DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcr and CD109

DIOPT Version :9

Sequence 1:NP_524688.1 Gene:Mcr / 44071 FlyBaseID:FBgn0267488 Length:1760 Species:Drosophila melanogaster
Sequence 2:NP_598000.2 Gene:CD109 / 135228 HGNCID:21685 Length:1445 Species:Homo sapiens


Alignment Length:1680 Identity:423/1680 - (25%)
Similarity:727/1680 - (43%) Gaps:328/1680 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   130 PTYFIVASRMVRPGLIYQVSVSILQ-AQYPITVHAS------------IACDGVQISGDSKDVKE 181
            |.:.:.|..::|||....:.|.:|: ....:||.|.            :..:||...|..|.:  
Human    26 PRFLVTAPGIIRPGGNVTIGVELLEHCPSQVTVKAELLKTASNLTVSVLEAEGVFEKGSFKTL-- 88

  Fly   182 GIPETLLMRIPPTSVTGSYKLRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTDKPLYMQGET 246
                 .|..:|..|....|:|||.|..|:   .:.|.|.|||.|..:.:::|:||||.||...:.
Human    89 -----TLPSLPLNSADEIYELRVTGRTQD---EILFSNSTRLSFETKRISVFIQTDKALYKPKQE 145

  Fly   247 VRFRTIPITTELKGFDNPVDVYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFGEWTIRVIA 311
            |:||.:.:.::.|.:...:::.:.||..:::::|||:||:||.:|..::||..|..|:|:|:|..
Human   146 VKFRIVTLFSDFKPYKTSLNILIKDPKSNLIQQWLSQQSDLGVISKTFQLSSHPILGDWSIQVQV 210

  Fly   312 QGQQEESHFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGY 376
            ..|.....|.|.||...:|||.:..|.|.......:.|.:.|.:|.|.||:|::|:  |..|:.:
Human   211 NDQTYYQSFQVSEYVLPKFEVTLQTPLYCSMNSKHLNGTITAKYTYGKPVKGDVTL--TFLPLSF 273

  Fly   377 FSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRNQYVV 441
            :..:                             :|....:.:.|                     
Human   274 WGKK-----------------------------KNITKTFKING--------------------- 288

  Fly   442 ERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSE 506
            ..::.|::|     ......|||                  ||..::      |:|..|...  |
Human   289 SANFSFNDE-----EMKNVMDSS------------------NGLSEY------LDLSSPGPV--E 322

  Fly   507 VLITATVGEKFYDEIISGYSVARVYNSSLRVVF--------LGDSPQVFKPAMPFTTYLAVEYHD 563
            :|.|.|       |.::|.|    .|.|..|.|        ..|...|.||::.||..:.|...|
Human   323 ILTTVT-------ESVTGIS----RNVSTNVFFKQHDYIIEFFDYTTVLKPSLNFTATVKVTRAD 376

  Fly   564 GSPIDPNLLRQGL---MEVSGFVE----SRNGGRRDWPAQRLPMSQQSDGIWEVKIDIRNDLNLD 621
            |:.:.....|..:   :....:.|    |.:|.::....|::..:....|.::::..|     |:
Human   377 GNQLTLEERRNNVVITVTQRNYTEYWSGSNSGNQKMEAVQKINYTVPQSGTFKIEFPI-----LE 436

  Fly   622 DRPQAR---DFLNGVQNMRLQANFVDPRGERIQTELLLVSHYSPRNQHIKVTTSTEKPVVGEYII 683
            |..:.:   .||....:|.:.:.|..|....||.:        .|:::|||.:..|..|.|    
Human   437 DSSELQLKAYFLGSKSSMAVHSLFKSPSKTYIQLK--------TRDENIKVGSPFELVVSG---- 489

