Protein Alignment Mcr and LOC1278851

DIOPT Version :10

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: XP_318490.3
• Gene: LOC1278851 / 1278851
• VectorBaseID: AGAMI1_009766
• Length: 1333
• Species: Anopheles gambiae
• Alignment Length: 1661
• Identity: 339/1661 - (20%)
• Similarity: 617/1661 - (37%)
• Gaps: 439/1661 - (26%)

  Fly   134 IVASRMVRPGLIYQVSVSIL---QAQYPITVHASIACD-GVQISGDSK--DVKEGIPETLLMRIP 192
            :|..:.:|....|.:.:|.:   |.:..:.|......| |:.:...:|  ||:..:...:...:|
Mosquito    29 VVGPKYIRANQEYTLVISNINSNQTKLDLIVKLEGETDNGLNVLNVTKTFDVRRNMNRMINFNMP 93

  Fly   193 PTSVTGSYKLRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTDKPLYMQGETVRFRTIPITTE 257
            .....|:||:.::|..     |.:|..|..|.:..:|::..:|.|||::..|:||.||.|.:.||
Mosquito    94 ENLAEGNYKITIDGQQ-----GFSFHKEAALVYLSKSISGLIQVDKPVFKPGDTVNFRVIVLDTE 153

  Fly   258 LKGFDNP------VDVYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFGEWTIRVIAQGQQE 316
            ||    |      |.|.:.||.|:::::|.|.:...|......:::.....|.|.|.|..:|::.
Mosquito   154 LK----PPARVKLVYVTIRDPQRNVIRKWSSAKLYTGVFEGYLQIAPTAMLGIWNILVQVEGEEL 214

  Fly   317 ESH-FTVEEYYQTRFE---------------VNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNL 365
            .|. |.|:||..:.|:               ||:|:.||:             :|  |.||:|..
Mosquito   215 VSKTFEVKEYVLSTFDVQVMPSVIPLEEHQAVNLTIEAYY-------------HF--GKPVQGVA 264

  Fly   366 TIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLS 430
            .::.      |..::::::|        ::..:|.:                  ||:
Mosquito   265 KVEL------YLDDELIDQK--------KELTVYGK------------------GQV-------- 289

  Fly   431 QDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLREL 495
             ::|:..::.:                  |:|
Mosquito   290 -ELLFFGKFEM------------------YED--------------------------------- 302

  Fly   496 ELLVPNLANSEVLITATVGEKFYDEIISGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYLAVE 560
                    ..:|.:..|..|::.:..:...|...:|..:.||.|:.:||. |.|.:||...|...
Mosquito   303 --------QQDVRVKVTFIEQYTNRTLVKLSQITIYKHAYRVEFIKESPH-FHPGIPFKFVLQFT 358

  Fly   561 YHDGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLPMSQQSDGIWEVKIDIRNDLNLDDRPQ 625
            :|||:|...   ..|.:||||.            ......:..:||:  :|::::.  |.|....
Mosquito   359 HHDGTPAKG---ITGKVEVSGI------------GFETTATSDNDGL--IKLELQK--NEDIESM 404

  Fly   626 ARDFLNGVQNMRLQANFVDPRGERIQTELLLVSHY------SP--RNQHIKVT-TSTEKPVVGEY 681
            ...|:|.......:.|        :..::...:.|      ||  .|::::.| |.||
Mosquito   405 HVSFVNNNDGFVFEHN--------VDRDVFATNAYIKIELKSPIKLNKNMRFTVTCTE------- 454

  Fly   682 IIFHIRTNFYLEEFNYLIMSKGVIL------VNDRETITEGIKTIAVVLSSEMAPVATIVVWKIN 740
                 |..|::    |.::|||.|:      .|.::..     ::.:..:.:|.|.|.|:|..:.
Mosquito   455 -----RMTFFV----YYVVSKGNIVDAGFMRPNKQKKY-----SLQLDATEKMIPKAKILVATLV 505

  Fly   741 QQGQVVADSLTFPVNGISRNNFTVYINNRKARTGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGN 805
            .. .:|.|.:.....|. |:||.:.|:.::.....::|:::.|.||:||||:..|.|.......:
Mosquito   506 NH-TMVNDIVDIDFQGF-RHNFDLSIDEQEIMPERQIELSMSGRPGAYVGLAAYDKALPLFNKNH 568

  Fly   806 ELTYAKIITKMSNFDEQTNGTYKHIWYSHEGNPDELVYFPASSFGVDANRTFEYSGLIVFTDGYV 870
            :|.:..|......|            :|::.|..:|               |...||....|..:
Mosquito   569 DLFWEDIGQVFDGF------------HSYDTNEFDL---------------FHNMGLFARMDNIM 606

  Fly   871 PRRQDTCNRTLGFGECLSGRCYRLEKQCDGLFDCDDGTDEINCHARNDTELLNYRKYRFNRVLRH 935
                        |.:. :.:..|..:|.||..                     :||        .
Mosquito   607 ------------FDQS-NDKSARSGQQADGTV---------------------FRK--------Q 629

  Fly   936 YENVWLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEM 1000
            :...||||...||..|.......|||....|.::.||:.|..|.|::.|.:|...||||.:...:
Mosquito   630 FLESWLWKTAIIGNSGTLKLIEVVPDTTTTWYLTGFSIDPVYGLGIVKKPIEITTVQPFVVMESL 694

