Protein Alignment Mcr and C3

DIOPT Version :10

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: NP_058690.2
• Gene: C3 / 24232
• RGDID: 2232
• Length: 1663
• Species: Rattus norvegicus
• Alignment Length: 1786
• Identity: 407/1786 - (22%)
• Similarity: 682/1786 - (38%)
• Gaps: 478/1786 - (26%)

  Fly   119 ATFLESLHSREPTYFIVASRMVRPGLIYQVSVSILQA-----QYPITVHASIACDGV--QISGDS 176
            |:.|.:|.|  |.|.|:...::|   :......||:|     ..|:||...   |.:  |:....
  Rat    17 ASSLLALGS--PMYSIITPNVLR---LESEETFILEAHDAQGDVPVTVTVQ---DFLKKQVLTSE 73

  Fly   177 KDVKEGIP---ETLLMRIPPTSVTGSYKLRVEGFYQNV-----FGGLAFLNETRLDFSQRSMTIF 233
            |.|..|..   ..:.::||     .|.:...:..::.|     ||  |.:.|..:..|.:|..:|
  Rat    74 KTVLTGATGHLNRVSIKIP-----ASKEFNADKGHKYVTVVANFG--ATVVEKAVLVSFQSGYLF 131

  Fly   234 VQTDKPLYMQGETVRFRTIPITTELKGFDNPVDVYMLDPNRHILKR-WLSRQSNLGSVSLEYKLS 297
            :||||.:|..|.||.:|...:...|......|.:.:..|:...:|| .||..:..|.:.|.:.:.
  Rat   132 IQTDKTIYTPGSTVFYRIFTVDNNLLPVGKTVVIVIETPDGVPIKRDILSSHNQYGILPLSWNIP 196

  Fly   298 DQPTFGEWTIRVI---AQGQQEESHFTVEEYYQTRFEVNV-TMPAYFFTTDP-FIYGRVMANFTS 357
            :....|:|.||..   |..|...:.|.|:||....|||.| ....:::..|| .:...:.|.|..
  Rat   197 ELVNMGQWKIRAFYEHAPKQTFSAEFEVKEYVLPSFEVLVEPTEKFYYIDDPKGLEVSITARFLY 261

  Fly   358 GLPVRGNLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQL 422
            |..|.|...:        .|..|..::|..|.:|                          :...|
  Rat   262 GKNVDGTAFV--------IFGVQDEDKKISLAQS--------------------------LTRVL 292

  Fly   423 PQDGADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFD 487
            .:||:         .:.|:.|....|...|          ||.||
  Rat   293 IEDGS---------GEAVLSRKVLMDGVRP----------SSPEA-------------------- 318

  Fly   488 FKWPLRELELLVPNLANSEVLITATVGEKFYDEIISGYSVARVYNSSLRVV------FLGDSPQV 546
                          |....:.::.||      .:.||..:.....|.:.:|      ....:|:.
  Rat   319 --------------LVGKSLYVSVTV------ILHSGSDMVEAERSGIPIVTSPYQIHFTKTPKF 363

  Fly   547 FKPAMPFTTYLAVEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLPM---------SQ 602
            |||||||...:.|...|||                            ||:|:|:         ..
  Rat   364 FKPAMPFDLMVFVTNPDGS----------------------------PARRVPVVTQGSDAQALT 400

  Fly   603 QSDGIWEVKIDIRND---LNLDDRPQARDFLNGVQNMRLQANFVDPRGERIQTELLLVSHYSPRN 664
            |.||:.::.::..|:   |.:..|.:.    .|:.:.| ||.      ..:|.:.....|.|...
  Rat   401 QDDGVAKLSVNTPNNRQPLTITVRTKK----EGIPDAR-QAT------RTMQAQPYSTMHNSNNY 454

  Fly   665 QHIKVTTSTEKPVVGEYIIFHIRTNFYLEE----FNYLIMSKGVILVNDRETITEG--IKTIAVV 723
            .|:.|:....||.....:.||:||:...|.    :.||:|:||.:|...|:....|  :..:::.
  Rat   455 LHLSVSRVELKPGDNLNVNFHLRTDAGQEAKIRYYTYLVMNKGKLLKAGRQVREPGQDLVVLSLP 519

