DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcr and A2M

DIOPT Version :9

Sequence 1:NP_524688.1 Gene:Mcr / 44071 FlyBaseID:FBgn0267488 Length:1760 Species:Drosophila melanogaster
Sequence 2:XP_006719119.1 Gene:A2M / 2 HGNCID:7 Length:1512 Species:Homo sapiens


Alignment Length:1698 Identity:387/1698 - (22%)
Similarity:662/1698 - (38%) Gaps:342/1698 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   127 SREPTYFIVASRMVRPGLIYQVSVSILQAQYPITVHASIACDGVQISGDSK-----DVKEGIPET 186
            |.:|.|.::...::......:..|.:......:||.||:.    .:.|:..     :.:..:...
Human    26 SGKPQYMVLVPSLLHTETTEKGCVLLSYLNETVTVSASLE----SVRGNRSLFTDLEAENDVLHC 86

  Fly   187 LLMRIPPTSVTGS---YKLRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTDKPLYMQGETVR 248
            :...:|.:|....   ..::|:|..|.      |...|.:........:||||||.:|..|:||:
Human    87 VAFAVPKSSSNEEVMFLTVQVKGPTQE------FKKRTTVMVKNEDSLVFVQTDKSIYKPGQTVK 145

  Fly   249 FRTIPITTELKGFDNPVD-VYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFGEWTIRVIAQ 312
            ||.:.:.......:..:. ||:.||..:.:.:|.|.|...|.....:.||.:|..|.:  :|:.|
Human   146 FRVVSMDENFHPLNELIPLVYIQDPKGNRIAQWQSFQLEGGLKQFSFPLSSEPFQGSY--KVVVQ 208

  Fly   313 ---GQQEESHFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPI 374
               |.:.|..|||||:...:|||.||:|......:..:...|...:|.|.||.|::|:.      
Human   209 KKSGGRTEHPFTVEEFVLPKFEVQVTVPKIITILEEEMNVSVCGLYTYGKPVPGHVTVS------ 267

  Fly   375 GYFSNQVLNEKYR-LGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRNQ 438
                   :..||. ......|.:..:.|::               .|||...|.           
Human   268 -------ICRKYSDASDCHGEDSQAFCEKF---------------SGQLNSHGC----------- 299

  Fly   439 YVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLA 503
                 .||..:...|.:::.||                                 |::|    ..
Human   300 -----FYQQVKTKVFQLKRKEY---------------------------------EMKL----HT 322

  Fly   504 NSEVLITATVGEKFYDEIISGYSVARVYNSSLRVVFLG-DSPQVFKPAMPFTTYLAVEYHDGSPI 567
            .:::....||.|      ::|...:.:..:..::.|:. ||.  |:..:||...:.:....|.||
Human   323 EAQIQEEGTVVE------LTGRQSSEITRTITKLSFVKVDSH--FRQGIPFFGQVRLVDGKGVPI 379

  Fly   568 ----------DPNLLRQGLMEVSGFVESRNGGRRDWPAQRLPMSQQSDGIWEVKIDIRNDLNLDD 622
                      :.|.......:..|.|:               .|..:..:....:.:|  :|..|
Human   380 PNKVIFIRGNEANYYSNATTDEHGLVQ---------------FSINTTNVMGTSLTVR--VNYKD 427

  Fly   623 RPQARDFLNGVQNMRLQANFVDPRGERIQTELLLVSHYSPRNQHIKVTTSTEKPVVGEYIIFHIR 687
            |.....:           .:|....|.......||  :||....:.:     :|:..|....|.:
Human   428 RSPCYGY-----------QWVSEEHEEAHHTAYLV--FSPSKSFVHL-----EPMSHELPCGHTQ 474