  Fly   684 FHIRTNFYLEEFNYLIMSKGVILVNDRETITEGIKTIAVVLSSEMAPVATIVVWKINQQGQVVAD 748
                 |..|:|.:|:::|:|.::...::..|    ..::...:...|.|.::|:.|...|::::|
Human   490 -----NKRLKELSYMVVSRGQLVAVGKQNST----MFSLTPENSWTPKACVIVYYIEDDGEIISD 545

  Fly   749 SLTFPVNGISRNNFTVYINNRKARTGEKVEVAI-FGEPGSYVGLSGIDSAFYTMQAGNELTYAKI 812
            .|..||..:.:|...:|.:..||...|||.:.| ..:|.|.||:..:|.:...|.|.|::|...:
Human   546 VLKIPVQLVFKNKIKLYWSKVKAEPSEKVSLRISVTQPDSIVGIVAVDKSVNLMNASNDITMENV 610

  Fly   813 ITKMSNFDEQTNGTYKHIWYSHEGNPDELVYFPASSFGVDANRTFEYSGLIVFTDGYVPRRQDTC 877
            :.::..::   .|.|..::              .:||.|     |:..||.|.||         .
Human   611 VHELELYN---TGYYLGMF--------------MNSFAV-----FQECGLWVLTD---------A 644

  Fly   878 NRTLGFGECLSGRCYRLEKQCDGLFDCDDGTDEINCHARNDTELLNYRKYRFN---RVLRHYENV 939
            |.|..:              .||::|..:..:..  ...|:..:::...:...   .|.:|:...
Human   645 NLTKDY--------------IDGVYDNAEYAERF--MEENEGHIVDIHDFSLGSSPHVRKHFPET 693

  Fly   940 WLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEAC 1004
            |:|.|.|:|......|.|.|||....|:.:.|.:|...|.|:....:|....|||||.:.:|.:.
Human   694 WIWLDTNMGYRIYQEFEVTVPDSITSWVATGFVISEDLGLGLTTTPVELQAFQPFFIFLNLPYSV 758

  Fly  1005 RQGEQVGIRVTVFNYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSYNPRTSFGEHQFFIYLEAQG 1069
            .:||:..:.:|:|||:....|..|::..|..:        .|:.:.|...:.|..|..:.....|
Human   759 IRGEEFALEITIFNYLKDATEVKVIIEKSDKF--------DILMTSNEINATGHQQTLLVPSEDG 815

  Fly  1070 TTVVYVPVVPQRLGNVDVTLHVATLLGTDTITRTLHVESDGLPQYRHQSVLLDLSNRAYVLEYMH 1134
            .||:: |:.|..||.:.:|:...:...:|.:|:.:.|:::|:.:...||:||||::.........
Human   816 ATVLF-PIRPTHLGEIPITVTALSPTASDAVTQMILVKAEGIEKSYSQSILLDLTDNRLQSTLKT 879

  Fly  1135 VNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNA-SSLLSLPMESGEQNAFSFAA 1198
            ::.:..|..        |.||.:.:|:.:|||:||     .:|. :||:.:|...||||..:||.
Human   880 LSFSFPPNT--------VTGSERVQITAIGDVLGP-----SINGLASLIRMPYGCGEQNMINFAP 931

  Fly  1199 NLYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSD--SSVWLTSYC 1261
            |:|.:.|:....|....|::.|...|..||||:|.:.|.|||||.|    .|.|  .|.||:::.
Human   932 NIYILDYLTKKKQLTDNLKEKALSFMRQGYQRELLYQREDGSFSAF----GNYDPSGSTWLSAFV 992

  Fly  1262 LRVFQEASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPDRKMNRTNFDKN---ITL 1323
            ||.|.||     :.:|.||..::.:...||..||...|.|    |.|.|.::......|   :||
Human   993 LRCFLEA-----DPYIDIDQNVLHRTYTWLKGHQKSNGEF----WDPGRVIHSELQGGNKSPVTL 1048

