DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcr and C4a

DIOPT Version :9

Sequence 1:NP_524688.1 Gene:Mcr / 44071 FlyBaseID:FBgn0267488 Length:1760 Species:Drosophila melanogaster
Sequence 2:NP_113692.2 Gene:C4a / 24233 RGDID:620005 Length:1737 Species:Rattus norvegicus


Alignment Length:1821 Identity:399/1821 - (21%)
Similarity:665/1821 - (36%) Gaps:484/1821 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   136 ASRMVRPGLIYQVSVSILQAQYPITVHASI--ACDGVQISGD-------------SKDVK--EGI 183
            ||.:.:|.|:. .|.|::....|::|...:  |..|.::.|.             .||.|  .|.
  Rat    15 ASSLQKPRLLL-FSPSVVNLGTPLSVGVQLLDAPAGQEVKGSVYLRNPTSGPCSPKKDFKLSSGN 78

  Fly   184 PETLL-MRIPPTSV--TGSYKLRVEGFYQNVFGGLAFLN------ETR---LDFSQRSMTIFVQT 236
            ...|| :.:|...|  .|.:.||.....|.|.......|      ||:   |.||.|...|||||
  Rat    79 DFVLLRLEVPLKDVRSCGLFGLRRAPHIQLVAHSPWLKNTASKATETQGVNLLFSSRRGHIFVQT 143

  Fly   237 DKPLYMQGETVRFRTIPITTELKGFDNPVDVYMLDPNRHILKRWLSRQSNLGSVSL---EYKLSD 298
            |:|:|..|:.||:|...:..:::...:.:.|.:  .|.|.|:  :.::......|:   ::.:.|
  Rat   144 DQPIYNPGQRVRYRVFALDQKMRPSTDTLTVTV--ENSHGLR--VRKKEVFAPTSIFQDDFIIPD 204

  Fly   299 QPTFGEWTIRV-IAQG--QQEESHFTVEEYYQTRFEVNVT-MPAYFFTTDPF---IYGRVMANFT 356
            ....|.|.|.. .:.|  ....:||.|::|....|||.:| ...|..|...:   |...|.|.:.
  Rat   205 ISEPGTWKISARFSDGLESNRSTHFEVKKYVLPNFEVKLTPWKPYILTVPSYREEIQLDVQARYV 269

  Fly   357 SGLPVRGNLTIKATIRPIGYFSNQVLNE--KYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVP 419
            .|.||:|          :.|....:::|  |....|....||.|...:...:......|...   
  Rat   270 YGKPVQG----------VAYTRFALMDEQGKKSFLRGLETQTKLVEGQTHISISRDQFQAAL--- 321

  Fly   420 GQLPQDGADLSQDILYRNQYVVERHYQFDEEWPFWVRKP--EYQDSSYEAWSGTYRKTLPYLRYF 482
            |::..:..||....||....|:|              .|  |.:::...:|        |:    
  Rat   322 GKVNTEIGDLEGLRLYAAVAVIE--------------SPGGEMEEAELTSW--------PF---- 360

  Fly   483 NGTFDFKWPLRELELLVPNLANSEVLITATVGEKFYDEIISGYSVARVYNSSLRVVFLGDSPQVF 547
                                                  :.|.:|:.           |..:.|..
  Rat   361 --------------------------------------VSSAFSLD-----------LSHTKQHL 376

  Fly   548 KPAMPFTTYLAVEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLPMSQQSDGIWEVKI 612
            .|..||.....|....||......::.....:||.           .::.|...|.::||.:|..
  Rat   377 VPGAPFLLQALVREMSGSEASDVPVKVSATLLSGS-----------DSKVLDFQQNTNGIGQVSF 430

  Fly   613 DIRNDLNLDDRPQARDFLNGVQNMRLQANFVDPRGERIQTEL-LLVSHYSPRNQHIKVTTST--- 673
            .|.                           |.|    ..||| ||||..|......|:|...   
  Rat   431 SIH---------------------------VPP----TITELRLLVSAGSLYPAVAKLTVQAPPS 464

  Fly   674 -------------EKPVVGEYIIFHIRT---------NFYLEEFNYLIMSKGVILVNDRETITEG 716
                         ..|.||:..:..:||         ::|     |:|:|:|.|:...||. ...
  Rat   465 RGPGFLSIEPLDLRSPRVGDTFVLSLRTVGIPMPTFSHYY-----YMIISRGQIMAMSREP-RRA 523