  Fly   688 T---NFYLE----------EFNYLIMSKGVILVNDRETITEGIK----------TIAVVLSSEMA 729
            |   ::.|.          .|.||||:||.|:    .|.|.|:.          :|::.:.|::|
Human   475 TVQAHYILNGGTLLGLKKLSFYYLIMAKGGIV----RTGTHGLLVKQEDMKGHFSISIPVKSDIA 535

  Fly   730 PVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYINNRKARTGEKVEVAIFGEPGSYVGLSGI 794
            |||.::::.:...|.|:.||..:.|.....|...:..:..::.......:.:...|.|...|..:
Human   536 PVARLLIYAVLPTGDVIGDSAKYDVENCLANKVDLSFSPSQSLPASHAHLRVTAAPQSVCALRAV 600

  Fly   795 DSAFYTMQAGNELTYAKIITKMSNFD---------EQTNGTYKHIWYSHEGNPDELVYFPASSFG 850
            |.:...|:...||:.:.:...:...|         :|.|   :.....|....:.:.|.|.||  
Human   601 DQSVLLMKPDAELSASSVYNLLPEKDLTGFPGPLNDQDN---EDCINRHNVYINGITYTPVSS-- 660

  Fly   851 VDANRTFEYS-----GLIVFTDGYVPRRQDTCNRTLGFGECLSGRCYRLEK-QCDGLFDCDDGTD 909
              .|....||     ||..||:..:.:.:               .|.:|:: :..|......|..
Human   661 --TNEKDMYSFLEDMGLKAFTNSKIRKPK---------------MCPQLQQYEMHGPEGLRVGFY 708

  Fly   910 EINCHARNDTELLNYRKYRFNRVLRHYENVWLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVS 974
            |.:...|....|::..:.....|.:::...|:|..|.:...|.....|.|||....|...||.:|
Human   709 ESDVMGRGHARLVHVEEPHTETVRKYFPETWIWDLVVVNSAGVAEVGVTVPDTITEWKAGAFCLS 773

  Fly   975 PSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDSPDYKFV 1039
            ...|.|:.:.| .....||||:.:.||.:..:||...::.||.||:...|...|.|..||.:..|
Human   774 EDAGLGISSTA-SLRAFQPFFVELTMPYSVIRGEAFTLKATVLNYLPKCIRVSVQLEASPAFLAV 837

  Fly  1040 HVEEDGIVRSYNPRTSFGEHQFFIYLEAQGTTVVYVPVVPQRLGNVDVT-----LHVATLLGT-- 1097
            .||::               |....:.|.|...|...|.|:.||||:.|     |....|.||  
Human   838 PVEKE---------------QAPHCICANGRQTVSWAVTPKSLGNVNFTVSAEALESQELCGTEV 887

  Fly  1098 ---------DTITRTLHVESDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVY 1153
                     ||:.:.|.||.:||.:....:.||..|..       .|:...:.::|..|    |.
Human   888 PSVPEHGRKDTVIKPLLVEPEGLEKETTFNSLLCPSGG-------EVSEELSLKLPPNV----VE 941

  Fly  1154 GSNKARISVVGDVVGPIFPTMPVNASSLLSLPMESGEQNAFSFAANLYTIMYMRLINQRNKTLEK 1218
            .|.:|.:||:||::|....    |..:||.:|...||||...||.|:|.:.|:....|....::.
Human   942 ESARASVSVLGDILGSAMQ----NTQNLLQMPYGCGEQNMVLFAPNIYVLDYLNETQQLTPEIKS 1002

  Fly  1219 NAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQEASFYEWENFIWIDATI 1283
            .|..::|.||||||::...|||:|.|...:..:..:.|||::.|:.|.:|..|     |:||...
Human  1003 KAIGYLNTGYQRQLNYKHYDGSYSTFGERYGRNQGNTWLTAFVLKTFAQARAY-----IFIDEAH 1062

