DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcr and Cpamd8

DIOPT Version :9

Sequence 1:	NP_524688.1	Gene:	Mcr / 44071	FlyBaseID:	FBgn0267488	Length:	1760	Species:	Drosophila melanogaster
Sequence 2:	XP_038963368.1	Gene:	Cpamd8 / 297572	RGDID:	1566313	Length:	1493	Species:	Rattus norvegicus

Alignment Length:	1724	Identity:	387/1724 - (22%)
Similarity:	654/1724 - (37%)	Gaps:	417/1724 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   107 SLTRGKSSYNIKATFLESLHSREPTYFIVASRMVRPGLIY-----QVSVSILQAQYPITVHAS-I 165
            :|....||:|..:.::                ::.|..:|     ::.:.:......:||.|| |
  Rat    17 ALLPSASSFNGNSKYM----------------VLVPSQLYTDTPEKICLHLYHLNETVTVTASLI 65

  Fly   166 ACDGVQISGDSKDVKEGIPETL---LMRIPPTSVTGSYKLRVEGFYQNVFGGLAFLNETRLDFSQ 227
            :..|.:...|...|.:.:...|   :.|:|.:....|..:.:||              .:..||:
  Rat    66 SQRGTRKLFDELVVDKDLFHCLSFTIPRLPSSEEEESLDINIEG--------------AKHKFSK 116

  Fly   228 RSM--------TIFVQTDKPLYMQGETVRFRTIPITTELKGFDNPVD-----VYMLDPNRHILKR 279
            |.:        .:|||||||:|..|::|:||.:.:...|    :|::     .|:.||..:.:.:
  Rat   117 RRVVLVKNKESVVFVQTDKPVYKPGQSVKFRIVSMDKNL----HPLNELFPLAYIEDPKINRIMQ 177

  Fly   280 WLSRQSNLGSVSLEYKLSDQPTFGEWTIRVIAQ-GQQEESHFTVEEYYQTRFEVNVTMPAYFFTT 343
            |...::..|...|.:.||.:|..|.:.|.::.| |.:||..|||.|:...||.|:|.:|......
  Rat   178 WQDIKTENGLKQLSFSLSAEPIQGPYKIVILKQSGVKEEHSFTVMEFVLPRFGVDVKVPNAISVY 242

  Fly   344 DPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNP 408
            |..|.....|.:|.|.||.|.:.|...                                  :.||
  Rat   243 DEIISVTACATYTYGKPVPGRVKISLC----------------------------------HGNP 273

  Fly   409 NQNPQVQ---YNVPGQLPQDGADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSG 470
            :...|.:   .....:|..:|....:                       |...|::
  Rat   274 SFRSQTKSACKEEDSELDNNGCSTQE-----------------------VNITEFR--------- 306

  Fly   471 TYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEVLITATVGEKFYDEIISGYSVARVYNSSL 535
                                 |:|..|.|....:    :.|||.|:......||.....|..:..
  Rat   307 ---------------------LKENYLKVRQAFH----VNATVTEEGTGSEFSGSGRIEVKRTRN 346

  Fly   536 RVVFL-GDSPQVFKPAMPFTTYLAVEYHDGSPIDPN----LLRQGLMEVSGFVESRNGGRRDWPA 595
            :.:|| .||.  |:..:||...:.:....|.|| ||    :..||    :||..:....:.....
  Rat   347 KFLFLKADSH--FRHGIPFFVKVRLVNIKGDPI-PNQQVFIKAQG----AGFTNATTTDQHGLAK 404

  Fly   596 QRLPMSQQSDGIWEVKI-------DIRNDLNLDDRPQARDFLNGVQNMRLQANFVDP-------- 645
            ..:..|..|..|..:|:       .|.:....:...:|......|.::.....::|.
  Rat   405 FSIDTSGISRYILNIKVYHKEENSCIHSSCTAERHAEAHHTAYAVYSLSKSYIYLDTEAGVLPCN 469

