Protein Alignment Mcr and ovos2

DIOPT Version :10

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: XP_002941671.3
• Gene: ovos2 / 100487907
• XenbaseID: XB-GENE-6461109
• Length: 1443
• Species: Xenopus tropicalis
• Alignment Length: 1724
• Identity: 379/1724 - (21%)
• Similarity: 642/1724 - (37%)
• Gaps: 475/1724 - (27%)

  Fly    99 GYQDNEEPSLTRGKSSYNIKATFLESLHSREPTYFIVASRMVRPGLIYQVSVSILQAQYPITVHA 163
            ||:.:...|:|......|| ..|.|.:  :.|:||.....||.                  || .
 Frog    47 GYEQSVALSVTLEHQRVNI-TIFAEKV--QPPSYFRCNEFMVP------------------TV-T 89

  Fly   164 SIACDGVQISGDSKDVKEGIPETLLMRIPPTSVTGSYKLRVEGFYQNVFGGLAFLNETRLDFSQR 228
            ..|.|.|.:|....|  |.:.:...:.|.||.
 Frog    90 KTAPDFVTLSVSGGD--EAVKDRKAVVIAPTE--------------------------------- 119

  Fly   229 SMTIF-VQTDKPLYMQGETVRFRTIPITTELKGFDNPVD-VYMLDPNRHILKRWLSRQSNLGSVS 291
              ||| :|||||:|..|:.||||.|.:.|.|....|... ||:.||....:.:|.:::|..|.|.
 Frog   120 --TIFLIQTDKPVYKPGQKVRFRLISLNTMLLPVSNKYPAVYLEDPLGSRIAQWQNQESVGGVVQ 182

  Fly   292 LEYKLSDQPTFGEWTIRV-IAQGQQEESHFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANF 355
            ||:.|......|.:.|.. .|.||.....|||:||...||.|....|:.....|..:.....|.:
 Frog   183 LEFSLISDAAPGFYIITAERASGQPVREGFTVDEYILPRFSVTADPPSIISILDNVLILNASAIY 247

  Fly   356 TSGLPVRGNLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNV-- 418
            |.|.||.|.:|:|.......|:..:  ...::..|...  ||:..:.    :|:   ...|.|
 Frog   248 TYGQPVPGFVTMKCCREATFYYGRK--GNCFKGNRDVC--TNVIKDL----DPD---GAFYGVID 301

  Fly   419 --PGQLPQDGADLSQDILYRNQYVVERH---YQFDEEWPFWVRKPEYQDSSY----EAWSGTYRK 474
              |.||.|.|..:|.::    ...||..   .|..:::...:..   |.::.    :..:|.|::
 Frog   302 LLPFQLGQSGFQMSLEV----DLTVEEDGTGVQVTQQFSIMITS---QLATLVFDTDTMNGFYKR 359

  Fly   475 TLPYLRYFNGTFDFKWPLRELELLVPNLANSEVLITATV---GEKFYDEIISG-----YSVARVY 531
            .:|||.....|.::..|:...|:.|.  ...|.|.||..   |:..|....||     ::|...|
 Frog   360 GIPYLAKMILTDEYGNPMANEEVEVE--LGGETLGTALTDAEGKAEYAIDTSGFVQENFTVVANY 422

  Fly   532 NSSLRVVFLGDSPQVFKPAMPFTTYLAVEYHD--GSPIDPNLLRQGLMEVSGFVESRNGGRRDWP 594
            .:..:..:    .:...|..|...|..:.::.  ||          .:|:.|..|..:.|:....
 Frog   423 KNPTQCYY----TEWEGPDYPTAQYFVLRFYSETGS----------FLEIQGLSEELSCGQVHNV 473

  Fly   595 AQRLPMSQQSDGIWEVKIDIRNDLNLDDRPQARDFLNGVQNMRLQANFVDPRGERIQTELLLVSH 659
            :.|..:|  .||:.|
 Frog   474 SVRYTLS--PDGVGE-------------------------------------------------- 486

