Protein Alignment Mcr and Tep3

DIOPT Version :9

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: NP_523507.2
• Gene: Tep3 / 34045
• FlyBaseID: FBgn0041181
• Length: 1469
• Species: Drosophila melanogaster
• Alignment Length: 1677
• Identity: 394/1677 - (23%)
• Similarity: 669/1677 - (39%)
• Gaps: 370/1677 - (22%)

  Fly   127 SREPTYFIVASRMVRPGLIYQVSVSILQAQYPITVHASIACDGVQISGDSKDVKEGIPETLLMRI 191
            |.:..|.|:|...:||...:.|:||:..|....|....|......   |.|.|:.....|.|:..
  Fly    26 SAQGLYSIIAPNTLRPNSQFHVAVSLHNAPESATFKVGILGSSYT---DFKTVELRPFSTQLLHF 87

  Fly   192 P-PTSVTGSYKLRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTDKPLYMQGETVRFRTIPIT 255
            . |...|..|:|..||     .||:.|.|||:|.|..:..|:.|||||.:|..|:.|.:|.:.:.
  Fly    88 EIPALRTDRYRLTAEG-----LGGVQFTNETQLHFESKQHTVLVQTDKSIYKPGDLVHYRVLILD 147

  Fly   256 TELK---GFDNPVDVYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFGEWTIRVIAQGQQEE 317
            ..||   |:.. |.|.:.|...:|::.:...:......|.|.:|||.|.||.|:|.|....|:..
  Fly   148 ANLKPARGYGR-VHVDIKDSGDNIIRSYKDIRLTNSIYSNELRLSDSPRFGTWSIVVDVSDQEHT 211

  Fly   318 SHFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIK------ATIRPIGY 376
            ..|.:.::...:|.|::..|.:....|..|...|.|::..|.|:.|..|:.      .:::|
  Fly   212 QTFEILDHILPKFVVDIDTPKHAIYKDGKIAATVRAHYAFGQPIVGEATLSIYPTFFGSLQP--- 273

  Fly   377 FSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRNQYVV 441
            |.|.::..|.                                   :|.||          |.|
  Fly   274 FVNDLITRKV-----------------------------------VPIDG----------NAY-- 291

  Fly   442 ERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSE 506
               ::||.|....::    ||  ||                                      .:
  Fly   292 ---FEFDIENELHLK----QD--YE--------------------------------------RQ 309

  Fly   507 VLITATVGEKFYDEIISGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSPI---D 568
            .|:.|.|.||....:.:..:|..::.:..||..: ..|..:.|.:||.....:..:||..:   :
  Fly   310 YLLDALVEEKSTGSVQNYSTVLTLHLNHYRVEAV-KVPSYYIPGVPFEATARIARNDGGQLRDFN 373

  Fly   569 PNLLRQGLMEVSGFVESRNGGRRDWPAQRLPMSQQSDGIWEVKIDIRNDLNLDDRPQARDFLNGV 633
            |.:... |..|.|..|..|         |...|..:.|    :|.::..:.:.||.:....:
  Fly   374 PQITAY-LTNVYGSSEMYN---------RTAYSLDASG----EIKMKFTVPIGDRDEFHSII--- 421

  Fly   634 QNMRLQANFVDPRGERIQTELLLVSHYSPRNQHIKVTTSTEKPVVGEYIIFHIRTNFYLEEFNYL 698
                     ||.:|...:...:...|...:| :|......::|.|.:.|...:|:...::.|.|.
  Fly   422 ---------VDYQGVISEVGKIPSKHLHSKN-YITAKVLNDRPTVNQEISVVVRSFAPIKYFMYQ 476

  Fly   699 IMSKGVILVNDRETITEG-IKTIAVVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNGISRNNF 762
            ::.:|.|:::....:..| ..||..:.|..|.|.|.::|:.: ..|:.|.|.....:.....|..
  Fly   477 VVGRGDIILSRNVDVAPGTFHTIKFLASFAMMPRANLLVYTV-IDGEFVYDEQVIQLEENLLNAV 540

  Fly   763 TVYINNRKARTGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQTNGTY 827
            .|....| |..|:.:::.|..:|.|||||..:|.....:::|::||:.:::..:.:::.....|
  Fly   541 QVDAPIR-APPGQDIDIGISTKPYSYVGLMLVDQNANDLRSGHDLTHKRLMDALRSYELSDVNT- 603

  Fly   828 KHIWYSHEGNPDELVYFPASSFGVDANRTFEYSGLIVFTDGYVPRRQDTCNRTLGFGECLSGRCY 892
                             |..|.|.:       ||:|.                      :|...|
  Fly   604 -----------------PMGSPGKE-------SGVIT----------------------MSNTDY 622

  Fly   893 RLEKQCDGLFDCDDGTD-EINCHARNDTELLNYRK--------------------YRFN------ 930
            .:||:.:.    :...| |::.....| :|...||                    |.|:
  Fly   623 FIEKEAES----NPALDREVSTGPEED-KLTTVRKTDIGPAHKIEVNTLPPGKGRYAFSYTPKPF 682

  Fly   931 ------RVLRHYENVWLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMM--NKALE 987
                  .|:|...:.||:.:::....||...:..:|.....|:||||::.|..|.|:.  |..||
  Fly   683 WHNPRVHVMRDPADTWLFLNISASSDGRNSIHRRIPSEMTSWVVSAFALDPVNGLGLSPPNGKLE 747

  Fly   988 YVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDSP-DYKFVHVEEDGI----V 1047
              ..:.|:|:.|:|.:.::.|.:.|...|.|...:.:...|..::|. |:.|..::....    |
  Fly   748 --AYKEFYISTELPYSIKRDELIAIPFVVHNNRDSDLNVEVTFYNSALDFDFPQLDPKATNQPKV 810

