Protein Alignment Mcr and c3a.1

DIOPT Version :10

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: NP_571317.1
• Gene: c3a.1 / 321046
• ZFINID: ZDB-GENE-990415-35
• Length: 1643
• Species: Danio rerio
• Alignment Length: 1800
• Identity: 383/1800 - (21%)
• Similarity: 670/1800 - (37%)
• Gaps: 486/1800 - (27%)

  Fly   117 IKATFLES-------LHSREPTYFIVASRMVRPGLIYQVSVSILQAQ--------YPITV----- 161
            :|..||.:       |...:|.|.:.|..::|.|....|.|   :||        ..|||
Zfish     2 VKLLFLSAVLLSSALLTLCDPLYVLSAPNLLRVGSSENVFV---EAQDYSKNAFEVKITVKNHPK 63

  Fly   162 -HASIACDGVQISGDSK-----DVKEGIPETLLMRIPPTSVTGSYKLRVEGFY-QNVFGGLAFLN 219
             ...|....|.::..:.     |:|....:.|....|         |..:..| |.:|.......
Zfish    64 KDKQILTKSVNLNAQNNFQILTDIKIPDDQNLFSDDP---------LEKQYVYLQAIFPDHTLEK 119

  Fly   220 ETRLDFSQRSMTIFVQTDKPLYMQGETVRFRTIPITTELKGFD---------NPVDVYMLDPNRH 275
            ...|.|  :|..||||||||:|....||::||:.:|..||...         ||.::.:.....:
Zfish   120 VVLLSF--QSGYIFVQTDKPIYTPSSTVQYRTLSLTPNLKPLSQTGITVEIMNPQNITVSSDKVY 182

  Fly   276 ILKRWLSRQSNLGSVSLEYKLSDQPTFGEW-TIRVIAQGQQE--ESHFTVEEYYQTRFEVNVTMP 337
            .:|         |..|.:|.:.:..:.|.| .:...|...|:  .:.|.|:||....|||.: .|
Zfish   183 PVK---------GMKSGKYAIPEVASLGIWKVVTRFANTPQKTFTAEFEVKEYVLPTFEVKL-QP 237

  Fly   338 A--YFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYN 400
            :  :::..|..:...:.|.:..|..|.||..:...:
Zfish   238 SKLFYYVGDESLTVDIEAKYLFGKQVEGNAFVMFGV----------------------------- 273

  Fly   401 ERWRYNNPNQNPQVQYNVPGQLPQ-------DGADLSQDILYRNQYVVERHYQFDEEWPFWVRKP 458
                     .:.:.:..:.|.|.:       ..|:|::.::
Zfish   274 ---------MDGETKTGITGSLQKIQILKGVGTAELTKQMI------------------------ 305

  Fly   459 EYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEVLITATVGEKFYDEII- 522
                       .||:.                                  |...||:..|..:.
Zfish   306 -----------ETYKS----------------------------------IDKLVGQSIYVSVSL 325

  Fly   523 ---SGYSVARVYNSSLRVVFLGDSP---------QVFKPAMPFTTYLAVEYHDGSPIDPNLLRQG 575
               ||..:.......:|:|   .||         |.|||.|||...:.|...|.:|.. |::
Zfish   326 LTESGSEMVEAERRGIRIV---TSPYTINFKKTAQFFKPGMPFDVSIYVTNPDETPAQ-NVI--- 383

  Fly   576 LMEVSGFVESRNGGRRDWPAQRLPMSQQSDGIWEVKIDIR------------NDLNLDDRPQARD 628
                   ||...||.|.        ..:::||.:|.::.:            .|.::.|..||
Zfish   384 -------VEVNPGGVRG--------QTKANGIAKVTVNTQGNVLTQEITAQTKDPDITDEEQA-- 431

  Fly   629 FLNGVQNMRLQANFVDPRGERIQTELLLVSHYSPRNQHIKVTTST-EKPVVGEYIIFHIRTNFYL 692
                |:.|...| :|...|.:....:.:.:........:||..:| :.|.|.:
Zfish   432 ----VKKMTAHA-YVPKGGSKNYLHIGIDAAELEIGDQMKVNLNTGQSPGVKD------------ 479