  Fly  1001 PEACRQGEQVGIR-VTVFNYMITPIEAIVVLHDSPDYKFV--HVEEDGIVRSYNPRTSFGEHQFF 1062
            |.:.::||.:.|: :.:.|........:.:.:::.:.:|:  .:......:|.:.....|:...|
Mosquito   695 PYSIKRGEAIEIQFILISNLQEEYTVDVTLYNENNEMEFLGRSISNVSYTKSVSVPPKVGKPVSF 759

  Fly  1063 IYLEAQGTTVVYVPVVPQRLGN--VDVTLHVATLLGTDTITRTLHVESDGLPQYRHQS--VLLDL 1123
            :             |..::||.  |.|...:|..|.||.:.:.:.|..:.|.|...:|  ..:|.
Mosquito   760 L-------------VKAKKLGEMMVRVKASIANELATDALEKVIRVTPESLVQSGVESFGFFMDT 811

  Fly  1124 -SNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNASSLLSLPME 1187
             .||.:::         .|.|..:.|.                  |.|...:.:|.:.|:.:...
Mosquito   812 HQNRTFLV---------NPNIDKKADN------------------GSIAIELRINPNLLIKVKEN 849

  Fly  1188 SGE--------QNAFSFAANLYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLF 1244
            ..:        :|......|.....|:.......:.|.:||...::..|...::.:..|.||...
Mosquito   850 LNDLHTALPSCRNVIRLGLNFAVADYLIACGLNAQNLPENAVDALSKEYMLLMTCLNSDSSFDSV 914

  Fly  1245 RSDWNNSDSSVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPD 1309
            :    |..|:::.|::.......|.    :|........:||...||...|...|||.|:    :
Mosquito   915 Q----NIVSNIFYTAFVANTLDTAP----KNVRQTSNVKLEKAFDWLASRQQRFGSFREI----E 967

  Fly  1310 RKMNRTNFDKNITLTSHVLITLATVKDISGTLGSRVALATQRALAYIERNMDFLRHQ----AQPF 1370
            ..::.|.  ..|.|||:||  .|.:::.|..:...|.         ||:.|.||.:|    ....
Mosquito   968 SDLHYTR--SEIALTSYVL--AAMIENESAKVKHAVV---------IEKGMWFLSNQFDLITSAN 1019

  Fly  1371 DVAITAYALQLCNSPIAEEVFAILRRQARTI---GDFMYWGNQEIPQPPRKLENQKWFSLPRLPY 1432
            |:||..||:.|......:..|..|...: ||   |...||..
Mosquito  1020 DLAIVTYAMMLYGHWRKDAAFEKLIDMS-TITNNGAERYWNT----------------------- 1060

  Fly  1433 EYDSLNIETTAYALLVYVARREFFVD-PIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRL 1496
               |.::|.|:||||.:|...:.... ||:|||.:|:......:..:.|...||||
Mosquito  1061 ---SNSVEATSYALLSHVLVNKLLAALPIMRWLVNQKSEIDSVSGQETTYLRLKAL--------- 1113

  Fly  1497 REVSSLTVEIEASSQGGKTQTLYIDDTNLAK-------LQSIEIPDAWGTIKVQAKGAGYAILQM 1554
               |.:|.:|..|......|..|...|.|.:       :|:|..|.....||:..:|.|..:|::
Mosquito  1114 ---SRMTKKISPSRNDYMVQLKYKQSTRLLRFDSYRNMIQNITTPQDVRKIKITVEGIGVGLLEV 1175

  Fly  1555 HVQYNVDIEKFQTKPPVPAFGLHTKAIFHGRNQSHISYVACQNWINQNESERSGMAVLDVAIPTG 1619
            ..:|.:::..|:.:..:.....:|.      :.:.:....|.|:|.......|.|.:::|.:|:|
Mosquito  1176 MYKYRLNLVNFEHRFQLDLQKQNTS------SDNELRLNVCANYIPTLRDSHSNMTLIEVTLPSG 1234

  Fly  1620 YWIQQQKLDTYVLSNRVRNLRRARYLERKIVFYFDYLDHEDICVNFTIERWYPVANMSRYLPVRI 1684
            |.:.:..:......|.::|: ..||....:|.|:..:..|..|...|..|.:.|| :.|...|.:
Mosquito  1235 YVVDRNPISEQTTVNPIQNM-EIRYGGTSVVLYYYNMGTERNCFTVTAYRRFKVA-LKRPAYVVV 1297

  Fly  1685 YDYYAPERFNESIFDALPTYLL---NICEVCGSSQC 1717
            ||||...:      :|:..|.:   |:||:|....|
Mosquito  1298 YDYYDTNQ------NAIKVYEVDKQNVCEICDVCDC 1327

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	YfaS	<226..1575	CDD:441940	284/1416 (20%)
		A2M_BRD	667..801	CDD:462235	34/140 (24%)
		A2M	939..1030	CDD:459711	27/91 (30%)
		TED_complement	1160..1490	CDD:462227	76/345 (22%)
		A2M_recep	1605..1699	CDD:462226	24/93 (26%)
LOC1278851	XP_318490.3	None