Protein Alignment Mcr and CPAMD8

DIOPT Version :10

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: XP_011526219.1
• Gene: CPAMD8 / 27151
• HGNCID: 23228
• Length: 1920
• Species: Homo sapiens
• Alignment Length: 1873
• Identity: 433/1873 - (23%)
• Similarity: 713/1873 - (38%)
• Gaps: 523/1873 - (27%)

  Fly   130 PTYFIVASRMVRPGLIYQVSVSILQAQYPITVHASIACDGVQISGDSKDVKEGIPETLLMRIPPT 194
            |.|.|.|..:.|.|:...:||:|..:...:||.|.:      ::.|...:|..:         ||
Human    78 PGYLIAAPSVFRAGVEEVISVTIFNSPREVTVQAQL------VAQDKGTIKLKV---------PT 127

  Fly   195 SVTGSYKLRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTDKPLYMQGETVRFRTIPITTELK 259
            .:.|...|:|.|.......|..|.|:|.:....|..::|:|||||:|.....|......::..|:
Human   128 GLRGQALLKVWGRGWQAEEGPLFHNQTSVTVDGRGASVFIQTDKPVYRPQHRVLISIFTVSPNLR 192

  Fly   260 GFDNPVDVYMLDPNRHILKRWLS-RQSNLGSVSLEYKLSDQPTFGEWTIRVIAQGQQEESHFTVE 323
            ..:..::.|:|||....:..|.. :....|..::.:.|||||..|||.|.|..||......|.|:
Human   193 PVNEKLEAYILDPRGSRMIEWRHLKPFCCGITNMSFPLSDQPVLGEWFIFVEMQGHAYNKSFEVQ 257

  Fly   324 EYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNEKYRL 388
            :|...:||:.:..|.|....|....|.|.|.:|.|.||.|.|.|..|:..:||:|::|
Human   258 KYVLPKFELLIDPPRYIQDLDACETGTVRARYTFGKPVAGALMINMTVNGVGYYSHEV------- 315

  Fly   389 GRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRNQYVVERHYQFDEEWPF 453
            ||..|..|.:...|      :.:..|:..:|..:|:
Human   316 GRPVLRTTKILGSR------DFDICVRDMIPADVPE----------------------------- 345

  Fly   454 WVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEVLITATVGEK-- 516
                                       :|.|.... |                .::|:..|.:
Human   346 ---------------------------HFRGRVSI-W----------------AMVTSVDGSQQV 366

  Fly   517 -FYDEIISGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSP-------IDPNLLR 573
             |.|.       ..|....:.:.:..|:.:.|||.:.:...:.:.|.||||       |...|..
Human   367 AFDDS-------TPVQRQLVDIRYSKDTRKQFKPGLAYVGKVELSYPDGSPAEGVTVQIKAELTP 424

  Fly   574 QGLMEVSGFVESRNGGRRDWPAQRLPMSQQSDGIW-EVKIDIRNDLNLDDRPQARDFLNGVQNMR 637
            :..:..|..|..|  |...:....:|.|.|.  :| |.|:     :.|:.:|....:|
Human   425 KDNIYTSEVVSQR--GLVGFEIPSIPTSAQH--VWLETKV-----MALNGKPVGAQYL------- 473

  Fly   638 LQANFVDPRGERIQTELLLVSHYSPRNQHIKVTTSTEKPVVGEYIIFHIRT----NFYLEEFNYL 698
                         .:.|.|.|.|||...::::...:....|||...|.:::    ||.|   .|.
Human   474 -------------PSYLSLGSWYSPSQCYLQLQPPSHPLQVGEEAYFSVKSTCPCNFTL---YYE 522

  Fly   699 IMSKGVILVNDRE-------------------------TITEG-----------IKTIAVVLSSE 727
            :.::|.|:::.::                         :.||.           :.::.:.::..
Human   523 VAARGNIVLSGQQPAHTTQQRSKRAAPALEKPIRLTHLSETEPPPAPEAEVDVCVTSLHLAVTPS 587

