Protein Alignment Mcr and LOC100487580

DIOPT Version :9

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: XP_031761620.1
• Gene: LOC100487580 / 100487580
• -ID: -
• Length: 1472
• Species: Xenopus tropicalis
• Alignment Length: 1677
• Identity: 372/1677 - (22%)
• Similarity: 620/1677 - (36%)
• Gaps: 383/1677 - (22%)

  Fly   129 EPTYFIVASRMVRPGLIYQVSVSILQAQYPITVHASIACDGVQISGDSKDVKEGIPETLL----M 189
            :|.|.:....:::.|......::||....|:.::.::...|...|..|:.|:|   :|:.    .
 Frog    46 KPRYALSVPAVLKSGENSTACINILDNDSPLQLNVNLEFYGANYSIFSETVQE---KTIFKCKEF 107

  Fly   190 RIPPTSVTGSYKLRVEGFYQNVFGGLAFLNETRLDFSQRSMTI-------FVQTDKPLYMQGETV 247
            .:|..|:|      |..|...|..|   ..:|.::  :||..|       |||.||.:|..|:.|
 Frog   108 TVPAVSMT------VPVFITMVATG---PRDTIME--RRSAVIGKMENINFVQLDKSIYKAGQKV 161

  Fly   248 RFRTIPITTELKGFDNPVD-----VYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFGEWTI 307
            :.|.|.:...|:    ||.     :|:|||....:.:||::.|..|.|:|||.|....|.|  |.
 Frog   162 QCRLISLNPLLR----PVQETYTAIYILDPLGSRIFQWLNKTSRQGLVALEYLLLSDATLG--TY 220

  Fly   308 RVIAQ---GQQEESHFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKA 369
            .::|:   |......|.|.||...|:.|.|..|......|..|..:|.|.:|.|..|.|.|:
 Frog   221 NIVAERISGPAVSQPFEVAEYALPRYSVTVAAPNTISIQDQNITFQVNAKYTYGQGVPGKLS--- 282

  Fly   370 TIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQ-VQYNVPGQLPQDG-----AD 428
                            .||.|.       ||..:...:.|:.|: :..|:.|.:...|     ||
 Frog   283 ----------------GRLCRK-------YNYYYPGMSCNRKPEGLCQNIAGDVDPSGTFNYTAD 324

  Fly   429 LSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLR 493
            |:...|.|....:...||.                           ||..    |||.
 Frog   325 LALFQLERGGLDMVLSYQI---------------------------TLTE----NGTG------- 351

  Fly   494 ELELLVPNLANSEVLITATVGEKFYDEIISGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYLA 558
                 |....:..|.|:..:....:|     |...:.|               :||.:|:...:.
 Frog   352 -----VQVTESGSVSISNLIARVSFD-----YQAIQPY---------------YKPGIPYRVAMT 391

  Fly   559 VEYHDGSPIDPNLLRQGLMEVSG-----FVESRNGGRRDWPAQRLPMSQQSDGIWEVKIDIRNDL 618
            :....|:|:....:.   :.|||     ....|||                      |:....|:
 Frog   392 LVNAAGNPLSNETIE---LRVSGNNVQNLTTDRNG----------------------KVRYELDV 431

  Fly   619 NLDDRPQARDFLNGVQNMRLQA-----------NFVDPRGERIQTELLLVSHYSPR-NQHIKVTT 671
            :..::||          :.|||           |:|.|   ....::..|:.:..| ..:::::.
 Frog   432 SGYEQPQ----------LDLQAIYKNAETCYDPNWVMP---IYSNDVYTVTRFFSRTGSYVEISA 483

  Fly   672 STEKPVVGEYIIFHIRTNFYLE----------EFNYLIMSKGVILVNDRETIT------EGIKTI 720
            ..::...|.  .:.|:.::.|.          .|.||:|||..|:.:....:.      .|..::
 Frog   484 PQQELSCGN--SYTIKAHYSLSPKALGNVTNVSFYYLVMSKTKIVKSGEHLVALNSRPQRGTFSL 546

  Fly   721 AVVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYINNRKARTGEKVEVAIFGEP 785
            .:.:|.|:||...::|:.: .|.:|:|..:.........:..::..:..:...|..|.:.:..:|
 Frog   547 NLTVSQELAPGFDVIVYSM-LQSEVIAHKIHLNTEKCFEHQVSLSFSASQGTPGSNVNLTLRADP 610

  Fly   786 GSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQTNGTYKHIWYSHE--GNP---------- 838
            .|..||..|||:...:..|.:||..::...:...  ..|| |....|:.|  ..|
 Frog   611 RSLCGLLAIDSSLILLGPGTQLTAERVYNALQYL--SLNG-YSVGEYNVEPAAPPCIDSENRVLD 672

  Fly   839 DELVYFPASSFGV-DANRTFEYSGLIVFTDG--YVPRRQDTCNRTLGFGECLSGRCYRLEKQCDG 900
            |.|||.|....|. :....|:.:||...|:.  |.|........||||
 Frog   673 DGLVYQPVQFPGQGNTYNEFKSAGLHFATNSSIYKPELCGFYGYTLGF----------------- 720

  Fly   901 LFDCDDGTDEINCHARNDTEL-------LNYRKYRFNRVLRHYENVWLWKDVNIGPHGRYIFNVE 958
                        .|:...|.|       ::......:.|.:.:..||.:..|.:|..|.....::
 Frog   721 ------------FHSNMATPLSATLPVSVSVPGEPISTVRKSFPEVWNFDIVAVGDTGSASPALK 773