  Fly   693 EEFNYLIMSKGVILVNDR-ETITEGIKTIAVVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNG 756
            :::.::|:|||.|:..|| :...:.:.|::..::.||.|....|.:......:||:||:...|..
Zfish   480 QDYTFMILSKGQIVKIDRFKRQGQALITLSQPVTKEMVPSFRFVAYYHVGANEVVSDSVWVDVKD 544

  Fly   757 ISRNNFTVYINNRK--ARTGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNF 819
            .......:.:.|::  ..|||:|::.|.|:||:.|||..:|.|.:.:.. |.||..||...:...
Zfish   545 TCMGKLKLQVKNKQNNYNTGEEVKLQISGDPGARVGLVVVDKAVHVLNK-NRLTQTKIWDVIEKH 608

  Fly   820 DEQ-TNGTYKHIWYSHEGNPDELVYFPASSFGVDANRTFEYSGLIVFTDGYV-------PRRQ-- 874
            |.. |.|          |..|.:..|.      ||...|| |.....||..:       |:|:
Zfish   609 DTGCTAG----------GGRDVMGVFS------DAGLMFE-SNTAGGTDTRLNPECPDPPKRRRR 656

  Fly   875 -------DTCNRTLGFGECLSGRCYRLEKQC--DGLFD--------------------------- 903
                   .|...||. |:...|     ::||  ||:.|
Zfish   657 RTESENLRTITATLA-GQYADG-----QRQCCIDGMKDNKLGYTCERRATYIGDGPECVKAFLHC 715

  Fly   904 CDDGTDEINCHARNDTELL-------NYRKYRFNRVLR-HYENVWLWKDVNI---GPHGRYIFNV 957
            ||:.....|.....:..:|       :|.......|.| .:...|||:::::   .|.......:
Zfish   716 CDEMKKRKNIKTEEEEMILARSDDDDDYYTDSEEIVSRTQFPESWLWEEIDLCDNCPASAMEKAM 780

  Fly   958 EVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMIT 1022
            .:.|....|.|.|.|:||:.|. .:.:..|.|..:..||:::||.:..:|||:.|:..:.||
Zfish   781 YLKDSITTWQVLAVSMSPTLGI-CVAEPEEIVVFKSLFIDLKMPYSAVRGEQLEIKAIIHNY--- 841

  Fly  1023 PIEAIVVLHDSPDYKFVHVE--EDGIVRSYNPRTSFGEHQFFIYLEAQGTTVVYVPVVPQRLGN- 1084
                      :||.:.|.||  |...|.|...:.  |:::..:.:..:.:..|...::|..|||
Zfish   842 ----------TPDKRKVRVEFMESADVCSLASKK--GKYRTTVTIPKESSLSVPYVIIPMTLGNH 894

  Fly  1085 -VDVTLHVATLLGTDTITRTLHVESDGL--PQYRHQSVLLDLSN-------RAYV--------LE 1131
             ::|.......:.||.:.:.|.|.|:|:  |..|....|..:.|       ||.:        ..
Zfish   895 MIEVKAAAYDAVYTDGVRKGLKVVSEGVLFPLQRPNVELNPVKNGDSPIIVRADIPADRVPGTPA 959

  Fly  1132 YMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNASSLLSLPMESGEQNAFSF 1196
            :.|:::| ..||...|::           ::.|..:|           .|:..|...||||....
Zfish   960 HTHISIT-GEEISQTVEQ-----------AISGSFMG-----------QLIVQPHGCGEQNMIFM 1001

  Fly  1197 AANLYTIMYMRLINQRNKTLEK---NAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLT 1258
            ...:....|:...||......|   .|..|:..||.||.::.:||||::.    |.:..||.|||
Zfish  1002 TLPVIATHYLDSTNQWEAIGMKRRDEAIGHIKTGYNRQQAYRKPDGSYAA----WIDRPSSTWLT 1062

