Protein Alignment Mcr and LOC3291704

DIOPT Version :10

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: XP_061514081.1
• Gene: LOC3291704 / 3291704
• VectorBaseID: AGAMI1_013130
• Length: 1452
• Species: Anopheles gambiae
• Alignment Length: 1690
• Identity: 405/1690 - (23%)
• Similarity: 711/1690 - (42%)
• Gaps: 353/1690 - (20%)

  Fly    97 GGGYQDNEEPSLTRGKSSYNIKATFLESLHSREPTYFIVASRMVRPGLIYQVSVSILQAQYPITV 161
            |||.:...|           :|.|..:....::..|.|:.:|::||..:|:..||....:..|..
Mosquito     5 GGGMRFGGE-----------VKRTVPDPKDHKDGHYSIIGARILRPNSVYRCVVSTFDTKVAIVF 58

  Fly   162 HASIACDGVQI--------SGDSKDVK---EGIPETLLMRIPPTSVTGSYKLRVEGFYQNVFGGL 215
            ..|||.....|        |.:|:.:.   :.|||.            .|:|..||     ..||
Mosquito    59 RISIAAKDKPIATEEITLNSNESRLISFTIDSIPEE------------EYELVAEG-----LSGL 106

  Fly   216 AFLNETRLDFSQRSMTIFVQTDKPLYMQGETVRFRTIPITTELKGF---DNPVDVYMLDPNRHIL 277
            .|..::||||..:..::.:||||.:|..|:|||:|.:.:...:|..   |:.:.||:.|...:.:
Mosquito   107 EFKTKSRLDFDNKFCSVLIQTDKSVYKPGDTVRYRVLVLDRCMKPLPAGDSGMMVYIRDGKGNRI 171

  Fly   278 KRWLSRQSNLGSVSL---EYKLSDQPTFGEWTIRVIAQGQQEESHFTVEEYYQTRFEVNVTMPAY 339
            |:|  ..::||...:   |..||.:|..|||||.|...|.:|...|.|:||....:||.|..|.|
Mosquito   172 KQW--SNASLGECGVFQAELTLSTEPVLGEWTINVEVVGLKESKTFDVDEYVLPTYEVTVESPGY 234

  Fly   340 FFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWR 404
            .|..|..:...|.:.:|.|.||.|.||:...:.....|.           |.|.|
Mosquito   235 TFLDDELLKVVVNSKYTYGKPVAGELTVSVKLASSMCFR-----------REPTE---------- 278

  Fly   405 YNNPNQNPQVQYNVPGQLPQDGADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWS 469
                                                                            :
Mosquito   279 ----------------------------------------------------------------T 279

  Fly   470 GTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEVLITATVGEKFYDEIISGYSVARVYNSS 534
            ...:|.||    .:|..|.::.|:  |:|.......|:.|.|.|.|........|.:..::::..
Mosquito   280 SICQKVLP----IDGKTDVEFNLK--EILSSKTYIRELTIEAEVCETLTGRTQKGSTTVQLHDER 338

  Fly   535 LRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLP 599
            .:|..:.:|.  :.|.:|:..::.|...||||:
Mosquito   339 YQVRMIEESS--YFPGLPYNAWIQVTNLDGSPV-------------------------------- 369

  Fly   600 MSQQSDGIWEVKIDIRN---DLN-----LDDRPQARDFLNGVQNMRLQANFVDPRGERIQTELLL 656
                .||..||:|.:||   ||:     |||:..|:  || |:...|..::|....:....:..:
Mosquito   370 ----QDGAKEVEIVLRNYNIDLHKQSSTLDDKGMAQ--LN-VKLDELDFDYVSVEVKYRGKDYYV 427

  Fly   657 VSHYSPRNQH---IKVTTSTEKPVVGEYIIFHIRTNFYLEEFNYLIMSKGVILVNDRETITEGIK 718
            .....||:..   ::|..|.::|..|:.:.|.:.....|:..:|.::::|.:|.......:|...
Mosquito   428 QGITKPRDYEEALMRVRLSEKEPTAGKDLTFDVACTKPLQCVSYSLLARGELLAGGAVKGSEAST 492

  Fly   719 TIAVVLSS--EMAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYINNRKARTGEKVEVAI 781
            ||::.:.|  .|.|.|.::|..|:..|.:|:...|.....:..|...:.::..:.:..|.:::.|
Mosquito   493 TISITIPSTFAMVPRAKLLVHYISSAGYIVSSYDTVEFKRVFENQIQLTLSKDELKPVETLDIDI 557

  Fly   782 FGEPGSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQTNGTYKHIWYSHEGNPDELVYFPA 846
            ..|..|:|||..:|.:...:::||:::..:::.::..::...|    :.|.::..:..:.|
Mosquito   558 RTEKDSFVGLLAVDQSVLLLKSGNDISRDEVVQQLEMYESAQN----YHWDAYSTSDCQSV---- 614

  Fly   847 SSFGVDANRTFEYSGLIVFTDGYVPR------RQDTCNRTL-GFGEC-LSGRCYRLEKQCDGLFD 903
                          |.::.::.::||      |...|:.:. |||.. :...|    |....:.:
Mosquito   615 --------------GAVLLSNRFIPRDIFPQARLFACSTSAGGFGAAPMMAAC----KMKGVIME 661

  Fly   904 CDDGTDEINCHARNDTELLNYRKYRFNRVLRHYENVWLWKDVNIGPHGRYIFNVEVPDRPAYWMV 968
            .:..|..:|    ..|            |...:...|:|:.::.......|..: |||....|::
Mosquito   662 SEMATAPVN----EPT------------VRSKFPETWIWESISKCKEMESIRKI-VPDTITSWII 709

