DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcr and LOC108646250

DIOPT Version :9

Sequence 1:	NP_524688.1	Gene:	Mcr / 44071	FlyBaseID:	FBgn0267488	Length:	1760	Species:	Drosophila melanogaster
Sequence 2:	XP_031755350.1	Gene:	LOC108646250 / 108646250	-ID:	-	Length:	1656	Species:	Xenopus tropicalis

Alignment Length:	1675	Identity:	394/1675 - (23%)
Similarity:	657/1675 - (39%)	Gaps:	443/1675 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 YQNVFGGLAFLNE-TRLDFSQRSMTIFVQTDKPLYMQGETVRFRTIPITTELKGFDNPVDVYMLD 271
            |.:|..|...|.: ..|.:|  |..||:||||.:|..|..|.:|...:..::.....|:.|..|:
Frog   102 YVSVSSGSCTLEKAVMLQYS--SGYIFIQTDKTIYTPGSKVMYRVFSMNYKMNPITKPMVVEFLN 164

  Fly   272 PNRHILKRWLSRQSNLGSVSLE-YKLSDQPTFGEWTIRVIAQGQQEESHFTVEEYYQTRFEVNVT 335
            |:..::.|...|.::...:|.| |.|....:.|.||:    ..:.|:   |.::.|.|.|||...
Frog   165 PDGIVVMRETFRPTSKSGISSETYDLPKLVSVGIWTV----SAKYED---TPQQDYTTNFEVKEY 222

  Fly   336 MPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYN 400
            :                      ||     ||:.|::|...|
Frog   223 V----------------------LP-----TIEVTLKPENTF----------------------- 237

  Fly   401 ERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRNQYVVERHYQFDEEWP--------FWVRK 457
                           |.:|.:      ..|.||        |.||.|..  |        |.|:|
Frog   238 ---------------YYIPSE------KFSVDI--------EAHYLFGR--PVEGHAFVLFGVQK 271

  Fly   458 PEYQDSSYEAWS------GTYRKTLP--YLRYFNGTFDFKWPLRELELLVPNLANSEVLITATVG 514
            ...:....|:.:      |..|..|.  :||.:         |..:|:|...|..:..:.|||..
Frog   272 DGTRTGIPESLARVQINKGKGRAELKGVHLRKY---------LNAVEMLNYKLYMTVSVATATGT 327

  Fly   515 EKFYDEIISGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSPID--PNLLRQGLM 577
            :....::...|.|:..|    |::| ..|||.|||.:.:...:.|...||||.:  |.::..|
Frog   328 DMVEAQLEEIYIVSSPY----RILF-SKSPQYFKPGLSYDLTVLVTNPDGSPANQIPVVVHPG-- 385

  Fly   578 EVSGFVESRNGGRRDWPAQRLPMSQQSDGIWEVKIDIRNDLNLDDRPQARDFLNGVQNMRLQANF 642
            .:.|  |::..|     ..||.::.| :|:..:.|.::.|            ..|||........
Frog   386 NIRG--ETQADG-----TARLKLNTQ-EGMAAMNISVKTD------------KKGVQPQHQATAT 430

  Fly   643 VDPRGERIQTELLLVSHYSPRNQ-HIKVTTSTEKPVVGEYII-FHIRTNF-----YLEEFNYLIM 700
            :..:..|        ..||..|. ||.|..| |..:.|..|: |:|:|:.     ....|.||:|
Frog   431 MSAKAYR--------PSYSFNNYLHISVPGS-ELKLGGTLIVTFYIKTDSPDVAEQTRHFTYLVM 486

  Fly   701 SKG-VILVNDRE-TITEGIKTIAVVLSSEMAPVATIVVWKI--NQQGQ-VVADSL---------- 750
            |:| :|.|..|| :..:.:..:::.::.:..|...||.:.:  ..:|: :|:||:
Frog   487 SRGRIIKVGRRERSPNQPVVAMSLNITEDYLPSFRIVAYYMVTTTKGRDIVSDSVWVDVVDTCMG 551

