DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcr and A2ml1

DIOPT Version :9

Sequence 1:NP_524688.1 Gene:Mcr / 44071 FlyBaseID:FBgn0267488 Length:1760 Species:Drosophila melanogaster
Sequence 2:NP_001001179.2 Gene:A2ml1 / 232400 MGIID:3039594 Length:1456 Species:Mus musculus


Alignment Length:1706 Identity:374/1706 - (21%)
Similarity:660/1706 - (38%) Gaps:405/1706 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   129 EPTYFIVASRMVRPGLIYQVSVSILQAQYPITVHASIACDGVQISGDSKDVKEGIPETLLMRIPP 193
            ||.|.:..|.:|:.....:..:.:|.....:::..::..||...:...:.|.||          .
Mouse    21 EPRYILWVSSVVQRFSSEKACLHLLNLNESVSLSVTLEYDGSSTTIFDQPVDEG----------N 75

  Fly   194 TSVTGSYKLRVEGFYQNVFGGLAFLNETRLDFSQRSMTI-------FVQTDKPLYMQGETVRFRT 251
            ......:|:......|..|..|.....|.....:||:.|       |||||.|::..|:||.||.
Mouse    76 FYACADFKVSQMSSEQLAFVALLVQGNTLKISERRSVAIAAEENATFVQTDTPVHKPGDTVHFRV 140

  Fly   252 IPITTELKGFDNPVDVYML----DPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFGEWTIRVIAQ 312
            :.:...||..|   |:|.|    ||..:::.:|::..:......|.::|:.:|..|::||.:..|
Mouse   141 VTLNIWLKPVD---DLYPLITVQDPQSNVIFQWINVTTFRNITQLSFQLTPEPILGDYTIVIKTQ 202

  Fly   313 -GQQEESHFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGY 376
             |.....||||......:|||.:|.|......|........|.:|.|.||:|...||        
Mouse   203 SGTTVMDHFTVNRDVLPKFEVELTAPETITIADSQFQMVTCAKYTYGQPVQGKAQIK-------- 259

  Fly   377 FSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRNQYVV 441
                |..|             |::.....:|.|:..: |:.|  || :||.        .:..:.
Mouse   260 ----VCRE-------------LFSPAHCESNENEICE-QFTV--QL-KDGC--------ASHIIN 295

  Fly   442 ERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSE 506
            .:.:|.|.                   ||.:.           |.:....:.|....|.......
Mouse   296 TKVFQLDR-------------------SGLFM-----------TLNVNEVVTESGTGVQMSKTHS 330

  Fly   507 VLITATVGEKFYDEIISGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSPIDPNL 571
            |.||:.:|...::.:...|.....|..:|:.....::|.|.|       .|.:|. ||.|     
Mouse   331 VFITSVLGTVSFENMDPFYRRGITYFGTLKFSGPNNTPLVDK-------LLQLEL-DGKP----- 382

  Fly   572 LRQGLMEVSGFVESRNGGRRDWPAQRLPMSQQSDGIWEVKIDIRNDLNLDDRPQARDFLNGVQNM 636
                   |..:....||                        :.|..:|..:       :.|.| :
Mouse   383 -------VGNYTTDENG------------------------EARFSINTSE-------IFGAQ-I 408

  Fly   637 RLQANFVDPRG---------ERIQTELLLVSHYSPRNQHIKVTTSTEK-PVVGE---YIIFHIRT 688
            .|:|.:|.||.         |.:.........||..:...|:....:: |...|   .:::.:..
Mouse   409 SLKAVYVRPRSCHRSSWLSPEYLDAYFSASRFYSQTSSFTKIILEPKQLPCDQEKMFSVLYSLNP 473

  Fly   689 NFYLE----EFNYLIMSKGVILVNDRETIT----EGIKTIAVVLSSEMAPVATIVVWKINQQGQV 745
            ..|.|    .|.||:|.:|.|..:.::.:.    .|..:..:.:::::||.|.:.|:.::..|::
Mouse   474 EAYKEASDVTFFYLVMVRGGISRSGQKQVRVQAWNGNFSFPISINADLAPSADLFVYTLHPSGEI 538

  Fly   746 VADSLTFPVNGISRNNFTVYINNRKARTGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYA 810
            |||::...:....:|..::..:..|...|....|.:...|.|:..|..:|.:...:..|.|:|..
Mouse   539 VADNVRLQIEKCFKNKVSINFSRDKDLPGSNTSVHLQAAPDSFCALRAVDKSALLLNHGQEMTPE 603

  Fly   811 KIITKMS------------NFDEQT------------NGTYKHIWYSHEGNPDELVYFPASSFGV 851
            .:...:.            |.|:|.            ||.|    |:..||          .:..
Mouse   604 SVYFTLPYIHQYGYFYNGLNLDDQQAEPCIPQKDLFYNGLY----YTPTGN----------IWDG 654

  Fly   852 DANRTFEYSGLIVFTDGYVPRRQDTC----NRTLGFGECLSGRCYRLEKQCDGLFDCDDGTDEIN 912
            |.:......||.:||:.:. |:.:.|    |:.|                   |...|...:.|.
Mouse   655 DLSNLLSNMGLKIFTNLHY-RKPEVCSSQENQPL-------------------LRTFDHPNERIM 699

  Fly   913 CHA---------RNDTELLNYRKYRFNRVLR-HYENVWLWKDVNIGPHGRYIFNVEVPDRPAYWM 967
            .:.         .:..:.:::.|......:| ::...|:|..|::...|....:..|||....|.
Mouse   700 MYGGGAPPSSAFHDSVDSISHAKVAIKETVRTNFPRTWIWNLVSVDSSGTANVSFLVPDTITQWE 764