  Fly   717 IKTIAVVLSSEMAPVATIVVWKINQQGQVVADSLTFPVN-GISRNNFTVYINNRKA-RTGEKVEV 779
            :.:|:|::...:||....|.: ...||..||:||...|. |.......:.::..|. |.|:.:::
  Rat   524 LTSISVLVDHHLAPSFYFVAY-FYHQGLPVANSLLINVQPGDCEGKLELKVDGAKEYRNGDSMKL 587

  Fly   780 AIFGEPGSYVGLSGIDSAFYTM--QAGNELTYAKIITKMSNFDEQTNGTYKHIWYSHEGNPDELV 842
            .:..:..:.|.|..:|:|.|.:  ::...|..:|:...|::::                    |.
  Rat   588 QLQTDSEALVALGAVDTALYAVGGRSHKPLDMSKVFEVMNSYN--------------------LG 632

  Fly   843 YFPASSFGVDANRTFEYSGLIVFTDG----------YVPR-RQDTCNRTLGFGECLSGRCYRLE- 895
            ..|..  |.||.:.|:.:|| .|:||          ..|: ::....|.:.|.:.:|.:..:.. 
  Rat   633 CGPGG--GDDALQVFQTAGL-AFSDGDRLTQTKENLSCPKEKKSRQKRNVNFQKAISEKLGQYSS 694

  Fly   896 ---KQCDGLFDCDDGTDEI----NCHAR-----------------NDTELLNYRKYRFNRVLRHY 936
               |:|     |.||..::    .|..|                 ...|.|...:.|....|...
  Rat   695 PDTKRC-----CQDGMTKLPMARTCEQRAARVPQPACREPFLSCCKFAEDLRRNQTRSQAGLARA 754

  Fly   937 ENV---------------------WLWKDVNIGPHGR-YIFNVEVPDRPAYWMVSAFSVSPSKGF 979
            :::                     |||:   :.|..| .:..|.:||....|.:...|:|.|||.
  Rat   755 QDMLQEEDLIDEDDILVRSFFPENWLWR---VEPVDRSKLLTVWLPDSLTTWEIHGVSLSKSKGL 816

  Fly   980 GMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDSPDYKFVHVEED 1044
             .:.|.......:.|.:::.:|.:.|:.||:.:|..::||:..  :..|.:|.|| .:.:.:...
  Rat   817 -CVAKPTRVRVFREFHLHLRLPISVRRFEQLELRPVLYNYLSE--DVTVSVHVSP-VEGLCLAGG 877

  Fly  1045 GIVRSYNPRTSFGEHQFFIYLEAQGTTVVYVPVVPQRLGNV--DVTLHVATLLGTDTITRTLHVE 1107
            |::...            :.:.|.....|...|||....::  .|....:..:| |.:::.|.:|
  Rat   878 GLLAQQ------------VSVPAGSARPVAFSVVPTAAASIPLKVVARGSFTIG-DAVSKILQIE 929

  Fly  1108 SDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGD------- 1165
            .:| ..:|.:.|        |.|:.:: |:.::.|||         ||:...:...||       
  Rat   930 KEG-AIHREEIV--------YNLDPLN-NLGRSLEIP---------GSSDPNVIPDGDFSSFVRV 975

  Fly  1166 -------VVGPIFPTMPVNASSLLSLPMESGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAFYH 1223
                   .:|......|...:|||.||....||.....|..|....|:....|.:|...:...:.
  Rat   976 TASEPLETLGSEGALSPGGVASLLRLPRGCAEQTMIYLAPTLTASHYLDRTEQWSKLPPETKDHA 1040

  Fly  1224 MNI---GYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQEASFYEWENFIWIDATIIE 1285
            :::   |:.|...|.:.||||..    |.:.|||.|||::.|::...|     :..|......::
  Rat  1041 VDLIQKGHMRIQQFRKKDGSFGA----WLHRDSSTWLTAFVLKILSLA-----QEQIGDSPEKLQ 1096

  Fly  1286 KNMRWLLQHQTPQGSFFEVTWLPDRKM--NRTNFDKNITLTSHVLIT----LATVKD-ISGTLGS 1343
            :...|||..|...|||.:...:..|.|  .....|:.:.||:.|:|.    ||..:| .|..|..
  Rat  1097 ETAGWLLGQQLDDGSFHDPCPVIHRGMQGGLVGTDETVALTAFVVIALHHGLAVFQDENSQQLKK 1161

