Protein Alignment Mcr and A2ML1

DIOPT Version :9

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: XP_011518868.1
• Gene: A2ML1 / 144568
• HGNCID: 23336
• Length: 1467
• Species: Homo sapiens
• Alignment Length: 1704
• Identity: 356/1704 - (20%)
• Similarity: 643/1704 - (37%)
• Gaps: 440/1704 - (25%)

  Fly   157 YPITVHASIACDGVQ-----ISGDSKDVK-----------------EGIPETLLMRI-----PPT 194
            |.:|:.|.:....||     :|....|||                 .|:.:..|..|     ||.
Human    23 YLVTLPARLNFPSVQKVCLDLSPGYSDVKFTVTLETKDKTQKLLEYSGLKKRHLHCISFLVPPPA 87

  Fly   195 SVTGSY-KLRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTDKPLYMQGETVRFRTIPITTEL 258
            ..|... .:||.|...|:    :|..:.::...::....|||||||||..|:.|.||.:.:.:..
Human    88 GGTEEVATIRVSGVGNNI----SFEEKKKVLIQRQGNGTFVQTDKPLYTPGQQVYFRIVTMDSNF 148

  Fly   259 KGFDNPVD-----VYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFGEWTIRVIAQGQQEES 318
            .    ||:     |.:.|||.:.:.:||......|.|.|.::|:.:...|.:|: .:|:|:...:
Human   149 V----PVNDKYSMVELQDPNSNRIAQWLEVVPEQGIVDLSFQLAPEAMLGTYTV-AVAEGKTFGT 208

  Fly   319 HFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFSNQVLN 383
             |:||||...:|:|.|..|....|.......::...:|.|.|:.|.:.:....:...|:..:|..
Human   209 -FSVEEYVLPKFKVEVVEPKELSTVQESFLVKICCRYTYGKPMLGAVQVSVCQKANTYWYREVER 272

  Fly   384 EKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDG-----ADLSQDILYRNQYVVER 443
            |                         |.|....|:.||..:.|     .|::
Human   273 E-------------------------QLPDKCRNLSGQTDKTGCFSAPVDMA------------- 299

  Fly   444 HYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEVL 508
                                                     |||          |:....:.::.
Human   300 -----------------------------------------TFD----------LIGYAYSHQIN 313

  Fly   509 ITATVGEKFYDEIISGYSVARVYNS-SLRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSPIDPNLL 572
            |.|||.|:  ...:...:...:|.| .:..:...|:...:.|..||:..:.|..||.|.:..:|:
Human   314 IVATVVEE--GTGVEANATQNIYISPQMGSMTFEDTSNFYHPNFPFSGKIRVRGHDDSFLKNHLV 376

  Fly   573 RQGLMEVSG-----FVESRNGGRRDWPAQRLPMSQQSDGIWEVKIDIRNDLNLDDRPQARDFLNG 632
            ...:...:|     .|...||        ..|.:.::.| |.     ..|::|:.:.|..|.:..
Human   377 FLVIYGTNGTFNQTLVTDNNG--------LAPFTLETSG-WN-----GTDVSLEGKFQMEDLVYN 427

  Fly   633 VQNMRLQANFVDPRGERIQTELLLVSHYSPRNQHIKVTTSTEKPVVGEYII---------FHIRT 688
            .:.:        ||            :|.....|::...||.:..:|.:.:         ..:..
Human   428 PEQV--------PR------------YYQNAYLHLRPFYSTTRSFLGIHRLNGPLKCGQPQEVLV 472

  Fly   689 NFYLE----------EFNYLIMSKGVILVNDRETIT---EGIK---TIAVVLSSEMAPVATIVVW 737
            ::|::          .|:|.::.||.:::..::.:.   :|:|   ::::..:|.:||..::|::
Human   473 DYYIDPADASPDQEISFSYYLIGKGSLVMEGQKHLNSKKKGLKASFSLSLTFTSRLAPDPSLVIY 537

  Fly   738 KINQQGQVVADSLTFPVN-------------GISRNNFTVYINNRKARTGEKVEVAIFGEPGSYV 789
            .|...|.||||.:.|.|.             .:|....::..:..:...|.:||:.:...|||..
Human   538 AIFPSGGVVADKIQFSVEMCFDNQADLIPKLYLSLPQVSLGFSPSQQLPGAEVELQLQAAPGSLC 602

  Fly   790 GLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQTNGTYKHIWYSH-------------------- 834
            .|..:|.:...::...||:           :....|.:. .||.|
Human   603 ALRAVDESVLLLRPDRELS-----------NRSVYGMFP-FWYGHYPYQVAEYDQCPVSGPWDFP 655

  Fly   835 --------EGNPDE--LVYFPASSFGVDANRTFEYSGLIVFTDGYVPRRQDTCNRT------LGF 883
                    :|:..:  :::.|:.|.|.|....|...||.:.::..:.:..|..:|:      :|.
Human   656 QPLIDPMPQGHSSQRSIIWRPSFSEGTDLFSFFRDVGLKILSNAKIKKPVDCSHRSPEYSTAMGA 720

  Fly   884 GECLSGRCYRLEKQCDGLFDCDDGTDEINCHARNDTELLNYRKYRFNRVLRHYENVWLWKDVNIG 948
            |   .|.....|....             .|...|:::..|           :...|||....||
Human   721 G---GGHPEAFESSTP-------------LHQAEDSQVRQY-----------FPETWLWDLFPIG 758

