Protein Alignment Mcr and Tep1

DIOPT Version :10

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: NP_523578.1
• Gene: Tep1 / 34937
• FlyBaseID: FBgn0041183
• Length: 1354
• Species: Drosophila melanogaster
• Alignment Length: 1660
• Identity: 371/1660 - (22%)
• Similarity: 672/1660 - (40%)
• Gaps: 374/1660 - (22%)

  Fly   117 IKATFLES--LHSREPTYFIVASRMVRPGLIYQVSVSILQAQYPITVHASIACDGVQI------- 172
            :.:|.|..  |.:....|.::|.:.:|....|.|.|:|.....  |...|::..|..:
  Fly     6 LSSTILHCVLLSNANGLYSVLAPKTLRSNSAYNVVVAIHNTTR--TTEVSVSLTGPSLNSRKYVD 68

  Fly   173 --SGDSKDVKEGIPETLLMRIPPTSVTGSYKLRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQ 235
              |..||.|:..||:.         ..|.|:|:|.|     .||:.|.|.|:|.|:.....:::|
  Fly    69 VQSMSSKSVRFDIPKL---------TEGDYELKVMG-----SGGIEFQNSTKLSFAPDLNWLYIQ 119

  Fly   236 TDKPLYMQGETVRFRTIPI--TTELKGFDNPVDVYMLDPNRHILKRWLSRQSNLGSVSLEYKLSD 298
            :||..|..|:.::||.:.:  .|.....|.|:.:.:.|.:::::|.|...:...|..|.|.:|||
  Fly   120 SDKATYKPGDKIQFRVLFLDKNTRPAVIDKPIKIEIRDGDQNLIKSWKDIKPAKGVYSGELQLSD 184

  Fly   299 QPTFGEWTIRVIAQGQQEESH-FTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVR 362
            :|..|.||:....|.:.:.:: ..|::|...:|||.|........:..:|...:.|.:|...||:
  Fly   185 RPVLGNWTVTATVQDEGKVTNVLVVDKYVVPKFEVVVLTAKNVAASAGYIRATIKARYTFKKPVK 249

  Fly   363 GNLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGA 427
            |:  :.|||.                 .|..||:                         ||.||
  Fly   250 GH--VVATIE-----------------GSSTEQS-------------------------LPIDG- 269

  Fly   428 DLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPL 492
                              :.:.|:|.               |.|.::.|.
  Fly   270 ------------------EVNVEFPI---------------SATAKRLLK--------------- 286

  Fly   493 RELELLVPNLANSEVLITATVGEKFYDEIISG--YSVARVYNSSLRVVFLGDSPQVFKPAMPFTT 555
                            |||.|.|:..|...:|  |.....:...|..:|.   |..::|.:....
  Fly   287 ----------------ITAIVTEELTDIKHNGTAYVTVHQHRHKLEDLFW---PTHYRPGVSSEF 332

  Fly   556 YLAVEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLPMSQQSDGIWEVKIDIRNDLNL 620
            ...|...||||:         |:.|..|                                 :.|:
  Fly   333 KTVVRNLDGSPV---------MDSSKMV---------------------------------NFNV 355

  Fly   621 DDRPQARDFLNGVQNMRLQANFVDPRGERIQTELLL--------VSHYSPR-NQHIKVTTSTEKP 676
            .....:::|...:||.....:.:.|  |..|:.|:.        :..|..: |:.:.:..:|:||
  Fly   356 LCCQVSKNFSASLQNSIATEHIMLP--ETCQSCLVTSTFDTAENIERYIYKLNKPLMIAINTKKP 418

  Fly   677 VVGEYIIFHIRTNFYLEEFNYLIMSKGVILVNDRETITEGIKTIAVVLSSEMA--PVATIVVWKI 739
            .:.:.:..:|.::.||..|...::::|.|:::..:.:.|..|:..:......|  |.|||.|..|
  Fly   419 QLRKLLKINIISDTYLPYFILTVVARGNIVLSLFQEMKEKKKSQEIEFEPTFALVPQATIFVHYI 483

  Fly   740 NQQGQVVADSLTFPVNGISRNNFTVYINNRKARTGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAG 804
             ..|.:::|..|..:.....|...:...| :|...::|.:.:...|.|:|||.|:|.:...:::|
  Fly   484 -IDGVLMSDEKTVDIERDFENTIEILTTN-EALPRDEVSLKVKTNPHSFVGLLGVDQSVLLLRSG 546

  Fly   805 NELTYAKIITKMSNFDEQTNGTYKHIWYSHEGNPDELVYFPASSFGVDANRTFEYSGLIVFTDGY 869
            |:|....|:..::.:.                                       :.|::.|:..
  Fly   547 NDLNRDLILNNLATYS---------------------------------------TDLVILTNAN 572

  Fly   870 VP--RRQDTCNRTLGFGEC---LSGRCYRLEKQCDGLFDCDDGTDEINCHARNDTELLNYRKYRF 929
            :.  |....|....|:..|   |.||.....:...     :.|...|....|....|...||.
  Fly   573 INIYRSSGGCYTNPGYTNCTGSLIGRTMFKNEPTK-----NSGPVPIVGSTRAQASLPPVRKL-- 630

