DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcr and Mug2

DIOPT Version :9

Sequence 1:NP_524688.1 Gene:Mcr / 44071 FlyBaseID:FBgn0267488 Length:1760 Species:Drosophila melanogaster
Sequence 2:XP_006505762.1 Gene:Mug2 / 17837 MGIID:99836 Length:1490 Species:Mus musculus


Alignment Length:1632 Identity:362/1632 - (22%)
Similarity:634/1632 - (38%) Gaps:382/1632 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   224 DFSQRS--------MTIFVQTDKPLYMQGETVRFRTIPITTELKGFDNPVDV-YMLDPNRHILKR 279
            :||:|:        ..:|||||||:|..|::|:||.:.:...|:..:..:.: |:.||.::.:.:
Mouse   113 EFSKRNAVLVKNKESVVFVQTDKPVYKPGQSVKFRVVSMDKTLRPLNELLPLAYIEDPKKNRIMQ 177

  Fly   280 WLSRQSNLGSVSLEYKLSDQPTFGEWTIRVIAQ-GQQEESHFTVEEYYQTRFEVNVTMPAYFFTT 343
            |...::..|...:.:.|:.:|..|.:.|.|..| |.:||..|||.|:...||.|::.:|......
Mouse   178 WRDIKTENGLKQMSFSLAAEPIQGPYKIVVHKQSGVKEEHSFTVMEFVLPRFNVDLKVPNAISVN 242

  Fly   344 DPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNP 408
            |..:...|...:|.|.||.|.:.|            .:.:|.    .:..::.|           
Mouse   243 DEVLQVTVCGKYTYGKPVPGQVKI------------SICHET----EAGCKEVN----------- 280

  Fly   409 NQNPQVQYNVPGQLPQDGADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYR 473
                       .:|..:|.. :|::........:|:|:                           
Mouse   281 -----------SKLDNNGCS-TQEVNITELQSKKRNYE--------------------------- 306

  Fly   474 KTLPYLRYFNGTFDFKWPLRELELLVPNLANSEVLITATVGEKFYDEIISGYSVARVYNSSLRVV 538
                 ::.|:                         :.|||.|:......:||...::...:.:::
Mouse   307 -----VQLFH-------------------------VNATVTEEGTGLEFNGYGTTKIERITNKLI 341

  Fly   539 FL-GDSPQVFKPAMPFTTYLAVEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLPMSQ 602
            || .||.  |:..:||...:.:....|.|| ||.......:|.|:..:              .:.
Mouse   342 FLKADSH--FRHGIPFFVKVRLVDIKGDPI-PNERVFIKAQVLGYTSA--------------TTT 389

  Fly   603 QSDGIWEVKIDIR----NDLNLDDRPQARDFLNGVQNMRLQANFVDPRGER-IQTELLLVSHYSP 662
            ...|:.:..||..    :.|::....:.:|          ...|.....|| ...|.:..:.||.
Mouse   390 DQHGLAKFSIDTAGFSGSSLHIKVNHKGKD----------SCYFFYCMEERYASAEHVAYAVYSL 444

  Fly   663 RNQHIKVTTSTEKPVVGEYIIFHIRTNFYLE---------EFNYLIMSKGVIL--------VNDR 710
            ...:|.:...|.. ::....|..::.:|.|:         .|.||:|::|.|:        |...
Mouse   445 SKSYIYLVKETSS-ILPCNQIHTVQAHFILKGDLGVLKELVFYYLVMAQGSIIQTGNHTHQVEPG 508

  Fly   711 ETITEGIKTIAVVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYINNRKARTGE 775
            |...:|...:.:.:...|||:|.::::.|...|:|:|||:.|.:....||...:..::.::....
Mouse   509 EAPVKGNFDLEIPVEFSMAPMAKMLIYTILPDGEVIADSVNFEIEKCLRNKVDLSFSSSQSLPAS 573

  Fly   776 KVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQTNGTYKHIWYSHEGNPDE 840
            :..:.:...|.|..||..:|.:...::..:||:.:                    |..:......
Mouse   574 QTRLQVTASPQSLCGLRAVDQSVLLLKPEDELSPS--------------------WIYNLPGMQH 618

  Fly   841 LVYFPASSFGVDANRTFEYSGLIV--FTDGYVP--RRQDTCNRTLGFGECLSGRCY-----RLEK 896
            ..:.|:||...|......||..:.  .|| :||  |.:|...    :.|.:..:.:     :|.|
Mouse   619 NKFIPSSSLSEDREDCILYSSWVAEKHTD-WVPHGREKDVYR----YVEDMDLKAFTNLKIKLPK 678

  Fly   897 QC---------DGLFDCD-----DGTDEINCHAR-------------NDTELLNYRKYRFNRVLR 934
            .|         .|.||..     .||.:.....|             .|......|||       
Mouse   679 ICFDSAPMSGPRGKFDLAFSSEVSGTLQKGSSKRPQPEEPPREDPPPKDPLAETIRKY------- 736

  Fly   935 HYENVWLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVE 999
             :...|:|..|.:...|.....:.|||....|...|..:|...|.| ::..:.....||||:.|.
Mouse   737 -FPETWVWDIVTVNSTGVAEVEMTVPDTITEWKAGALCLSNDTGLG-LSSVVPLQAFQPFFVEVS 799

  Fly  1000 MPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSYNPRTSFGEHQFFIY 1064
            :|.:..:||...::.||.||:.|.:...|.|..|||:..|.|.:|              |..:. 
Mouse   800 LPYSVVRGEAFMLKATVMNYLPTSMRMSVQLEASPDFTAVPVGDD--------------HDSYC- 849

