Protein Alignment Mcr and LOC101730963

DIOPT Version :10

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: XP_031761242.1
• Gene: LOC101730963 / 101730963
• XenbaseID: XB-GENE-29084979
• Length: 1477
• Species: Xenopus tropicalis
• Alignment Length: 1717
• Identity: 369/1717 - (21%)
• Similarity: 653/1717 - (38%)
• Gaps: 416/1717 - (24%)

  Fly   116 NIKATFLESLHSREPTYFIV-ASRMVRPGLIYQVSVSILQAQYPITVHASIACDGVQISGDSKDV 179
            ::..|....||     |.:: .|.:|.|                   |:..||  |.:||...|.
 Frog    15 HLSGTLEAKLH-----YVVIFPSELVAP-------------------HSEQAC--VHLSGAEGDS 53

  Fly   180 KEGIPETLLM-----------------------RIPPTSVTGSYKLRVEGFYQNVFGGLAFLNET 221
            :  |..||.|                       ::||.|........:|...::  .|....|.:
 Frog    54 R--IQVTLNMAERNSTVIERNLQQKSLFSCVTFQVPPPSEGNEEVATMEILIES--AGETITNSS 114

  Fly   222 RLDFSQRSMTIFVQTDKPLYMQGETVRFRTIPITTELKGFDNPVDV-YMLDPNRHILKRWLSRQS 285
            ::...:|..:.|:||||.||..|:||:.|.:.:...|:..:....| |:.|||:..:..|.:...
 Frog   115 KVLVRKRRTSTFIQTDKVLYKPGDTVQIRVVNLEENLQLKETRFRVIYIQDPNQRHIAWWQNVNL 179

  Fly   286 NLGSVSLEYKLSDQPTFGEWTIRVIAQGQQEESHFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGR 350
            ..|...|.:.||.:|:||.:.|.|   |..:: ||.|..:...::||....|....:.......:
 Frog   180 TQGIAELSFPLSPEPSFGFYYIHV---GDIKQ-HFFVTRFALHKYEVVFQFPKAVLSNSEQFQLK 240

  Fly   351 VMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQ 415
            :...:.:|.||:|  |.:||:.                             ||.::
 Frog   241 ICGRYPNGQPVQG--TYQATVC-----------------------------RWAFS--------- 265

  Fly   416 YNVPGQLPQDGADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKT-LPYL 479
                              :|.:     ||::            .:.|...: :||...:: ...|
 Frog   266 ------------------VYWS-----RHFK------------NFSDLCVD-FSGKLEQSGCSIL 294

  Fly   480 RYFNGTFDFKWPLRELELLVPNLANSEVLITAT---VGEKFYDEIISGYSVARVYNSSLRVVFLG 541
            :..:.||...:...|::|        |.:.|.|   .|.|:     ||.....:........||
 Frog   295 QVKSDTFRIAYNTHEMDL--------EGVATITEEETGLKY-----SGRGRTTISPKLKSCRFL- 345

  Fly   542 DSPQVFKPAMPFTTYLAVEYHDGSPIDPN----LLRQGLMEVSGFVESRNGGRRDWPAQRLPMSQ 602
            |....:||.:|::..:.|...:..|: ||    |....:......|...||          .:|.
 Frog   346 DGDITYKPGIPYSGTIKVMDGNDDPL-PNQKVSLTISPMNITENLVSDENG----------LVSF 399

  Fly   603 QSDG--IWEVKIDIRNDLNLDDRPQARDFLNGVQNMRLQANFVDPRGERIQTELLLVSHYSPRNQ 665
            |.|.  .||.|:.:.....::   ::.|..:|:         :.|...:...||.|..  ||...
 Frog   400 QLDNTTAWEGKLRLTASPEME---KSADMYSGL---------IIPVFGKDSLELKLFE--SPSKS 450

  Fly   666 HIKV-TTSTEKPVVG------EYIIFHIRTNFYLE--EFNYLIMSKGVILVNDRETI-------- 713
            .:|: :...|.|..|      ||||.:.......:  |.:||::||..|  .|..::
 Frog   451 FLKLHSQQGELPCEGQRDVRVEYIIPNSALGMEAKHMELHYLVISKESI--KDSGSLEVPITSEG 513

  Fly   714 -----TEGIKTIAVVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYINNRKART 773
                 ..|..:|.:.||::::|....:.:.....|::||||.||.:....:|..:|..:..:...
 Frog   514 GGSSELRGEVSIKLTLSADVSPTLRALAFISLPNGELVADSATFKLQRCFKNKVSVGFSPDEVLP 578

  Fly   774 GEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQTNGTYKHIWYSHEGNP 838
            |..|.:.:....||..||..:|.   .::...::|..:|......|    ||||.   |..:...
 Frog   579 GADVSLQVQAAAGSLCGLRVVDK---IVKPEVDVTADRIHKLFPYF----NGTYD---YRIKDAD 633

  Fly   839 DELVYFPASSFGVDANRTFEYSGLIVFTDGYVPRRQDTCNRTLGFGECLSGRCYRLE-------- 895
            |....  ...:.||....|:...|.:.|:.|..|               ..||:..:
 Frog   634 DNCTL--NQKYRVDVYSLFKDMQLKIVTNAYNKR---------------PSRCWEEDVEEMLYVP 681

  Fly   896 --------KQCDGLFDCD-DGTDEINCHAR--------NDTELLNYRKYRFNR---------VLR 934
                    |....||..: |.|.|:..|..        .|..:|:..||..::         ::|
 Frog   682 NEVYIPYLKARAKLFGVNPDWTVELPTHIEPTPKLSRVEDFSVLSKTKYFRDKDGITKGAAEIIR 746