  Fly   930 NRVLRHYENVWLWKDV-NIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQP 993
                  :...||:.:: ::|.:|.||....|||....|:::.||:||..|..:..........||
  Fly   631 ------FPETWLFSNITDVGANGEYIIKETVPDTLTSWVITGFSLSPQSGLAVTRNPSRIRVFQP 689

  Fly   994 FFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDSP-DYKFVHVEEDGI---VRSYNPRT 1054
            |||...:|.:.::||.:.|.|.||||:...::|.|::.:|. .|:|:......:   :|....:.
  Fly   690 FFITTNLPYSVKRGEVIAIPVIVFNYLGMDVKAKVLMDNSDGQYEFIETTNKNVSQYLRGVRRKK 754

  Fly  1055 SFGEHQFFIYLEAQGTTVVYVPVVPQRLGNVDVTLHVATLLGTDTITRTLHVESDGLPQYRHQSV 1119
            :       :::.|.....:...:.|:::|...:.:...:....|.:.:.|.||:||:.:|.:::|
  Fly   755 T-------LWIPANTGRGISFMIRPKKVGLTTLKITAISKYAGDRLHQILKVEADGVQKYVNKAV 812

  Fly  1120 LLD---LSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNASSL 1181
            |::   |:.|:.......:.:.:...:        :.||......|.|....|...    :...|
  Fly   813 LINVQRLNRRSLAPPEKTIIIEKADNV--------IEGSETVEFEVCGTSQAPQLE----HLDDL 865

  Fly  1182 LSLPMESGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRS 1246
            :.||...||||.|:|..::..:.|::..|::::.:|..|..::..|||.:|::.|.|||||.
  Fly   866 VHLPCGCGEQNMFNFVPSILALSYLKAKNRQDQEIENKAKRYVETGYQIELNYKRNDGSFSA--- 927

  Fly  1247 DWNNSDS--SVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPD 1309
             |...|:  |.|||:|.:|.|.:|:.|     |.||..::...:.:|:..|:..|.|.|:
  Fly   928 -WGQHDALGSTWLTAYVIRSFHQAAKY-----IDIDKNVLVAGLDFLVSRQSTDGKFKEL----- 981

  Fly  1310 RKMNRTNFDKNITLTSHVLITLATVKDISGTLGSRVALATQRALAYIERNMDFLRHQA-QPFDVA 1373
            ..:...:....:.|||.||:|....::..    .:......||:.::...:    ||: :|:|:|
  Fly   982 GMVIHNSHGSPLALTSFVLLTFFENEEYM----PKYKHVIDRAVEFVVTEV----HQSNEPYDLA 1038

  Fly  1374 ITAYALQLCNSPIAEEVFAILRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLN 1438
            |.|.||.|..:..|.:|...|.:.|...||..:|...:                     :..|..
  Fly  1039 IAALALSLARNRNAYKVLDKLDKLATRRGDHKWWTGSD---------------------KCKSSE 1082

  Fly  1439 IETTAYALLVYVARREFFVD---PIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVS 1500
            :|||:|.||..:...  ..|   |||.||.|:|.::||:.|:|||...:.||.:|.::|   ..|
  Fly  1083 VETTSYVLLALLEHN--ISDEPKPIVDWLISKRNSNGGFVSSQDTVVGIMALTKYELQS---HAS 1142

  Fly  1501 SLTVEIEASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNVDIEKF 1565
            :..::||........:.:.:...|..|:|:.::|:....:|:.|||.|.|.:|:..:|||
  Fly  1143 TEAIDIEFWHLNEDKKHVRVTKENEFKVQTHQLPENTNEVKLLAKGQGRAQVQLTYRYNV----- 1202

  Fly  1566 QTKPPVPAFGLHTKAIFHGRNQSH---ISYVACQNWINQNESER---SGMAVLDVAIPTGYWIQQ 1624
            .||...|:|.|.|..     .:||   :....|..:.....|||   :.||::.|.:|:||...
  Fly  1203 ATKEARPSFKLTTTV-----KKSHKGRLILGICGTYTPIAASERNKTTNMALMQVQLPSGYVCD- 1261

  Fly  1625 QKLDTYVLSNRVRNLRR--ARYLERKIVFYFDYLDHED-ICVNFTIERWY--PVANMSRYLP--V 1682
              ::.:.....:.:::|  .:..:.::..||:.|...| .|:  |:|..|  .|||:.   |  |
  Fly  1262 --IEPFADIEAISDVKRVETKNEDTEVHIYFEKLSPGDRKCL--TLEAIYTHAVANLK---PSWV 1319

  Fly  1683 RIYDYYAPERFNESIFDALPTYLLNICEVCGSSQC 1717
            |:|||||.|| :.:.|..:.|   ::|::|..::|
  Fly  1320 RLYDYYATER-SATEFYHVDT---SLCDICHGNEC 1350

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	YfaS	<226..1575	CDD:441940	298/1383 (22%)
		A2M_BRD	667..801	CDD:462235	32/135 (24%)
		A2M	939..1030	CDD:459711	31/91 (34%)
		TED_complement	1160..1490	CDD:462227	93/335 (28%)
		A2M_recep	1605..1699	CDD:462226	30/103 (29%)
Tep1	NP_523578.1	YfaS	<117..1200	CDD:441940	292/1359 (21%)
		A2M_2	859..1135	CDD:239227	90/324 (28%)
		A2M_recep	1243..1336	CDD:462226	29/101 (29%)