Protein Alignment Mcr and Cd109

DIOPT Version :9

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: NP_694738.1
• Gene: Cd109 / 235505
• MGIID: 2445221
• Length: 1442
• Species: Mus musculus
• Alignment Length: 1665
• Identity: 415/1665 - (24%)
• Similarity: 726/1665 - (43%)
• Gaps: 300/1665 - (18%)

  Fly   132 YFIVASRMVRPGLIYQVSVSILQAQYP-ITVHASI------------ACDGVQISGDSKDVKEGI 183
            :.:.|..::|||....:.|.:|:...| :.|.|.:            ..:||...|..|.:
Mouse    27 FLVTAPGIIRPGANVTIGVDLLENSPPQVLVKAQVFKIASNKSRSILEAEGVFHRGHFKTL---- 87

  Fly   184 PETLLMRIPPTSVTGSYKLRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTDKPLYMQGETVR 248
               :|..:|.:|....|:|.:.|..:|   .:.|.|.|||.|..:|:::.:||||..|...:.|:
Mouse    88 ---VLPALPLSSADKIYELHINGQSEN---EIVFSNRTRLTFESKSISVLIQTDKAFYKPKQEVK 146

  Fly   249 FRTIPITTELKGFDNPVDVYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFGEWTIRVIAQG 313
            ||.:.:.::||.:...||:::.||..:::::|.|::.:||.||..::||..|.||:|:|:|....
Mouse   147 FRVLTLCSDLKPYRTSVDIFIKDPKSNVIQQWFSQKGDLGVVSKTFQLSSNPIFGDWSIQVQVND 211

  Fly   314 QQEESHFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFS 378
            ||....|.|.||...:|||.|..|.|.......:.|.|:|.:|.|.||:|:|::  |..|:.::.
Mouse   212 QQYYQSFQVLEYVLPKFEVTVQTPLYCSLKSKQLNGSVIAKYTYGKPVKGSLSL--TFLPLSFWG 274

  Fly   379 NQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRNQYVVER 443
            .:                             :|....:.:.|              :.|
Mouse   275 KK-----------------------------KNITKSFEING--------------FAN------ 290

  Fly   444 HYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEVL 508
             :.||.   :.::|........:...|:|....|         .|..|...:..:..:|.....:
Mouse   291 -FSFDN---YEMKKVMNLKPLTDVSEGSYENVDP---------SFPGPAEIIATVTESLTGISRM 342

  Fly   509 ITATVGEKFYDEIISGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSPIDPNLLR 573
            .:..|..|.:|.||.              :|  |...|.||::.||..:.|...||:.:.|..:.
Mouse   343 ASTNVFFKQHDYIIE--------------IF--DYTTVLKPSLNFTATVKVSRSDGNQLTPEEIE 391

  Fly   574 QGLMEV-----SGFVESRNGGRRDWPAQRLPMSQQSDGIWEVK---IDIRNDLNLDDRPQARDFL 630
            ..|:.|     :...||:.....|: .|.:..:...:||.:::   :.|..:|.|     ...||
Mouse   392 NDLVTVVTQRKNNHPESQRDQEMDY-IQTVNYTIPQNGIIKIEFPVMSISGELQL-----KAYFL 450

  Fly   631 NGVQNMRLQANFVDPRGERIQTELLLVSHYSPRNQHIKVTTSTEKPVVGEYIIFHIRTNFYLEEF 695
            :|..::.:.:.|..|....||.:        .|:::|||.:..:..|.|         |...::.
Mouse   451 DGTSSVTVHSMFTSPSKTYIQLK--------TRDEYIKVGSPFDLMVSG---------NRQFKDL 498

  Fly   696 NYLIMSKGVILVNDRETITEGIKTIAVVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNGISRN 760
            :|:::|||.::...:::    .:|.::...:..||.|.|:.:.|.:.|:::.|.|..||..:..|
Mouse   499 SYMVISKGQLVAAGKQS----SRTFSLTPEASWAPKACIIAYYIAEDGEIINDILKIPVQLVFEN 559

  Fly   761 NFTVYINNRKARTGEKVEVAIFG-EPGSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQTN 824
            ...::.:....:..:||.:.|.. :..|.||:..:|.:...|:..|.:|...::.::..:
Mouse   560 KVKLFWSKPTVKPSDKVSLRISATQSDSLVGIVAVDKSVTLMENSNSITMETMVHELELY----- 619

  Fly   825 GTYKHIWYSHEGNPDELVYFPASSFGVDANRTFEYSGLIVFTDGYVPRRQ-----DTCNRTLGFG 884
                        |.:..:....:||.|     |:..||.|.||..:.|..     ||...:..|.
Mouse   620 ------------NTEYYLGMFMNSFAV-----FQECGLWVLTDATLIRDSIDEVYDTEEYSERFA 667

  Fly   885 ECLSGRCYRLEKQCDGLFDCDDGTDEINCHARNDTELLNYRKYRFNRVLRHYENVWLWKDVNIGP 949
            |         |.:.: |.|.:|.:...|.|.|                 :::...|:|.|..:|.
Mouse   668 E---------ENEAN-LVDFEDASSVNNVHVR-----------------KNFPETWIWLDAYMGS 705

  Fly   950 HGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRV 1014
            .....|.|.|||....|:.|||.:|...|||:.....|....||||:.:.:|.:..:||:..:.|
Mouse   706 KIYEEFEVTVPDSITSWVASAFVISEDLGFGLTTVPAELQAFQPFFLFLNLPYSVIRGEEFALEV 770

