Protein Alignment Mcr and LOC108647609

DIOPT Version :9

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: XP_031758762.1
• Gene: LOC108647609 / 108647609
• -ID: -
• Length: 1389
• Species: Xenopus tropicalis
• Alignment Length: 1636
• Identity: 376/1636 - (22%)
• Similarity: 616/1636 - (37%)
• Gaps: 357/1636 - (21%)

  Fly   131 TYFIVASRMVRPGLIYQVSVSILQAQY-PITVHASIACDGVQ-ISGDSKDVKEGIPETLLMRIPP 193
            :|:|.|..:|..|:...:||....:.| .|.|.|.|....|. :.......|:.|.   :|.||.
 Frog    27 SYYISAPNIVSSGINTTLSVHWFGSSYSEINVTAGILHQDVTVVQATQVFQKDSIG---IMSIPA 88

  Fly   194 TSVTGS-YKLRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTDKPLYMQGETVRFRTIPITTE 257
            |.:..| |.|.|.|...|   .|.|.|...|...|.....|::|||..|...|||:.|.|.:.|:
 Frog    89 TPLDSSNYFLFVNGSAGN---ELIFSNNFGLTIKQIQTKTFIETDKKNYRPQETVKIRIITVYTD 150

  Fly   258 LKGFDNPVDVYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFGEWTIRVIAQGQQEESHFTV 322
            |..:..|:::|:.|.:..|:|:.|::.:.||..|.|..|..:...|..:|.....|.:......|
 Frog   151 LTPYKGPINIYIRDSSYDIIKQILNQNTELGVFSTEVLLPAKSALGSLSISAGPNGYESYESIVV 215

  Fly   323 EEYYQTRFEVNVTMPAYFF--TTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNEK 385
            .:.....|:|.:..|:|::  :...|: |:|.||:::|.||:|.:|:.             ||
 Frog   216 VQNEPPDFDVTIVAPSYYYKQSKQDFV-GKVFANYSNGRPVKGTVTLS-------------LN-- 264

  Fly   386 YRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRNQYVVERHYQFDEE 450
                   .:..|:|               .|:   ..|:|..|:::  ::.....|...:.:.|.
 Frog   265 -------FDTYNIY---------------YYD---SYPEDLTDVNK--IFEIYGSVNFSFSYSEA 302

  Fly   451 W--PFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEVLITATV 513
            :  |||.|                                                  :::||:|
 Frog   303 FKCPFWQR--------------------------------------------------LILTASV 317

  Fly   514 GEKFYDEIISGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSPIDPNLLRQGLME 578
            .|:...:.::.....:...|..|:..:|.....| |....|..:.::..|.
 Frog   318 TEEKTGKTVTASWYIQRATSQYRIFVVGQLDYSF-PNQAITAKIQIQRSDD-------------- 367

  Fly   579 VSGFVESRNGGRRDWPAQRLPMSQQSDGIWEVKIDIRNDLNLDDRPQARDF---LNGVQNMRLQA 640
                               ||::|:.... .|.|...|.|     |..|.:   .:|:.|  :|.
 Frog   368 -------------------LPLTQEEMNT-NVLITFGNYL-----PITRTYSISASGILN--IQI 405

  Fly   641 NFVDPRGERIQTELLLVSHYSPRNQH--IKVTTSTEKPVVGEYIIFHIRTNFYLEEFNYLIMSKG 703
            .|.|               ||..:.|  :...|:|.|....::.:|...|.::    |..:..||
 Frog   406 PFYD---------------YSFHSSHSYVLYMTATYKDSTHQWTVFTPDTWYW----NPAVNIKG 451

  Fly   704 VILVNDRETITEGIK-TIAVVLSSEMAPVATIVVWKINQQGQVVAD--------SLTFPVNGISR 759
                 ....:..||. ||:|    ...|....|.:.::..|.:||.        :||...:.:..
 Frog   452 -----PDTPVQTGIPFTISV----GTVPEVQYVYYVVSGGGVIVAAGKTSNSSFTLTAETSWLPS 507

  Fly   760 NNFTVYINNRKARTGEKV--EVAIFGEPGSYVGLS-----GIDSAFYTMQAGN--------ELTY 809
            ...|.|..|...|.|..:  ...||...|:.|.||     ...|.:.::...|        .|..
 Frog   508 VQVTAYFINPDERFGSDIGFNTKIFHITGNKVALSWSKSKAKPSEYVSLTISNITKTPAIVGLKV 572

  Fly   810 AKIITKMSNFDEQTNGTYKHIWYSHEGNPDELVYFPASSFGVDANRTFEYSGLIVFTDGYVPRRQ 874
            |.|..|:|.   .||.....:...:.||.    |.|.|    |.|....||
 Frog   573 ADINDKLSG---NTNSLAAKVENIYSGNS----YSPYS----DGNIGDPYS-------------- 612

  Fly   875 DTCNRTLGFGECLSGRCYRLEKQCDGLFDCDDGTDEINCHARNDTELLNYRKYRFNRVLRHYENV 939
                             |.|:     |...|...|.||       :.:|.|..        ....
 Frog   613 -----------------YGLQ-----LHSNDPNNDPIN-------QPVNLRPL--------IPET 640

