Protein Alignment Mcr and LOC100489060

DIOPT Version :9

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: XP_002938549.2
• Gene: LOC100489060 / 100489060
• -ID: -
• Length: 1482
• Species: Xenopus tropicalis
• Alignment Length: 1652
• Identity: 374/1652 - (22%)
• Similarity: 624/1652 - (37%)
• Gaps: 435/1652 - (26%)

  Fly   202 LRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTDKPLYMQGETVRFRTIPITTELKGFDNPVD 266
            |.|:|      ..|.|.::.::........:|:|||||:|..|:.|:||...:....    :||.
 Frog   100 LDVQG------DALHFKSQRKILIKPLQNPVFIQTDKPIYKPGQKVQFRIASLDENF----HPVS 154

  Fly   267 -----VYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFGEWTIRVIAQGQQEESH-FTVEEY 325
                 ||:.||..:.:.:||:.:...|.....::||.:||.|.:.:.|..:.....:| |:||||
 Frog   155 EKFPAVYITDPQGNRISQWLNVELKKGLTQESFQLSSEPTLGIYKLTVGREKSAPVTHSFSVEEY 219

  Fly   326 YQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNEKYRLGR 390
            ...::||.|.:|......|..|...|...:|.|.||.|.:.::..         :..:::|.|.:
 Frog   220 VLPKYEVQVKLPPVVGIMDKGIKVTVCGRYTYGKPVLGRIKVRVC---------RKFSDRYNLCK 275

  Fly   391 SPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYR-------NQYVVERHYQFD 448
            .                               .:||  :.::|.:|       ::.|..|.:|
 Frog   276 G-------------------------------EEDG--VCEEINHRAGPNGCFSEVVSTRMFQ-- 305

  Fly   449 EEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEVLITATV 513
                  :|:..|:|.                            :|....::.:  .:.|.:||.|
 Frog   306 ------MRRSGYEDK----------------------------IRASATIIED--GTGVELTAAV 334

  Fly   514 GEKFYDEIISGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSPIDPNLLRQGLME 578
            ..:...      ::|:|   |.|                   :|...|..|.|:...|
 Frog   335 SSEIKK------TLAKV---SFR-------------------HLDSHYRKGLPLFGQL------- 364

  Fly   579 VSGFVESRNGGRRDWPAQRLPMSQQS-----------------DGIWEVKIDIRNDLNLDDRPQA 626
               |:|..:|.         ||:.::                 ||..|..||..|
 Frog   365 ---FLEDASGN---------PMANETVVIFVGYGTNFTYTTGQDGTAEFLIDTSN---------- 407

  Fly   627 RDFLNGVQNMRLQANFVDPRGER-IQTELLLVSH----------YSPRNQHIKVTTSTEKPVV-- 678
                  ||...||.......||. .|...:.||:          ||....::|:     :|:.
 Frog   408 ------VQKSSLQIRARYKEGESCYQYRWVSVSYQGDERSVKEFYSRAKSYLKI-----QPIYKI 461

  Fly   679 -----GEYIIFHI---------RTNFYLEEFNYLIMSKGVILVNDRETI-------TEGIKTIAV 722
                 .|.:|.|.         .||   ..|:||:||||.|..:.|..|       ..|.....:
 Frog   462 LECQKQEKVIVHFILSAEGVGETTN---AVFHYLVMSKGGIAGHGRHEIEISPNQNASGTFWFRL 523

  Fly   723 VLSSEMAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYINNRKARTGEKVEVAIFGEPGS 787
            ...:::||.|..:|:.|.:.|:|:|||::..|.....|...:..:..:|..|...::.:...|.|
 Frog   524 TAGTDIAPSANFLVYLILESGEVIADSISLKVEKCFGNKVELSFSPSEALPGAPADLHLLTAPSS 588

  Fly   788 YVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQTNGTYKHIWYSHEGNPDE------------ 840
            ...|..:|.:...::...||: |:.|..:....:.:.       |.|:||..|
 Frog   589 LCALRAVDESVLILKPEAELS-AQTIYNLLPLQDLSG-------YIHDGNFLEELWDDPCIKMEP 645

  Fly   841 -----LVYFPAS-SFGVDANRTFEYSGLIVFTDGYVPRRQDTCNRTLGFGECLSGRCYRLEKQCD 899
                 :.|.|.: .:..|.....:..||.|||:..: |....|.....:....:|..:.:.....
 Frog   646 LFINGIYYMPTNPEWDTDTYTILKNLGLKVFTNARI-RPPLVCGPRSFYEHYGTGGPFAVPMSLS 709

  Fly   900 -GL-----FDCDDGTDEINCH-ARN----DTELLNYRKYRFNRVLRHYENVWLWKDVNIGPHGRY 953
             |:     .....|......| .||    :..:...|||        :...|||:.|.....|:.
 Frog   710 AGMGVQAGMGVQAGMSGAGLHIGRNIPVAEPVIETVRKY--------FPETWLWQLVETDADGKA 766

  Fly   954 IFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFN 1018
            ...|.|||....|....|..|...||| :::.:..|..||||:.:.:|.:..:||...::.||||
 Frog   767 DLAVTVPDTITTWKAGMFCTSQGAGFG-LSETISLVAFQPFFLELTLPYSAIRGEIFTLKATVFN 830

