Protein Alignment Mcr and Mug6

DIOPT Version :10

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: XP_038963368.1
• Gene: Mug6 / 297572
• RGDID: 1566313
• Length: 1493
• Species: Rattus norvegicus
• Alignment Length: 1724
• Identity: 387/1724 - (22%)
• Similarity: 654/1724 - (37%)
• Gaps: 417/1724 - (24%)

  Fly   107 SLTRGKSSYNIKATFLESLHSREPTYFIVASRMVRPGLIY-----QVSVSILQAQYPITVHAS-I 165
            :|....||:|..:.::                ::.|..:|     ::.:.:......:||.|| |
  Rat    17 ALLPSASSFNGNSKYM----------------VLVPSQLYTDTPEKICLHLYHLNETVTVTASLI 65

  Fly   166 ACDGVQISGDSKDVKEGIPETL---LMRIPPTSVTGSYKLRVEGFYQNVFGGLAFLNETRLDFSQ 227
            :..|.:...|...|.:.:...|   :.|:|.:....|..:.:||              .:..||:
  Rat    66 SQRGTRKLFDELVVDKDLFHCLSFTIPRLPSSEEEESLDINIEG--------------AKHKFSK 116

  Fly   228 RSM--------TIFVQTDKPLYMQGETVRFRTIPITTELKGFDNPVD-----VYMLDPNRHILKR 279
            |.:        .:|||||||:|..|::|:||.:.:...|    :|::     .|:.||..:.:.:
  Rat   117 RRVVLVKNKESVVFVQTDKPVYKPGQSVKFRIVSMDKNL----HPLNELFPLAYIEDPKINRIMQ 177

  Fly   280 WLSRQSNLGSVSLEYKLSDQPTFGEWTIRVIAQ-GQQEESHFTVEEYYQTRFEVNVTMPAYFFTT 343
            |...::..|...|.:.||.:|..|.:.|.::.| |.:||..|||.|:...||.|:|.:|......
  Rat   178 WQDIKTENGLKQLSFSLSAEPIQGPYKIVILKQSGVKEEHSFTVMEFVLPRFGVDVKVPNAISVY 242

  Fly   344 DPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNP 408
            |..|.....|.:|.|.||.|.:.|...                                  :.||
  Rat   243 DEIISVTACATYTYGKPVPGRVKISLC----------------------------------HGNP 273

  Fly   409 NQNPQVQ---YNVPGQLPQDGADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSG 470
            :...|.:   .....:|..:|....:                       |...|::
  Rat   274 SFRSQTKSACKEEDSELDNNGCSTQE-----------------------VNITEFR--------- 306

  Fly   471 TYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEVLITATVGEKFYDEIISGYSVARVYNSSL 535
                                 |:|..|.|....:    :.|||.|:......||.....|..:..
  Rat   307 ---------------------LKENYLKVRQAFH----VNATVTEEGTGSEFSGSGRIEVKRTRN 346

  Fly   536 RVVFL-GDSPQVFKPAMPFTTYLAVEYHDGSPIDPN----LLRQGLMEVSGFVESRNGGRRDWPA 595
            :.:|| .||.  |:..:||...:.:....|.|| ||    :..||    :||..:....:.....
  Rat   347 KFLFLKADSH--FRHGIPFFVKVRLVNIKGDPI-PNQQVFIKAQG----AGFTNATTTDQHGLAK 404

  Fly   596 QRLPMSQQSDGIWEVKI-------DIRNDLNLDDRPQARDFLNGVQNMRLQANFVDP-------- 645
            ..:..|..|..|..:|:       .|.:....:...:|......|.::.....::|.
  Rat   405 FSIDTSGISRYILNIKVYHKEENSCIHSSCTAERHAEAHHTAYAVYSLSKSYIYLDTEAGVLPCN 469

  Fly   646 RGERIQTELLLVSHYSPRNQHIKVTTSTEKPVVGEYIIFHIRTNFYLEEFNYLIMSKGVIL---- 706
            :...:|      :|:..:.|.:.|...         |:||           ||:|::|.||
  Rat   470 QSHTVQ------AHFILKGQVLGVLPQ---------IVFH-----------YLVMAQGSILQTGN 508

  Fly   707 ----VNDRETITEGIKTIAVVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYIN 767
                |...|:..:|...:.:.:...|.|:|.::::.|...|:|:|||:.|.|....|:...:..:
  Rat   509 HTHQVEPGESPVQGNFALEIPVEFSMVPMAKMLIYTILPDGEVIADSVKFQVEKCLRHEVHLSFS 573

  Fly   768 NRKARTGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQTNGTYKHIWY 832
            ..::....:..:.:...|.|..||..:|.:...::...||: ..:|..:....|.     |.|..
  Rat   574 PSQSLPASQTHMRVTASPQSLCGLRAVDQSVLLLKPEAELS-PSLIYDLPGMQES-----KFIPR 632

  Fly   833 SHEGNPDE---LVYFP----ASSFGVDANR---TFEY---SGLIVFTDGYVPRRQDTCNRTLGFG 884
            ||....||   ::|.|    ..::.|...|   .|.|   :||...|:
  Rat   633 SHYPFEDEDGCVIYRPRVIGKLTYSVPYGREKDVFRYMRDTGLTALTN----------------- 680

  Fly   885 ECLSGRCYRLEKQCDGLFDCDDGTDEINCHARNDTELLN---YRKYRFNRV-------------- 932
                   .:|...|   ||.|  ...:...|...::|.|   |..:|..||
  Rat   681 -------LKLRTFC---FDYD--MVPLAVPAARSSDLFNSDGYGSWRSARVKSLPPKKAPHKDPP 733