  Fly   646 RGERIQTELLLVSHYSPRNQHIKVTTSTEKPVVGEYIIFHIRTNFYLEEFNYLIMSKGVIL---- 706
            :...:|      :|:..:.|.:.|...         |:||           ||:|::|.||
  Rat   470 QSHTVQ------AHFILKGQVLGVLPQ---------IVFH-----------YLVMAQGSILQTGN 508

  Fly   707 ----VNDRETITEGIKTIAVVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYIN 767
                |...|:..:|...:.:.:...|.|:|.::::.|...|:|:|||:.|.|....|:...:..:
  Rat   509 HTHQVEPGESPVQGNFALEIPVEFSMVPMAKMLIYTILPDGEVIADSVKFQVEKCLRHEVHLSFS 573

  Fly   768 NRKARTGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQTNGTYKHIWY 832
            ..::....:..:.:...|.|..||..:|.:...::...||: ..:|..:....|.     |.|..
  Rat   574 PSQSLPASQTHMRVTASPQSLCGLRAVDQSVLLLKPEAELS-PSLIYDLPGMQES-----KFIPR 632

  Fly   833 SHEGNPDE---LVYFP----ASSFGVDANR---TFEY---SGLIVFTDGYVPRRQDTCNRTLGFG 884
            ||....||   ::|.|    ..::.|...|   .|.|   :||...|:
  Rat   633 SHYPFEDEDGCVIYRPRVIGKLTYSVPYGREKDVFRYMRDTGLTALTN----------------- 680

  Fly   885 ECLSGRCYRLEKQCDGLFDCDDGTDEINCHARNDTELLN---YRKYRFNRV-------------- 932
                   .:|...|   ||.|  ...:...|...::|.|   |..:|..||
  Rat   681 -------LKLRTFC---FDYD--MVPLAVPAARSSDLFNSDGYGSWRSARVKSLPPKKAPHKDPP 733

  Fly   933 --------LRHY-ENVWLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEY 988
                    :|:| ...|:|..|.:...|.....:.|||....|...|..:|...|.|:.:.| ..
  Rat   734 PKDPVIETIRNYFPETWVWDLVTVNSSGAAELEMTVPDTITEWKAGALCLSNDTGLGLSSVA-TL 797

  Fly   989 VGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSYNPR 1053
            ...||||:.:.||.:..:||...::.||.||:.|.:...|.|..|||:..|.|
  Rat   798 QAFQPFFVELTMPYSVIRGEAFTLKATVMNYLPTSLPMAVQLEASPDFTAVPV------------ 850

  Fly  1054 TSFGEHQFFIYLEAQGTTVVYVPVVPQRLGNVDVTL-------------HVATLLGT---DTITR 1102
               |..|....|.|.|.......|.|:.||||:.::             .|||:..|   ||:.:
  Rat   851 ---GNDQDSYCLGANGRHTSSWLVTPKSLGNVNFSVSAEAQQSPEPCGSEVATVPETGRKDTVVK 912

  Fly  1103 TLHVESDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVV 1167
            .|.||.:|:.:....|.||..|: |.:.|.:.:.:..|          .|..|.:|..||:||::
  Rat   913 VLIVEPEGIKREHTFSSLLCASD-AELSETLSLLLPPT----------VVKDSARAHFSVMGDIL 966

  Fly  1168 GPIFPTMPVNASSLLSLPMESGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQL 1232
            .....    |..:|:.:|...||||...||.::|.:.|:....|..:.::..|..::..||||:|
  Rat   967 SSAIK----NTQNLIQMPYGCGEQNMVLFAPSIYVLKYLNETQQLTEKIKSKALGYLRAGYQREL 1027

  Fly  1233 SFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLLQHQTP 1297
            ::...|||:|.|.........:.|||::.|:.|.:|     :.||:||.:.|.....||...|..
  Rat  1028 NYKHKDGSYSAFGDHDGKGQGNTWLTAFVLKSFSQA-----QAFIFIDESHITDAFTWLSHQQKD 1087