  Fly   660 YSPRNQHIKVTTSTEKPVVGEYIIFHIRTNFYLEEFNYLIMSKGVILVNDRETIT-----EGIKT 719
                    :.||:|                     |.||:||:..|:.:.::.:|     .|:..
 Frog   487 --------QATTAT---------------------FYYLVMSRAKIVEHGQQDVTLSQSKSGLFI 522

  Fly   720 IAVVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYINNRKARTGEKVEVAIFGE 784
            |.:.:||::||.|.::.:.|... :::||:::..:.....|..::..:.........:.:.:...
 Frog   523 IGLNVSSDLAPGAQLIAYSILSL-ELIADTVSLYIEKCFPNQVSLSFSEDLGPPASNISLNLSAA 586

  Fly   785 PGSYVGLSGIDSAFYTMQAGNELTYAKI---ITKMSNFDEQTNGTYKHIWYSHEG------NPDE 840
            |||..|:..|||:...:.....|:.:.:   :..:|.|.      |.:..::.||      :|:.
 Frog   587 PGSLCGVKVIDSSLLLINPYESLSASGVYYSLPYLSLFG------YNYGGFNVEGPEPPCEDPNT 645

  Fly   841 LV------YFP-ASSFGVDANRTFEYSGLIVFTDGYVPRRQDTCNRTLGFGECLSGRCYRLEKQC 898
            :|      |.| :||...|..:.....||::.|...: |:...|           |...:|....
 Frog   646 VVFCKGRYYVPVSSSTEGDTYQNLRRVGLVLGTSSRI-RKPVVC-----------GMETKLSVTR 698

  Fly   899 DGLFDCDD--GTDEINCHARNDTELLNYRKYRFNRVLRHYENVWLWKDVNIGPHGRYIFNVEVPD 961
            ..:.|...  ||...|.:.              |.:.:::...::|:.|::..:|:......|||
 Frog   699 KSVMDSVPAFGTSASNGNV--------------NTLRQNFSETFMWQMVSVDSYGQSTITGTVPD 749

  Fly   962 RPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEA 1026
            ....|..|.|.||.::||||...:..:....|||:.:.:|.:..:.|.:.:...|.||:...::.
 Frog   750 TITKWQGSMFCVSENEGFGMTKYSANFTSFLPFFVELSLPYSLTREEILMMNAFVSNYLKECVKV 814

  Fly  1027 IVVLHDSPDYKFV--HVEED-----GIVRSYN---PRTSFGEHQFFIYLEAQGTTVV-------Y 1074
            .|.|..|.|::.|  :|.:|     |...||:   ...|.||..|.:..|   ||.:       :
 Frog   815 NVTLKPSADFQAVPQNVVQDKCICSGSRGSYSWNIIALSLGEISFTVSAE---TTHIGASCDGPF 876

  Fly  1075 VPVVPQRLGNVDVTLHVATLLGTDTITRTLHVESDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQ 1139
            .|..|.|               .||:.:|:.||.:|:.:....|.|:.:.:..:.|.   :|:|
 Frog   877 DPSQPTR---------------KDTVIQTILVEPEGIRKEDTSSNLVCVEDSNFELP---INIT- 922

  Fly  1140 TPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPV-NASSLLSLPMESGEQNAFSFAANLYTI 1203
                   :.:..|.||..|.:::||||:|     :|: |..:||.:|...||||....|...|.:
 Frog   923 -------LPKNMVQGSAAAFVTLVGDVLG-----LPLSNLQNLLQMPYGCGEQNLARMAPIPYVL 975

  Fly  1204 MYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDW-NNSDSSVWLTSYCLRVFQE 1267
            .|:...||....|.:.|..::|.||.|||.:..|.|::..|   | :.|..|.||::|..:.|::
 Frog   976 EYLNGTNQLTDVLLQIAIQYLNEGYYRQLRYKLPSGAYDAF---WGSTSHGSSWLSAYTFKTFEK 1037

