DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcr and c3a.1

DIOPT Version :9

Sequence 1:NP_524688.1 Gene:Mcr / 44071 FlyBaseID:FBgn0267488 Length:1760 Species:Drosophila melanogaster
Sequence 2:NP_571317.1 Gene:c3a.1 / 321046 ZFINID:ZDB-GENE-990415-35 Length:1643 Species:Danio rerio


Alignment Length:1800 Identity:383/1800 - (21%)
Similarity:670/1800 - (37%) Gaps:486/1800 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   117 IKATFLES-------LHSREPTYFIVASRMVRPGLIYQVSVSILQAQ--------YPITV----- 161
            :|..||.:       |...:|.|.:.|..::|.|....|.|   :||        ..|||     
Zfish     2 VKLLFLSAVLLSSALLTLCDPLYVLSAPNLLRVGSSENVFV---EAQDYSKNAFEVKITVKNHPK 63

  Fly   162 -HASIACDGVQISGDSK-----DVKEGIPETLLMRIPPTSVTGSYKLRVEGFY-QNVFGGLAFLN 219
             ...|....|.::..:.     |:|....:.|....|         |..:..| |.:|.......
Zfish    64 KDKQILTKSVNLNAQNNFQILTDIKIPDDQNLFSDDP---------LEKQYVYLQAIFPDHTLEK 119

  Fly   220 ETRLDFSQRSMTIFVQTDKPLYMQGETVRFRTIPITTELKGFD---------NPVDVYMLDPNRH 275
            ...|.|  :|..||||||||:|....||::||:.:|..||...         ||.::.:.....:
Zfish   120 VVLLSF--QSGYIFVQTDKPIYTPSSTVQYRTLSLTPNLKPLSQTGITVEIMNPQNITVSSDKVY 182

  Fly   276 ILKRWLSRQSNLGSVSLEYKLSDQPTFGEW-TIRVIAQGQQE--ESHFTVEEYYQTRFEVNVTMP 337
            .:|         |..|.:|.:.:..:.|.| .:...|...|:  .:.|.|:||....|||.: .|
Zfish   183 PVK---------GMKSGKYAIPEVASLGIWKVVTRFANTPQKTFTAEFEVKEYVLPTFEVKL-QP 237

  Fly   338 A--YFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYN 400
            :  :::..|..:...:.|.:..|..|.||..:...:                             
Zfish   238 SKLFYYVGDESLTVDIEAKYLFGKQVEGNAFVMFGV----------------------------- 273

  Fly   401 ERWRYNNPNQNPQVQYNVPGQLPQ-------DGADLSQDILYRNQYVVERHYQFDEEWPFWVRKP 458
                     .:.:.:..:.|.|.:       ..|:|::.::                        
Zfish   274 ---------MDGETKTGITGSLQKIQILKGVGTAELTKQMI------------------------ 305

  Fly   459 EYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEVLITATVGEKFYDEII- 522
                       .||:.                                  |...||:..|..:. 
Zfish   306 -----------ETYKS----------------------------------IDKLVGQSIYVSVSL 325

  Fly   523 ---SGYSVARVYNSSLRVVFLGDSP---------QVFKPAMPFTTYLAVEYHDGSPIDPNLLRQG 575
               ||..:.......:|:|   .||         |.|||.|||...:.|...|.:|.. |::   
Zfish   326 LTESGSEMVEAERRGIRIV---TSPYTINFKKTAQFFKPGMPFDVSIYVTNPDETPAQ-NVI--- 383

  Fly   576 LMEVSGFVESRNGGRRDWPAQRLPMSQQSDGIWEVKIDIR------------NDLNLDDRPQARD 628
                   ||...||.|.        ..:::||.:|.::.:            .|.::.|..||  
Zfish   384 -------VEVNPGGVRG--------QTKANGIAKVTVNTQGNVLTQEITAQTKDPDITDEEQA-- 431

  Fly   629 FLNGVQNMRLQANFVDPRGERIQTELLLVSHYSPRNQHIKVTTST-EKPVVGEYIIFHIRTNFYL 692
                |:.|...| :|...|.:....:.:.:........:||..:| :.|.|.:            
Zfish   432 ----VKKMTAHA-YVPKGGSKNYLHIGIDAAELEIGDQMKVNLNTGQSPGVKD------------ 479

