DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcr and C3

DIOPT Version :9

Sequence 1:NP_524688.1 Gene:Mcr / 44071 FlyBaseID:FBgn0267488 Length:1760 Species:Drosophila melanogaster
Sequence 2:NP_058690.2 Gene:C3 / 24232 RGDID:2232 Length:1663 Species:Rattus norvegicus


Alignment Length:1786 Identity:407/1786 - (22%)
Similarity:682/1786 - (38%) Gaps:478/1786 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   119 ATFLESLHSREPTYFIVASRMVRPGLIYQVSVSILQA-----QYPITVHASIACDGV--QISGDS 176
            |:.|.:|.|  |.|.|:...::|   :......||:|     ..|:||...   |.:  |:....
  Rat    17 ASSLLALGS--PMYSIITPNVLR---LESEETFILEAHDAQGDVPVTVTVQ---DFLKKQVLTSE 73

  Fly   177 KDVKEGIP---ETLLMRIPPTSVTGSYKLRVEGFYQNV-----FGGLAFLNETRLDFSQRSMTIF 233
            |.|..|..   ..:.::||     .|.:...:..::.|     ||  |.:.|..:..|.:|..:|
  Rat    74 KTVLTGATGHLNRVSIKIP-----ASKEFNADKGHKYVTVVANFG--ATVVEKAVLVSFQSGYLF 131

  Fly   234 VQTDKPLYMQGETVRFRTIPITTELKGFDNPVDVYMLDPNRHILKR-WLSRQSNLGSVSLEYKLS 297
            :||||.:|..|.||.:|...:...|......|.:.:..|:...:|| .||..:..|.:.|.:.:.
  Rat   132 IQTDKTIYTPGSTVFYRIFTVDNNLLPVGKTVVIVIETPDGVPIKRDILSSHNQYGILPLSWNIP 196

  Fly   298 DQPTFGEWTIRVI---AQGQQEESHFTVEEYYQTRFEVNV-TMPAYFFTTDP-FIYGRVMANFTS 357
            :....|:|.||..   |..|...:.|.|:||....|||.| ....:::..|| .:...:.|.|..
  Rat   197 ELVNMGQWKIRAFYEHAPKQTFSAEFEVKEYVLPSFEVLVEPTEKFYYIDDPKGLEVSITARFLY 261

  Fly   358 GLPVRGNLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQL 422
            |..|.|...:        .|..|..::|..|.:|                          :...|
  Rat   262 GKNVDGTAFV--------IFGVQDEDKKISLAQS--------------------------LTRVL 292

  Fly   423 PQDGADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFD 487
            .:||:         .:.|:.|....|...|          ||.||                    
  Rat   293 IEDGS---------GEAVLSRKVLMDGVRP----------SSPEA-------------------- 318

  Fly   488 FKWPLRELELLVPNLANSEVLITATVGEKFYDEIISGYSVARVYNSSLRVV------FLGDSPQV 546
                          |....:.::.||      .:.||..:.....|.:.:|      ....:|:.
  Rat   319 --------------LVGKSLYVSVTV------ILHSGSDMVEAERSGIPIVTSPYQIHFTKTPKF 363

  Fly   547 FKPAMPFTTYLAVEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLPM---------SQ 602
            |||||||...:.|...|||                            ||:|:|:         ..
  Rat   364 FKPAMPFDLMVFVTNPDGS----------------------------PARRVPVVTQGSDAQALT 400

  Fly   603 QSDGIWEVKIDIRND---LNLDDRPQARDFLNGVQNMRLQANFVDPRGERIQTELLLVSHYSPRN 664
            |.||:.::.::..|:   |.:..|.:.    .|:.:.| ||.      ..:|.:.....|.|...
  Rat   401 QDDGVAKLSVNTPNNRQPLTITVRTKK----EGIPDAR-QAT------RTMQAQPYSTMHNSNNY 454

  Fly   665 QHIKVTTSTEKPVVGEYIIFHIRTNFYLEE----FNYLIMSKGVILVNDRETITEG--IKTIAVV 723
            .|:.|:....||.....:.||:||:...|.    :.||:|:||.:|...|:....|  :..:::.
  Rat   455 LHLSVSRVELKPGDNLNVNFHLRTDAGQEAKIRYYTYLVMNKGKLLKAGRQVREPGQDLVVLSLP 519

