DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcr and tep-1

DIOPT Version :9

Sequence 1:NP_524688.1 Gene:Mcr / 44071 FlyBaseID:FBgn0267488 Length:1760 Species:Drosophila melanogaster
Sequence 2:NP_001367060.1 Gene:tep-1 / 173367 WormBaseID:WBGene00013969 Length:1516 Species:Caenorhabditis elegans


Alignment Length:1655 Identity:409/1655 - (24%)
Similarity:707/1655 - (42%) Gaps:280/1655 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   131 TYFIVASRMVRPGLIYQVSVSIL--------------QAQYPITVHASIACDGVQISGDSKDVKE 181
            ||.:||..:|||...:.|.:::|              :.:...|:.|.:.          .::|.
 Worm    39 TYMLVAPAVVRPDQPFSVCMNLLKQATDEDMIVRIEVRTERNETIAARVI----------SNLKP 93

  Fly   182 GIPETL-LMRIPPTSVT--GSYKLRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTDKPLYMQ 243
            ||.:|: |..:|..|:|  .||||.:.|  :.:...|.|.||..|.:.|:::::|:|||:.:|..
 Worm    94 GIAQTVSLSEMPAQSLTPRQSYKLYIRG--ETLNAELIFENENELKYDQKALSVFIQTDRAIYRP 156

  Fly   244 GETVRFRTIPITTELKGFDNPVDVYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFGEWTIR 308
            ...||:|.|.:.::||.:.....:.:.||:|:::.:.:....:.|..|.|.:|:::...|:|.|.
 Worm   157 ASLVRYRAIVVKSDLKPYVGNATIKIFDPSRNLISQTIGVTLDRGVYSGELQLAEETLLGDWFIE 221

  Fly   309 V-IAQGQQEESHFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIR 372
            | .:.|.|::|.|||:.|...:||||:...: |.|.:..:...|.|.:|.|..|.|    ||.: 
 Worm   222 VETSNGVQDKSSFTVDTYVLPKFEVNIKTSS-FITINDDLSVFVDAKYTYGKGVAG----KAKV- 280

  Fly   373 PIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRN 437
                                  ...|...||           ...||..:.::|....::::   
 Worm   281 ----------------------SLELPWHRW-----------HAMVPTIIDENGVKKEEELM--- 309

  Fly   438 QYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNL 502
               |||..:.:.           |..:...:|....|....|..:.|     ..:|.:..:..::
 Worm   310 ---VERTVKLNR-----------QGEAAVVFSNDELKRHKLLHEWGG-----GSIRIVASVTEDI 355

  Fly   503 ANSEVLITATVGEKFYDEIISGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSPI 567
            ...|...|..: ..|.:|:            .|.|...||:   |||.:.:...:|::..|.:|:
 Worm   356 TEIERNATHQI-STFREEV------------KLDVEKQGDT---FKPGLTYNVVVALKQMDDTPV 404

  Fly   568 DPNLLRQGLMEVSGFVESRNGGRRDWPAQRLPMSQQSDGIWE------VKIDIRNDLNLDDRPQA 626
            ...|.::  ::||.|             ...|.:..:..:.|      |::|......|..:|..
 Worm   405 KATLPKR--VQVSTF-------------YNYPYNHDTSSLQEEKETKIVEVDAHGTSVLTLQPPI 454

  Fly   627 RDFLNGVQNMRLQANFVDPRGE------RIQTELLLVSHYSPRNQHIKVTTSTEKPV-VGEYIIF 684
                 ...:.|::|:: |..|:      .|.:.|.:.:..||....:::....|..| ||:.:.|
 Worm   455 -----NCTSARIEAHY-DIGGKDNFTATPIYSSLYVEAAVSPTKSFLQLLADNEGAVDVGKSLSF 513

  Fly   685 HIRTNFYLEEFNYLIMSKGVILVNDRETITEGIKTIAVVLSSEMAPVATIVVWKINQQGQ-VVAD 748
            .::....|....|.:||:..|:|:.:.|:.....||:...::.|||.:.::|:.|.:..| |:.|
 Worm   514 SLKATQPLSTITYQVMSRSNIVVSQQMTVNSEHATISFPATANMAPKSRLIVYAIIESSQEVLVD 578

  Fly   749 SLTFPVNGISRNNFTVYINNRKARTGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKII 813
            :|.|.|.||.:|...:.|:.:....|:.|:..:..:..|:|||..:|.:...::.||::|..|:.
 Worm   579 ALDFKVEGIFQNQVALSIDKQAVEPGQNVKFKVTSDKNSFVGLLVVDQSVLLLKTGNDITREKVE 643

  Fly   814 TKMSNFDEQTNG--------------TYKHIWYSHEGNPDELVYFPASSFGVDANRTFEYSGLIV 864
            ..:.|:|....|              ..:.||....|           ..|.||...|..:||:|
 Worm   644 QDLENYDSNNVGGGFGGPRPWEAIDRKKRSIWRPWWG-----------IGGSDAQSIFSNAGLVV 697

  Fly   865 FTDGYV---PRRQDTCNRTLGFGECLSGRCYRLEKQCDGLFDCDDGTDEINCHA----RNDTELL 922
            .||..:   |:|           |.:||...|..|..  :.|...|..|....|    .:.....
 Worm   698 LTDALLYREPQR-----------EFMSGTFMRRNKVM--MMDGAPGMAEAAFAAPPMGGSSPPPP 749

  Fly   923 NYRKYRFNRVLRHYENVWLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALE 987
            ..||:        :.:.|:|.|:| ...|.....:|.||....|:.|.|:::...|.|:.....:
 Worm   750 TVRKF--------FPHTWIWSDLN-STSGEVEMEIEAPDTITSWVASTFAINEENGLGVAPTTSK 805