  Fly  1324 TSHVLITLATVKDISGTLGSR---VALATQRALAYIERNMDFLRHQAQPFDVAITAYALQLCNSP 1385
            |::::.:|         ||.|   ..:..|.::.::|  .:|.|..:..:.:|:..|||....||
Human  1049 TAYIVTSL---------LGYRKYQPNIDVQESIHFLE--SEFSRGISDNYTLALITYALSSVGSP 1102

  Fly  1386 IAEEVFAILRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYV 1450
            .|:|...:|..:|...|...:|.:.|     .|| :..|  .||      ||:||..|||||.:.
Human  1103 KAKEALNMLTWRAEQEGGMQFWVSSE-----SKL-SDSW--QPR------SLDIEVAAYALLSHF 1153

  Fly  1451 ARREFFVD---PIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQG 1512
            .  :|...   ||:|||:.||.:.||:||||||:.|||||.|:   :.|.......:::..:...
Human  1154 L--QFQTSEGIPIMRWLSRQRNSLGGFASTQDTTVALKALSEF---AALMNTERTNIQVTVTGPS 1213

  Fly  1513 GKTQTLYIDDT-NLAKLQSIEI----PDAWGTIKVQAKGAGYAILQMHVQYNVDI-------EKF 1565
            ..:...::.|| |...||:.|:    |.|   :.:.|.|.|:||.|::|.|||..       ...
Human  1214 SPSPVKFLIDTHNRLLLQTAELAVVQPTA---VNISANGFGFAICQLNVVYNVKASGSSRRRRSI 1275

  Fly  1566 QTKPPVPAFGLHTKAIFHGRNQSHISYVACQNWINQNESERSGMAVLDVAIPTGYWIQQQKLDTY 1630
            |.:   .||.|......:..:.:|:....|.::....   |||||:::|.:.:|:.:..:.:.  
Human  1276 QNQ---EAFDLDVAVKENKDDLNHVDLNVCTSFSGPG---RSGMALMEVNLLSGFMVPSEAIS-- 1332

  Fly  1631 VLSNRVRNLRRARYLERKIVFYFDYLDHEDICVNFTIERWYPVANMSRYLPVRIYDYYAPERFNE 1695
             ||..|   ::..|...|:..|.|.::....|||....|.:.|:| ::...|.|.|||.|.|   
Human  1333 -LSETV---KKVEYDHGKLNLYLDSVNETQFCVNIPAVRNFKVSN-TQDASVSIVDYYEPRR--- 1389

  Fly  1696 SIFDALPTY----LLNICEVCGSSQ-CPYCSIYNMGWRASMSMSLLFFSVFIYLL 1745
               .|:.:|    .|:.|::|...| |..|.....|.....|:..:|....:|.:
Human  1390 ---QAVRSYNSEVKLSSCDLCSDVQGCRPCEDGASGSHHHSSVIFIFCFKLLYFM 1441

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
McrNP_524688.1 A2M_N 232..332 CDD:280081 34/99 (34%)
A2M_N_2 669..799 CDD:285005 33/130 (25%)
LDLa 886..913 CDD:238060 3/26 (12%)
A2M 940..1030 CDD:278630 30/89 (34%)
ISOPREN_C2_like 1177..1490 CDD:298658 111/324 (34%)
A2M_comp 1226..1492 CDD:284982 95/276 (34%)
A2M_recep 1607..1695 CDD:284981 26/87 (30%)
CD109NP_598000.2 YfaS <66..>1000 CDD:225248 276/1141 (24%)
A2M_N 130..221 CDD:280081 30/90 (33%)
A2M_N_2 470..596 CDD:285005 36/146 (25%)
Bait region (approximate). /evidence=ECO:0000250 593..702 28/155 (18%)
A2M 693..782 CDD:278630 29/88 (33%)
A2M_2 907..1194 CDD:239227 111/326 (34%)
A2M_comp 959..1196 CDD:284982 95/279 (34%)
A2M_recep 1311..1395 CDD:284981 27/96 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 74 1.000 Domainoid score I9204
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.920

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