  Fly  1298 QGSFFEVTWLPDRKMNRTNFDKNITLTSHVLITL--ATVKDISGTLGSRVALATQRALAYIER-- 1358
            .|.|.....|.:..| :...|..|||::::.:.|  :...|....:.|:.....:.:...||:
  Rat  1088 SGCFRSSGSLFNNAM-KGGVDDEITLSAYITVALLESLPPDTEHPVVSKALSCLESSWENIEQGG 1151

  Fly  1359 NMDFLRHQAQPFDVAITAYALQLC-NSPIAEEVFAILRRQARTIGDFMYWGNQEIPQPPRKLENQ 1422
            |..|:      :..|:.|||..|. |.....|:...|.::|....:.::|   |.||.|.|....
  Rat  1152 NGSFV------YTKALMAYAFALAGNQEKRNEILKSLDKEAIKEDNSIHW---ERPQKPMKSARS 1207

  Fly  1423 KWFSLPRLPYEYDSLNIETTAYALLVYVARREFFVDP--------IVRWLNSQRLNDGGWASTQD 1479
            .:      ..:..|..:|..||.:|..:..:. ...|        .::||..|:.:.||::||||
  Rat  1208 LY------KPQASSAEVEMNAYVILARLTAQS-APSPKDLALSMGTIKWLTKQQNSRGGFSSTQD 1265

  Fly  1480 TSAALKALVEY--TVRSRLREVSSLTVEIEASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIKV 1542
            |..||.||.:|  ...|:.::..|:||:    |.|...|...:|::|...||.:.:||..|...|
  Rat  1266 TVVALDALSKYGAATFSKSQKTPSVTVQ----SSGSFFQKFQVDNSNRLLLQQVSLPDIPGNYTV 1326

  Fly  1543 QAKGAGYAILQMHVQYNVDIEKFQTKPPVPAFGLHTKAIFHGRNQSHISYVACQNWINQNESE-- 1605
            ...|.|....|..::||:.:||.|     |||.|..:.:          .:.|.|...||..:
  Rat  1327 SVSGEGCVYAQTMLRYNLPLEKQQ-----PAFALKVQTV----------PLTCNNPKGQNSFQIS 1376

  Fly  1606 ----------RSGMAVLDVAIPTGYWIQQQKLDTYVLSNRVRNLRRARYLER------KIVFYFD 1654
                      .|.|.:.||.:.:|:         ..|...|:.|.|..::.|      .::.|.|
  Rat  1377 LEISYTGSRPASNMVIADVKMLSGF---------IPLKPTVKKLERLEHVSRTEVTTNNVLLYLD 1432

  Fly  1655 YLDHEDICVNFTIERWYPVANMSRYLPVRIYDYY 1688
            .:.::.:..:|.|::..||.|:...: |::||||
  Rat  1433 QVTNQTLSFSFIIQQDIPVKNLQPAI-VKVYDYY 1465

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	A2M_N	232..332	CDD:280081	35/105 (33%)
		A2M_N_2	669..799	CDD:285005	30/137 (22%)
		LDLa	886..913	CDD:238060	5/26 (19%)
		A2M	940..1030	CDD:278630	27/89 (30%)
		ISOPREN_C2_like	1177..1490	CDD:298658	87/325 (27%)
		A2M_comp	1226..1492	CDD:284982	75/280 (27%)
		A2M_recep	1607..1695	CDD:284981	22/88 (25%)
Cpamd8	XP_038963368.1	A2M_N	129..221	CDD:396416	30/95 (32%)
		MG3	223..309	CDD:407663	23/172 (13%)
		MG4	348..443	CDD:407661	21/101 (21%)
		A2M_N_2	457..607	CDD:400170	34/175 (19%)
		A2M	749..839	CDD:395153	27/90 (30%)
		A2M_2	969..1276	CDD:239227	87/332 (26%)
		A2M_recep	1388..1475	CDD:400149	22/88 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010