  Fly  1284 IEKNMRWLLQHQTPQGSFFEVTWLPDRKMNRTNFDKNITLTSHVLITLATVKDISGTLGSRVALA 1348
            |.:.:.||.|.|...|.|.....|.:..: :...:..:||::::.|.|.   :|..|:...|   
Human  1063 ITQALIWLSQRQKDNGCFRSSGSLLNNAI-KGGVEDEVTLSAYITIALL---EIPLTVTHPV--- 1120

  Fly  1349 TQRALAYIERNMDFLR---HQAQPFDVAITAYALQLC-NSPIAEEVFAILRRQARTIGDFMYWGN 1409
            .:.||..:|......:   |.:..:..|:.|||..|. |....:||...|..:|....:.::|  
Human  1121 VRNALFCLESAWKTAQEGDHGSHVYTKALLAYAFALAGNQDKRKEVLKSLNEEAVKKDNSVHW-- 1183

  Fly  1410 QEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVARREFFVDP------------IVR 1462
             |.||.|:.....  |..|:.|    |..:|.|:|.||.|:.     ..|            ||:
Human  1184 -ERPQKPKAPVGH--FYEPQAP----SAEVEMTSYVLLAYLT-----AQPAPTSEDLTSATNIVK 1236

  Fly  1463 WLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQGGKTQTLYIDDTNLAK 1527
            |:..|:...||::|||||..||.||.:|...:..|...:..|.|::|  |..:....:|:.|...
Human  1237 WITKQQNAQGGFSSTQDTVVALHALSKYGAATFTRTGKAAQVTIQSS--GTFSSKFQVDNNNRLL 1299

  Fly  1528 LQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNVDIEKFQTKPPVP-AFGLHTKAIFHGRNQSHIS 1591
            ||.:.:|:..|...::..|.|...||..::||:..||.:    .| |.|:.|........::|.|
Human  1300 LQQVSLPELPGEYSMKVTGEGCVYLQTSLKYNILPEKEE----FPFALGVQTLPQTCDEPKAHTS 1360

  Fly  1592 YVACQNWINQNESERSGMAVLDVAIPTGYWIQQQKLDTYVLSNRVRNLRRARYLER------KIV 1650
            :....:.........|.||::||.:.:|:         ..|...|:.|.|:.::.|      .::
Human  1361 FQISLSVSYTGSRSASNMAIVDVKMVSGF---------IPLKPTVKMLERSNHVSRTEVSSNHVL 1416

  Fly  1651 FYFDYLDHEDICVNFTIERWYPVANMSRYLPVRIYDYYAPERFNESIFDA-----LPTYLLNICE 1710
            .|.|.:.::.:.:.||:.:..||.::...: |::||||..:.|..:.::|     .|..||... 
Human  1417 IYLDKVSNQTLSLFFTVLQDVPVRDLKPAI-VKVYDYYETDEFAIAEYNAPCSKGKPLTLLQKA- 1479

  Fly  1711 VCGSSQCP 1718
            |...|.||
Human  1480 VRAPSACP 1487

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
McrNP_524688.1 A2M_N 232..332 CDD:280081 34/103 (33%)
A2M_N_2 669..799 CDD:285005 32/152 (21%)
LDLa 886..913 CDD:238060 5/27 (19%)
A2M 940..1030 CDD:278630 29/89 (33%)
ISOPREN_C2_like 1177..1490 CDD:298658 97/328 (30%)
A2M_comp 1226..1492 CDD:284982 82/281 (29%)
A2M_recep 1607..1695 CDD:284981 23/93 (25%)
A2MXP_006719119.1 YfaS <124..>1071 CDD:225248 256/1134 (23%)
A2M_N 129..221 CDD:280081 29/93 (31%)
A2M_N_2 461..606 CDD:285005 32/153 (21%)
A2M 738..828 CDD:278630 29/90 (32%)
A2M_2 958..1264 CDD:239227 97/335 (29%)
A2M_comp 1010..1266 CDD:284982 82/281 (29%)
A2M_recep 1376..1463 CDD:284981 23/96 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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