  Fly   751 TFPVNGISRNNFTVYINNRKARTGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKIITK 815
            |..|.|....      :|...:....|::.:..:..:.|||..:|...:.:....:||.:|:...
Frog   552 TLEVTGYKDK------DNEVQKLPASVQLKLRADHKANVGLVIVDKGVFLLNKKYKLTQSKVWDS 610

  Fly   816 MSNFDEQ-TNGTYKHIWYSHEGNPDELVYFPA-----SSFGVDANRTFEYSGLIVFTDGYVPRRQ 874
            :...|.. |.|:         |...|.|::.|     :||.|..::..|            |:.:
Frog   611 VEKSDTGCTPGS---------GANSEGVFYDAGLALQTSFSVTTDQRIE------------PQCK 654

  Fly   875 DTCNR----TLGFGE----------------CLSG--------RC-----YRLE-KQC-DGLFDC 904
            |...|    |:...|                ||.|        .|     |.|: |:| |...||
Frog   655 DRAPRKRRSTVALMEIKNRKASEYKDKAKQCCLDGMQENLMGHSCERRTRYILDGKECVDAFLDC 719

  Fly   905 ---------DD--GTDEINCHARNDTELLNYRKYRFNRVLRHYENVWLWKDVNI-GPHGR----- 952
                     |:  ..|| :..||:: |..||..|....:...:...|.|::..: |...:
Frog   720 CKYYEKRREDERKSKDE-DTLARSE-EDTNYMLYSEIDIRSDFPESWFWREEEMTGAADKDKIST 782

  Fly   953 YIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVF 1017
            .|.||::.|....|.|.|.|:|.:||. .:....|...::.|||::::|.:..:.|||.||..|.
Frog   783 KILNVQLKDSITTWEVLAVSLSENKGL-CVAPPYEIKAMKDFFIDLKLPYSVVRNEQVEIRAVVH 846

  Fly  1018 NYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSY----NPRTSFGEHQFFIYLEAQGTTVVYVPVV 1078
            ||....|:.:|              |.|..:.:    .|:..|.:.   :::.|:.:.||...:|
Frog   847 NYNSNRIKVLV--------------EFGYNKEFCSLSKPKKKFRQE---VWVGAESSAVVPFVIV 894

  Fly  1079 PQRLG--NVDVTLHVATLLGTDTITRTLHVESDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQTP 1141
            |..||  .|:|...:.....:|.|.:.|:|..:||        ||..:....:||         |
Frog   895 PLELGQHEVEVKAAIYKQFKSDGIRKKLNVVPEGL--------LLSKTLNFVILE---------P 942

  Fly  1142 EIPYQ--VDRYFVYGSNKARISVVGDV-VGPIFPTMPVN-----------ASSLLSLPMESGEQN 1192
            |:..:  |....:...:...|....|: :..|....|::           ...|:..|:.|||||
Frog   943 EVKGKGGVQEVKIKALSAPNIVPKSDIDIKVILQGTPISQLVESAIDGSKLRHLIQKPVGSGEQN 1007

  Fly  1193 AFSFAANLYTIMYMRLINQRNKT-LEKNAFYHMNI--GYQRQLSFMRPDGSFSLFRSDWNNSDSS 1254
            ..:...|:.|..|:....|..:. :::.|....||  ||||:|::.:||.||:.|:    |..||
Frog  1008 MMTMTTNVITTRYLDATAQWQRVGVDRRATAIGNIKHGYQRELAYRKPDSSFAAFQ----NRPSS 1068

  Fly  1255 VWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLL-QHQTPQGSFFEVTWLPDRKMNRTN-- 1316
            .|||:|..:||  |..||   :.:||..::...:.||| :.|.|.|.|.|...:..::|...|
Frog  1069 TWLTAYVAKVF--AMSYE---YTYIDDNVLCGAINWLLKERQMPDGMFIEHGLVIHKEMVGGNKK 1128