  Fly   693 EEFNYLIMSKGVILVNDR-ETITEGIKTIAVVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNG 756
            :::.::|:|||.|:..|| :...:.:.|::..::.||.|....|.:......:||:||:...|..
Zfish   480 QDYTFMILSKGQIVKIDRFKRQGQALITLSQPVTKEMVPSFRFVAYYHVGANEVVSDSVWVDVKD 544

  Fly   757 ISRNNFTVYINNRK--ARTGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNF 819
            .......:.:.|::  ..|||:|::.|.|:||:.|||..:|.|.:.:.. |.||..||...:...
Zfish   545 TCMGKLKLQVKNKQNNYNTGEEVKLQISGDPGARVGLVVVDKAVHVLNK-NRLTQTKIWDVIEKH 608

  Fly   820 DEQ-TNGTYKHIWYSHEGNPDELVYFPASSFGVDANRTFEYSGLIVFTDGYV-------PRRQ-- 874
            |.. |.|          |..|.:..|.      ||...|| |.....||..:       |:|:  
Zfish   609 DTGCTAG----------GGRDVMGVFS------DAGLMFE-SNTAGGTDTRLNPECPDPPKRRRR 656

  Fly   875 -------DTCNRTLGFGECLSGRCYRLEKQC--DGLFD--------------------------- 903
                   .|...||. |:...|     ::||  ||:.|                           
Zfish   657 RTESENLRTITATLA-GQYADG-----QRQCCIDGMKDNKLGYTCERRATYIGDGPECVKAFLHC 715

  Fly   904 CDDGTDEINCHARNDTELL-------NYRKYRFNRVLR-HYENVWLWKDVNI---GPHGRYIFNV 957
            ||:.....|.....:..:|       :|.......|.| .:...|||:::::   .|.......:
Zfish   716 CDEMKKRKNIKTEEEEMILARSDDDDDYYTDSEEIVSRTQFPESWLWEEIDLCDNCPASAMEKAM 780

  Fly   958 EVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMIT 1022
            .:.|....|.|.|.|:||:.|. .:.:..|.|..:..||:::||.:..:|||:.|:..:.||   
Zfish   781 YLKDSITTWQVLAVSMSPTLGI-CVAEPEEIVVFKSLFIDLKMPYSAVRGEQLEIKAIIHNY--- 841

  Fly  1023 PIEAIVVLHDSPDYKFVHVE--EDGIVRSYNPRTSFGEHQFFIYLEAQGTTVVYVPVVPQRLGN- 1084
                      :||.:.|.||  |...|.|...:.  |:::..:.:..:.:..|...::|..||| 
Zfish   842 ----------TPDKRKVRVEFMESADVCSLASKK--GKYRTTVTIPKESSLSVPYVIIPMTLGNH 894

  Fly  1085 -VDVTLHVATLLGTDTITRTLHVESDGL--PQYRHQSVLLDLSN-------RAYV--------LE 1131
             ::|.......:.||.:.:.|.|.|:|:  |..|....|..:.|       ||.:        ..
Zfish   895 MIEVKAAAYDAVYTDGVRKGLKVVSEGVLFPLQRPNVELNPVKNGDSPIIVRADIPADRVPGTPA 959

  Fly  1132 YMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNASSLLSLPMESGEQNAFSF 1196
            :.|:::| ..||...|::           ::.|..:|           .|:..|...||||....
Zfish   960 HTHISIT-GEEISQTVEQ-----------AISGSFMG-----------QLIVQPHGCGEQNMIFM 1001

  Fly  1197 AANLYTIMYMRLINQRNKTLEK---NAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLT 1258
            ...:....|:...||......|   .|..|:..||.||.::.:||||::.    |.:..||.|||
Zfish  1002 TLPVIATHYLDSTNQWEAIGMKRRDEAIGHIKTGYNRQQAYRKPDGSYAA----WIDRPSSTWLT 1062

