Protein Alignment Mcr and LOC100492134

DIOPT Version :10

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: XP_031755348.1
• Gene: LOC100492134 / 100492134
• XenbaseID: XB-GENE-29081027
• Length: 1656
• Species: Xenopus tropicalis
• Alignment Length: 1682
• Identity: 385/1682 - (22%)
• Similarity: 642/1682 - (38%)
• Gaps: 445/1682 - (26%)

  Fly   208 YQNVFGGLAFLNE-TRLDFSQRSMTIFVQTDKPLYMQGETVRFRTIPITTELKGFDNPVDVYMLD 271
            |.:|..|...|.: ..|.:|  |..||:||||.:|..|..|......:..::.....|:.:..::
 Frog   102 YVSVSSGSCTLEKAVMLQYS--SGYIFIQTDKTIYTPGSKVMCWVFSMNYKMNPITKPMVIKFVN 164

  Fly   272 PNRHILKRWLSR-QSNLGSVSLEYKLSDQPTFGEWTIRVIAQ-----GQQEESHFTVEEYYQTRF 330
            |:..|:.|...| .|..|..|..|.|....:.|.||  |:|:     .|...::|.|:||.....
 Frog   165 PDGIIVMRETFRPTSKSGIFSKTYALPKLVSPGIWT--VLAKYEDTPQQDYTTNFEVKEYVLPTI 227

  Fly   331 EVNVTMP--AYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNEKYRLGRSPL 393
            || :..|  ::::|:.......:.|::..|.||.|:..:...::..|
 Frog   228 EV-ILKPENSFYYTSSETFSVDIEAHYLFGRPVEGHAFVLFGVQKDG------------------ 273

  Fly   394 EQTNLYNERWRYNNPNQNPQVQYNV-PGQLPQDGADLSQDILYRNQYVVERHYQFDEEWPFWVRK 457
                     .|...|....:||.|. .|:....|..|.
 Frog   274 ---------TRTGIPESLARVQINEGEGRAELKGVHLQ--------------------------- 302

  Fly   458 PEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEVLITATVGEKFYDEII 522
                                  :|.|..          |:|...|..:..:.|||..:....::.
 Frog   303 ----------------------KYLNAA----------EMLNYKLYMTVSVATATGTDMVEAQLE 335

  Fly   523 SGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSP-------IDPNLLRQGLMEVS 580
            ..|.|:..|    |::| ..|||.|||.:.:...:.|...||||       :||...| |..:..
 Frog   336 EIYIVSSPY----RILF-SKSPQYFKPGLTYDLTVLVTNPDGSPANRIPVVVDPGNFR-GETQAD 394

  Fly   581 GFVESRNGGRRDWPAQRLPMSQQSDGIWEVKIDIRNDLNLDDRPQARDFLNGVQNMRLQANFVDP 645
            |             ..||.::.:: |...:.|.::.|            ..|||          |
 Frog   395 G-------------TARLTLNPEA-GKAAMPISVKTD------------KKGVQ----------P 423

  Fly   646 RGERIQTELLLVSHYSPRNQ-----HIKVTTSTEKPVVGEYIIFHIRTNF-----YLEEFNYLIM 700
            |.:  .|..:....|||...     ||.|..|..|......:.|:|:|:.     .:..|.||:|
 Frog   424 RHQ--ATATMSAKAYSPAYSFNNYLHISVPGSELKLGGTLAVYFYIKTDSPEVAEQIRHFTYLVM 486

  Fly   701 SKGVILVNDRETITEGIKTIAVVLS--SEMAPVATIVVWKI---NQQGQVVADSL---------- 750
            |:|.|:...|:..:.....:|:.||  .:..|...||.:.:   .:.|.:|:||:
 Frog   487 SRGRIIKVGRQERSPNKPVVAMSLSVTEDYLPSFRIVAYYMVTTTKGGDIVSDSVWVDVVDTCMG 551

  Fly   751 TFPVNGI-SRNNFTVYINNRKARTGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKIIT 814
            |..|.|. .::|...|       ....|::.:..:..:.|||..:|...:.:....:||.:|:..
 Frog   552 TLEVTGYKDKDNAVQY-------PSASVQLKLTADHKANVGLVIVDKGVFLLNKKYKLTQSKVWD 609

  Fly   815 KMSNFDEQ-TNGTYKHIWYSHEGNPDELVYFPA-----SSFGVDANRTFE-------------YS 860
            .:...|.. |.|:         |.....|::.|     :||.:..::..|             :.
 Frog   610 SVEKSDTGCTPGS---------GANSAGVFYDAGLALQTSFSITTDQRIEPQCKDWAPRKQRSFV 665

  Fly   861 GLIVFTDGYVPRRQDTCNRTL--GFGECLSGR-C-----YRLE-KQC-DGLFDC----------- 904
            .::....|.....:|...:..  |..|.|.|. |     |.|: |:| |...||
 Frog   666 AVMEIKTGKASEYKDKAKQCCLDGMQENLMGHSCERRTRYILDGKECVDAFLDCCKYYEKRREDE 730

  Fly   905 ----DDGTDEINCHARNDTELLNYRK---YRFN---RVLRHYENVWLWKDVNI-GPHGR-----Y 953
                |:.|.||            |.:   |..|   .:...:...|.|::..: |...:     .
 Frog   731 RKSKDEDTLEI------------YEEDSGYMMNNEIEIRSDFPESWYWREEQMTGAADKDKISTK 783

  Fly   954 IFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFN 1018
            |.||::.|....|.|.|.|:|.:||. .:....|...::.|.|::::|.:..:.|||.||..|.|
 Frog   784 ILNVQLKDSITTWEVLAVSLSENKGL-CVAPPHEIKAMKDFSIDLKLPSSVVRNEQVEIRAVVHN 847