  Fly   969 SAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDS 1033
            :.||:|.|.|.|:::...:.....|||:::::|.:.:.||.:.|.|.|||||.....|.|:.:::
Mosquito   710 TGFSLSKSHGLGLVDNPSKVNVFMPFFLSIDLPYSVKLGETIRIPVVVFNYMDEDQLADVIFYNN 774

  Fly  1034 PD-YKFV---------HVEEDGIVRSYNPRTSFGEHQFFIYLEAQGTTVVYVPVVPQRLGNVDVT 1088
            .| ::||         |.:|...|    ||             ..|.|:.:| :.|.::|:|.:.
Mosquito   775 DDEFEFVSDTKDQKEKHRQEQITV----PR-------------GTGKTLTFV-LKPTKVGHVTLK 821

  Fly  1089 LHVATLLGTDTITRTLHVESDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVY 1153
            :.....|..|.|.|.|.||.:|||||.::::|:||.        :...:.|..|:...||.  |.
Mosquito   822 ITAKCALAGDGIERQLLVEPEGLPQYINKALLVDLR--------LVKEIKQPFEVEIPVDA--VP 876

  Fly  1154 GSNKARISVVGDVVGPIFPTMPVNASSLLSLPMESGEQNAFSFAANLYTIMYMRLINQRNKTLEK 1218
            .|....:||:|||:|....    |..||:.:|...||||..:|...:..:.|::...:....:|.
Mosquito   877 DSTNVEVSVIGDVLGSSIE----NLDSLIRMPFGCGEQNMLNFVPCIVVLDYLKACKRLTVEIES 937

  Fly  1219 NAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQEASFYEWENFIWIDATI 1283
            .|...|.|||||:|::...|||||.|..  ::...|.|||::..:.||:|:     ..:.|:..:
Mosquito   938 KAKRCMEIGYQRELTYKHQDGSFSAFGE--SDKSGSTWLTAFVAKSFQQAA-----KHMTIEEDV 995

  Fly  1284 IEKNMRWLLQHQTPQGSFFEVTWLPDRKMNRTNFDKNITLTSHVLITLATVKDISGTLGSRVALA 1348
            |:..:.||.:.||..|:|.||..:..:.| :......|.||::.:|....    :..||.:...:
Mosquito   996 IDSALGWLSKVQTADGAFPEVGTICHKDM-QGGAGSGIALTAYTVIAFLE----NPKLGEKYKAS 1055

  Fly  1349 TQRALAYIERNMDFLRHQAQPFDV---AITAYALQLCNSPIAEEVFAILRRQARTIGDFMYWGNQ 1410
            ..:||.|::      .|.::..||   |:.|||||:.:.|:..||:|.|..::...||..:| ::
Mosquito  1056 VDKALTYVK------EHISELDDVYAHALAAYALQIADHPLKNEVYASLLSKSNKQGDIQWW-SK 1113

  Fly  1411 EIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVARREFFVD--PIVRWLNSQRLNDGG 1473
            |||:  :...|..|:      |...|:|:|.:||.||..:......::  ||::||.|||.:.||
Mosquito  1114 EIPE--KNDSNCCWW------YRPCSVNVEMSAYGLLATLEASSAGLEGLPIMKWLVSQRNDKGG 1170

  Fly  1474 WASTQDTSAALKALVEYTVRSRLREVS-SLTVEIEASSQGGKTQTLYIDDTNLAKLQSIEIPDAW 1537
            :.|||||...|:||.:...:....|.. ||.|.|    .|.:.:.|.::..|:..||..|:....
Mosquito  1171 FESTQDTVVGLQALSKMAAQLSSSEADMSLKVII----TGEQEKCLQVNGGNILVLQKHELAANT 1231

  Fly  1538 GTIKVQAKGAGYAILQMHVQYNV-DIE---KFQTKPPVPAFGLHTKAIFHGRNQSHISYVACQNW 1598
            ..:::.|.|.|.|:.|:..:||: |::   :|..||...          .|..:|.|......::
Mosquito  1232 RKLEMIATGTGCALFQLSYKYNIKDVDNSPRFTLKPEAK----------QGSIKSCIDLSITTSF 1286

  Fly  1599 INQNESERSGMAVLDVAIPTGYWIQQQKLDTYVLSNRVRNLRRARYLERKIVFYFDYLDHEDICV 1663
            |.:.:...|.|||::|.:|:|:.::...|........|:.:...| .:..:|.|||.:..|.:.:
Mosquito  1287 IPKEDQAVSNMAVMEVDMPSGFIVESDTLKQLKQHEMVKKVETKR-SDTTVVLYFDNIGEEAVHL 1350

  Fly  1664 NFTIERWYPVANMSRYLPVRIYDYYAPERFNESIFDALPT-----------YLLNICEVCGSSQC 1717
            ..:..:.:.|.| ::...|.|||||.    |...||...|           |..::|.:....:|
Mosquito  1351 QMSAFQKHEVEN-AKPANVIIYDYYD----NSKCFDESCTIIAGCSNKYYSYSSSLCSIVLRDRC 1410

  Fly  1718  1717
            Mosquito  1411  1410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	YfaS	<226..1575	CDD:441940	336/1395 (24%)
		A2M_BRD	667..801	CDD:462235	30/135 (22%)
		A2M	939..1030	CDD:459711	28/90 (31%)
		TED_complement	1160..1490	CDD:462227	105/334 (31%)
		A2M_recep	1605..1699	CDD:462226	24/93 (26%)
LOC3291704	XP_061514081.1	None