  Fly   933 --------LRHY-ENVWLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEY 988
                    :|:| ...|:|..|.:...|.....:.|||....|...|..:|...|.|:.:.| ..
  Rat   734 PKDPVIETIRNYFPETWVWDLVTVNSSGAAELEMTVPDTITEWKAGALCLSNDTGLGLSSVA-TL 797

  Fly   989 VGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSYNPR 1053
            ...||||:.:.||.:..:||...::.||.||:.|.:...|.|..|||:..|.|
  Rat   798 QAFQPFFVELTMPYSVIRGEAFTLKATVMNYLPTSLPMAVQLEASPDFTAVPV------------ 850

  Fly  1054 TSFGEHQFFIYLEAQGTTVVYVPVVPQRLGNVDVTL-------------HVATLLGT---DTITR 1102
               |..|....|.|.|.......|.|:.||||:.::             .|||:..|   ||:.:
  Rat   851 ---GNDQDSYCLGANGRHTSSWLVTPKSLGNVNFSVSAEAQQSPEPCGSEVATVPETGRKDTVVK 912

  Fly  1103 TLHVESDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVV 1167
            .|.||.:|:.:....|.||..|: |.:.|.:.:.:..|          .|..|.:|..||:||::
  Rat   913 VLIVEPEGIKREHTFSSLLCASD-AELSETLSLLLPPT----------VVKDSARAHFSVMGDIL 966

  Fly  1168 GPIFPTMPVNASSLLSLPMESGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQL 1232
            .....    |..:|:.:|...||||...||.::|.:.|:....|..:.::..|..::..||||:|
  Rat   967 SSAIK----NTQNLIQMPYGCGEQNMVLFAPSIYVLKYLNETQQLTEKIKSKALGYLRAGYQREL 1027

  Fly  1233 SFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLLQHQTP 1297
            ::...|||:|.|.........:.|||::.|:.|.:|     :.||:||.:.|.....||...|..
  Rat  1028 NYKHKDGSYSAFGDHDGKGQGNTWLTAFVLKSFSQA-----QAFIFIDESHITDAFTWLSHQQKD 1087

  Fly  1298 QGSFFEVTWLPDRKMNRTNFDKNITLTSHVLITL--ATVKDISGTLGSRVALATQRALAYIER-- 1358
            .|.|.....|.:..| :...|..|||::::.:.|  :...|....:.|:.....:.:...||:
  Rat  1088 SGCFRSSGSLFNNAM-KGGVDDEITLSAYITVALLESLPPDTEHPVVSKALSCLESSWENIEQGG 1151

  Fly  1359 NMDFLRHQAQPFDVAITAYALQLC-NSPIAEEVFAILRRQARTIGDFMYWGNQEIPQPPRKLENQ 1422
            |..|:      :..|:.|||..|. |.....|:...|.::|....:.::|   |.||.|.|....
  Rat  1152 NGSFV------YTKALMAYAFALAGNQEKRNEILKSLDKEAIKEDNSIHW---ERPQKPMKSARS 1207

  Fly  1423 KWFSLPRLPYEYDSLNIETTAYALLVYVARREFFVDP--------IVRWLNSQRLNDGGWASTQD 1479
            .:      ..:..|..:|..||.:|..:..:. ...|        .::||..|:.:.||::||||
  Rat  1208 LY------KPQASSAEVEMNAYVILARLTAQS-APSPKDLALSMGTIKWLTKQQNSRGGFSSTQD 1265

  Fly  1480 TSAALKALVEY--TVRSRLREVSSLTVEIEASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIKV 1542
            |..||.||.:|  ...|:.::..|:||:    |.|...|...:|::|...||.:.:||..|...|
  Rat  1266 TVVALDALSKYGAATFSKSQKTPSVTVQ----SSGSFFQKFQVDNSNRLLLQQVSLPDIPGNYTV 1326

  Fly  1543 QAKGAGYAILQMHVQYNVDIEKFQTKPPVPAFGLHTKAIFHGRNQSHISYVACQNWINQNESE-- 1605
            ...|.|....|..::||:.:||.|     |||.|..:.:          .:.|.|...||..:
  Rat  1327 SVSGEGCVYAQTMLRYNLPLEKQQ-----PAFALKVQTV----------PLTCNNPKGQNSFQIS 1376

  Fly  1606 ----------RSGMAVLDVAIPTGYWIQQQKLDTYVLSNRVRNLRRARYLER------KIVFYFD 1654
                      .|.|.:.||.:.:|:         ..|...|:.|.|..::.|      .::.|.|
  Rat  1377 LEISYTGSRPASNMVIADVKMLSGF---------IPLKPTVKKLERLEHVSRTEVTTNNVLLYLD 1432

  Fly  1655 YLDHEDICVNFTIERWYPVANMSRYLPVRIYDYY 1688
            .:.::.:..:|.|::..||.|:...: |::||||
  Rat  1433 QVTNQTLSFSFIIQQDIPVKNLQPAI-VKVYDYY 1465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	YfaS	<226..1575	CDD:441940	338/1463 (23%)
		A2M_BRD	667..801	CDD:462235	30/141 (21%)
		A2M	939..1030	CDD:459711	27/90 (30%)
		TED_complement	1160..1490	CDD:462227	91/342 (27%)
		A2M_recep	1605..1699	CDD:462226	22/102 (22%)
Mug6	XP_038963368.1	YfaS	<129..1352	CDD:441940	334/1447 (23%)
		A2M	749..839	CDD:459711	27/90 (30%)
		A2M_2	969..1276	CDD:239227	87/332 (26%)
		A2M_recep	1386..1476	CDD:462226	22/90 (24%)