  Fly  1019 YMITPIEAIVVLHDSPDYKFVHVEEDGIVRSYNPRTSFGEHQFFIYLEAQGTTVVYVPVVPQRLG 1083
            |....|:.:|        ||.:.:|  ......|:..|.:.   :::.|:.:.||...:||..||
 Frog   848 YNSHKIKVLV--------KFGYNKE--FCSLSKPKQKFRQE---VWVGAESSAVVPFIIVPLELG 899

  Fly  1084 N--VDVTLHVATLLGTDTITRTLHVESDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQTPEIPYQ 1146
            .  |:||..|.....:|.:.:||:|..:|        |||..:..:.:||         ||:..:
 Frog   900 QHVVEVTAVVYRQFVSDGVRKTLNVVPEG--------VLLSKTLNSVILE---------PEVKGR 947

  Fly  1147 --VDRYFVYGSNKARISVVGDV-VGPIFPTMPVN-----------ASSLLSLPMESGEQNAFSFA 1197
              |....:...:...|....|: :..|....|::           ...|:..|:.|||||.....
 Frog   948 GGVQEVTIKALSAPNIVPKSDIDIKVILQGTPISQLVESAIDGSKLRHLIQKPVGSGEQNMMRMT 1012

  Fly  1198 ANLYTIMYMRLINQRNKT---LEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTS 1259
            .|:.|..|:....|..:.   ..:.|..::..||||:|::.:|||||:.|:.    ..||.|||:
 Frog  1013 TNVITTRYLDATAQWQRVGVDRRETAIGNIKDGYQRELAYRKPDGSFAAFQI----RPSSTWLTA 1073

  Fly  1260 YCLRVFQEASFYEWENFIWIDATIIEKNMRWLL-QHQTPQGSFFEVTWLPDRKMNRTN----FDK 1319
            |..:||  |..||:..   ||..::...::||. :.|.|.|.|.|...:...:|...|    .:.
 Frog  1074 YVAKVF--AMSYEYTE---IDDYVLCGAIKWLFNERQMPDGMFVENGPVLQMEMGGGNKAGAAEP 1133

  Fly  1320 NITLTSHVLITLATVKDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDVAITAYALQLCNS 1384
            :..||:.|||.:...::|.....|.:..|..||..::......||   :|:.||||:|||.|...
 Frog  1134 DAALTAFVLIAMLESREICTQRLSNLGDAINRATNFLRGKYSQLR---KPYSVAITSYALALAGK 1195

  Fly  1385 PIAEEVFAILRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSL--NIETTAYALL 1447
              .::...:|  .|.|  |..:|                        .|.|||  .:|.|:||||
 Frog  1196 --LQDTNTLL--NAAT--DKSHW------------------------KEPDSLFITLEATSYALL 1230

  Fly  1448 VYVARREFFVDP---IVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEAS 1509
            ..:..::.  :|   ||||||.||.....:.|||.|....:||.:|  ::.:..||.|.:::...
 Frog  1231 TLLKMKQH--NPTSAIVRWLNEQRYYGAVFDSTQATIILYQALAQY--QTDVPNVSDLNMDVSVF 1291

  Fly  1510 SQGGKTQ-TLYIDDTNLAKLQSIEIPDAWGTIK----VQAKGAGYAILQMHVQY----------- 1558
            ....|.. :::||:.:..:|:|.||     |:.    |:|||.|.|:|.:...|
 Frog  1292 FPEKKDPVSIHIDNKSALRLRSEEI-----TVNQDFVVKAKGKGQALLTVVSVYHALTTEKQMEC 1351

  Fly  1559 -NVDI-----EKFQTKPP---VPAFGLHTKAIFHGRNQSHISYVACQNWINQNESERSGMAVLDV 1614
             |.|:     |:...|.|   |.|                :|...|..::.::::.   |:::|:
 Frog  1352 KNFDLSVTVNEEKNLKLPDGVVAA----------------VSIEVCARYLKKSDAT---MSIVDI 1397

  Fly  1615 AIPTGYWIQQQKLDTYVLSNRVRNLRR--ARYLERK-------IVFYFDYLDH-EDICVNFTIER 1669
            ::.||:     ..||..|:|.::.:.:  ::|...|       ::.|.|.:.| |..||.|...:
 Frog  1398 SMMTGF-----SPDTNSLNNLMKGVDKYISKYEINKGANERGTLILYLDKISHTEPECVKFYAHQ 1457

  Fly  1670 WYPVANMSRYLPVRIYDYYAPE-------RFNESIFDALPTYLL--NICEVCGSSQC 1717
            :: |..:.:...|.:||||.||       ..|||  .||...:.  ::|. |....|
 Frog  1458 YF-VVGLVQPASVTVYDYYTPENRCTKFYHVNES--SALYGKICQGDVCR-CAEENC 1510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	YfaS	<226..1575	CDD:441940	345/1500 (23%)
		A2M_BRD	667..801	CDD:462235	35/154 (23%)
		A2M	939..1030	CDD:459711	28/96 (29%)
		TED_complement	1160..1490	CDD:462227	100/354 (28%)
		A2M_recep	1605..1699	CDD:462226	28/110 (25%)
LOC100492134	XP_031755348.1	YfaS	65..1340	CDD:441940	342/1482 (23%)
		complement_C3_C4_C5	989..1274	CDD:239226	96/328 (29%)
		A2M_recep	1388..1486	CDD:462226	25/106 (24%)
		NTR_complement_C3	1505..1654	CDD:239638	2/6 (33%)