Protein Alignment Mcr and A2m

DIOPT Version :10

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: NP_036620.2
• Gene: A2m / 24153
• RGDID: 2004
• Length: 1472
• Species: Rattus norvegicus
• Alignment Length: 1705
• Identity: 392/1705 - (22%)
• Similarity: 672/1705 - (39%)
• Gaps: 408/1705 - (23%)

  Fly   136 ASRMVRPGLIYQVSV-SILQAQYPITVHASIACDGVQISGDSKDVKEGIPETLLMRIPPTSVTGS 199
            ||...:|  ||.|.| |:|.|..|     ..||          .:...:.||:.:|:...||.|:
  Rat    27 ASAPQKP--IYMVMVPSLLHAGTP-----EKAC----------FLFSHLNETVAVRVSLESVRGN 74

  Fly   200 YKL------------------------RVEGFYQNVFGGL-AFLNETRLDFSQRSMTIFVQTDKP 239
            ..|                        .|..|...|.|.. .|...:.:...::...:|.|||||
  Rat    75 QSLFTDLVVDKDLFHCTSFTVPQSSSDEVMFFTVQVKGATHEFRRRSTVLVKKKESLVFAQTDKP 139

  Fly   240 LYMQGETVRFRTIPITTELKGFDNPVD-VYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFG 303
            :|..|:|||||.:.:.......:..:. :|:.||..:.:.:|.:.....|...|.:.||.:||.|
  Rat   140 IYKPGQTVRFRVVSLDESFHPLNELIPLLYIQDPKNNRIAQWQNFNLEGGLKQLSFPLSSEPTQG 204

  Fly   304 EWTIRVIAQ-GQQEESHFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTI 367
            .:.:.:..: |:..|..|:|||:...:|||.||:|......:..:...|...:|.|.||.|.:|:
  Rat   205 SYKVVIRTESGRTVEHPFSVEEFVLPKFEVRVTVPETITILEEEMNVSVCGIYTYGKPVPGRVTV 269

  Fly   368 KATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGAD-LSQ 431
                                            |...:|:||:       |..|:......: |||
  Rat   270 --------------------------------NICRKYSNPS-------NCFGEESVAFCEKLSQ 295

  Fly   432 DILYR---NQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLR 493
            .:..|   :|.|..:.:|        :::.||
  Rat   296 QLDGRGCFSQLVKTKSFQ--------LKRQEY--------------------------------- 319

  Fly   494 ELELLVPNLANSEVLITATVGEKFYDEIISGYSVARVYNSSLRVVFLG-DSPQVFKPAMPFTTYL 557
            |::|.|    ::::....|..|:      :|..:.::..:..::.|:. ||.  |:..:||...:
  Rat   320 EMQLDV----HAKIQEEGTGVEE------TGKGLTKITRTITKLSFVNVDSH--FRQGIPFVGQV 372

  Fly   558 AVEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLPMSQQSDGIWEVKIDIRNDLNLDD 622
            .:....|:||....:..|..|.:.::.:               :....|:      .|..:|.||
  Rat   373 LLVDGRGTPIPYETIFIGADEANLYINT---------------TTDKHGL------ARFSINTDD 416

  Fly   623 RPQARDFLNGVQNMRLQANFVDPRG---------ERIQTELLLVSHYSPRNQHIKVTTSTEK--- 675
                   :.|. ::.::|.:.|...         |.::......:.:||....:.:.:..:|
  Rat   417 -------IMGT-SLTVRAKYKDSNACYGFRWLTEENVEAWHTAYAVFSPSRSFLHLESLPDKLRC 473

  Fly   676 ----PVVGEYIIFHIRTNFYLEE-----FNYLIMSKGVILVNDRETI------TEGIKTIAVVLS 725
                .|...||:    ....::|     |.||:|:||.|:......:      ..|..:|.:.:.
  Rat   474 DQTLEVQAHYIL----NGEAMQELKELVFYYLMMAKGGIVRAGTHVLPLKQGQMRGHFSILISME 534

  Fly   726 SEMAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYINNRKARTGEKVEVAIFGEPGSYVG 790
            :::||||.:|::.|...|:||.|:..:.:.....|...:...........:..:::...|.|..|
  Rat   535 TDLAPVARLVLYAILPNGEVVGDTAKYEIENCLANKVDLVFRPNSGLPATRALLSVMASPQSLCG 599

  Fly   791 LSGIDSAFYTMQAGNELTYAKI-----ITKMSNF-------DEQTNGTYKH-------IWYSHEG 836
            |..:|.:...|:...||:.:.|     :..::.|       :|.|||..|.       |.||...
  Rat   600 LRAVDQSVLLMKPETELSASLIYDLLPVKDLTGFPQGADQREEDTNGCVKQNDTYINGILYSPVQ 664

  Fly   837 NPDELVYFPASSFGVDANRTFEYSGLIVFTDGYVPRRQDTCNR---TLGFGECLSGRCYRLEKQ- 897
            |.:|          .|.....:..||.|||:..: |:...|.|   ..|.     ...|.|..|
  Rat   665 NTNE----------EDMYGFLKDMGLKVFTNSNI-RKPKVCERLRDNKGI-----PAAYHLVSQS 713

  Fly   898 -CDGLFDCDDGTDEINCHARNDTELLNYRKYRFNRVLRHYENVWLWKDVNIGPHGRYIFNVEVPD 961
             .|...:..:...|..            |.|        :...|:|..|.:...|.....|.|||
  Rat   714 HMDAFLESSESPTETR------------RSY--------FPETWIWDLVVVDSAGVAEVEVTVPD 758