  Fly  1268 ASFYEWENFIWIDATIIEKNMRWLLQHQTP----------QGSFFEVTWLPDRKMNRTNFDKNIT 1322
            |     :.:|:||..|.::.   |:..||.          ||:.|         |.:...::::.
 Frog  1038 A-----KKYIYIDEKIQQQT---LISLQTSQKLENGCFKLQGNLF---------MGQCGQERDLC 1085

  Fly  1323 LTSHVLITLATVKDISG-TLGSRVALATQRALAYIERNMDFLRHQAQPFDVAITAYALQLC---- 1382
            .|:::.|.|......|| ||       ...||..:|..:  :.....||. |.:.|...|.
 Frog  1086 FTAYLAIALLESNYSSGMTL-------LDDALRCLEAAI--VNASTLPFK-AYSLYVFTLAKNWE 1140

  Fly  1383 -NSPIAEEVFAILRRQARTIGD--FMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAY 1444
             .:|:..|:      :|:.|.:  .::|.....|.|    |....|.....|.|     :|.|||
 Frog  1141 IRNPLLNEL------KAKAISERGTLHWERDGRPGP----EGVPLFYPNNAPAE-----VEITAY 1190

  Fly  1445 AL-------------LVYVARREFFVDPIVRWLNSQRLNDGGWASTQDTSAALKALVEY------ 1490
            .|             |.|:|.       |..||..|:.:.||:.|||||..||:||..|
 Frog  1191 MLLSIAKGPSLTHDDLTYMAE-------ISVWLIQQQNSYGGFRSTQDTVMALQALAFYAQLIFK 1248

  Fly  1491 -------TVRSRLREVSSLTVEIEASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIKVQAKGAG 1548
                   .:|:...:|..||:.                :.|...:|:..:|.|.|...:...|.|
 Frog  1249 PNAHHNVVLRNEFGDVGQLTLR----------------ENNRLVVQTQALPKASGNYSISVNGTG 1297

  Fly  1549 YAILQMHVQYNVDIEKFQTKPPVPAFGLHTKAIFHGRNQSHISYV----ACQNWIN--------- 1600
            ..::|..::||:         |||             .::...||    |.:|.:|
 Frog  1298 CCLVQSTIRYNI---------PVP-------------KENSAFYVVADSASENCLNGVAYTITIT 1340

  Fly  1601 -----QNESERSGMAVLDVAIPTGYWIQQQKLDTYVLSNRVRNLRRARYLER------KIVFYFD 1654
                 |.....:.|.::|:.:.:||     :.|.:.|    |.|..::.:.|      .|..|..
 Frog  1341 LSVSYQGLRNETNMVIIDIKMLSGY-----QADYFSL----RQLENSKQVSRTEEQNNHIFLYLS 1396

  Fly  1655 YLDHEDICVNFTIERWYPVANMSRYLPVRIYDYY 1688
            .:..:.|.::|.:.....|.|: :...|.:||||
 Frog  1397 SVPQKPIQLSFKMLLGSRVLNV-KSGSVYVYDYY 1429

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	YfaS	<226..1575	CDD:441940	329/1458 (23%)
		A2M_BRD	667..801	CDD:462235	28/138 (20%)
		A2M	939..1030	CDD:459711	24/90 (27%)
		TED_complement	1160..1490	CDD:462227	98/362 (27%)
		A2M_recep	1605..1699	CDD:462226	20/90 (22%)
ovos2	XP_002941671.3	YfaS	<126..1244	CDD:441940	308/1351 (23%)
		A2M	727..818	CDD:459711	24/90 (27%)
		A2M_2	947..1242	CDD:239227	92/346 (27%)
		A2M_recep	1350..1440	CDD:462226	20/90 (22%)