  Fly  1048 RSYNPRTSFGEHQFFIYLEAQGTTV--VYVPVVPQRLGNVDVTLHVATLLGTDTITRTLHVESDG 1110
            ..|..|:          |:..|.:.  |...|.|:|:|.:.|....|:....||:.:.|.||..|
  Fly   811 ELYRRRS----------LQVPGRSARSVSFIVTPKRVGPLLVKAMAASSQAGDTVEQNLLVEHPG 865

  Fly  1111 LPQYRHQSVLLDLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMP 1175
                     .::..||.::.| ::.|......:...|.|..:..|.:..:|.|||::|    ::.
  Fly   866 ---------AMERINRGFLFE-LNSNAQNRRNVTIAVPRNAIPESTRIEVSAVGDLIG----SLV 916

  Fly  1176 VNASSLLSLPMESGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGS 1240
            .|..||:.||...|||...:|..||..:.|:..:.|....:|..|..::.|||||.|.:...:|:
  Fly   917 GNLDSLILLPTGCGEQTMVNFVPNLIVLRYLGRLRQLTPEVELRATNNLAIGYQRILYYRHENGA 981

  Fly  1241 FSLFRSDWNNSDSSVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVT 1305
            ||.|..|...  ||.|||:|..|..::|:     .|..:|:.:::|.:.:|...|:..|.|.|..
  Fly   982 FSAFGLDIKR--SSTWLTAYVARSLRQAA-----PFTQVDSNVLQKALTYLGSVQSANGGFEERG 1039

  Fly  1306 WLPDRKMNRTNF-DKNITLTSHVLITLATVKDISGTLGSRVALATQRALAYIERNMDFLRHQAQP 1369
            .:.:|      | |..|:||:.|.:.|....|:.....:.:    .:||.:|.|.:|   ..:..
  Fly  1040 DVFER------FGDDGISLTAFVTLALMENVDLYPEYRNNI----NKALDFITRGLD---GSSNL 1091

  Fly  1370 FDVAITAYALQLCNSPIAEEVFAILRRQARTIGDFMYWGNQEIP----QPPRKLENQKWFSLPRL 1430
            ..:||..|.|...|.. |:..|........|..|.:.|.|:..|    |.|       |::..|
  Fly  1092 HAMAIGTYVLSRANHN-AKAAFLQRLDSMATNKDGLKWWNKTAPAGEQQSP-------WYNATR- 1147

  Fly  1431 PYEYDSLNIETTAYALLVYVARREFFVD--PIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVR 1493
                 |:|||.:|||.|. :.......|  |::.||..||...||:.::|||...|:||:.:..|
  Fly  1148 -----SVNIEISAYAALA-LLENNLVGDALPVLNWLMDQRNPKGGFVASQDTVVGLQALLMFAER 1206

  Fly  1494 SRLREVSSLTVEIEASSQGGKTQ-----------TLYIDDTNLAKLQSIEIPDAWGTIKVQAKGA 1547
                          .||||...|           .:.::..|...||::|:|:....:.|.|.|.
  Fly  1207 --------------FSSQGNNLQIGFHYGEGAETIINVNAENSLALQTVELPNNLKNLSVSATGR 1257

  Fly  1548 GYAILQMHVQYNVDI----EKFQTKPPVPAFGLHTKAIFHGRNQSHISYV---ACQNWIN---QN 1602
            |.|:.|:...||.::    .:|...|.|            .|| ||..|:   ||.::::   :|
  Fly  1258 GMALAQVSYTYNTNVTSAWPRFVLDPTV------------NRN-SHADYLHLSACASFVSVVGEN 1309

  Fly  1603 ESERSGMAVLDVAIPTGYWIQQQKLDTYVLSNRVRNLRRARYLERKIVFYFDYLDHEDICVNFTI 1667
            | :||.|||::|.:|:|:.:.:..|.|...|.|::.: ..:....|:|.||||||..::|...
  Fly  1310 E-QRSNMAVMEVHLPSGFVVDRDTLPTLESSERIKKV-ETQNRNTKVVIYFDYLDRREVCPTL-- 1370

  Fly  1668 ERWYPVANMSRYLPVRI--YDYYAPERFNESIFDALPTYLLNICEVCGSSQC 1717
             ..|....::::.||.:  ||||...|.....:.|..:   |||::|..:.|
  Fly  1371 -HAYKTVKVTKHRPVAVVMYDYYDSARRARQFYRAPKS---NICDICEHANC 1418

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	A2M_N	232..332	CDD:280081	30/102 (29%)
		A2M_N_2	669..799	CDD:285005	32/130 (25%)
		LDLa	886..913	CDD:238060	6/27 (22%)
		A2M	940..1030	CDD:278630	25/91 (27%)
		ISOPREN_C2_like	1177..1490	CDD:298658	94/319 (29%)
		A2M_comp	1226..1492	CDD:284982	79/272 (29%)
		A2M_recep	1607..1695	CDD:284981	28/89 (31%)
Tep3	NP_523507.2	A2M_N	124..215	CDD:280081	28/91 (31%)
		A2M_N_2	448..573	CDD:285005	31/126 (25%)
		A2M	697..787	CDD:278630	24/91 (26%)
		A2M_2	918..1203	CDD:239227	94/319 (29%)
		A2M_comp	967..1200	CDD:284982	77/267 (29%)
		A2M_recep	1313..1402	CDD:284981	28/92 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2373
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	76	1.000	Inparanoid score	I382
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10215at33392
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.970