Protein Alignment Mcr and LOC100487726

DIOPT Version :10

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: XP_031758487.1
• Gene: LOC100487726 / 100487726
• XenbaseID: XB-GENE-29078871
• Length: 1413
• Species: Xenopus tropicalis
• Alignment Length: 1656
• Identity: 407/1656 - (24%)
• Similarity: 669/1656 - (40%)
• Gaps: 351/1656 - (21%)

  Fly   121 FLESLHSRE--PTYFIVASRMVRPGLIYQVSVSIL-QAQYPITVHASIACDGVQISGDSKDVKEG 182
            ||..||..:  |:|.|.....|.||:...::|... |....|||.|.|..:|:.::..||..::.
 Frog    15 FLFILHCSDARPSYMISVPTFVIPGVSTTLAVHWFGQNHSEITVTAEIWDNGISLANSSKVFQKD 79

  Fly   183 IPETLLMRIPPTSV---TGSYKLRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTDKPLYMQG 244
            |  ..|:.|||.||   :.||.:||.|...|   .|.|.|...:....:::::.::|||..|..|
 Frog    80 I--LGLLSIPPLSVISSSASYLIRVYGTAGN---ELLFSNNYTMQLETKNVSLLIETDKSAYKPG 139

  Fly   245 ETVRFRTIPITTELKGFDNPVDVYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFGEWTIRV 309
            :||:.|.|.|..:|:.:...|:|.:.||..:|:|:||.|:..||.::.|:.||.....|.|.:..
 Frog   140 QTVKIRIISIRRDLRPYKGLVNVVIRDPKSNIIKQWLQRKPELGVITEEFLLSVNAMAGTWRVHA 204

  Fly   310 IAQGQQEESHFTVEEYYQTRFEVNVTMPAYFFTTDP---FIYGRVMANFTSGLPVRGNLTIKATI 371
            .....:.....:|..:...:|:|.:..|:::  .||   .:.|.|:||:|.|.||:||.|:..
 Frog   205 ETDMTENIEEISVIHFEHPKFDVTIKTPSFY--VDPKQQNLIGTVIANYTYGRPVKGNATVLI-- 265

  Fly   372 RPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYR 436
                                    |:||                                ||...
 Frog   266 ------------------------TSLY--------------------------------DIQAA 274

  Fly   437 NQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPN 501
            |                .::|      :||               .:|:.||.:...||..|...
 Frog   275 N----------------GIKK------TYE---------------MSGSADFTFTYAELSRLPSG 302

  Fly   502 LANSEVLITATVGEKFYDEIISGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSP 566
            |.   :.|||.|.|:.....||..|..:..:|...:|.: ..|.|..|.:.|.|.:.::..|...
 Frog   303 LT---LNITAVVKEELTGIAISKSSYVKKVDSEYELVIV-SQPPVLIPGINFITKIQLQRKDRLH 363

  Fly   567 IDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLPMSQQSDGIWEVKIDIRNDLNLDDRPQARDFLN 631
                 |.||        |..|..........:|...:::|:              :.|.....||
 Frog   364 -----LTQG--------ERENNISVKVTQSFMPWLVETEGV--------------NTPTGATNLN 401

  Fly   632 GVQNMRLQANFVDPRGERIQTELLL---------------VSHYSPRNQHIKVTTST-----EKP 676
            .|:.  ||.|.  |....|..||.|               ::.....::.:.:::|.     :.|
 Frog   402 YVET--LQYNI--PESGIISVELPLQNSVLLIIIEAVYQNITQKWQMHRDLGISSSAQIQLPDSP 462

  Fly   677 V-VGEYIIFHIRTNFYLEEFNYLIMSKGVILVNDRETITEGIKTIAVVLSSEMAPVATIVVWKI- 739
            . ||......::|...::...|:||::|:|:..::...|    |..:......||.|.::|:.:
 Frog   463 AQVGTPFDVRVKTTPEIQNLYYVIMARGIIVAAEKTNST----TFTLTPEYSWAPSAVLMVYFLN 523

  Fly   740 --NQQGQVVADSLTFPVNGISRNNFTVYINNRKARTGEKVEVAI-FGEPGSYVGLSGIDSAFYTM 801
              |...:::..|.|..:.|:..|..::..:..|....|.|.:.: ..|.||.|||..:|.:...:
 Frog   524 FNNNSFEIIQASRTIDIKGMFENKVSLSWSVTKTAPSENVRLNVDITEAGSLVGLRVVDISDKLL 588

  Fly   802 QAGNELTYAKIITKMSNFDEQ-----TNGTYKHIWYSHEGNPDELVYFPASSFGVDANRTFEYSG 861
            ..||.|. .|:..:|.::.:.     |:|                              ...|.|
 Frog   589 SNGNHLK-EKVEAEMKSYTKDFVNSLTDG------------------------------IISYDG 622

  Fly   862 LIVFTDGYVPRRQDTCNRTLGFGECLSGRCYRLEKQCDGLFDCDDGTDEINCHARNDTELLNYRK 926
            :::  :.::|.                            ||..   .:||...|
 Frog   623 ILL--EEFIPE----------------------------LFII---REEIEPPA----------- 643

  Fly   927 YRFNRVLRHYENVWLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGV 991
                .|...:...|:|.:.||....|....|.||:....|..|||.:|...|.|::.:::|....
 Frog   644 ----NVPIVFPETWIWLETNISSGIRTSLPVTVPNAVTSWTASAFVISDVLGLGLIEESVELQAF 704