  Fly   949 PHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIR 1013
            ..|:...:|.|||....|...:|..|.|:||| ::..:.....:|||:::.:|.:..:||...:.
Human   759 NSGKEAVHVTVPDAITEWKAMSFCTSQSRGFG-LSPTVGLTAFKPFFVDLTLPYSVVRGESFRLT 822

  Fly  1014 VTVFNYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSYNPRTSFGEHQFFIYLEAQGTTVVYVPVV 1078
            .|:|||:...|.....|..|.:|:.               .|:.:.|....|.|......:..:.
Human   823 ATIFNYLKDCIRVQTDLAKSHEYQL---------------ESWADSQTSSCLCADDAKTHHWNIT 872

  Fly  1079 PQRLGNVDVTLHVATLLG----------------TDTITRTLHVESDG-LPQYRHQSVLLDLSNR 1126
            ..:||:::.|:....|..                :||:.:.:.|:.:| |.:..|.|:|......
Human   873 AVKLGHINFTISTKILDSNEPCGGQKGFVPQKGRSDTLIKPVLVKPEGVLVEKTHSSLLCPKGKV 937

  Fly  1127 AYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNASSLLSLPMESGEQ 1191
            |        :.:.:.|:|..:    |..|.||.::|:||::|    |...|...|:.:|...|||
Human   938 A--------SESVSLELPVDI----VPDSTKAYVTVLGDIMG----TALQNLDGLVQMPSGCGEQ 986

  Fly  1192 NAFSFAANLYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVW 1256
            |...||..:|.:.|:.......:.:...|...:.||||::|.:...:||:|.|..  .:.:.:.|
Human   987 NMVLFAPIIYVLQYLEKAGLLTEEIRSRAVGFLEIGYQKELMYKHSNGSYSAFGE--RDGNGNTW 1049

  Fly  1257 LTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPDRKMNRTNFDKNI 1321
            ||::..:.|.:|     :.||:||...|:..::|:..:|.|.|.:..|..|....| :...|..:
Human  1050 LTAFVTKCFGQA-----QKFIFIDPKNIQDALKWMAGNQLPSGCYANVGNLLHTAM-KGGVDDEV 1108

  Fly  1322 TLTSHVLITLATV-KDISGTLGSRVALATQRALAYIERNMDFLRHQAQP----FDVAITAYALQL 1381
            :||::|...|..: ||:...:              :.:.:..|::.|..    :..|:.||...|
Human  1109 SLTAYVTAALLEMGKDVDDPM--------------VSQGLRCLKNSATSTTNLYTQALLAYIFSL 1159

  Fly  1382 CNS-PIAEEVFAILRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYA 1445
            ... .|...:...|.:||...|:.:||.     |.|....|...:|.|.      ::::|.||||
Human  1160 AGEMDIRNILLKQLDQQAIISGESIYWS-----QKPTPSSNASPWSEPA------AVDVELTAYA 1213

  Fly  1446 LLVYVARREFF------VDPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRL-REVSSLT 1503
            ||..:.:....      ...||.||..|....||::|||||..||:||.:|...:.: .|..:|.
Human  1214 LLAQLTKPSLTQKEIAKATSIVAWLAKQHNAYGGFSSTQDTVVALQALAKYATTAYMPSEEINLV 1278

  Fly  1504 VEIEASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYN--------- 1559
            |:...:.|    :|..|...|....|...:|:..|...::|.|.|...:|..::||
Human  1279 VKSTENFQ----RTFNIQSVNRLVFQQDTLPNVPGMYTLEASGQGCVYVQTVLRYNILPPTNMKT 1339

  Fly  1560 ----VDIEKFQTKPPVPAFGLHTKAIFHGRNQSHISYVACQNWINQNESERSGMAVLDVAIPTGY 1620
                |:|.|.:.:.|.....| |..|       |.|||..::        .|.||:::|.:.:|:
Human  1340 FSLSVEIGKARCEQPTSPRSL-TLTI-------HTSYVGSRS--------SSNMAIVEVKMLSGF 1388

  Fly  1621 --------WIQQQKLDTYVLSNRVRNLRRARYLERKIVFYFDYLDHEDICVNFTIERWYPVANMS 1677
                    .:.||.|           :::..:....:..|.|.|........|||.:...|.|:
Human  1389 SPMEGTNQLLLQQPL-----------VKKVEFGTDTLNIYLDELIKNTQTYTFTISQSVLVTNL- 1441

  Fly  1678 RYLPVRIYDYYAPE 1691
            :...:::||||.|:
Human  1442 KPATIKVYDYYLPD 1455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	A2M_N	232..332	CDD:280081	35/104 (34%)
		A2M_N_2	669..799	CDD:285005	31/167 (19%)
		LDLa	886..913	CDD:238060	2/26 (8%)
		A2M	940..1030	CDD:278630	28/89 (31%)
		ISOPREN_C2_like	1177..1490	CDD:298658	86/324 (27%)
		A2M_comp	1226..1492	CDD:284982	75/277 (27%)
		A2M_recep	1607..1695	CDD:284981	21/93 (23%)
A2ML1	XP_011518868.1	A2M_N	122..211	CDD:280081	30/94 (32%)
		YfaS	<123..>1055	CDD:225248	225/1135 (20%)
		A2M_N_2	455..613	CDD:285005	28/157 (18%)
		A2M	749..839	CDD:278630	28/90 (31%)
		A2M_2	969..1264	CDD:239227	86/327 (26%)
		A2M_comp	1021..1266	CDD:284982	75/277 (27%)
		A2M_recep	1375..1462	CDD:284981	21/93 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820