  Fly   940 WLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEAC 1004
            |:|.:.:|.........|.:|.:...|:.|||.:|...|.|:..:..|....||..:.:..|...
 Frog   641 WIWLETHISSGVNSSLQVTLPHKVMTWVASAFVISEGLGLGVSEQYPELEVFQPLLLTLNAPRTV 705

  Fly  1005 RQGEQVGIRVTVFNYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSYNPRTSFGEHQFFIYLEAQG 1069
            .:||...::||:..|:.|..:..|:|..|..::.       |:...|..:..|:...||  ::.|
 Frog   706 IRGENFILKVTLEAYIATDFQVTVMLEPSSSFEI-------IIPDNNTNSVPGQRSVFI--QSNG 761

  Fly  1070 TTVVYVPVVPQRLGNVDVTLHVATLLGTDTITRTLHVESDGLPQYRHQSVLLDLSNRAYVLEYMH 1134
            :..|..|:.|::||.:.:|:....|..:|:.|:|:.|:::|:..:...||:|
 Frog   762 SKEVLFPINPKKLGEMSLTVQANALGFSDSATQTVLVKAEGIQHFYSSSVIL------------- 813

  Fly  1135 VNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNASSLLSLPMESGEQNAFSFAAN 1199
             |.|...::.:......|..:.:|.:|:.|:.:.|....:    .||:.||...||||...||..
 Frog   814 -NGTDGKKLSFTFPVDVVVDTKQASLSITGNFLAPSIKGL----ESLIQLPTGCGEQNMIHFAPV 873

  Fly  1200 LYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRV 1264
            :|.:.|:....|..:.....|...|..|||.:|::....||||.|.|  .:..:|.||:::.||.
 Frog   874 IYILQYLIASKQITEDFRTKAIRFMEKGYQTELNYQTYYGSFSAFGS--TDFPASTWLSAFVLRC 936

  Fly  1265 FQEASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPDRKMNRTNFDKNITLTSHVLI 1329
            ..:|     ..||.|...::.:..:||..:...:...|:.:  ......|.....|..:..:..|
 Frog   937 LLQA-----RQFISISEDVLSRTKKWLFFNLNEETGIFQES--EQILKTRLQVGSNGVIAHNAYI 994

  Fly  1330 TLATVKDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDVAITAYALQLCNSPIAEEVFAIL 1394
            .:|.::|.|   ...||....:.:.|:|...:  ......:.::|.||||.:.||..|......|
 Frog   995 LIALLEDES---NKNVAYRMNKTIQYLENKTE--EGITSNYTLSIVAYALSVANSSKAAAALTQL 1054

  Fly  1395 RRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVARREFFVD- 1458
            ..:|.:.|...||.:...|       :..|..|        |.:|||.|||||.:..:......
 Frog  1055 NSRANSTGLQRYWSSGIDP-------SNDWQPL--------SADIETAAYALLSHCQQNRIAEGV 1104

  Fly  1459 PIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQGGKTQTLYIDDT 1523
            ||:.||:..|.:.||::|||||..||:||.::.........:||||.: ..|......|..|.:.
 Frog  1105 PIMNWLSQHRNHLGGYSSTQDTIMALQALTKFMTLVPTSNNTSLTVSV-TDSGSIVPNTFNITNE 1168

  Fly  1524 NLAKLQSIEI----PDAWGTIKVQAKGAGYAILQMHVQYN-----VDIEKFQTKPPVPAFGLHTK 1579
            ||..:||.:|    |   ..:.|.|.|.|.|:||::|.||     |..|.|:....|.....|.:
 Frog  1169 NLLVVQSQQIYALEP---LELVVSAAGEGAALLQLNVVYNSKGEAVPSEVFKLSATVDDSDSHNR 1230

  Fly  1580 AIFHGRNQSHISYVACQNWINQNESERSGMAVLDVAIPTGYWIQQQKLDTYVLSNRVRNLRRARY 1644
                      ||...|.::  |...:..||.:.:|.:.:|:     |||. |..|....|:....
 Frog  1231 ----------ISVNVCSSY--QGPEKEPGMILWEVDMLSGF-----KLDP-VGINLNDPLKLVET 1277

  Fly  1645 LERKIVFYFDYLDHEDICVNFTIERWYPVANMSRYLPVRIYDYYAPERFNESIFDALPTYLLNIC 1709
            .:.|:..|||.::..:.||...:.|...|......| :.|.|||.||.....|:::.......:|
 Frog  1278 KDEKVFLYFDSMNAIENCVAVPMVRTSMVVGSQPAL-ITILDYYNPEIRTTRIYNSDKLSKATVC 1341

  Fly  1710 EVCGSSQCPYC 1720
            |.||.: |..|
 Frog  1342 EFCGLN-CNNC 1351

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	A2M_N	232..332	CDD:280081	28/99 (28%)
		A2M_N_2	669..799	CDD:285005	32/145 (22%)
		LDLa	886..913	CDD:238060	6/26 (23%)
		A2M	940..1030	CDD:278630	23/89 (26%)
		ISOPREN_C2_like	1177..1490	CDD:298658	88/313 (28%)
		A2M_comp	1226..1492	CDD:284982	73/266 (27%)
		A2M_recep	1607..1695	CDD:284981	25/87 (29%)
LOC108647609	XP_031758762.1	YfaS	54..1112	CDD:225248	292/1344 (22%)
		ISOPREN_C2_like	848..1136	CDD:415487	88/320 (28%)
		A2M_recep	1247..1330	CDD:400149	25/89 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010