  Fly   959 VPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITP 1023
            .||....|..|.|.:|..||.|:......:....|||:.|.:|.:..:||.:.:|..|.||:...
 Frog   774 APDTITQWQASMFCLSEGKGLGVTKYPSNFTSSLPFFVEVSVPFSFTRGEMLLLRAFVSNYLNQC 838

  Fly  1024 IEAIVVLHDSPDYKFVHVE--EDGIVRSYNPRTSFGEHQFFIYLEAQGTTVVYVPVVPQRLGNVD 1086
            |:..|.|..|.||..|..|  :|..|   .|:   |...:...:.|....|:...|..|
 Frog   839 IKVRVTLQPSKDYTAVLQEGTQDMCV---CPK---GRASYSWNVTANSLGVISFNVTAQ------ 891

  Fly  1087 VTLHVATLLG---------TDTITRTLHVESDGL-PQYRHQSVLLDLSNRAYVLEYMHVNVTQTP 1141
            .|...||..|         :||:.:|:.||::|: .:..:.:::....|.|
 Frog   892 TTFIGATCGGPPNTTQPPRSDTVIKTVIVEAEGIEKEVTYSNLVCVEGNNA-------------- 942

  Fly  1142 EIPYQV--DRYFVYGSNKARISVVGDVVGPIFPTMPVNASSLLSLPMESGEQNAFSFAANLYTIM 1204
            :||:.:  ....|.||.||.::|:||.:|....    |..||:.:|...||||..........:.
 Frog   943 QIPFSITPPANMVKGSAKASVTVIGDPLGHAVN----NPDSLIQMPTGCGEQNLVKLLPIPAVLA 1003

  Fly  1205 YMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQEAS 1269
            |:....|..|.::..|..:|..||.|||.|.|.||:||.|..  .:.:.|.|||:..|..||:.
 Frog  1004 YLNCSGQLTKEIQDKAVQYMATGYVRQLGFKRYDGTFSAFGQ--RDPEGSSWLTALSLYTFQKI- 1065

  Fly  1270 FYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPDRKMNRTNFDKNITLTSHVLITLATV 1334
                :.:..:|.|:|.:.:..|.:.|..|...|:|:........:...:..|:.|::|:..|...
 Frog  1066 ----KQYTLVDPTVINQGLVALEKSQDLQSGCFKVSGTLFNSELKGGAENEISFTAYVVAILMET 1126

  Fly  1335 KDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDVAITAYALQLC-NSPIAEEVFAILRRQA 1398
            .........|..|....|.:..|:.:         :::|:..||..|. |........|.|::.|
 Frog  1127 NYPGAQTLLRNGLGCLDAASRREQTL---------YNLALLFYAFSLSGNEERRNATLAKLKKLA 1182

  Fly  1399 RTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEY---DSLNIETTAYALLVYV------ARRE 1454
            ......::|...:.|            ...:.|:.|   .|.:||.|.|.||.:.      ...:
 Frog  1183 IHENGGIHWEQTDKP------------IAEKYPFFYAPPPSADIEITGYVLLGFTKGPAPSQEEK 1235

  Fly  1455 FFVDPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQGGKTQTLY 1519
            .::..|..||..|:.:.||:.||.||..||:||.||   |.|......|..:..|.......|..
 Frog  1236 SYMTQIAVWLVRQQNSQGGFRSTADTVVALQALAEY---SCLVYKKGATNRVTVSLARQVIATFN 1297

  Fly  1520 IDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNVDIEKFQTKPPVPAFGLHTKAIFHG 1584
            :..:|...:|...:|...|.......|.|..::|..|:|||.:.:..:     .|.|..
 Frog  1298 VQPSNRLLVQRRMLPSQQGNYSFGVSGNGCCLIQSTVKYNVPVVRKNS-----TFSLSV------ 1351

  Fly  1585 RNQSHISYVACQNW------IN-----QNESERSGMAVLDVAIPTGYWIQQQKLDTYVLSNRVRN 1638
                :.|..:|.|.      ||     .....:|.|||:|:.:.:||.:|.|.|    |..| :.
 Frog  1352 ----NTSSGSCINGAAFIIPINLTLSYNGRKNQSNMAVVDMKLLSGYSVQYQSL----LQLR-QQ 1407

  Fly  1639 LRRARYLERKIVFYFDYLDHEDICVNFTIERWYPVANMSRYLP--VRIYDYY 1688
            :.:...:...::.|...:..|.|.:..::|....|.|   :.|  :.:||||
 Frog  1408 VPKVEQINNHLIIYLSSVQREPISLPVSLEMGNRVQN---FQPQSIYVYDYY 1456

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	A2M_N	232..332	CDD:280081	37/114 (32%)
		A2M_N_2	669..799	CDD:285005	28/145 (19%)
		LDLa	886..913	CDD:238060	0/26 (0%)
		A2M	940..1030	CDD:278630	26/89 (29%)
		ISOPREN_C2_like	1177..1490	CDD:298658	81/322 (25%)
		A2M_comp	1226..1492	CDD:284982	70/275 (25%)
		A2M_recep	1607..1695	CDD:284981	23/84 (27%)
LOC100487580	XP_031761620.1	A2M_N	147..238	CDD:396416	32/96 (33%)
		MG3	240..332	CDD:407663	29/117 (25%)
		MG4	377..461	CDD:407661	22/136 (16%)
		A2M_N_2	479..626	CDD:400170	28/149 (19%)
		A2M	754..845	CDD:395153	27/90 (30%)
		ISOPREN_C2_like	973..1271	CDD:415487	81/329 (25%)
		A2M_recep	1381..1465	CDD:400149	23/84 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010