  Fly   728 MAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYINNRKARTGEKVEVAIFGEPGSYVGLS 792
            |.|:..::|:.:.:.|:.|||||.|.|.....|..:|..:..:.:.||.|::.|....||.|.::
Human   588 MVPLGRLLVFYVRENGEGVADSLQFAVETFFENQVSVTYSANETQPGEVVDLRIRAARGSCVCVA 652

  Fly   793 GIDSAFYTMQAGNELTYAKIITKMSNFD-------EQTNGTYKHIWY----SHEGNPDELVYFPA 846
            .:|.:.|.:::|..||.|::..::.::|       .:.:|.:   |:    :.......:..:|
Human   653 AVDKSVYLLRSGFRLTPAQVFQELEDYDVSDSFGVSREDGPF---WWAGLTAQRRRRSSVFPWP- 713

  Fly   847 SSFGV--DANRTFEYSGLIVFTDGY-VPRRQDTCNRTLGFGECLSGRCYRLEKQCDGLFDCDDGT 908
              :|:  |:...|..:||:|.||.. :..|||                       .||: .|:..
Human   714 --WGITKDSGFAFTETGLVVMTDRVSLNHRQD-----------------------GGLY-TDEAV 752

  Fly   909 DEINCHARN-----------DTELLNYRKYRFNRVLRHYENVWLWKDVNIG-PHGRYIFNVEVPD 961
            .....|..:           .||   .||..|      :...|:|..:||. |.|....:|:|||
Human   753 PAFQPHTGSLVAVAPSRHPPRTE---KRKRTF------FPETWIWHCLNISDPSGEGTLSVKVPD 808

  Fly   962 RPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYM------ 1020
            ....|:..|.::|.|:|.|:...:| ....:|||::..:|....:||||.|.::|:|||
Human   809 SITSWVGEAVALSTSQGLGIAEPSL-LKTFKPFFVDFMLPALIIRGEQVKIPLSVYNYMGTCAEV 872

  Fly  1021 --------------------------ITPIEA---IVVL-------------------------- 1030
                                      :.|.||   .|||
Human   873 YMKLSVPKGIQFVGHPGKRHVTKKMCVAPGEAEPIWVVLSFSDLGLNNITAKALAYGDTNCCRDG 937

  Fly  1031 ----HDSPDY-------------KFVHVEEDGIVRSYNPRTSFGEHQ------------------ 1060
                |...::             :.|.||.:|:.|:|.....|...:
Human   938 RSSKHPEENHADRRVPIGVDHVRRSVMVEAEGVPRAYTYSAFFCPSERVHISTPNKYEFQYVQRP 1002

  Fly  1061 -----FFIYLEAQGTTVVYVPVVPQ-----------------------RLGNVDVTLHVATLLGT 1097
                 |.:.:.|.....|.:...||                       ::|....:.|.|.:|..
Human  1003 LRLTRFDVAVRAHNDARVALSSGPQDTAGMIEIVLGGHQNTRSWISTSKMGEPVASAHTAKILSW 1067

  Fly  1098 DTITRTLHVE-SDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQTPEIPY---------------- 1145
            |.. ||..:. ..||.|..|..   :.||.:.::.:   .:.:.||:.:
Human  1068 DEF-RTFWISWRGGLIQVGHGP---EPSNESVIVAW---TLPRPPEVQFIGFSTGWGSMGEFRIW 1125

  Fly  1146 ---QVDRYF------------VYGSNKARISVVGDVVGPIFPTMPVNASSLLSLPMESGEQNAFS 1195
               :||..:            :.||.:|..|::|||:||...    :.::||.||...||||...
Human  1126 RKMEVDESYSEAFTLGVPHGAIPGSERATASIIGDVMGPTLN----HLNNLLRLPFGCGEQNMIH 1186

  Fly  1196 FAANLYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSY 1260
            ||.|::.:.|::...|.:..:|:....::..||||||::.|.|||:|.|..  .::..|:|||::
Human  1187 FAPNVFVLKYLQKTQQLSPEVERETTDYLVQGYQRQLTYKRQDGSYSAFGE--RDASGSMWLTAF 1249