  Fly  1015 TVFNYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSYN-----PRTSFGEHQFFIYLEAQGTTVVY 1074
            ::.||:...|:.::::.:|..:..:....|.....|.     ||.:             |.|:|:
Mouse   771 SIVNYLKDTIKVVILIEESDSFDILMTSNDTNGTIYRKTVQVPRDN-------------GVTLVF 822

  Fly  1075 VPVVPQRLGNVDVTLHVATLLGTDTITRTLHVESDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQ 1139
             |:.|..||.:.:|:..|:...:|.:|:|:.|:.:|:.:...:||||||::.....:...:..:.
Mouse   823 -PIKPTHLGEIPITVTAASPTASDAVTQTIVVKPEGIEKSYSKSVLLDLTDSNVESKQQSMRFSF 886

  Fly  1140 TPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNA-SSLLSLPMESGEQNAFSFAANLYTI 1203
            .|:.        |.||.:.:|:.:||::|     ..:|. |||:.:|...||||...||.|:|.:
Mouse   887 PPDT--------VIGSERVQITAIGDILG-----SSINGLSSLIRMPYGCGEQNMIYFAPNIYIL 938

  Fly  1204 MYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQEA 1268
            .|:....|....|::.|..:|..||||:|.:.|.|||||.|..  .:|..|.||:::.||.|.||
Mouse   939 DYLTKQKQLTVNLKEKALSYMRQGYQRELLYQREDGSFSAFGD--IDSSGSTWLSAFVLRCFLEA 1001

  Fly  1269 SFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPDRKMN---RTNFDKNITLTSHVLIT 1330
            .:|     |.||..::.:...||..|:...|.|    |.|.|.::   :......:|||::::.:
Mouse  1002 DYY-----IDIDQDVLHRTYTWLNAHKKFNGEF----WEPGRVIHSELQGGTKSPVTLTAYIVTS 1057

  Fly  1331 LATVKDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDVAITAYALQLCNSPIAEEVFAILR 1395
            :...|.....:.      .|.::.::|  .:|.|..:..:.:||.:|||....||.|||...:|.
Mouse  1058 VLGYKKYQPNID------VQDSIKFLE--FEFSRGISDNYTLAIISYALSTVGSPKAEEALNLLM 1114

  Fly  1396 RQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVARREFFVDPI 1460
            :::...||..:|    :...|..  :..|  .||      |::||..|||||.:.........|:
Mouse  1115 QRSEKEGDTQFW----LSSGPAL--SGSW--QPR------SVDIEIAAYALLAHTLHHVSEGIPV 1165

  Fly  1461 VRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQG-GKTQTLYIDDTN 1524
            :|||..||.:.||:.|||||..|||||.|:   |.|....:..:::..:..| .::....||..|
Mouse  1166 MRWLIQQRNSLGGFVSTQDTVVALKALSEF---SALVHKENTDIQLTVTGPGIPRSIHFRIDSQN 1227

  Fly  1525 LAKLQSIEI----PDAWGTIKVQAKGAGYAILQMHVQYNV----DIEKFQTKPPVPAFGLHTKAI 1581
            |..|...|:    |.   |:.|.|.|:|:||.|::|.|||    ..::.::......|.|  ..|
Mouse  1228 LFLLHQEELHALDPI---TVNVSAHGSGFAICQLNVDYNVKGSGSSKRRRSTENQEVFDL--DVI 1287

  Fly  1582 FHGRNQ-SHISYVACQNWINQNESERSGMAVLDVAIPTGYWIQQQKLDTYVLSNRVRNLRRARYL 1645
            .:..:. ||::...|.:.:.   |||:||.:::|.:.:|:   ....|:..||   ..|::..|.
Mouse  1288 VNNEDDISHLNLNVCTSHLG---SERTGMVLMEVNLLSGF---SASSDSIPLS---ETLKKVEYD 1343

  Fly  1646 ERKIVFYFDYLDHEDICVNFTIERWYPVANMSRYLPVRIYDYYAPERFNESIFDALPTYLLNI-C 1709
            ..|:..|.|.::....|||....|.|.|:|: |...|.:.|||.|.|      .|:.:|...: .
Mouse  1344 NGKLNLYLDSVNESQFCVNIPTVRDYKVSNI-RDGSVSVMDYYEPRR------QAVRSYNTQVKL 1401

  Fly  1710 EVCGSSQCPYCSIYNMGWRASMSMS---LLFFSVFIYLLR 1746
            ..|..|....|..:..|...|:..|   |:|.||.:|.::
Mouse  1402 SSCYLSPDTNCKSHTDGATDSLRRSSSLLVFCSVLLYFVQ 1441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	A2M_N	232..332	CDD:280081	35/99 (35%)
		A2M_N_2	669..799	CDD:285005	27/130 (21%)
		LDLa	886..913	CDD:238060	4/26 (15%)
		A2M	940..1030	CDD:278630	29/89 (33%)
		ISOPREN_C2_like	1177..1490	CDD:298658	103/316 (33%)
		A2M_comp	1226..1492	CDD:284982	86/268 (32%)
		A2M_recep	1607..1695	CDD:284981	26/87 (30%)
Cd109	NP_694738.1	YfaS	<122..>1002	CDD:225248	254/1064 (24%)
		A2M_N	129..220	CDD:280081	31/90 (34%)
		A2M_N_2	475..598	CDD:285005	30/135 (22%)
		Bait region (approximate). /evidence=ECO:0000250	595..704		29/157 (18%)
		A2M	695..782	CDD:278630	29/86 (34%)
		A2M_2	909..1195	CDD:239227	103/318 (32%)
		A2M_comp	961..1197	CDD:284982	86/271 (32%)
		A2M_recep	1311..1395	CDD:284981	27/96 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8874
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11412
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.920