Protein Alignment Mcr and LOC100487578

DIOPT Version :9

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: XP_012809164.2
• Gene: LOC100487578 / 100487578
• -ID: -
• Length: 1437
• Species: Xenopus tropicalis
• Alignment Length: 1722
• Identity: 369/1722 - (21%)
• Similarity: 631/1722 - (36%)
• Gaps: 458/1722 - (26%)

  Fly   144 LIYQVSVSIL--------QAQYPITVHASI-------AC-------------------DGVQISG 174
            |:..|.:|||        ||.:.|||.|.:       ||                   |..|:..
 Frog     4 LLISVCLSILDFGAAEPPQAHFMITVPAQLIHPSKEEACVTLLQLKGAVSLRMELHRDDHHQVVA 68

  Fly   175 DSKDVKEGIPETLLMRIPPTSVTGSYKLRVEGFYQNVFGGLAFLNETR--LDFSQRSMTIFVQTD 237
            |.|...|........::|.........|    |:.:..|....:|:|:  |...|..:|: :|||
 Frog    69 DDKITTESFTHCYPFKVPAAEEDREVWL----FHVSAEGDNININQTKKVLIMEQMYVTL-IQTD 128

  Fly   238 KPLYMQGETVRFRTIPITTELKGFDN--PVDVYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQP 300
            ||:|..|:.|.||.:.:..:....|:  |: |.:||||.:.:.:||......|.....::|:::.
 Frog   129 KPMYKPGQIVNFRVVTLGKDFHAQDDKYPL-VELLDPNDNRIGQWLDVAPTQGIADFSFRLAEEV 192

  Fly   301 TFGEWTIRVIAQGQQEESHFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNL 365
            ..|.:.|.:.:..:..:| |.|.||...||:|::........||...:..|..::|.|.||||.:
 Frog   193 ELGRYKINIPSTERSSQS-FIVAEYVLKRFKVDIHAQEDVSPTDDSFHLEVCGSYTYGKPVRGVM 256

  Fly   366 TIKATIRPIG------YFSNQVLNEKYRLGRSPLEQ-----TNLYNERWRYN--------NPNQN 411
            .|  |:.|:.      |:.:        ..|.|.|:     ....::|..:.        |.:.|
 Frog   257 NI--TVFPLNIAWWRLYYGD--------FDREPTEELMPTMQGRTDDRGCFTKDIDLHPFNVSTN 311

  Fly   412 PQVQYNVPGQLPQDGADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTL 476
            |:|:..:...|.:|...|                  :|....::...::|...:......|:|.:
 Frog   312 PRVKIVILALLTEDNTGL------------------EESGSHFIEFTDHQTVEFVNLDSYYQKGI 358

  Fly   477 PYLRYFNGTFDFKWPLRELELLVPNLANSEVLITATVGEKFYDEIISGYSVARVYNSSLRVVFLG 541
            |    |.|....:...||     |. .|.:|.:...|     ||:
 Frog   359 P----FTGMLKARTLKRE-----PR-KNEKVYLVVNV-----DEV-------------------- 388

  Fly   542 DSPQVFKPAMPFTTYLAVEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLPMSQQSDG 606
                        .|.:.:|      .|.|.:.:..::.|.
 Frog   389 ------------DTNITLE------TDANGIARFTLDTSE------------------------- 410

  Fly   607 IWEVKIDIRNDLNLDDRPQARDFLNGVQNMRLQANFVDPRGERIQTELLLVSHYSPRNQHIKVTT 671
             |...:.:....:|:|.          .:|.:..|::.|             .||..|..:||.|
 Frog   411 -WNDMVSLTGKFSLEDG----------DDMFVALNWLFP-------------FYSESNSFLKVQT 451

  Fly   672 -------STEKPVVGEYII---------FHIRTNFYLEEFNYLIMSKGVILVNDRE--------- 711
                   ||::.|..||.|         .|:       .|.|::||||.|:.|...
 Frog   452 VAEDLLCSTKQSVSVEYTIDKNELDPESDHL-------SFFYILMSKGEIITNKEHKVDVPNLPS 509

  Fly   712 -TITEGIKTIAVVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYINNRKARTGE 775
             .|.:|...|...::..:.||||::|:.|...|:|.||...:.|.....|...:.......|.|.
 Frog   510 GPILQGSFNITFSVNVNLVPVATLLVYAIFPDGEVAADRARYRVPVCFDNKVQLEFTENNVRPGG 574

  Fly   776 KVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQ------------------ 822
            .|.:.:..:.||...:..:|.....:|   |....:|::::..:.|.
 Frog   575 NVNLDVKADAGSLCSVRSVDKGLLLLQ---EHKTNEILSRVMGYYEYMFEINRRGFPYTIEDFEP 636

  Fly   823 ----------TNGTYKHI----WYSHEGNPDELVYFPASSFGVDANRTFEYSGLIVFTDGYVPRR 873
                      .|...:.|    ||..|               .|....|:.|.|.|||:..: |:
 Frog   637 YPCLEDAPVLPNRAKRSIKRAPWYQSE---------------ADVYSLFKSSNLKVFTNTRI-RK 685

  Fly   874 QDTCNRTLGFGECLSGRCYRLEKQCDGLFDCDDGTDEINCHARNDTELLNYRKYRFNRVLRHYEN 938
            ..||.        |.....|...: ||:...|...|..:....:          :.:.|.:.:..
 Frog   686 PVTCE--------LPEYTRRFSIK-DGVGAADRKLDSPSTAPAS----------KEHPVRKFFPE 731

