Protein Alignment Mcr and LOC1278910

DIOPT Version :10

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: XP_061509338.1
• Gene: LOC1278910 / 1278910
• VectorBaseID: AGAMI1_012911
• Length: 1417
• Species: Anopheles gambiae
• Alignment Length: 1643
• Identity: 373/1643 - (22%)
• Similarity: 603/1643 - (36%)
• Gaps: 432/1643 - (26%)

  Fly   134 IVASRMVRPGLIYQVSVSILQAQYPITVHAS--IACDGVQISGDSKDVKEGIP--------ETLL 188
            ||..:.:|.|..|.|.:|..::.   |...:  :..||:. :|..|.:..|.|        ..:.
Mosquito   111 IVGPKHIRAGQNYTVILSSFESN---TNERNLLLQLDGLS-AGGKKLLHLGQPARVQLLSNSVIS 171

  Fly   189 MRIPPTSVTGSYKLRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTDKPLYMQGETVRFRTIP 253
            ..:|.:...|||||.::|  ||   |..|..|..|..:..:.|..||..||:|..|:.::||.|.
Mosquito   172 FPLPESLPAGSYKLTIDG--QN---GFKFHREADLLLAASTTTALVQLSKPIYKPGDVLQFRVIV 231

  Fly   254 ITTELKGFDNP------VDVYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFGEWTIRVIAQ 312
            :..:||    |      ..|.:.||.|::::||.:....||....:.::...|..|.:||.|...
Mosquito   232 LGGDLK----PPAPSVTATVIVHDPQRNVIRRWTAVSLQLGVFEEQLQIGTVPLLGRYTITVTVT 292

  Fly   313 GQQE--ESHFTVEEYYQTRFEV---------------NVTMPAYFFTTDPFIYGRVMANFTSGLP 360
            |..|  ...|.|.||....|||               |:|:.|.::|               |.|
Mosquito   293 GANEIVSKTFDVREYVLPAFEVAVKARAVPLEKHQRLNLTLSARYYT---------------GQP 342

  Fly   361 VRGNLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQD 425
            |||..|::.      |..:..|:::..:|        :|.            .:|..:|......
Mosquito   343 VRGVATVEL------YLEDDKLDQRRVVG--------VYG------------AIQLELPFNEHLS 381

  Fly   426 GADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKW 490
            ..|.:||        |..|..|.::        |...:.|:
Mosquito   382 VYDDAQD--------VRVHVAFTQD--------ETNRTIYK------------------------ 406

  Fly   491 PLRELELLVPNLANSEVLITATVGEKFYDEIISGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTT 555
                           |..||                   ||....||..:.:.|: |:..:||..
Mosquito   407 ---------------EQRIT-------------------VYKLPYRVELVKEQPE-FRAKVPFDC 436

  Fly   556 YLAVEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLPMSQQSDGIWEVKIDIRNDLNL 620
            .|.|.|.||:|                                    .....:|||::  .....
Mosquito   437 QLRVRYQDGTP------------------------------------AKGAAFEVKVE--GAYTT 463

  Fly   621 DDRPQARDFLNGVQNMRLQANFVDPRGERIQ------TELLLVSHYSPRNQ-----HIKVTTSTE 674
            |.|........||..:.||.   :...|.|.      :|.||....|.|..     .:|:.:..:
Mosquito   464 DRRVAYTSDAAGVIKLTLQP---EASSESIDITVNAGSEELLYERISKREASKAFLQVKLDSDVK 525

  Fly   675 KPVVGEYIIFHIRTNFYLEEFNYLIMSKGVILVN---DRETITEGIKTIAVVLSSEMAPVATIVV 736
               :|:.....:..|..|..|.|.::|:|.|:.:   ..:.:||..  |.:..:.:|.|.:.::|
Mosquito   526 ---IGKPFKLKVTCNEELSFFMYYVVSRGAIVDSAFLQPKKVTEHF--IEIKAADQMVPRSKVIV 585

  Fly   737 WKINQQGQVVADSLTFPVNGISRNNFTVYINNRKARTGEKVEVAIFGEPGSYVGLSGIDSAFYTM 801
            ..: .:..|:.|.:......: ||||.:.|:..:.|.|:::::.:.|.||::|.|:..|.:....
Mosquito   586 VTV-AKNVVLCDFVDIDFEDL-RNNFDLQIDRTEIRPGDQLQLNMRGPPGAFVALAAYDKSLLQY 648

  Fly   802 QAGNELTYAKIITKMSNFDEQTNGTYKHIWYSHEGNPDELVYFPASSFGVDANRTFEYSGLIVFT 866
            ...:::           |.|...|.:.. :||.|.|..:|.:    |.|:.| ||.|:   |.|
Mosquito   649 SNNHDI-----------FWEDVWGVFDK-FYSVERNEFDLFH----SLGLFA-RTMEH---ITF- 692

  Fly   867 DGYVPRRQDTCNRTLGFGECLSGRCYRLEKQCDGLFDCDDGTDEINCHARNDTELLNYRKYRFNR 931
                .:..|...|                   ||.....:|........|.
Mosquito   693 ----DKANDQTAR-------------------DGSSSSKNGLSNSQVSFRT-------------- 720

