DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcr and Pzp

DIOPT Version :9

Sequence 1:	NP_524688.1	Gene:	Mcr / 44071	FlyBaseID:	FBgn0267488	Length:	1760	Species:	Drosophila melanogaster
Sequence 2:	NP_031402.3	Gene:	Pzp / 11287	MGIID:	87854	Length:	1495	Species:	Mus musculus

Alignment Length:	1688	Identity:	370/1688 - (21%)
Similarity:	666/1688 - (39%)	Gaps:	347/1688 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 EPTYFIVASRMVRPGLIYQVSVSI----------LQAQYP------ITVHA----SIACDGVQIS 173
            :|.|.::....|..|:..:..||:          |..:|.      :|..|    |..|....||
Mouse    28 KPQYVVLVPSEVYSGVPEKACVSLNHVNETVMLSLTLEYAMQQTKLLTDQAVDKDSFYCSPFTIS 92

  Fly   174 GDSKDVKEGIPETLLMRIPPTSVTGSYKLRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTDK 238
            |..              :|.|.:|    :.::|..|.      |:.:..:...:....:||||||
Mouse    93 GSP--------------LPYTFIT----VEIKGPTQR------FIKKKSIQIIKAESPVFVQTDK 133

  Fly   239 PLYMQGETVRFRTIPITTELKGFDN--PVDVYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPT 301
            |:|..|:.|:||.:.:....:..:.  || ||:..|.|:.:.:|.:.....|...|.:.||.:|.
Mouse   134 PIYKPGQIVKFRVVSVDISFRPLNETFPV-VYIETPKRNRIFQWQNIHLAGGLHQLSFPLSVEPA 197

  Fly   302 FGEWTIRVIAQ---GQQEESHFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRG 363
            .|.:  :|:.|   |::.|..|.|:||...:|||.:.|.......:..:.......:|.|.||.|
Mouse   198 LGIY--KVVVQKDSGKKIEHSFEVKEYVLPKFEVIIKMQKTMAFLEEELPITACGVYTYGKPVPG 260

  Fly   364 NLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGAD 428
            .:|::..             .||              .|:|....|||   ..::..:..|...|
Mouse   261 LVTLRVC-------------RKY--------------SRYRSTCHNQN---SMSICEEFSQQADD 295

  Fly   429 LSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLR 493
                                                    .|.:|:.:.     ...|..:....
Mouse   296 ----------------------------------------KGCFRQVVK-----TKVFQLRQKGH 315

  Fly   494 ELELLVPNLANSEVLITATVGEKFYDEIISGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYLA 558
            ::          ::.:.|.:.|:.....::|.....:.|:..::.|...:.. ::|.:||:..:.
Mouse   316 DM----------KIEVEAKIKEEGTGIELTGIGSCEIANALSKLKFTKVNTN-YRPGLPFSGQVL 369

  Fly   559 VEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLPMSQQSDGIWEVKIDIRNDLNLDDR 623
            :....|.|| ||.....::...|::..              .:....|:..:.||..|    ...
Mouse   370 LVDEKGKPI-PNKNITSVVSPLGYLSI--------------FTTDEHGLANISIDTSN----FTA 415

  Fly   624 PQARDFLNGVQNMRLQAN-FVDPRGERIQTELLLVSHYSPRNQHIKVTTSTEKPVVGEYIIF--- 684
            |..|..:...||.....| ::|....:......||  :||...:|::.           ::|
Mouse   416 PFLRVVVTYKQNHVCYDNWWLDEFHTQADHSATLV--FSPSQSYIQLE-----------LVFGTL 467

  Fly   685 ------HIRTNFYLEE----------FNYLIMSKGVI------LVNDRETITEGIKTIAVVLSSE 727
                  .||.::.|.|          |.|||.::|.|      :::..:...:|:.::.:.:...
Mouse   468 ACGQTQEIRIHYLLNEDIMKNEKDLTFYYLIKARGSIFNLGSHVLSLEQGNMKGVFSLPIQVEPG 532

  Fly   728 MAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYINNRKARTGEKVEVAIFGEPGSYVGLS 792
            |||.|.::::.|....::|||:..|.:.....|...:...:.::.......:.:...|.|...|:
Mouse   533 MAPEAQLLIYAILPNEELVADAQNFEIEKCFANKVNLSFPSAQSLPASDTHLKVKAAPLSLCALT 597

  Fly   793 GIDSAFYTMQAGNELTYAKIITKMSNFDEQTNGTY--KHIWYSHEG-------NPDELVYFPASS 848
            .:|.:...::...:|:...|...:..  :...|.:  ..::..||.       ..:.:||.|..|
Mouse   598 AVDQSVLLLKPEAKLSPQSIYNLLPG--KTVQGAFFGVPVYKDHENCISGEDITHNGIVYTPKHS 660

  Fly   849 FG-VDANRTFEYSGLIVFTDG------------YVPRRQDTCNRTLGFGECLSGRCYR-LEKQCD 899
            .| .||:..|:..|:.:||:.            :.|.......:.|.......|..:| :.....
Mouse   661 LGDNDAHSIFQSVGINIFTNSKIHKPRFCQEFQHYPAMGGVAPQALAVAASGPGSSFRAMGVPMM 725

  Fly   900 GLFDCDDGTDEINCHARNDTELLNYRKYRFNRVLRHYENVWLWKDVNIGPHGRYIFNVEVPDRPA 964
            ||    |.:||||       :::..|:    .|.:::...|:|..|.:...|.....|:|||...
Mouse   726 GL----DYSDEIN-------QVVEVRE----TVRKYFPETWIWDLVPLDVSGDGELAVKVPDTIT 775