  Fly   939 VWLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEA 1003
            .||:..|::||.|:...|:..|.....|:..||.|..| |||.::. :.....||:||::.:|.:
 Frog   732 TWLYDLVSVGPQGKKSLNLTAPHSITEWVTDAFCVGNS-GFGEVHD-IRMKTFQPYFIDLLLPYS 794

  Fly  1004 CRQGEQVGIRVTVFNYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSYNPRTSFGEHQFFIYLEAQ 1068
            ..|.|...:...|:||:...:...|.|...||:.             .|||...:.......|..
 Frog   795 VVQKEHFTLTALVYNYLNHCVLVEVALTIPPDFG-------------EPRTDIEKSACICGQETA 846

  Fly  1069 GTTVVYVPVVPQRLGNVDVTLHVATLLGT---DTITRTLHVES-------DGLPQYRHQSVLLDL 1123
            ..|           .|:     .||.|||   ...:|.||||.       |...:::|.:|
 Frog   847 SFT-----------WNI-----TATKLGTIPFKVTSRALHVEGDCSDVVLDPETKFKHDAV---- 891

  Fly  1124 SNRAYVLEYMHVNVTQT-------------PEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMP 1175
             .:..:::...|.|.:|             .||...:....|.||..|.::|:||::|.|..
 Frog   892 -QKTILVKPSGVEVDKTHTSLLCPTGDSVRGEISLVLPDNVVEGSGHAHVTVLGDIMGNIIS--- 952

  Fly  1176 VNASSLLSLPMESGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGS 1240
             |..:||.||...||||...||.|:|.:.|:.........::.....::..||||||.|...:|:
 Frog   953 -NLGNLLQLPTGCGEQNMALFAPNVYVLEYLESAKALTPEIKDKVLNYLTTGYQRQLMFKHDNGA 1016

  Fly  1241 FSLFRSDWNNSDSSVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVT 1305
            :|.|..  .:.:.:.|||:..:|.|.:|     :..::||...|:..::||..||...|.|..|.
 Frog  1017 YSAFGK--KDEEGNTWLTAMVVRCFSKA-----QKTVFIDEKHIQDAIKWLGSHQLDNGCFRSVG 1074

  Fly  1306 WLPDRKMNRTNFDKNITLTSHVLITLATVKDISGTLGSRVALATQRALAYIERNMDFLRHQA--- 1367
            .|.:..: :...|..:.:::::.:.|..    .||:.:.         :.:|..:..|:..|
 Frog  1075 KLFNNGL-KGAVDDEMAISAYITVALLE----HGTVHNS---------SLVENALRCLKDAANTV 1125

  Fly  1368 -QPFDVAITAYALQLC-NSPIAEEVFAILRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRL 1430
             ..::.||.|||..|. :..:.:.:...|.::....|...:|..|             |
 Frog  1126 NNTYNEAILAYAFTLSGDKDLRQHMLDELEKEVIEEGGSKHWSEQ-------------W------ 1171

  Fly  1431 PYEYDSLNIETTAYALLVYVARREF------FVDPIVRWLNSQRLNDGGWASTQDTSAALKALVE 1489
                 |..:|.::|.||..::..|.      ....|:.|:..|:...||:.|||||..|:.||.:
 Frog  1172 -----SGAVEISSYVLLALLSGDEVTKKDLELSSNIISWVIKQQNPWGGFYSTQDTVVAVHALSK 1231

  Fly  1490 YTVRSRLREVSSLTVEIEASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQM 1554
            | .|:...|...:.:.:.:...|.:.: .::||:|...||...:||..||..:.|.|.|...:|.
 Frog  1232 Y-ARATYHEKRDVALTVHSGLIGYQNR-FHVDDSNRLLLQRAPLPDELGTYIITATGTGCVYVQG 1294

  Fly  1555 HVQYNV-DIEKFQ-------TKP------PVPAFGLHTKAIFHGRNQSHISYVACQNWINQNESE 1605
            |::|:. ..|.||       |:|      ...:|.:|....:.|...:
 Frog  1295 HLKYHTHPAESFQHFTLKVTTEPDNCTAEAERSFEIHMAVSYSGNRAT----------------- 1342

  Fly  1606 RSGMAVLDVAIPTGYWIQQQKLDTYVLSNRVRNLRRARYLERKIVFYFDYLDHEDICVNFTIERW 1670
             :.|.::||...:|:....:.|.   |..:..|::|....:.|:..|.:.|.||....:..:::.
 Frog  1343 -TNMGIIDVYHVSGFAPVARSLK---LLEKKENVKRTEVTDEKVSIYLEELTHETETFSIVVKQE 1403

  Fly  1671 YPVANMSRYLP--VRIYDYYAPERFNESIFDA 1700
            .||:|:.   |  |.:||||.|....|:.:.|
 Frog  1404 TPVSNLQ---PANVIVYDYYDPRERAEAEYHA 1432

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	A2M_N	232..332	CDD:280081	30/101 (30%)
		A2M_N_2	669..799	CDD:285005	38/155 (25%)
		LDLa	886..913	CDD:238060	6/26 (23%)
		A2M	940..1030	CDD:278630	27/89 (30%)
		ISOPREN_C2_like	1177..1490	CDD:298658	78/323 (24%)
		A2M_comp	1226..1492	CDD:284982	65/276 (24%)
		A2M_recep	1607..1695	CDD:284981	23/89 (26%)
LOC100487578	XP_012809164.2	YfaS	<125..>1043	CDD:225248	242/1141 (21%)
		A2M_N	125..223	CDD:396416	30/99 (30%)
		A2M_N_2	447..600	CDD:400170	39/159 (25%)
		A2M	732..821	CDD:395153	27/90 (30%)
		A2M_2	951..1232	CDD:239227	78/329 (24%)
		A2M_recep	1343..1430	CDD:400149	24/92 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010