  Fly   962 RPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEA 1026
            ....|...||.:|...|.| ::..:::...||||:.:.||.:..:||...::.||.||:.|.|..
  Rat   759 TITEWKAGAFCLSNDTGLG-LSPVVQFQAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPTCIRV 822

  Fly  1027 IVVLHDSPDYKFVHVEEDGIVRSY----NPRTSFGEHQFFIYLEAQGTTVVYVPVVPQRLGNVDV 1087
            .|.|..|||  |:...|:...||:    |.|     |           |..:. |:|:.||||:.
  Rat   823 AVQLEASPD--FLAAPEEKEQRSHCICMNQR-----H-----------TASWA-VIPKSLGNVNF 868

  Fly  1088 T-----LHVATLLGT-----------DTITRTLHVESDGLP-QYRHQSVLLDLSNRAYVLEYMHV 1135
            |     |:...|.|.           |||.::|.||.:||. :....|:|..:.  |.|.|.:.:
  Rat   869 TVSAEALNSKELCGNEVPVVPEQGKKDTIIKSLLVEPEGLENEVTFNSLLCPMG--AEVSELIAL 931

  Fly  1136 NVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNASSLLSLPMESGEQNAFSFAANL 1200
                  ::|..|    |..|.:|.::|:||::|....    |...||.:|...||||...||.|:
  Rat   932 ------KLPSDV----VEESARASVTVLGDILGSAMQ----NTQDLLKMPYGCGEQNMVLFAPNI 982

  Fly  1201 YTIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVF 1265
            |.:.|:....|..:.::..|..::|.||||||::...|||:|.|......:.::.|||::.|:.|
  Rat   983 YVLDYLNETQQLTQEIKTKAIAYLNTGYQRQLNYKHRDGSYSTFGDKPGRNHANTWLTAFVLKSF 1047

  Fly  1266 QEASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPDRKMNRTNFDKNITLTSHVLIT 1330
            .:|     ..:|:||...|.:.:.||.|.|...|.|.....|.:..| :...:..:||::::.|.
  Rat  1048 AQA-----RKYIFIDEVHITQALLWLSQQQKDNGCFRSSGSLLNNAM-KGGVEDEVTLSAYITIA 1106

  Fly  1331 LATVKDISGTLGSRVALATQRALAYIERNMDFLRHQA---QPFDVAITAYALQLC-NSPIAEEVF 1391
            |.   ::|..:...|   .:.||..::......|..|   ..:..|:.|||..|. |....:|:.
  Rat  1107 LL---EMSLPVTHPV---VRNALFCLDTAWKSARGGAGGSHVYTKALLAYAFALAGNQDTKKEIL 1165

  Fly  1392 AILRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVARREFF 1456
            ..|..:|....|.::|..   ||.| .:....|:. |:.|    |..:|.|||.||.|:.
  Rat  1166 KSLDEEAVKEEDSVHWTR---PQKP-SVSVALWYQ-PQAP----SAEVEMTAYVLLAYLT----- 1216

  Fly  1457 VDP------------IVRWLNSQRLNDGGWASTQDTSAALKALVEY--TVRSRLREVSSLTVEIE 1507
            .:|            ||:||..|:.:.||::|||||..||.||.:|  ...:|.::.:.:|:.
  Rat  1217 TEPAPTQEDLTAAMLIVKWLTKQQNSHGGFSSTQDTVVALHALSKYGSATFTRAKKAAQVTIH-- 1279

  Fly  1508 ASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNV--DIEKF----- 1565
              |.|..:....:::.|...||.:.:|...|...|:..|.|...||..::|:|  ..|:|
  Rat  1280 --SSGTFSTKFQVNNNNQLLLQRVTLPTVPGDYTVKVTGEGCVYLQTSLKYSVLPREEEFPFTVV 1342

  Fly  1566 -QTKPPV---PAFGLHTKAIFHGRNQSHISYVACQNWINQNESERSGMAVLDVAIPTGYWIQQQK 1626
             ||.|..   |              ::|.|:....|.........|.||:.||.:.:|:
  Rat  1343 VQTLPGTCEDP--------------KAHTSFQISLNISYTGSRSESNMAIADVKMVSGF------ 1387

  Fly  1627 LDTYVLSNRVRNLRRARYLER------KIVFYFDYLDHEDICVNFTIERWYPVANMSRYLPVRIY 1685
               ..|...|:.|.|:.::.|      .::.|.|.:.::.:.::||:::..|:.::...: |::|
  Rat  1388 ---IPLKPTVKMLERSVHVSRTEVSNNHVLIYLDKVSNQTVNLSFTVQQDIPIRDLKPAV-VKVY 1448

  Fly  1686 DYYAPERFNESIFDA 1700
            |||..:.|..:.:.|
  Rat  1449 DYYEKDEFAVAKYSA 1463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	YfaS	<226..1575	CDD:441940	341/1456 (23%)
		A2M_BRD	667..801	CDD:462235	30/151 (20%)
		A2M	939..1030	CDD:459711	29/90 (32%)
		TED_complement	1160..1490	CDD:462227	101/345 (29%)
		A2M_recep	1605..1699	CDD:462226	22/99 (22%)
A2m	NP_036620.2	YfaS	<132..1328	CDD:441940	333/1422 (23%)
		Bait region	620..750		33/165 (20%)
		A2M	736..826	CDD:459711	29/90 (32%)
		TED_complement	946..1262	CDD:462227	101/345 (29%)
		A2M_recep	1372..1462	CDD:462226	22/99 (22%)