DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcr and A2m

DIOPT Version :9

Sequence 1:NP_524688.1 Gene:Mcr / 44071 FlyBaseID:FBgn0267488 Length:1760 Species:Drosophila melanogaster
Sequence 2:NP_036620.2 Gene:A2m / 24153 RGDID:2004 Length:1472 Species:Rattus norvegicus


Alignment Length:1705 Identity:392/1705 - (22%)
Similarity:672/1705 - (39%) Gaps:408/1705 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   136 ASRMVRPGLIYQVSV-SILQAQYPITVHASIACDGVQISGDSKDVKEGIPETLLMRIPPTSVTGS 199
            ||...:|  ||.|.| |:|.|..|     ..||          .:...:.||:.:|:...||.|:
  Rat    27 ASAPQKP--IYMVMVPSLLHAGTP-----EKAC----------FLFSHLNETVAVRVSLESVRGN 74

  Fly   200 YKL------------------------RVEGFYQNVFGGL-AFLNETRLDFSQRSMTIFVQTDKP 239
            ..|                        .|..|...|.|.. .|...:.:...::...:|.|||||
  Rat    75 QSLFTDLVVDKDLFHCTSFTVPQSSSDEVMFFTVQVKGATHEFRRRSTVLVKKKESLVFAQTDKP 139

  Fly   240 LYMQGETVRFRTIPITTELKGFDNPVD-VYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFG 303
            :|..|:|||||.:.:.......:..:. :|:.||..:.:.:|.:.....|...|.:.||.:||.|
  Rat   140 IYKPGQTVRFRVVSLDESFHPLNELIPLLYIQDPKNNRIAQWQNFNLEGGLKQLSFPLSSEPTQG 204

  Fly   304 EWTIRVIAQ-GQQEESHFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTI 367
            .:.:.:..: |:..|..|:|||:...:|||.||:|......:..:...|...:|.|.||.|.:|:
  Rat   205 SYKVVIRTESGRTVEHPFSVEEFVLPKFEVRVTVPETITILEEEMNVSVCGIYTYGKPVPGRVTV 269

  Fly   368 KATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGAD-LSQ 431
                                            |...:|:||:       |..|:......: |||
  Rat   270 --------------------------------NICRKYSNPS-------NCFGEESVAFCEKLSQ 295

  Fly   432 DILYR---NQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLR 493
            .:..|   :|.|..:.:|        :::.||                                 
  Rat   296 QLDGRGCFSQLVKTKSFQ--------LKRQEY--------------------------------- 319

  Fly   494 ELELLVPNLANSEVLITATVGEKFYDEIISGYSVARVYNSSLRVVFLG-DSPQVFKPAMPFTTYL 557
            |::|.|    ::::....|..|:      :|..:.::..:..::.|:. ||.  |:..:||...:
  Rat   320 EMQLDV----HAKIQEEGTGVEE------TGKGLTKITRTITKLSFVNVDSH--FRQGIPFVGQV 372

  Fly   558 AVEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLPMSQQSDGIWEVKIDIRNDLNLDD 622
            .:....|:||....:..|..|.:.::.:               :....|:      .|..:|.||
  Rat   373 LLVDGRGTPIPYETIFIGADEANLYINT---------------TTDKHGL------ARFSINTDD 416

  Fly   623 RPQARDFLNGVQNMRLQANFVDPRG---------ERIQTELLLVSHYSPRNQHIKVTTSTEK--- 675
                   :.|. ::.::|.:.|...         |.::......:.:||....:.:.:..:|   
  Rat   417 -------IMGT-SLTVRAKYKDSNACYGFRWLTEENVEAWHTAYAVFSPSRSFLHLESLPDKLRC 473