  Fly   724 LSSEMAP----VATIVVWKINQQGQVVADSL----------TFPVNGISRNNFTVYINNRKARTG 774
            ::.|..|    ||...:...|.|.:|||||:          |..|.|..|       :||:...|
  Rat   520 ITPEFIPSFRLVAYYTLIGANGQREVVADSVWVDVKDSCVGTLVVKGDPR-------DNRQPAPG 577

  Fly   775 EKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFD-EQTNGTYKHIWYSHEGNP 838
            .:..:.|.|..|:.|||..:|...:.:...|:||.:||...:...| ..|.|:.|:.
  Rat   578 HQTTLRIEGNQGARVGLVAVDKGVFVLNKKNKLTQSKIWDVVEKADIGCTPGSGKNY-------- 634

  Fly   839 DELVYFPASSFGVDANRTFEYS-GLIVFTDGYVPRRQDTCNRTLGFGECLSGRCYR------LEK 896
                   |..| :||..||:.: ||  .||    :|:|.        ||......|      :|:
  Rat   635 -------AGVF-MDAGLTFKTNQGL--QTD----QREDP--------ECAKPAARRRRSVQLMER 677

  Fly   897 QCD--------GLFD-CDDGTDEI----NCHARND------------TELLNY-----RKYRFNR 931
            :.|        ||.. |:||..:|    :|..|..            .:..||     .::|.:.
  Rat   678 RMDKAGQYTDKGLRKCCEDGMRDIPMKYSCQRRARLITQGESCLKAFMDCCNYITKLREQHRRDH 742

  Fly   932 VL--------------------RHYENVWLW-----KDVNIGPHGRYIFNVEVPDRPAYWMVSAF 971
            ||                    .|:...|||     |:.........:.|:.:.|....|.:.|.
  Rat   743 VLGLARSDVDEDIIPEEDIISRSHFPESWLWTIEELKEPEKNGISTKVMNIFLKDSITTWEILAV 807

  Fly   972 SVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDSPDY 1036
            |:|..||..:.: ..|...:|.|||::.:|.:..:.|||.||..:|||           .:....
  Rat   808 SLSDKKGICVAD-PYEITVMQDFFIDLRLPYSVVRNEQVEIRAVLFNY-----------REQEKL 860

  Fly  1037 KFVHVEEDGIVRSYNP---RTSFGEHQFFIYLEAQGTTVVYVP--VVPQRLG--NVDVTLHVATL 1094
            | |.||     ..:||   ..:..:.:::..:|....:.|.||  :||.::|  .|:|...|...
  Rat   861 K-VRVE-----LLHNPAFCSMATAKKRYYQTIEIPPKSSVAVPYVIVPLKIGLQEVEVKAAVFNH 919

  Fly  1095 LGTDTITRTLHVESDGL------------PQY-------RHQSVLLDLSNRAYVLEYMHVNVTQT 1140
            ..:|.:.:.|.|..:|:            |::       |......|||:             |.
  Rat   920 FISDGVKKILKVVPEGMRVNKTVAVRTLDPEHLGQGGVQREDVPAADLSD-------------QV 971

  Fly  1141 PEIPYQVDRYFVYGSNKARI---SVVGDVVGPIFPTMPVNASSLLSLPMESGEQNAFSFAANLYT 1202
            |:...:. |..:.|:..|::   :|.|:           ....|:..|...||||.......:..
  Rat   972 PDTDSET-RILLQGTPVAQMAEDAVDGE-----------RLKHLIVTPSGCGEQNMIGMTPTVIA 1024

  Fly  1203 IMYMRLINQRNK-TLEK--NAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRV 1264
            :.|:....|..| .|||  .|...:..||.:||:|.:|..:::.|    ||...|.|||:|.::|
  Rat  1025 VHYLDQTEQWEKFGLEKRQEALELIKKGYTQQLAFKQPSSAYAAF----NNRPPSTWLTAYVVKV 1085

