

  Fly   299 QPTFGEWTIRVIAQGQQE-----ESHFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSG 358
            .|.:|.|||:  |:.:::     .::|.|:||...||.|::...:.|.....|      .||
  Rat   198 NPKYGVWTIK--AKYKKDFTTTGTAYFEVKEYVLPRFSVSIEPESNFIGYKNF------KNF--- 251

  Fly   359 LPVRGNLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLP 423
                 .:|:||.     ||.|:::                             |..:..:...|.
  Rat   252 -----EITVKAR-----YFYNKMV-----------------------------PDAEVYIFFGLR 277

  Fly   424 QDGADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNG---- 484
            :|                             :::.|.|         ...|.:......||
  Rat   278 ED-----------------------------IKEDEKQ---------MMHKAMQAATLVNGVAQI 304

  Fly   485 TFDFKWPLRELEL-LVPNLANSEVLITATVGEK---FYDE--------IISGYSVARVYNSSLRV 537
            :||.:..::||.. .:.:|.|..:.|..||.|.   |.:|        ::|.|::..|
  Rat   305 SFDSETAVKELSYESLEDLNNKYLYIAVTVTESSGGFSEEAEIPGIKYVLSPYTLNLV------- 362

  Fly   538 VFLGDSPQVFKPAMPFTTYLAVEYHD-------GSPIDPNLLRQGL---MEVSGFVESRNGGRRD 592
                .:|...||.:||:  :.|:..|       |.|:  .|:.|.:   .|.|.....|:
  Rat   363 ----ATPLFLKPGIPFS--IKVQVKDSLEQLVGGVPV--TLMAQTVNVNQETSDLEPKRS----- 414

  Fly   593 WPAQRLPMSQQSDGIWEVKIDIRND---LNLDDRPQARDFLNGVQNMRLQANFVDPRGERIQTEL 654
                   ::..:||:....:::.::   |..:.:..|.:.               |...:...|.
  Rat   415 -------ITHSADGVASFVVNLPSEVTSLKFEVKTDAPEL---------------PEENQASKEY 457

  Fly   655 LLVSHYSPRNQHIKV-TTSTEKP-VVGEYI-IFHIRTNFYLEE---FNYLIMSKGVILV--NDRE 711
            ..|::.|....:|.: .|...|| :||||: |.....:.|:::   :||||:|||.|:.  ...:
  Rat   458 EAVTYSSLSQSYIYIGWTENYKPMLVGEYLNIIVTPKSPYIDKITHYNYLILSKGKIVQYGTKEK 522

  Fly   712 TITEGIKTIAVVLSSEMAPVATIVVWKI---NQQGQVVADSLTFPVNGISRNNFTVYINNRK--A 771
            .:....:.|.:.::.:|.|.|.::|:.|   .|..::|||::...:.....|...|:::..|  .
  Rat   523 LLYSSYQNINIPVTQDMVPSARLLVYYIVTGEQTAELVADAVWINIEEKCGNQLQVHLSPDKDVY 587

  Fly   772 RTGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQTNGTYKHIWYSHEG 836
            ..|:.|.:.:..|..|:|.||.:|||.|.::...:....::   ...||::::     :.....|
  Rat   588 SPGQTVSLDMVTEADSWVALSAVDSAVYGVRGKAKRAMQRV---FQAFDDKSD-----LGCGAGG 644

  Fly   837 NPDELVYFPASSFGVDANRTFEYSGLIVFTDGYVPRRQ---DTCNRTL-----------GFGECL 887
            ..|          .||   .|..:||...|:......|   |:|...|           ...|..
  Rat   645 GRD----------NVD---VFHLAGLTFLTNANADDSQYHDDSCKEILRPKRDLQLLHQKVEEQA 696

  Fly   888 SGRCYRLEKQCDGLFDCDDGTDEINCHARNDTELLNYRKYR----------FN------------ 930
            :...:|:.|:|     |.||..|      |..|....|..|          ||
  Rat   697 AKYKHRVPKKC-----CYDGARE------NKYETCEQRVARVTIGPHCIRAFNECCTIADKIRKE 750

  Fly   931 ----------------------RVLRHYENVWLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSV 973
                                  .:..::...||| :|:..|. |....|.:||....|.:....:
  Rat   751 SHHKGMLLGRIQIKALLPVMKAEIRSYFPESWLW-EVHRVPK-RNQLQVALPDSLTTWEIQGIGI 813

  Fly   974 SPSKGFGMMN--KALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNY---------MITPIEAI 1027
            | ..|..:.:  ||..:..|   |:.:.:|.:..:|||:.::.||:||         .::.:|.|
  Rat   814 S-DNGICVADTLKAKVFKDV---FLEMNIPYSVVRGEQIQLKGTVYNYRTSGTMFCVKMSAVEGI 874

  Fly  1028 VVLHDSPDYKFVHVEEDGIVRSYNPRTSFGEHQFFIYLEAQGTTVVYVPVVPQRLGNVDVTLHVA 1092
            .....|               :.:|:||.........:|...:.:|...::|..:|...:...:.
  Rat   875 CTPGSS---------------AASPQTSRSSRCVRQRIEGSSSHLVTFSLLPLEIGLHSINFSLE 924