  Fly   965 YWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVV 1029
            .|..|||.:|.:.|.| ::..:.....||||:.:.:|.:..:||...::.||.|||...|:..|.
Mouse   776 EWKASAFCLSGTTGLG-LSSTISLQAFQPFFLELTLPYSVVRGEAFTLKATVLNYMSHCIQIRVD 839

  Fly  1030 LHDSPDYKFVHV------------EEDGIVRSYNPRTSFGEHQFFIYLEAQGTTVVYVPVVPQRL 1082
            |..|||:..|.|            |...:..:..|: |.||..|....||..:        |:..
Mouse   840 LEISPDFLAVPVGGHENSHCICGNERKTVSWAVTPK-SLGEVNFTATAEALQS--------PELC 895

  Fly  1083 GNVDVTLHVATLLGTDTITRTLHVESDGLPQYRHQSVLL-----DLSNRAYVLEYMHVNVTQTPE 1142
            ||  ....|..|:..||:.:::.||.:|:.:.:..:.||     :|.:            ..:.|
Mouse   896 GN--KLTEVPALVHKDTVVKSVIVEPEGIEKEQTYNTLLCPQDTELQD------------NWSLE 946

  Fly  1143 IPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNASSLLSLPMESGEQNAFSFAANLYTIMYMR 1207
            :|..|    |.||.:|..||:||::|....    |..:||.:|...||||...|..|:|.:.|:.
Mouse   947 LPPNV----VEGSARATHSVLGDILGSAMQ----NLQNLLQMPYGCGEQNMVLFVPNIYVLNYLN 1003

  Fly  1208 LINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLF-RSDWNNSDSSVWLTSYCLRVFQEASFY 1271
            ...|..:.::..|..::..||||||::...|||:|.| .....|:..:.|||::.|:.|.:|
Mouse  1004 ETQQLTEAIKSKAINYLISGYQRQLNYQHSDGSYSTFGNHGGGNTPGNTWLTAFVLKAFAQA--- 1065

  Fly  1272 EWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPDRKMNRTNFDKNITLTSHVLITLATVK- 1335
              ::.|:|:.|.|.....||...|...|.|.:..:|.:..| :...|..:||::::.|.|..:.
Mouse  1066 --QSHIFIEKTHITNAFNWLSMKQKENGCFQQSGYLLNNAM-KGGVDDEVTLSAYITIALLEMPL 1127

  Fly  1336 DISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDVAITAYALQLC-NSPIAEEVFAILRRQAR 1399
            .::.:.........:.|.|.|.::     .::..:..|:.|||..|. |.....|:...|.:.|.
Mouse  1128 PVTHSAVRNALFCLETAWASISQS-----QESHVYTKALLAYAFALAGNKAKRSELLESLNKDAV 1187

  Fly  1400 TIGDFMYWGNQEIPQPPRKLENQKWFSL--PRLPYEYDSLNIETTAYALLVYVARRE-------- 1454
            ...|.::|      |.|..::..|..|.  ||.|    |..:|.|||.||.|:....
Mouse  1188 KEEDSLHW------QRPGDVQKVKALSFYQPRAP----SAEVEMTAYVLLAYLTSESSRPTRDLS 1242

  Fly  1455 ----FFVDPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQGGKT 1515
                .....||:|::.|:.:.||::|||||..||:||.:|...:..|....:.|.||:|  |..:
Mouse  1243 SSDLSTASKIVKWISKQQNSHGGFSSTQDTVVALQALSKYGAATFTRSQKEVLVTIESS--GTFS 1305

  Fly  1516 QTLYIDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNVDIEKFQTKPPVPAFGLHTKA 1580
            :|.:::..|...||.:.:||..|....:..|:|...||..::||: :.....|.|. |..::|..
Mouse  1306 KTFHVNSGNRLLLQEVRLPDLPGNYVTKGSGSGCVYLQTSLKYNI-LPVADGKAPF-ALQVNTLP 1368

  Fly  1581 IFHGRNQSHISYVACQNWINQNESERSGMAVLDVAIPTGY--------WIQQQKLDTYVLSNRVR 1637
            :...:...|.::....|.....|...|.|.::||.:.:|:        .:|.|.
Mouse  1369 LNFDKAGDHRTFQIRINVSYTGERPSSNMVIVDVKMVSGFIPMKPSVKKLQDQP----------- 1422

  Fly  1638 NLRRARYLERKIVFYFDYLDHEDICVNFTIERWYPVANMSRYLPVRIYDYYAPERFNESIFDA 1700
            |::|.......::.|.:.|.::.:..:|.:|:..||.|: :..|:::||||..:.|....:.|
Mouse  1423 NIQRTEVNTNHVLIYIEKLTNQTLGFSFAVEQDIPVKNL-KPAPIKVYDYYETDEFTVEEYSA 1484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	A2M_N	232..332	CDD:280081	34/104 (33%)
		A2M_N_2	669..799	CDD:285005	26/154 (17%)
		LDLa	886..913	CDD:238060	8/27 (30%)
		A2M	940..1030	CDD:278630	29/89 (33%)
		ISOPREN_C2_like	1177..1490	CDD:298658	92/329 (28%)
		A2M_comp	1226..1492	CDD:284982	79/282 (28%)
		A2M_recep	1607..1695	CDD:284981	22/95 (23%)
Pzp	NP_031402.3	A2M_N	127..219	CDD:280081	30/94 (32%)
		A2M_N_2	460..605	CDD:285005	26/155 (17%)
		Bait region	686..744		12/72 (17%)
		A2M	750..840	CDD:278630	29/90 (32%)
		A2M_2	970..1282	CDD:239227	92/336 (27%)
		A2M_comp	1022..1284	CDD:284982	79/282 (28%)
		A2M_recep	1395..1482	CDD:284981	22/98 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	41	1.000	Domainoid score	I12441
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920