  Fly  1261 CLRVFQEASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPDRKMNRT---NFDKNIT 1322
            .|:.|.:|     .:||::|...:.....|::|.|...|||..|    .|.:|:.   .....:.
Human  1250 VLKSFAQA-----RSFIFVDPRELAAAKSWIIQQQQADGSFLAV----GRVLNKDIQGGIHGTVP 1305

  Fly  1323 LTSHVLITLATVKDISGTLGSRVALATQRALAYIER----NMDFLRHQAQPFDVAITAYALQLCN 1383
            ||::|::.|..    :||.......:|.:|..::|.    .||       |:..|:|.|||.|..
Human  1306 LTAYVVVALLE----TGTASEEERGSTDKARHFLESAAPLAMD-------PYSCALTTYALTLLR 1359

  Fly  1384 SPIAEEVFAILRRQARTIGDFMYWGNQEIPQPPRKLENQKW---------FSLPRLPYEYDSLNI 1439
            ||.|.|....||..|.......:|          .|.| .|         || .|:.....|..:
Human  1360 SPAAPEALRKLRSLAIMRDGVTHW----------SLSN-SWDVDKGTFLSFS-DRVSQSVVSAEV 1412

  Fly  1440 ETTAYALLVYVARREFFVD-PIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLT 1503
            |.||||||.|....:.... |:|:||:.||...||::|||||..||:||.||.:.|....: :||
Human  1413 EMTAYALLTYTLLGDVAAALPVVKWLSQQRNALGGFSSTQDTCVALQALAEYAILSYAGGI-NLT 1476

  Fly  1504 VEIEASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNV-------- 1560
            |.: ||:.....:|..:..||...||:..||.....:.|.|||.|..::|:.|.|||
Human  1477 VSL-ASTNLDYQETFELHRTNQKVLQTAAIPSLPTGLFVSAKGDGCCLMQIDVTYNVPDPVAKPA 1540

  Fly  1561 --------DIEKFQTKPPVPAFGLHTKAIFHGR-------------NQSHISY----VACQNWIN 1600
                    :.|.....||:||     .|....|             :|.|..|    ..|..|::
Human  1541 FQLLVSLQEPEAQGRPPPMPA-----SAAEGSRGDWPPADDDDPAADQHHQEYKVMLEVCTRWLH 1600

  Fly  1601 QNESERSGMAVLDVAIPTGYWIQQQKLDTYVLSNRVRNLRRARYLERKIVFYFDYLDHEDI-CVN 1664
            ...   |.||||:|.:.:|:....:.|:..:|...: .::|.....|:::||||.:....: ||.
Human  1601 AGS---SNMAVLEVPLLSGFRADIESLEQLLLDKHM-GMKRYEVAGRRVLFYFDEIPSRCLTCVR 1661

  Fly  1665 FTIERWYPVANMSRYLPVRIYDYYAPERFNESIFDALPTYLLNICEVCGSSQC 1717
            |...|...|...|. |||.:||||.| .|..:.|..:.|:.....|:|....|
Human  1662 FRALRECVVGRTSA-LPVSVYDYYEP-AFEATRFYNVSTHSPLARELCAGPAC 1712

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	YfaS	<226..1575	CDD:441940	367/1615 (23%)
		A2M_BRD	667..801	CDD:462235	34/173 (20%)
		A2M	939..1030	CDD:459711	34/126 (27%)
		TED_complement	1160..1490	CDD:462227	109/346 (32%)
		A2M_recep	1605..1699	CDD:462226	30/94 (32%)
CPAMD8	XP_011526219.1	YfaS	<158..>925	CDD:441940	195/931 (21%)
		MG2	164..256	CDD:426464	28/91 (31%)
		A2M_BRD	490..661	CDD:462235	34/173 (20%)
		A2M	785..876	CDD:459711	30/91 (33%)
		Methyltransf_FA	1020..1121	CDD:463505	18/107 (17%)
		A2M_2	1176..1464	CDD:239227	100/321 (31%)
		A2M_recep	1602..1695	CDD:462226	31/98 (32%)
		PHA03247	<1675..1879	CDD:223021	14/40 (35%)
		KAZAL	1747..>1779	CDD:197624