  Fly   988 YVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDSPDYKFVHVEEDG-IVRSYN 1051
            ....:||||.:.:|.|.|:||:..:.|.|||||....:..|.|....|..:..:::|| :||   
 Worm   806 LRVFRPFFIQLNLPYAVRRGEKFALLVLVFNYMEKEQDVTVTLKYDKDSGYDLLKKDGTVVR--- 867

  Fly  1052 PRTSFGEHQFFIYLEAQGTT--VVYVPVVPQRLGNVDVTLHVATLLGTDTITRTLHVESDGLPQY 1114
             |...|:....|...|.|.|  .||.|:||..:|.:.|.:......|.|.:...|.|:..|....
 Worm   868 -RDEVGQQNVRIVSVAGGGTSKAVYFPIVPSSIGEIPVHISAIASQGGDAVEMNLRVDPQGYKVD 931

  Fly  1115 RHQSVLLDLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNAS 1179
            |:...::||:|.:       .:.::..|:.:..|  .|.||.|||:.|:||::||:..    ||.
 Worm   932 RNIPFVIDLNNNS-------SDFSKNLELIWPND--VVDGSQKARLDVIGDMMGPVLN----NAH 983

  Fly  1180 SLLSLPMESGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLF 1244
            .|:.:|...||||..:...|:..:.|:|..|:....||..|...:..|.||:|::.|.|.|||.|
 Worm   984 KLVQMPYGCGEQNMLNLVPNILVVKYLRATNRNESQLETKAIKFIEQGIQRELTYKRADNSFSAF 1048

  Fly  1245 RSDWNNSD--SSVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWL 1307
                .:||  .|.|||::.:|     ||:..:.:.::|..:|.:.:.:|...|...|:|.|...:
 Worm  1049 ----GDSDKAGSTWLTAFVVR-----SFHHAKQYAFVDPNVISRAVAFLNSQQMESGAFAERGEV 1104

  Fly  1308 PDRKMNRTNFDKNITLTSHVLITLATVKDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDV 1372
            ..:.|.....|..:.||:.|||::.           ...:...:|:.|:|:::|.:...|  :.:
 Worm  1105 HHKDMQGGAQDGGVALTAFVLISIL-----------ENGMENGKAVTYLEKHLDEVSGNA--YTM 1156

  Fly  1373 AITAYALQLCNSPIAEEVFAILRRQ--ARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYD 1435
            |:.||||||..|..|.:.|..|::.  ....||..:...|   :...||:..:.:.....|    
 Worm  1157 AVVAYALQLAKSKQAGKAFENLKKHKIVEKSGDVKFASAQ---KKVEKLKESRAYMFQARP---- 1214

  Fly  1436 SLNIETTAYALLVYVARREFFVD-PIVRWLNSQRLNDGGWASTQDTSAALKALVEY-TVRSRLRE 1498
             ::||||:||:|.|:|:.:.... .|:|||.|||...||:.|||||..||:||..| .|....:.
 Worm  1215 -VDIETTSYAVLSYLAQNQTSESLSIIRWLVSQRNELGGFTSTQDTVMALQALSSYAAVTYSDKH 1278

  Fly  1499 VSSLTVEIEASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNVDIE 1563
            .|.:|:     ..|..|.:..|:..|...|||.::......:.:.|.|.|....|:...|..|  
 Worm  1279 TSQVTI-----LNGKHTHSFDINIRNAIVLQSYQLSSLNDAVSINANGTGVVFAQLSYSYYRD-- 1336

  Fly  1564 KFQTKPPVPAFGLHTKAIFHGRNQSHISYVACQNWINQNESERSGMAVLDVAIPTGYWIQQQKLD 1628
              ......|.|  .::.|...|..:.:....|.|:....   :|.||:.::...:||....:::.
 Worm  1337 --SLNDDAPFF--CSQEIKEIRAGNRLQLDLCCNYTRPG---KSNMALAEIDALSGYRFDAEQVH 1394

  Fly  1629 TYVLSNRVRNLRRARYLER---KIVFYFDYLDHEDICVNFTIERWYPVANMSRYLPV--RIYDYY 1688
            |.   ..:.:|:|.. :|:   |:..||:.|....:|::...:..|.||:..   |.  |:.|||
 Worm  1395 TL---TSIEDLQRVE-MEKDDTKMNVYFNPLGGRPVCLSLYSDVTYQVADQK---PANFRLVDYY 1452

  Fly  1689 APERFNESIFDALPTYLLNICEVCGSSQCP 1718
            .||...:..:.|..|..|.  |.||....|
 Worm  1453 DPEEQLKMTYAAKQTRSLQ--EKCGEDCWP 1480

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
McrNP_524688.1 A2M_N 232..332 CDD:280081 30/100 (30%)
A2M_N_2 669..799 CDD:285005 36/131 (27%)
LDLa 886..913 CDD:238060 7/26 (27%)
A2M 940..1030 CDD:278630 29/89 (33%)
ISOPREN_C2_like 1177..1490 CDD:298658 97/317 (31%)
A2M_comp 1226..1492 CDD:284982 83/271 (31%)
A2M_recep 1607..1695 CDD:284981 24/92 (26%)
tep-1NP_001367060.1 YfaS <100..1316 CDD:225248 351/1400 (25%)
A2M_N_2 495..631 CDD:400170 36/135 (27%)
A2M 758..848 CDD:395153 29/90 (32%)
A2M_2 978..1269 CDD:239227 97/324 (30%)
A2M_recep 1373..1462 CDD:400149 24/95 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
33.020

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