  Fly  1344 RVALATQRALAYI--ERNMDFLRHQAQPFDVAITAYALQLCNSPIAEEVFAI----LRRQARTIG 1402
            ||..:..:|.:::  :.:...|...|.    |||||||.|..:  :|::..:    |...|...|
  Rat  1162 RVEASITKANSFLGQKASAGLLGAHAS----AITAYALTLTKA--SEDLRNVAHNSLMAMAEETG 1220

  Fly  1403 DFMYWGN---------QEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVAR--REFF 1456
            :.:|||:         ...|.|....|     .:|:.|    :|.||||||.||..:.|  :...
  Rat  1221 ENLYWGSAIGSQDNVVSSTPAPRNPSE-----PVPQAP----ALWIETTAYGLLHLLLREGKGEM 1276

  Fly  1457 VDPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQGG-KTQTLYI 1520
            .|.:..||..|....||:.|||||...|.||..|.:.|...|..:|.|.:.:..:.| |:..|.:
  Rat  1277 ADKVATWLTHQGSFQGGFRSTQDTVVTLDALSAYWIASHTTEEKALNVTLSSMGRNGYKSHLLQL 1341

  Fly  1521 DDTNLAKLQSIEIPDAWGT---IKVQAKGAG-------YAILQM----------------HVQY- 1558
            ::..:..|:. |:..:.|:   :||.....|       |.:|.|                :|:| 
  Rat  1342 NNHQVKGLEE-ELKFSLGSTINVKVGGNSKGTLKILRTYNVLDMKNTTCQDLRIEVTVTGYVEYT 1405

  Fly  1559 ---NVDIEKFQTKPPVPAFGLHTKAI-----FHGR--------------NQSHISYVACQNWINQ 1601
               |.|.|.....|......:|::.:     |.||              .:|.:.|..| .|.|.
  Rat  1406 REANEDYEYDYDMPAADDPSVHSQPVTPLQLFEGRRSRRRREAPKAADEQESRVQYTVC-IWRNG 1469

  Fly  1602 NESERSGMAVLDVAIPTGYWIQQQKLDTYV-LSNRVRNLRRARYLER------KIVFYFDYLDHE 1659
            |.. .||||:.|:.:.:|:...:..|:... ||:        ||:..      .::.|||.:...
  Rat  1470 NLG-LSGMAIADITLLSGFQALRADLEKLTSLSD--------RYVSHFETDGPHVLLYFDSVPTT 1525

  Fly  1660 DICVNFTIERWYPVANMSRYLPVRIYDYYAPERFNESIFDALPT---YLLNICEV----CGSSQC 1717
            ..||.|...:...|..:.....| :||||:|:. ..|:|.|.||   .|..:|..    |...:|
  Rat  1526 RECVGFGALQEVAVGLVQPASAV-LYDYYSPDH-KCSVFYAAPTKSKLLSTLCSADVCQCAEGKC 1588

  Fly  1718 P 1718
            |
  Rat  1589 P 1589

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
McrNP_524688.1 A2M_N 232..332 CDD:280081 27/105 (26%)
A2M_N_2 669..799 CDD:285005 34/156 (22%)
LDLa 886..913 CDD:238060 6/34 (18%)
A2M 940..1030 CDD:278630 24/90 (27%)
ISOPREN_C2_like 1177..1490 CDD:298658 97/339 (29%)
A2M_comp 1226..1492 CDD:284982 86/292 (29%)
A2M_recep 1607..1695 CDD:284981 24/94 (26%)
C4aNP_113692.2 A2M_N 139..231 CDD:280081 24/95 (25%)
A2M_N_2 475..608 CDD:285005 33/139 (24%)
ANATO 684..752 CDD:237984 11/72 (15%)
A2M 779..866 CDD:278630 24/92 (26%)
complement_C3_C4_C5 991..1310 CDD:239226 98/342 (29%)
A2M_comp 1046..1312 CDD:284982 86/289 (30%)
A2M_recep 1474..1563 CDD:284981 25/98 (26%)
NTR_complement_C4 1581..1735 CDD:239639 3/9 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.920

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