  Fly  1065 LEAQGTTVVYVPVVPQRLGNVDVTL-------------HVATLLGT---DTITRTLHVESDGLPQ 1113
            |.|.|.......|.|:.||||:.::             .|||:..|   ||:.:.|.||.:|:.|
Mouse   850 LSANGRHTSSWLVTPKSLGNVNFSVSVEAQQSSEPCGSEVATVPETGRKDTVVKVLIVEPEGIKQ 914

  Fly  1114 YRHQSVLLDLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNA 1178
             .|....|..::.|.:.|.|.:.:..|          .|..|.:|..||:||::.....    |.
Mouse   915 -EHTFNSLFCASDAEISEKMSLVLPPT----------VVKDSARAHFSVMGDILSSAIK----NT 964

  Fly  1179 SSLLSLPMESGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSL 1243
            .:||.:|...||||...||.|:|.:.|:....|..:.::..|...:..||||:|::...|||:|.
Mouse   965 QNLLHMPYGCGEQNMVLFAPNIYVLKYLDKTQQLTQKIKTKALGFLRAGYQRELNYKHKDGSYSA 1029

  Fly  1244 FRSDWNNSDSSVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLP 1308
            |.......:.:.|||::.|:.|.:|     ..||:||.:.|.....||.|.|...|.|.....|.
Mouse  1030 FGDQNGEREGNTWLTAFVLKSFAQA-----RAFIFIDESHITHAFTWLSQQQKDNGCFRSSGSLF 1089

  Fly  1309 DRKMNRTNFDKNITLTSHVLITLATVKDISGTLGSRVALATQRALAYIE---------RNMDFLR 1364
            ...: :...|..:||::::.:.|     :..:|.:|..:.: :||:.:|         ||.:|: 
Mouse  1090 HNDI-KGGVDDEMTLSAYITMAL-----LESSLPARHPVVS-KALSCLESSWKTIEQGRNANFV- 1146

  Fly  1365 HQAQPFDVAITAYALQLC-NSPIAEEVFAILRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLP 1428
                 :..|:.|||..|. |.....|:...|..:|....:.::|   |.||.|||.|:..:    
Mouse  1147 -----YTKALMAYAFALAGNQDKRNEILKSLDEEAIKEDNSIHW---ERPQKPRKSEHNLY---- 1199

  Fly  1429 RLPYEYDSLNIETTAYALLVYVARREFFVDP----------IVRWLNSQRLNDGGWASTQDTSAA 1483
              ..:..|:.:|..||.:|   ||......|          .:.||..|:.::||::|||||..|
Mouse  1200 --KPQASSVEVEMNAYVVL---ARLTAQPAPSPEDLTLSRSTIMWLTKQQNSNGGFSSTQDTVVA 1259

  Fly  1484 LKALVEY--TVRSRLREVSSLTVEIEASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIKVQAKG 1546
            |.||.:|  ...||.::.|.:|::    |.|..:|...::::|...||.:.:||..|...:...|
Mouse  1260 LDALSKYGAVTFSRRQKTSLVTIQ----STGSFSQKFQVENSNCLLLQQVPLPDIPGDYTISVSG 1320

  Fly  1547 AGYAILQMHVQYNVDIEKFQTKPPVPAFGLHTKAIFHGRNQSHISYVACQNWINQNESE------ 1605
            .|....|..::||:.:||.|:     ||.|..:.:          .:.|.|....|..:      
Mouse  1321 EGCVYAQTTLRYNMHLEKQQS-----AFALRVQTV----------PLTCNNPKGHNSFQISLEIS 1370

  Fly  1606 ------RSGMAVLDVAIPTGYWIQQQKLDTYVLSNRVRNLRRARYLER------KIVFYFDYLDH 1658
                  .|.|.:.||.:.:|:         ..|...|:.|.|..::.|      .::.|.|.:.:
Mouse  1371 YTGSRPASNMVIADVKMLSGF---------IPLKPTVKKLERLEHISRTEVSNNNVLLYLDQVTN 1426

  Fly  1659 EDICVNFTIERWYPVANMSRYLPVRIYDYYAPERFNESIFDALPTYLLNICEVCGSSQCPYCSIY 1723
            :.:..:|.|::...|.|:...: |::||||..:....:.:.:          .|.|.:.|.|...
Mouse  1427 QTLAFSFIIQQDISVRNLQPAI-VKVYDYYETDEVAYAEYSS----------PCSSGEHPACLPQ 1480

  Fly  1724 NMGWRAS 1730
            .:.|..|
Mouse  1481 ALLWTPS 1487

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
McrNP_524688.1 A2M_N 232..332 CDD:280081 33/101 (33%)
A2M_N_2 669..799 CDD:285005 31/146 (21%)
LDLa 886..913 CDD:238060 8/45 (18%)
A2M 940..1030 CDD:278630 26/89 (29%)
ISOPREN_C2_like 1177..1490 CDD:298658 94/332 (28%)
A2M_comp 1226..1492 CDD:284982 80/287 (28%)
A2M_recep 1607..1695 CDD:284981 21/93 (23%)
Mug2XP_006505762.1 A2M_N 129..221 CDD:376626 28/91 (31%)
MG3 223..299 CDD:375334 18/114 (16%)
MG4 340..434 CDD:375332 22/120 (18%)
A2M_N_2 459..599 CDD:377903 30/139 (22%)
A2M 740..830 CDD:365945 26/90 (29%)
A2M_2 960..1266 CDD:239227 94/339 (28%)
A2M_recep 1378..1465 CDD:369460 21/96 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 41 1.000 Domainoid score I12441
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.820

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