  Fly  1317 --FDKNITLTSHVLITLATVKDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDVAITAYAL 1379
              .:.:..||:.|||.:...:::.....||:..|..||..::......||   :|:.||||:|||
Frog  1129 GAAEPDAALTAFVLIAMLESRELCTQQLSRLGDAINRATNFLRGKYSQLR---KPYSVAITSYAL 1190

  Fly  1380 QLCNSPIAEEVFAILRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDS--LNIETT 1442
            .|...  .::...:|  .|.|  |..:|                        .|.||  :.:|.|
Frog  1191 ALAGK--LQDTNTLL--NAAT--DKSHW------------------------KEPDSSFITLEAT 1225

  Fly  1443 AYALLVYVARREFFVDP---IVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTV 1504
            :||||..:..::.  ||   ||||||.||.....::|||.|....:||.:|  ::.:..||.|.:
Frog  1226 SYALLTLLKVKQH--DPTGAIVRWLNEQRYYGAAYSSTQATIIVFQALAQY--QTDVPNVSDLNM 1286

  Fly  1505 EIEASSQGGKTQ-TLYIDDTN--LAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQY-------- 1558
            :|.......|.. ::.|::.|  :.:|:...|..   ...|:|||.|.|:|.:...|
Frog  1287 DISVCLPEKKDPVSIRINNENALMPRLEETAINQ---DFVVKAKGKGQALLTVVSVYHALTTEKQ 1348

  Fly  1559 ----NVDI-----EKFQTKPP---VPAFGLHTKAIFHGRNQSHISYVACQNWINQNESERSGMAV 1611
                |.|:     |:...|.|   |.|                :|...|..::...::.   |::
Frog  1349 MECKNFDLSVTVNEEKNLKLPDGVVAA----------------VSIEVCARYLRNPDAT---MSI 1394

  Fly  1612 LDVAIPTGYWIQQQKLDTYVLSNRVRNLRR--ARYLERK-------IVFYFDYLDH-EDICVNFT 1666
            :|:::.||:     ..||..|:|.::...:  ::|...|       ::.|.|.:.| |..||.|.
Frog  1395 VDISMMTGF-----SPDTNSLNNLMKGADKYISKYEINKGANERGTLILYLDKISHTEPECVKFY 1454

  Fly  1667 IERWYPVANMSRYLPVRIYDYYAPERFNESIFDALPTYLL--NIC--EVC 1712
            ..:::.| .:.:...|.:||||.||......:....:..|  .||  :||
Frog  1455 AHQYFAV-GLIQPASVTVYDYYTPENRCTKFYHVKESSALYGKICQGDVC 1503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	A2M_N	232..332	CDD:280081	28/100 (28%)
		A2M_N_2	669..799	CDD:285005	34/150 (23%)
		LDLa	886..913	CDD:238060	14/52 (27%)
		A2M	940..1030	CDD:278630	29/95 (31%)
		ISOPREN_C2_like	1177..1490	CDD:298658	99/336 (29%)
		A2M_comp	1226..1492	CDD:284982	87/277 (31%)
		A2M_recep	1607..1695	CDD:284981	25/97 (26%)
LOC108646250	XP_031755350.1	MG1	19..118	CDD:407662	4/15 (27%)
		A2M_N	124..219	CDD:396416	28/101 (28%)
		MG3	221..304	CDD:407663	26/163 (16%)
		MG4	346..436	CDD:407661	26/112 (23%)
		A2M_N_2	446..596	CDD:400170	36/156 (23%)
		ANATO	670..733	CDD:237984	12/62 (19%)
		A2M	763..858	CDD:395153	29/109 (27%)
		complement_C3_C4_C5	989..1274	CDD:239226	99/328 (30%)
		A2M_recep	1390..1485	CDD:400149	25/103 (24%)
		NTR_like	1505..1654	CDD:413349
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010