  Fly  1265 FQEASFYEWENFIWIDATIIEKNMRWL-LQHQTPQGSFFEVTWLPDRKM---NRTNFDKNITLTS 1325
            |..|:     |.|.||:.::...::|| |:.|.|.|.|.|...:..::|   .|...:.:::||:
  Rat  1086 FSLAA-----NLIAIDSQVLCGAVKWLILEKQKPDGVFQEDGPVIHQEMIGGFRNTKEADVSLTA 1145

  Fly  1326 HVLITLATVKDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDVAITAYALQLCNSPIAEEV 1390
            .|||.|...:||.....:.:..:..:|..|:|.:  :|..| :|:.|||..|||.|.|.  .||.
  Rat  1146 FVLIALQEARDICEGQVNSLPGSINKAGEYLEAS--YLNLQ-RPYTVAIAGYALALMNK--LEEP 1205

  Fly  1391 FAILRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVARREF 1455
            :  |.:...|..|...|     .:|.::|                 .|:|.|:||||..:..::|
  Rat  1206 Y--LTKFLNTAKDRNRW-----EEPGQQL-----------------YNVEATSYALLALLLLKDF 1246

  Fly  1456 -FVDPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQGGKTQTLY 1519
             .|.|:|||||.||...||:.|||.|....:||.:|.......:..::.|.:...|:...|....
  Rat  1247 DSVPPVVRWLNEQRYYGGGYGSTQATFMVFQALAQYQTDVPDHKDLNMDVSLHLPSRSSPTVFRL 1311

  Fly  1520 IDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNVDI------EKFQ---TKPPVPAFG 1575
            :.::. :.|:|.|.....| ..:.|||.|...|.:...|:..:      :||.   |..|.|...
  Rat  1312 LWESG-SLLRSEETKQNEG-FSLTAKGKGQGTLSVVTVYHAKVKGKATCKKFDLRVTIKPAPETA 1374

  Fly  1576 LHTKAIFHGRNQSHISYVACQNWINQNESERSGMAVLDVAIPTGYWIQQQKLDTYVLSNRVRNLR 1640
            ...:..     :|.:....|..::...::.   |::||:::.||:......|:  :||:.|
  Rat  1375 KKPQDA-----KSSMILDICTRYLGDVDAT---MSILDISMMTGFIPDTNDLE--LLSSGV---- 1425

  Fly  1641 RARYLER-----------KIVFYFDYLDH-EDICVNFTIERWYPVANMSRYLP--VRIYDYYAPE 1691
             .||:.:           .::.|.:.:.| |:.|::|.:.:::   |:....|  |::|.||..|
  Rat  1426 -DRYISKYEMDKAFSNKNTLIIYLEKISHSEEDCLSFKVHQFF---NVGLIQPGSVKVYSYYNLE 1486

  Fly  1692 R-----FNESIFDALPTYLLNICEVCGSSQC 1717
            .     ::....|.:      :.::|.:..|
  Rat  1487 ESCTRFYHPEKDDGM------LSKLCHNEMC 1511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	YfaS	<226..1575	CDD:441940	352/1501 (23%)
		A2M_BRD	667..801	CDD:462235	41/153 (27%)
		A2M	939..1030	CDD:459711	26/95 (27%)
		TED_complement	1160..1490	CDD:462227	101/340 (30%)
		A2M_recep	1605..1699	CDD:462226	23/112 (21%)
C3	NP_058690.2	MG1	26..124	CDD:465508	23/110 (21%)
		YfaS	<128..1345	CDD:441940	344/1468 (23%)
		complement_C3_C4_C5	996..1282	CDD:239226	100/334 (30%)
		A2M_recep	1397..1494	CDD:462226	23/109 (21%)
		NTR_complement_C3	1513..1661	CDD:239638
		Interaction with CFP/properdin. /evidence=ECO:0000250|UniProtKB:P01024	1634..1659