  Fly  1093 TLLGTDTITRTLHVESDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNK 1157
            |..|.:.:.:||.|..:|:.:..:..|.|| ....|.:      |.:..|.||::....|..:|.
  Rat   925 TSFGKEILVKTLRVVPEGIKRESYAGVTLD-PRGVYGI------VNRRKEFPYRIPLDLVPKTNV 982

  Fly  1158 ARI-SVVGDVVGPIFPTM--PVNASSLLSLPMESGEQNAFSFAANLYTIMYMRLINQ-------- 1211
            .|| ||.|.::|....|:  ......|..||..|.|....|.....|...|:...|.
  Rat   983 KRILSVKGLLIGEFLSTVLSKEGIDILTHLPKGSAEAELMSIVPVFYVFHYLEAGNHWNIFHPDT 1047

  Fly  1212 --RNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQEASFYEWE 1274
              |.::|:|.    :..|....:|:...|.|:|:    |..:.||.|||::.|||..:.:.|
  Rat  1048 LARKQSLQKK----IKEGLVSVMSYRNADYSYSM----WKGASSSAWLTAFALRVLGQVNKY--- 1101

  Fly  1275 NFIWIDATIIEKNMRWLLQH-QTPQGSFFEVT-WLPDRKMNRTNFDKNITLTSH-----VLITLA 1332
              :..|...|..::.||::. |...|||.|.: :||.:...        ||.:.     :.:|..
  Rat  1102 --VKQDQYSICNSLLWLIEKCQLENGSFKENSQYLPIKLQG--------TLPAEAQENTLYLTAF 1156

  Fly  1333 TVKDISGTLGSRVALA---TQRALAYIERNMDFLRHQAQP----FDVAITAYALQLCN--SPIAE 1388
            :|      :|.|.|:.   |::....:.:...||..:..|    |.:||.||||.|.:  .|...
  Rat  1157 SV------IGIRKAIGICPTEKIYTALAKADSFLLERTLPSKSTFTLAIVAYALSLGDRTHPKFR 1215

  Fly  1389 EVFAILRRQARTIGD---FMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYV 1450
            .:.:.|:|:|...||   :.:| ...:.:|.....|.....:           :||||||||..:
  Rat  1216 SIVSALKREALVKGDPPIYRFW-RDTLQRPDSSAPNSGTAGM-----------VETTAYALLTSL 1268

  Fly  1451 ARRE-FFVDPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQGGK 1514
            ..:| .:|:||::||:.::...||:.|||||..|::.|.||          ||.|
  Rat  1269 NLKETSYVNPIIKWLSEEQRYGGGFYSTQDTINAIEGLTEY----------SLLV---------- 1313

  Fly  1515 TQTLYID-DTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNVDIEKFQTKP-PVP----- 1572
             :.|::| |.|               :..:.||..|       ||.|..:.|..:| .||
  Rat  1314 -KQLHLDMDIN---------------VSYKHKGDFY-------QYKVTEKNFLGRPVEVPLNDDL 1355

  Fly  1573 ------AFGLHT---KAIFHGRN-------------------QSHISY--------VACQNWINQ 1601
                  :.||.|   |.:.|..:                   .|::||        :||.::...
  Rat  1356 IVTTGYSSGLATVYVKTVVHKTSVAEEFCSFYLKIDTQEVEASSYLSYSDSGHKRIIACASYKPS 1420

  Fly  1602 NESERSGM--AVLDVAIPTGYWIQQQKL-------DTYVLSNRVRNLRRARYLERKIVFYFDYLD 1657
            .|...||.  ||:|:.:|||....|:.|       |..:...:::        :..::...:.:.
  Rat  1421 KEESASGSSHAVMDILLPTGIGANQEDLRALVEGVDQLLTDYQIK--------DSHVILQLNSIP 1477

  Fly  1658 HED-ICVNFTIERWYPVANMSRYLPV--RIYDYYAPERFNESIFDALPTYLLNICE----VCGSS 1715
            ..| :||.|.|...:.|..::   |.  .:|:|:.|::....|:....|.|..:||    .|..:
  Rat  1478 SRDFLCVRFRIFELFQVGFLN---PATFTVYEYHRPDKQCTMIYSTSDTNLQRVCEGAACKCVEA 1539

  Fly  1716 QC 1717
            .|
  Rat  1540 DC 1541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	A2M_N	232..332	CDD:280081	27/105 (26%)
		A2M_N_2	669..799	CDD:285005	40/142 (28%)
		LDLa	886..913	CDD:238060	7/26 (27%)
		A2M	940..1030	CDD:278630	26/100 (26%)
		ISOPREN_C2_like	1177..1490	CDD:298658	89/342 (26%)
		A2M_comp	1226..1492	CDD:284982	79/285 (28%)
		A2M_recep	1607..1695	CDD:284981	21/99 (21%)
C5	NP_444179.1	MG1	25..125	CDD:375333	23/112 (21%)
		A2M_N	131..224	CDD:376626	22/95 (23%)
		MG3	226..310	CDD:375334	25/169 (15%)
		MG4	359..462	CDD:375332	22/144 (15%)
		A2M_N_2	475..615	CDD:377903	40/139 (29%)
		ANATO	691..759	CDD:237984	14/78 (18%)
		A2M	781..868	CDD:365945	24/92 (26%)
		complement_C3_C4_C5	1004..1309	CDD:239226	89/343 (26%)
		A2M_recep	1428..1518	CDD:369460	19/100 (19%)
		NTR_like	1536..1685	CDD:382999	2/6 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010