  Fly   676 ----PVVGEYIIFHIRTNFYLEE-----FNYLIMSKGVILVNDRETI------TEGIKTIAVVLS 725
                .|...||:    ....::|     |.||:|:||.|:......:      ..|..:|.:.:.
  Rat   474 DQTLEVQAHYIL----NGEAMQELKELVFYYLMMAKGGIVRAGTHVLPLKQGQMRGHFSILISME 534

  Fly   726 SEMAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYINNRKARTGEKVEVAIFGEPGSYVG 790
            :::||||.:|::.|...|:||.|:..:.:.....|...:...........:..:::...|.|..|
  Rat   535 TDLAPVARLVLYAILPNGEVVGDTAKYEIENCLANKVDLVFRPNSGLPATRALLSVMASPQSLCG 599

  Fly   791 LSGIDSAFYTMQAGNELTYAKI-----ITKMSNF-------DEQTNGTYKH-------IWYSHEG 836
            |..:|.:...|:...||:.:.|     :..::.|       :|.|||..|.       |.||...
  Rat   600 LRAVDQSVLLMKPETELSASLIYDLLPVKDLTGFPQGADQREEDTNGCVKQNDTYINGILYSPVQ 664

  Fly   837 NPDELVYFPASSFGVDANRTFEYSGLIVFTDGYVPRRQDTCNR---TLGFGECLSGRCYRLEKQ- 897
            |.:|          .|.....:..||.|||:..: |:...|.|   ..|.     ...|.|..| 
  Rat   665 NTNE----------EDMYGFLKDMGLKVFTNSNI-RKPKVCERLRDNKGI-----PAAYHLVSQS 713

  Fly   898 -CDGLFDCDDGTDEINCHARNDTELLNYRKYRFNRVLRHYENVWLWKDVNIGPHGRYIFNVEVPD 961
             .|...:..:...|..            |.|        :...|:|..|.:...|.....|.|||
  Rat   714 HMDAFLESSESPTETR------------RSY--------FPETWIWDLVVVDSAGVAEVEVTVPD 758

  Fly   962 RPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEA 1026
            ....|...||.:|...|.| ::..:::...||||:.:.||.:..:||...::.||.||:.|.|..
  Rat   759 TITEWKAGAFCLSNDTGLG-LSPVVQFQAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPTCIRV 822

  Fly  1027 IVVLHDSPDYKFVHVEEDGIVRSY----NPRTSFGEHQFFIYLEAQGTTVVYVPVVPQRLGNVDV 1087
            .|.|..|||  |:...|:...||:    |.|     |           |..:. |:|:.||||:.
  Rat   823 AVQLEASPD--FLAAPEEKEQRSHCICMNQR-----H-----------TASWA-VIPKSLGNVNF 868

  Fly  1088 T-----LHVATLLGT-----------DTITRTLHVESDGLP-QYRHQSVLLDLSNRAYVLEYMHV 1135
            |     |:...|.|.           |||.::|.||.:||. :....|:|..:.  |.|.|.:.:
  Rat   869 TVSAEALNSKELCGNEVPVVPEQGKKDTIIKSLLVEPEGLENEVTFNSLLCPMG--AEVSELIAL 931

  Fly  1136 NVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNASSLLSLPMESGEQNAFSFAANL 1200
                  ::|..|    |..|.:|.::|:||::|....    |...||.:|...||||...||.|:
  Rat   932 ------KLPSDV----VEESARASVTVLGDILGSAMQ----NTQDLLKMPYGCGEQNMVLFAPNI 982

  Fly  1201 YTIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVF 1265
            |.:.|:....|..:.::..|..::|.||||||::...|||:|.|......:.::.|||::.|:.|
  Rat   983 YVLDYLNETQQLTQEIKTKAIAYLNTGYQRQLNYKHRDGSYSTFGDKPGRNHANTWLTAFVLKSF 1047

  Fly  1266 QEASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPDRKMNRTNFDKNITLTSHVLIT 1330
            .:|     ..:|:||...|.:.:.||.|.|...|.|.....|.:..| :...:..:||::::.|.
  Rat  1048 AQA-----RKYIFIDEVHITQALLWLSQQQKDNGCFRSSGSLLNNAM-KGGVEDEVTLSAYITIA 1106