  Fly   935 -HYENVWLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINV 998
             .....|:|:...:|..||...:...||....|...||.:.|| ||| ::........||||:.:
 Frog   747 VSLPETWIWELAAVGESGRAEVHGSAPDTITEWNAGAFCMGPS-GFG-ISPPTSLRAFQPFFVEL 809

  Fly   999 EMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSYNPRTSFGEHQFFI 1063
            .:|.:..:||...::.:|||.:...|:...:|..|.:.:.               ....:.|:..
 Frog   810 TLPYSVVRGESFTLKASVFNSLKQCIKVQTILLPSQELEL---------------EPCADCQYSS 859

  Fly  1064 YLEAQGTTVVYVPVVPQRLGNVDVTLHVATLL----------------GTDTITRTLHVESDG-L 1111
            .|.|:.:...|..:....||.|::|:....|.                .:||:.:.|.|:..| |
 Frog   860 CLCAEESKTFYWNLKASNLGEVNITVRTEALNTQDMCNNEIAIVPKQGHSDTVIKPLLVQPGGIL 924

  Fly  1112 PQYRHQSVLLDLSNRAY-VLEYMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMP 1175
            .:..|.|::...:.:|: :.|.:.:||.:.          .:.||.:|.|:|:||::|    |..
 Frog   925 VEKSHNSLICRQNAKAHSIKEKISLNVPEN----------ILKGSERAYITVLGDLMG----TAM 975

  Fly  1176 VNASSLLSLPMESGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGS 1240
            .|...||::|:.:|||....||.::|.:.|:...:|.:..::..|...:..||||||:....|..
 Frog   976 QNLDRLLAMPLGNGEQKMIIFAPSIYILQYLENTHQLSPEIQSKAKRLLTDGYQRQLTCKVYDRY 1040

  Fly  1241 FSLFRSDWNNSDSSVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLLQH-QTPQGSFFEV 1304
            :.:||.   .|:.:.||.:|..:.|.:|..|     |:||...|.:.:..|..: :...|.|..|
 Frog  1041 YYVFRP---QSEENSWLNAYVTKSFSKARPY-----IFIDRVQIRQCILLLWNYCKKKCGCFRRV 1097

  Fly  1305 TWLPDRKMNRTNFDKNITLTSHVLITLATVKDISGTLGSRVALATQRALAYIERNMDFLRHQ--- 1366
            ....:..:.....|..::|::::.|.|..                    |.:.:..:.|||.
 Frog  1098 GKRFNNALKGGVDDDELSLSAYISIALMD--------------------AGLSKQGNLLRHALYC 1142

  Fly  1367 --------AQPFDVAITAYALQLC-NSPIAEEVFAILRRQARTIGDFMYWGNQEIPQPPRKLENQ 1422
                    :..:..|:.||...|. ::.:.|.:.|.|..:|......::|  ::||    ..|..
 Frog  1143 LREAAKNVSSAYIQALLAYTFSLSGDNKLREMLLAKLEEKAIRKDGQLHW--EQIP----AFEAF 1201

  Fly  1423 KWFSLPRLPYEYDSLNIETTAYALLVYVA-----RREFFVDPIVRWLNSQRLNDGGWASTQDTSA 1482
            ...|..|.|    |..:|..:|.||...:     ||:  ...||.||:.|:...||:.|||||..
 Frog  1202 NLSSWNRAP----SAEVELASYVLLALRSETKKDRRK--ASEIVNWLSKQQNPYGGFYSTQDTVV 1260

  Fly  1483 ALKALVEYTVRSRLREVSSLTVEIEASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIKVQAKGA 1547
            ||:||.|| ..:...:...:||.:  :|:.|..|..::|.||...||...:||..|...:.|.|:
 Frog  1261 ALQALAEY-AEATFSDKGDVTVTV--TSKTGFHQQFHVDQTNRLLLQKASLPDIPGEYSLSATGS 1322

  Fly  1548 GYAILQMHVQYNVD--------IEKFQTKP------PVPAFGLHTKAIFHGRNQSHISYVACQNW 1598
            |...:|..::||:.        ..:.:|:|      |:...|:          ..:|.|...:
 Frog  1323 GCVYVQTVLRYNIPPPRSDATFSVRVETQPQQCPQEPMKQMGI----------DIYIQYTGSR-- 1375

  Fly  1599 INQNESERSGMAVLDVAIPTGYWIQQQKLDTYVLSNRVRNLRRARYLERKIVFYFDYLDHEDICV 1663
                  |.|.:|:::|.:.:|:...:......|.||.::::.....:   :..|.:.|.|:.:.:
 Frog  1376 ------EESNLALVEVKMLSGFIPVRSTTHQLVSSNTIKHIETQNDV---LALYLNELGHDPVHL 1431

  Fly  1664 NFTIERWYPVANMSRYLPVRIYDYYAP 1690
            :|.:|:...|.|: :...|::||||.|
 Frog  1432 SFMVEQDIVVKNL-KPATVKVYDYYEP 1457

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	YfaS	<226..1575	CDD:441940	321/1466 (22%)
		A2M_BRD	667..801	CDD:462235	36/155 (23%)
		A2M	939..1030	CDD:459711	26/90 (29%)
		TED_complement	1160..1490	CDD:462227	89/347 (26%)
		A2M_recep	1605..1699	CDD:462226	21/86 (24%)
LOC101730963	XP_031761242.1	YfaS	<126..1464	CDD:441940	344/1576 (22%)
		A2M	752..841	CDD:459711	26/90 (29%)
		ISOPREN_C2_like	974..1268	CDD:415487	83/333 (25%)
		A2M_recep	1376..1466	CDD:462226	21/86 (24%)