  Fly   992 QPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDSPDYKFVHVEED-GIV---RSYNP 1052
            |||||.:..|.|..:|||..:||.::|.:...::..|.|..:..:..:..|.| |.:   |:.:.
 Frog   705 QPFFITLNAPYAVTRGEQFILRVLLYNCLEENLQVNVSLETNNAFDIIIPENDNGAIPWLRNVSI 769

  Fly  1053 RTSFGEHQFFIYLEAQGTTVVYVPVVPQRLGNVDVTLHVATLLGTDTITRTLHVESDGLPQYRHQ 1117
            |:...|             ::..||.|::||...:|:...:...:|..|:.:.|:::|:..:..|
 Frog   770 RSKESE-------------IILFPVSPKQLGVNFITVRAMSRTASDIATQKILVKAEGVQNFYTQ 821

  Fly  1118 SVLLDLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNASSLL 1182
            :::|:::....|          :.::.:......|.||.:|.:|||||.:||....:    .||:
 Frog   822 NLILEVNGTGSV----------SQQLSFTFPTNVVGGSEQASVSVVGDFLGPSIKGL----ESLI 872

  Fly  1183 SLPMESGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSD 1247
            .:|...||||..:||..:|.:.|:...:|:.:.:.:.|...|..|||.:|::.|.|.|||.| .|
 Frog   873 RMPYGCGEQNMINFAPIIYVLQYLTSTSQQTEDIRRRAISFMEQGYQSELNYRRGDDSFSAF-GD 936

  Fly  1248 WNNSDSSVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLLQHQTP-QGSFFEVTWLPDRK 1311
            .::|.|| ||:::.:|.|.:|     ..||.|...|:.:.:.||:|.|.| .|.|.|    |...
 Frog   937 RDSSGSS-WLSAFVVRCFLQA-----RTFINISPEILNRTVEWLIQQQDPVNGKFLE----PGHV 991

  Fly  1312 MN---RTNFDKNITLTSHVLITLATVKDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDVA 1373
            .|   :...:..||||::||.:|......|....|||..|.|    |:|:  :|....:..:.::
 Frog   992 FNSRLQGGLNGPITLTAYVLTSLLENSQYSIHYASRVGKAVQ----YLEK--EFEGGISSNYTLS 1050

  Fly  1374 ITAYALQLCNSPIAEEVFAILRRQARTIGDFMYW----GNQEIPQPPRKLENQKWFSLPRLPYEY 1434
            :.||||.:.||..|......|..:.......:||    |.....|||
 Frog  1051 VVAYALSVANSTKASAALTQLNSRTSNNDGQIYWSSPTGASNYWQPP------------------ 1097

  Fly  1435 DSLNIETTAYALLVYVARREFFVD-PIVRWLNSQRLNDGGWASTQDTSAALKALVEY-TVRSRLR 1497
             |.:|||.|||||.:..:...... ||:.||..||.|.||::|||||..||.||.:: .|...|:
 Frog  1098 -SADIETAAYALLSHCQQNRIAEGVPIMNWLVQQRNNLGGYSSTQDTIVALWALAQFMAVAPSLK 1161

  Fly  1498 EVSSLTVEIEASSQGGKTQTLYIDDTNLAKLQSIEIPDAWG-TIKVQAKGAGYAILQMHVQYNVD 1561
            | :||||.:....... .::..|.:.||..:|..:|..::. .:.|.|.|.|.||.|::..||..
 Frog  1162 E-TSLTVSVTGPGPFA-PKSFQITNDNLLAVQIQQIDISYPIVLNVSAVGRGIAIFQLNGIYNKR 1224

  Fly  1562 I--EKFQTKPPVPAFGLHTKAIFHGRNQSHISYVACQNWINQNESERSGMAVLDVAIPTGYWIQQ 1624
            :  .:.|..|...||.|.......|.|...:....|.::  |......||.:|||...:|:.:..
 Frog  1225 VLPRRKQNTPNKEAFALSVTTTDVGNNTELLYVDICSSY--QGTENEVGMVLLDVGFLSGFKLHP 1287

  Fly  1625 QKLDTYVLSNRVRNLRRARYLERKIVFYFDYLDHEDICVNFTIERWYPVANMSRYLPVRIYDYYA 1689
            :.:....|...|.......||      |||.:....:||...:.|...||. ||...|.|.|||.
 Frog  1288 RGIPESGLLKMVETKADRVYL------YFDSMTTNSVCVTVPVVRTALVAG-SREGIVTITDYYN 1345

  Fly  1690 PERFNESIFDALPTYLLNICEVCGSSQCPYC 1720
            |.......:::.....|:||:.|||: |..|
 Frog  1346 PTNSATRTYNSETMKNLSICDFCGSN-CILC 1375

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	YfaS	<226..1575	CDD:441940	331/1398 (24%)
		A2M_BRD	667..801	CDD:462235	31/143 (22%)
		A2M	939..1030	CDD:459711	30/90 (33%)
		TED_complement	1160..1490	CDD:462227	111/338 (33%)
		A2M_recep	1605..1699	CDD:462226	26/93 (28%)
LOC100487726	XP_031758487.1	YfaS	<131..1214	CDD:441940	323/1362 (24%)
		A2M_2	864..1153	CDD:239227	104/328 (32%)
		A2M_recep	1268..1355	CDD:462226	26/93 (28%)