  Fly  1259 SYCLRVFQEASFYEWENFIWIDATIIEKNMRWL-LQHQTPQGSFFEVTWLPDRKM--NRTNFDKN 1320
            :|..::|..|:     :.|.|:..::...::|| |..|.|.|||.|...:...:|  :....|..
Zfish  1063 AYVAKIFAMAN-----DLITIEEQVLCSALKWLVLNRQLPDGSFEEKAAVVHGEMVGDVQGRDAE 1122

  Fly  1321 ITLTSHVLITLATVKDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDVAITAYALQLCNSP 1385
            .:||:.|.|.:...:::.|.:...:..:.::|::::|..::.|   ..|:.||:|:||:     .
Zfish  1123 ASLTAFVTIAMQEGRELCGAIVGSLPESIRKAVSFLEGKLNKL---TNPYAVALTSYAM-----A 1179

  Fly  1386 IAEEVFAILRRQARTIGDF-MYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVY 1449
            .|:::...:..:..|.|:. .||                  ::|...|.    ..|.|:||:|..
Zfish  1180 GADKLNKAVLMKFSTKGEAGTYW------------------NVPGQQYH----TREATSYAVLAL 1222

  Fly  1450 VARREF-FVDPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQGG 1513
            |..|:| .....|.||.||..:.||..:||.|....:|:.||  |:::::..:..:|:|.:.:|.
Zfish  1223 VKARDFNAAGEAVHWLGSQHYSYGGSGTTQATIMVFQAVAEY--RTQVKDSQNFNLEVELAVEGR 1285

  Fly  1514 KTQTLYI---DDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQ-MHVQYNVDIEKFQTKPPVPAF 1574
            ...:.|.   |:.::::...::|..   ...|.|||.|.|.|. :.:.|...:||   |.....|
Zfish  1286 SKPSRYTIKRDNRHVSRSDKVDINK---DFNVTAKGTGKATLSVLTLYYARPVEK---KSDCTLF 1344

  Fly  1575 GLHTKAIFHGRNQSHI----SYVACQNWINQNESERSGMAVLDVAIPTGYWIQQQKLDTYVLSNR 1635
            .|..| |.......|.    ::....::..:|....:.|.:||:.||||:.::...|:.....  
Zfish  1345 DLSVK-IDKDPETKHADAIETFKLTMDFFYKNPKSPATMTILDIGIPTGFTVEYNDLEELTRG-- 1406

  Fly  1636 VRNLRRARYLER-----------KIVFYFDYLDH-EDICVNFTIERWYPVANMSRYLP--VRIYD 1686
                 :.:|||:           .::.|...:.: |...:.|   |.:.:.|:....|  |.||:
Zfish  1407 -----KEKYLEKFEMDKALSDRGSLILYLKMVSNKESERIAF---RMHKMLNVGLLQPAAVTIYE 1463

  Fly  1687 YYAPE-RFNESIFDALPTYLLNIC--EVCGSSQC--PYCSIYNMG 1726
            ||:|. |..:.........:..:|  ::|   ||  ..||:...|
Zfish  1464 YYSPNARCTKYFHPEREGVIYRLCKGDMC---QCAEENCSLQKKG 1505

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
McrNP_524688.1 A2M_N 232..332 CDD:280081 31/111 (28%)
A2M_N_2 669..799 CDD:285005 35/133 (26%)
LDLa 886..913 CDD:238060 8/55 (15%)
A2M 940..1030 CDD:278630 24/92 (26%)
ISOPREN_C2_like 1177..1490 CDD:298658 82/320 (26%)
A2M_comp 1226..1492 CDD:284982 72/270 (27%)
A2M_recep 1607..1695 CDD:284981 24/102 (24%)
c3a.1NP_571317.1 A2M_N 129..223 CDD:280081 27/102 (26%)
A2M_N_2 452..588 CDD:285005 35/147 (24%)
ANATO 666..735 CDD:237984 12/74 (16%)
A2M 759..851 CDD:278630 27/105 (26%)
complement_C3_C4_C5 979..1264 CDD:239226 84/334 (25%)
A2M_comp 1034..1264 CDD:284982 70/268 (26%)
A2M_recep 1380..1475 CDD:284981 24/104 (23%)
NTR_complement_C3 1494..1641 CDD:239638 3/11 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
43.870

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