  Fly   968 VSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHD 1032
            .|||.|:.:.|||:..|....:. ||||:.|..|.:..:.||..:.||||||:.|.:|..|.|..
Mouse   765 ASAFCVNGNAGFGISPKVSLQIS-QPFFVEVTSPFSVVRSEQSDMVVTVFNYLTTCVEISVQLEA 828

  Fly  1033 SPDYKFVHVEEDGIVRSYNPRTSF---GEHQFFIYLEAQGTTVVYVPVVPQRLGNVDVTLHVAT- 1093
            |.:|      |..|....|..:..   ||.:.:::           .::|:.||.|:||: ||| 
Mouse   829 SENY------EASINTQRNTDSEVLQAGEQKTYVW-----------TIIPKTLGKVNVTV-VATS 875

  Fly  1094 ---------------LLGTDTITRTLHVESDGLPQYRHQSVLL----DLSNRAYVLEYMHVNVTQ 1139
                           :...||:.:|:.||::|:.:...||.|:    ..:::..:|         
Mouse   876 KQSRACPNDASKEQDVHWKDTVVKTMLVEAEGIEKEATQSFLICPKGTKASKQTLL--------- 931

  Fly  1140 TPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNASSLLSLPMESGEQNAFSFAANLYTIM 1204
              |:|..|    |.||.::.:::|||::|....    |..|||.:|...||||....|:::|.:.
Mouse   932 --ELPSNV----VEGSVRSFVTIVGDILGVAMQ----NLESLLQMPYGCGEQNIAQLASDVYILD 986

  Fly  1205 YMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQEAS 1269
            |::..:|..:.|:..|...::.|||..|||...|||:.:|..  :|.:.|.||::...:..:   
Mouse   987 YLKATDQLTEELKSKAQRLLSNGYQNHLSFKNYDGSYDVFCQ--SNQEGSTWLSALSFKTVE--- 1046

  Fly  1270 FYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPDRK------MNRTNFDKNITLTSHVL 1328
              :.:.:|:|:.|:.::.:.||::.|...|.|..     |.|      ..|....::|.||::|:
Mouse  1047 --KMKEYIFIEETVPKQTLIWLVKKQKSNGCFRR-----DEKHVDTAQEGREGDQEDIALTAYVV 1104

  Fly  1329 ITLATVKDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDVAITAYALQLC-NSPIAEEVFA 1392
            .....|    |...|..||  :..|..:|.  .|.......:..||.||...|. ....|:.:.:
Mouse  1105 GVFLEV----GLNASFPAL--RNGLYCLEE--AFSNGVTNGYTQAILAYVFALAGKEQQAKSLLS 1161

  Fly  1393 ILRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVARREFFV 1457
            ||.:.|....:.:||...|.|:    .:|...|....|..|     .|.|.|.||..:::....:
Mouse  1162 ILDKSATKTNNMIYWERDEKPE----TDNSPSFIPSALSGE-----TEKTCYVLLAVLSQDTQDL 1217

  Fly  1458 D---PIVRWLNSQRLND-GGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQGGKTQTL 1518
            |   .||:|| :||:|. ||:::.|||:..|.||.:|...:.....:::|:..|.|.     :..
Mouse  1218 DYASKIVQWL-AQRMNSHGGFSAMQDTTVCLLALTQYMKLTGSNPQNTITLSSEESE-----EVF 1276

  Fly  1519 YIDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNVDIEK------------------- 1564
            |::......:|..::........|..:|.|.:.:|..::|||.:.|                   
Mouse  1277 YVNRNKRLLVQHSKVSKGHQQYTVDVEGDGCSFIQATLRYNVPLPKEASGFSLSVKTGKSNSSDE 1341

  Fly  1565 FQTKPPVPAFGLHTKAIFHGRNQSHISYVACQNWINQNESERSGMAVLDVAIPTGYW-----IQQ 1624
            ||||     |.|.....:.|..:|.::                  .::||.:.:|:.     .::
Mouse  1342 FQTK-----FELTVTLTYTGARESSVT------------------VLVDVKMLSGFTPVVSSTEE 1383

  Fly  1625 QKLDTYVLSNRVRNLRRARYLERKIVFYFDYLDHEDICVNFTIERWYPVANMSRYLPVRIYDY-- 1687
            .|.::.|....::|        ..::||.:.:..|...:.|:||:...|||: :..||.:|.|  
Mouse  1384 LKFNSQVTKTDIKN--------GHVLFYLENVPKEATSLTFSIEQTNHVANI-QPAPVTVYSYEK 1439

  Fly  1688 --YAPERFN-ESIFDA 1700
              ||.:.:| .||.|:
Mouse  1440 GEYAFDSYNINSISDS 1455

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
McrNP_524688.1 A2M_N 232..332 CDD:280081 34/111 (31%)
A2M_N_2 669..799 CDD:285005 27/141 (19%)
LDLa 886..913 CDD:238060 3/26 (12%)
A2M 940..1030 CDD:278630 33/89 (37%)
ISOPREN_C2_like 1177..1490 CDD:298658 90/323 (28%)
A2M_comp 1226..1492 CDD:284982 76/276 (28%)
A2M_recep 1607..1695 CDD:284981 22/97 (23%)
A2ml1NP_001001179.2 A2M_N 121..204 CDD:280081 27/85 (32%)
A2M_N_2 450..593 CDD:285005 27/142 (19%)
A2M 736..826 CDD:278630 33/90 (37%)
A2M_2 956..1253 CDD:239227 90/330 (27%)
A2M_comp 1008..1253 CDD:284982 75/274 (27%)
A2M_recep 1364..1447 CDD:284981 21/91 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 41 1.000 Domainoid score I12441
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.820

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