  Fly  1259 SYCLRVFQEASFYEWENFIWIDATIIEKNMRWL-LQHQTPQGSFFEVTWLPDRKM--NRTNFDKN 1320
            :|..::|..|:     :.|.|:..::...::|| |..|.|.|||.|...:...:|  :....|..
Zfish  1063 AYVAKIFAMAN-----DLITIEEQVLCSALKWLVLNRQLPDGSFEEKAAVVHGEMVGDVQGRDAE 1122

  Fly  1321 ITLTSHVLITLATVKDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDVAITAYALQLCNSP 1385
            .:||:.|.|.:...:::.|.:...:..:.::|::::|..::.|   ..|:.||:|:||:     .
Zfish  1123 ASLTAFVTIAMQEGRELCGAIVGSLPESIRKAVSFLEGKLNKL---TNPYAVALTSYAM-----A 1179

  Fly  1386 IAEEVFAILRRQARTIGDF-MYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVY 1449
            .|:::...:..:..|.|:. .||                  ::|...|.    ..|.|:||:|..
Zfish  1180 GADKLNKAVLMKFSTKGEAGTYW------------------NVPGQQYH----TREATSYAVLAL 1222

  Fly  1450 VARREF-FVDPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQGG 1513
            |..|:| .....|.||.||..:.||..:||.|....:|:.||  |:::::..:..:|:|.:.:|.
Zfish  1223 VKARDFNAAGEAVHWLGSQHYSYGGSGTTQATIMVFQAVAEY--RTQVKDSQNFNLEVELAVEGR 1285

  Fly  1514 KTQTLYI---DDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQ-MHVQYNVDIEKFQTKPPVPAF 1574
            ...:.|.   |:.::::...::|..   ...|.|||.|.|.|. :.:.|...:||   |.....|
Zfish  1286 SKPSRYTIKRDNRHVSRSDKVDINK---DFNVTAKGTGKATLSVLTLYYARPVEK---KSDCTLF 1344

  Fly  1575 GLHTKAIFHGRNQSHI----SYVACQNWINQNESERSGMAVLDVAIPTGYWIQQQKLDTYVLSNR 1635
            .|..| |.......|.    ::....::..:|....:.|.:||:.||||:.::...|:.....
Zfish  1345 DLSVK-IDKDPETKHADAIETFKLTMDFFYKNPKSPATMTILDIGIPTGFTVEYNDLEELTRG-- 1406

  Fly  1636 VRNLRRARYLER-----------KIVFYFDYLDH-EDICVNFTIERWYPVANMSRYLP--VRIYD 1686
                 :.:|||:           .::.|...:.: |...:.|   |.:.:.|:....|  |.||:
Zfish  1407 -----KEKYLEKFEMDKALSDRGSLILYLKMVSNKESERIAF---RMHKMLNVGLLQPAAVTIYE 1463

  Fly  1687 YYAPE-RFNESIFDALPTYLLNIC--EVCGSSQC--PYCSIYNMG 1726
            ||:|. |..:.........:..:|  ::|   ||  ..||:...|
Zfish  1464 YYSPNARCTKYFHPEREGVIYRLCKGDMC---QCAEENCSLQKKG 1505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	YfaS	<226..1575	CDD:441940	318/1488 (21%)
		A2M_BRD	667..801	CDD:462235	36/137 (26%)
		A2M	939..1030	CDD:459711	24/93 (26%)
		TED_complement	1160..1490	CDD:462227	84/337 (25%)
		A2M_recep	1605..1699	CDD:462226	24/108 (22%)
c3a.1	NP_571317.1	MG1	21..124	CDD:465508	22/114 (19%)
		YfaS	<128..1331	CDD:441940	313/1467 (21%)
		A2M	759..852	CDD:459711	28/106 (26%)
		complement_C3_C4_C5	979..1264	CDD:239226	84/334 (25%)
		A2M_recep	1380..1476	CDD:462226	24/105 (23%)
		NTR_complement_C3	1494..1641	CDD:239638	3/11 (27%)