  Fly   724 LSSEMAP----VATIVVWKINQQGQVVADSL----------TFPVNGISRNNFTVYINNRKARTG 774
            ::.|..|    ||...:...|.|.:|||||:          |..|.|..|       :||:...|
  Rat   520 ITPEFIPSFRLVAYYTLIGANGQREVVADSVWVDVKDSCVGTLVVKGDPR-------DNRQPAPG 577

  Fly   775 EKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFD-EQTNGTYKHIWYSHEGNP 838
            .:..:.|.|..|:.|||..:|...:.:...|:||.:||...:...| ..|.|:.|:.        
  Rat   578 HQTTLRIEGNQGARVGLVAVDKGVFVLNKKNKLTQSKIWDVVEKADIGCTPGSGKNY-------- 634

  Fly   839 DELVYFPASSFGVDANRTFEYS-GLIVFTDGYVPRRQDTCNRTLGFGECLSGRCYR------LEK 896
                   |..| :||..||:.: ||  .||    :|:|.        ||......|      :|:
  Rat   635 -------AGVF-MDAGLTFKTNQGL--QTD----QREDP--------ECAKPAARRRRSVQLMER 677

  Fly   897 QCD--------GLFD-CDDGTDEI----NCHARND------------TELLNY-----RKYRFNR 931
            :.|        ||.. |:||..:|    :|..|..            .:..||     .::|.:.
  Rat   678 RMDKAGQYTDKGLRKCCEDGMRDIPMKYSCQRRARLITQGESCLKAFMDCCNYITKLREQHRRDH 742

  Fly   932 VL--------------------RHYENVWLW-----KDVNIGPHGRYIFNVEVPDRPAYWMVSAF 971
            ||                    .|:...|||     |:.........:.|:.:.|....|.:.|.
  Rat   743 VLGLARSDVDEDIIPEEDIISRSHFPESWLWTIEELKEPEKNGISTKVMNIFLKDSITTWEILAV 807

  Fly   972 SVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDSPDY 1036
            |:|..||..:.: ..|...:|.|||::.:|.:..:.|||.||..:|||           .:....
  Rat   808 SLSDKKGICVAD-PYEITVMQDFFIDLRLPYSVVRNEQVEIRAVLFNY-----------REQEKL 860

  Fly  1037 KFVHVEEDGIVRSYNP---RTSFGEHQFFIYLEAQGTTVVYVP--VVPQRLG--NVDVTLHVATL 1094
            | |.||     ..:||   ..:..:.:::..:|....:.|.||  :||.::|  .|:|...|...
  Rat   861 K-VRVE-----LLHNPAFCSMATAKKRYYQTIEIPPKSSVAVPYVIVPLKIGLQEVEVKAAVFNH 919

  Fly  1095 LGTDTITRTLHVESDGL------------PQY-------RHQSVLLDLSNRAYVLEYMHVNVTQT 1140
            ..:|.:.:.|.|..:|:            |::       |......|||:             |.
  Rat   920 FISDGVKKILKVVPEGMRVNKTVAVRTLDPEHLGQGGVQREDVPAADLSD-------------QV 971

  Fly  1141 PEIPYQVDRYFVYGSNKARI---SVVGDVVGPIFPTMPVNASSLLSLPMESGEQNAFSFAANLYT 1202
            |:...:. |..:.|:..|::   :|.|:           ....|:..|...||||.......:..
  Rat   972 PDTDSET-RILLQGTPVAQMAEDAVDGE-----------RLKHLIVTPSGCGEQNMIGMTPTVIA 1024

  Fly  1203 IMYMRLINQRNK-TLEK--NAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRV 1264
            :.|:....|..| .|||  .|...:..||.:||:|.:|..:::.|    ||...|.|||:|.::|
  Rat  1025 VHYLDQTEQWEKFGLEKRQEALELIKKGYTQQLAFKQPSSAYAAF----NNRPPSTWLTAYVVKV 1085