  Fly   932 VLRHYENVWLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFI 996
               ::...||||...||..|.......|||....|.::.|||.|..|.|::.:.|:...||||:|
Mosquito   721 ---NFLESWLWKTDKIGSSGSTTIKESVPDTITAWHLTGFSVDPVYGLGIIKQPLQLTTVQPFYI 782

  Fly   997 NVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSYNPRTSFGEHQF 1061
            ...||.:.::||.|.::..|||......:|.|.|. |.|.:...|.......||...
Mosquito   783 VPNMPYSIKRGELVELQFIVFNNFPKKYKASVTLF-SVDNQTEFVGRPATETSYTKS-------- 838

  Fly  1062 FIYLEAQGTTVVYVP--VVPQRLGNVDVTLHVATLLGTDTITRTLHVESDGLPQ----------- 1113
               :||...|.|.|.  :..::||.:.|.:..:.....|:|...:.|..:.|.:
Mosquito   839 ---IEASPDTGVPVAFLIKARKLGEMTVRVDASIEPAKDSIESVIRVIPESLVKREMISRFFCHN 900

  Fly  1114 -YRHQSVLLDLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVN 1177
             |::||.:|.|                      ..||....|:.|....:..:::..:..    |
Mosquito   901 TYQNQSFVLGL----------------------DFDRKADAGTRKIDFILTPNILTSVMD----N 939

  Fly  1178 ASSLLSLPMESGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFS 1242
            ..||||:|...||||.......:..:.|:..|...:|.|...|...:..|||.|:.:.:|||||.
Mosquito   940 LESLLSVPTGCGEQNMMRLVPIVLVLDYLTSIGSADKQLTAKAIGLLRAGYQNQMRYRQPDGSFG 1004

  Fly  1243 LFRSDWNNSDSSVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWL 1307
            |    |..|..:|:||::..:....|:.|..|    |:.:::|:...||...|...|.|.||..:
Mosquito  1005 L----WEKSGGAVFLTAFVGKTLATAAKYISE----IEPSMVEQAFDWLAARQHSTGRFDEVGPV 1061

  Fly  1308 PDRKMNRTNFDKNITLTSHVLITLATVKDISGTLGSRVALATQRALAYIERNMDFLRHQ----AQ 1368
            ..|.| :....:.|.|||.|||.|.          .:..:||:...| ||:.:|::...    ..
Mosquito  1062 FHRDM-QGGLRQGIALTSFVLIALL----------EQPKVATKHRAA-IEKGIDYVTQTLGSIED 1114

  Fly  1369 PFDVAITAYALQL----CNSPIAEEVFAILRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPR 1429
            .:|:||..|||.|    ......|::..:...|..  |...:|..
Mosquito  1115 SYDLAIATYALLLQKHSSGERFLEKLIGLSTVQQN--GTERFWAR-------------------- 1157

  Fly  1430 LPYEYDSLNIETTAYALLVYVARREFFVD--PIVRWLNSQRLNDGGWASTQDTSAALKALV---- 1488
                 |:..||||||.||.:|. .|.:||  .|:|||..||...|.:..||||...||||.
Mosquito  1158 -----DAHGIETTAYGLLSFVL-AEKYVDGTSIMRWLVKQRYTPGSFPRTQDTFVGLKALTKLAE 1216

  Fly  1489 -------EYTVRSRLREVSSLTVEIEASSQGGKTQTLYIDDTNLAKLQSIEI-PDAWGTIKVQAK 1545
                   :|:|:.|               ..|:.:...:...::..||..:. .|....:::...
Mosquito  1217 KISPSRNDYSVQLR---------------HAGRKEEFRVTSQDIGTLQHAQQGVDETAQLELHVA 1266

  Fly  1546 GAGYAILQMHVQYNVDIEKFQTKPPVPAFGLHTKAIFHGRNQSHISYVACQNWINQNESERSGMA 1610
            |.|:.:||:..:|.||:..|..:     |.|..:......|. |:....|.::..|....||.|.
Mosquito  1267 GIGFGLLQVVYEYGVDLRNFTAQ-----FVLELQKSVTNANH-HLQLEVCSSFTPQLSDGRSNMV 1325

  Fly  1611 VLDVAIPTGYWIQQ--QKLDTYVLSNRVRNLRRARYLERKIVFYFDYLDHEDICVNFTIERWYPV 1673
            :::|..|:||.::|  |.:......|.::. ...|:....:|.|::.:..|..|...|..|...|
Mosquito  1326 LVEVNFPSGYTVEQRGQPITGATKHNPIQK-TEVRFGATSVVVYYNSMGPERNCFTITAYRRQKV 1389

  Fly  1674 ANMSRYLPVRIYDYYAPE 1691
             .:.|...|.::|||.|:
Mosquito  1390 -TLKRPAYVLVHDYYDPK 1406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	YfaS	<226..1575	CDD:441940	316/1421 (22%)
		A2M_BRD	667..801	CDD:462235	30/136 (22%)
		A2M	939..1030	CDD:459711	33/90 (37%)
		TED_complement	1160..1490	CDD:462227	97/350 (28%)
		A2M_recep	1605..1699	CDD:462226	24/89 (27%)
LOC1278910	XP_061509338.1	None