  Fly  1331 LATVKDISGTLGSRVALATQRALAYIERNMDFLRHQA---QPFDVAITAYALQLC-NSPIAEEVF 1391
            |.   ::|..:...|   .:.||..::......|..|   ..:..|:.|||..|. |....:|:.
  Rat  1107 LL---EMSLPVTHPV---VRNALFCLDTAWKSARGGAGGSHVYTKALLAYAFALAGNQDTKKEIL 1165

  Fly  1392 AILRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVARREFF 1456
            ..|..:|....|.::|..   ||.| .:....|:. |:.|    |..:|.|||.||.|:.     
  Rat  1166 KSLDEEAVKEEDSVHWTR---PQKP-SVSVALWYQ-PQAP----SAEVEMTAYVLLAYLT----- 1216

  Fly  1457 VDP------------IVRWLNSQRLNDGGWASTQDTSAALKALVEY--TVRSRLREVSSLTVEIE 1507
            .:|            ||:||..|:.:.||::|||||..||.||.:|  ...:|.::.:.:|:.  
  Rat  1217 TEPAPTQEDLTAAMLIVKWLTKQQNSHGGFSSTQDTVVALHALSKYGSATFTRAKKAAQVTIH-- 1279

  Fly  1508 ASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNV--DIEKF----- 1565
              |.|..:....:::.|...||.:.:|...|...|:..|.|...||..::|:|  ..|:|     
  Rat  1280 --SSGTFSTKFQVNNNNQLLLQRVTLPTVPGDYTVKVTGEGCVYLQTSLKYSVLPREEEFPFTVV 1342

  Fly  1566 -QTKPPV---PAFGLHTKAIFHGRNQSHISYVACQNWINQNESERSGMAVLDVAIPTGYWIQQQK 1626
             ||.|..   |              ::|.|:....|.........|.||:.||.:.:|:      
  Rat  1343 VQTLPGTCEDP--------------KAHTSFQISLNISYTGSRSESNMAIADVKMVSGF------ 1387

  Fly  1627 LDTYVLSNRVRNLRRARYLER------KIVFYFDYLDHEDICVNFTIERWYPVANMSRYLPVRIY 1685
               ..|...|:.|.|:.::.|      .::.|.|.:.::.:.::||:::..|:.::...: |::|
  Rat  1388 ---IPLKPTVKMLERSVHVSRTEVSNNHVLIYLDKVSNQTVNLSFTVQQDIPIRDLKPAV-VKVY 1448

  Fly  1686 DYYAPERFNESIFDA 1700
            |||..:.|..:.:.|
  Rat  1449 DYYEKDEFAVAKYSA 1463

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
McrNP_524688.1 A2M_N 232..332 CDD:280081 31/101 (31%)
A2M_N_2 669..799 CDD:285005 30/147 (20%)
LDLa 886..913 CDD:238060 5/28 (18%)
A2M 940..1030 CDD:278630 29/89 (33%)
ISOPREN_C2_like 1177..1490 CDD:298658 97/328 (30%)
A2M_comp 1226..1492 CDD:284982 82/283 (29%)
A2M_recep 1607..1695 CDD:284981 22/93 (24%)
A2mNP_036620.2 A2M_N 132..224 CDD:280081 27/91 (30%)
A2M_N_2 464..609 CDD:285005 30/148 (20%)
Bait region 620..750 33/165 (20%)
A2M 736..826 CDD:278630 29/90 (32%)
A2M_2 956..1262 CDD:239227 97/335 (29%)
A2M_comp 1008..1263 CDD:284982 81/280 (29%)
A2M_recep 1374..1461 CDD:284981 22/96 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 46 1.000 Domainoid score I11778
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.820

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