  Fly  1019 YMITPIEAIVVLHDSPDY--KFVHVEEDGIVRSYNPRTSFGEHQFFIYLEAQGTTVVYVPVVPQR 1081
            |:...|...::|.||..:  |...|:|||..                 :.|.|...:...|..:.
 Frog   831 YLSQTIRVGILLEDSNQFLAKPTKVQEDGYC-----------------VTANGQVTLSWEVTLKS 878

  Fly  1082 LGNVDVTLHVATLLG---------------TDTITRTLHVESDGL-PQYRHQSVLLDLSNRAYVL 1130
            ||.|:.|:...||.|               .||||:.:.||.:|: .:..|.:::....:..
 Frog   879 LGEVNFTMSAETLNGEGLCENEIVSPAQGRKDTITKHIIVEPEGVKKEETHSTMICGKGSEI--- 940

  Fly  1131 EYMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNASSLLSLPMESGEQNAFS 1195
                     |..||.::....|.||.:|..|.|||::|    |...|..:|:.:|...||||...
 Frog   941 ---------TENIPLKLPEKVVEGSARAYFSAVGDILG----TAMQNLGNLVQMPYGCGEQNMVL 992

  Fly  1196 FAANLYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSY 1260
            |...:|...|:...||....::.....:|:.|||:|||:..||||:|.|...:  .:.:.|||::
 Frog   993 FTPIIYISEYLNKTNQLTPEMKSKTLSYMSTGYQKQLSYKHPDGSYSAFGQRY--GEGNTWLTAF 1055

  Fly  1261 CLRVFQEASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPDRKMNRTNFDKNITLTS 1325
            .::.|..|..:     |:|:..:|...:.||...|.|.|.|..|..|.:..| :...|..:||.:
 Frog  1056 TMKSFARARAH-----IYIEEKLITGALLWLSIRQKPNGCFHSVGKLFNNAM-KGGVDDEVTLAA 1114

  Fly  1326 HVLITL---------ATVKD----ISGTLGSRVALATQRALAY---IERNMDFLRHQAQPFDVAI 1374
            ::.|.|         .||::    :...||.:..:.|:..:||   :...||..|...|..|
 Frog  1115 YITIALLEYPLPVTHPTVRNALFCLESALGGKNGIYTKALMAYAFTLAGRMDIRRQLLQSLD--- 1176

  Fly  1375 TAYALQLCNSPIAEEVFAILRRQARTIGDFMYWGNQEIPQPPRKLENQKWFS----LPRLPY-EY 1434
                    ...|.::                  |...:.:|.        ||    :.|.|| ..
 Frog  1177 --------EQAIKKD------------------GTVHLHRPE--------FSDDSGVDRFPYRRA 1207

  Fly  1435 DSLNIETTAYALLVYVARREF------FVDPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVR 1493
            .|..:|..:|.||..:::...      ....:|.|:..|:..:||::|||||..||:||..|
 Frog  1208 PSAEVEMNSYMLLALLSKHNVSDEDLTLATQVVSWMIKQQNPNGGFSSTQDTVVALQALSLY--- 1269

  Fly  1494 SRLREVSSLTVEIEA----SSQGGKTQT--LYIDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAIL 1552
                  .|||:..:|    |....||..  .:::|:|...||.|.:.:..|.......|:|...|
 Frog  1270 ------GSLTLSHDAMRTVSLSLDKTPVAEFHVEDSNRLLLQRIALKEVPGDYLATVSGSGCLYL 1328

  Fly  1553 QMHVQYNVDIEK--------FQTKPPV-PAFGLHTKAIFHGRNQSHISYVACQNWINQNESERSG 1608
            |..::|||.|.|        ..|.|.. ....|.|..|.     :::|||..:  :|.|
 Frog  1329 QTTLRYNVPIPKEDAPFTISVTTDPETCDRKSLKTFTIV-----ANVSYVGKR--LNSN------ 1380

  Fly  1609 MAVLDVAIPTGYWIQQQKLDTYVLSNRVRNLRRARYLERKIVFYFDYLDHEDICVNFTIERWYPV 1673
            |||::|.:|:||...:..:.....|||:  ::||.....:::.||:.|..:.....|::|:..|:
 Frog  1381 MAVVEVKLPSGYIPIKPSVKKMTASNRL--IQRAEAHANEVIVYFESLFKDIQSFRFSVEQEIPI 1443

  Fly  1674 ANMSRYLPVRIYDYYAPERFNESIFDA 1700
            .|: :...|.:||||..:....:.:||
 Frog  1444 GNL-QPATVVVYDYYETDDLAITKYDA 1469

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	A2M_N	232..332	CDD:280081	32/105 (30%)
		A2M_N_2	669..799	CDD:285005	35/152 (23%)
		LDLa	886..913	CDD:238060	3/32 (9%)
		A2M	940..1030	CDD:278630	29/89 (33%)
		ISOPREN_C2_like	1177..1490	CDD:298658	86/339 (25%)
		A2M_comp	1226..1492	CDD:284982	74/292 (25%)
		A2M_recep	1607..1695	CDD:284981	24/87 (28%)
LOC100489060	XP_002938549.2	YfaS	<124..>1065	CDD:225248	254/1148 (22%)
		A2M_N	124..216	CDD:280081	28/95 (29%)
		A2M_N_2	455..600	CDD:285005	35/152 (23%)
		A2M	752..838	CDD:278630	29/86 (34%)
		A2M_2	971..1269	CDD:239227	86/342 (25%)
		A2M_comp	1023..1270	CDD:284982	74/300 (25%)
		A2M_recep	1379..1467	CDD:284981	25/96 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010