  Fly  1265 FQEASFYEWENFIWIDATIIEKNMRWL-LQHQTPQGSFFEVTWLPDRKM---NRTNFDKNITLTS 1325
            |..|:     |.|.||:.::...::|| |:.|.|.|.|.|...:..::|   .|...:.:::||:
  Rat  1086 FSLAA-----NLIAIDSQVLCGAVKWLILEKQKPDGVFQEDGPVIHQEMIGGFRNTKEADVSLTA 1145

  Fly  1326 HVLITLATVKDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDVAITAYALQLCNSPIAEEV 1390
            .|||.|...:||.....:.:..:..:|..|:|.:  :|..| :|:.|||..|||.|.|.  .||.
  Rat  1146 FVLIALQEARDICEGQVNSLPGSINKAGEYLEAS--YLNLQ-RPYTVAIAGYALALMNK--LEEP 1205

  Fly  1391 FAILRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVARREF 1455
            :  |.:...|..|...|     .:|.::|                 .|:|.|:||||..:..::|
  Rat  1206 Y--LTKFLNTAKDRNRW-----EEPGQQL-----------------YNVEATSYALLALLLLKDF 1246

  Fly  1456 -FVDPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQGGKTQTLY 1519
             .|.|:|||||.||...||:.|||.|....:||.:|.......:..::.|.:...|:...|....
  Rat  1247 DSVPPVVRWLNEQRYYGGGYGSTQATFMVFQALAQYQTDVPDHKDLNMDVSLHLPSRSSPTVFRL 1311

  Fly  1520 IDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNVDI------EKFQ---TKPPVPAFG 1575
            :.::. :.|:|.|.....| ..:.|||.|...|.:...|:..:      :||.   |..|.|...
  Rat  1312 LWESG-SLLRSEETKQNEG-FSLTAKGKGQGTLSVVTVYHAKVKGKATCKKFDLRVTIKPAPETA 1374

  Fly  1576 LHTKAIFHGRNQSHISYVACQNWINQNESERSGMAVLDVAIPTGYWIQQQKLDTYVLSNRVRNLR 1640
            ...:..     :|.:....|..::...::.   |::||:::.||:......|:  :||:.|    
  Rat  1375 KKPQDA-----KSSMILDICTRYLGDVDAT---MSILDISMMTGFIPDTNDLE--LLSSGV---- 1425

  Fly  1641 RARYLER-----------KIVFYFDYLDH-EDICVNFTIERWYPVANMSRYLP--VRIYDYYAPE 1691
             .||:.:           .::.|.:.:.| |:.|::|.:.:::   |:....|  |::|.||..|
  Rat  1426 -DRYISKYEMDKAFSNKNTLIIYLEKISHSEEDCLSFKVHQFF---NVGLIQPGSVKVYSYYNLE 1486

  Fly  1692 R-----FNESIFDALPTYLLNICEVCGSSQC 1717
            .     ::....|.:      :.::|.:..|
  Rat  1487 ESCTRFYHPEKDDGM------LSKLCHNEMC 1511

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
McrNP_524688.1 A2M_N 232..332 CDD:280081 30/103 (29%)
A2M_N_2 669..799 CDD:285005 41/149 (28%)
LDLa 886..913 CDD:238060 10/45 (22%)
A2M 940..1030 CDD:278630 26/94 (28%)
ISOPREN_C2_like 1177..1490 CDD:298658 99/320 (31%)
A2M_comp 1226..1492 CDD:284982 87/270 (32%)
A2M_recep 1607..1695 CDD:284981 23/106 (22%)
C3NP_058690.2 A2M_N 129..224 CDD:280081 26/94 (28%)
A2M_N_2 457..603 CDD:285005 41/152 (27%)
ANATO 678..747 CDD:237984 14/68 (21%)
A2M 770..866 CDD:278630 30/113 (27%)
complement_C3_C4_C5 996..1282 CDD:239226 100/334 (30%)
A2M_comp 1051..1282 CDD:284982 86/268 (32%)
A2M_recep 1398..1493 CDD:284981 23/107 (21%)
NTR_complement_C3 1513..1661 CDD:239638
Interaction with CFP/properdin. /evidence=ECO:0000250|UniProtKB:P01024 1634..1659
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.910

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