Protein Alignment Mcr and LOC100487426

DIOPT Version :9

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: XP_017945276.2
• Gene: LOC100487426 / 100487426
• -ID: -
• Length: 1464
• Species: Xenopus tropicalis
• Alignment Length: 1677
• Identity: 356/1677 - (21%)
• Similarity: 619/1677 - (36%)
• Gaps: 400/1677 - (23%)

  Fly   156 QYPITVHASIACDGVQISGDSK-------DVKEGIPETLLMRIPPTS-------VTGSYKLRVEG 206
            ||..::.|.:.      ||:|.       |:.|.:...:::.:...:       :||....:.:.
 Frog    28 QYAFSIPALLK------SGESATACINFIDLTESMSLKVIVEVSGVNTTIFTDKLTGKEVFKCKS 86

  Fly   207 F-------YQNVFGGLAFLNETRLDFSQRSMTI-------FVQTDKPLYMQGETVRFRTIPITTE 257
            |       ...||..:....:|.....:|.:.|       .:|.|||:|.:.:.|..|.:.::..
 Frog    87 FKVPDVKTASPVFITMEATGKTSTIVERRPVVIDKMENINLIQLDKPIYKRAQKVMARVLSLSPN 151

  Fly   258 LKGFDNPVD-----VYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFGEWTIRVIAQ---GQ 314
            |:    ||.     :|:.||....:::|....|..|..:.|:.|.:..:.|.:||  .||   |.
 Frog   152 LR----PVPETYTLIYLTDPYGSRMRQWEDVTSVRGVAAFEFGLLNDASLGTYTI--TAQKKSGG 210

  Fly   315 QEESHFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFSN 379
            .....|.|.||...|..:.:..|......|..:.....|.:|.|..|.|.::        |....
 Frog   211 SISQVFEVAEYVLPRLSMTLEAPKTVSIQDHTVPISANAKYTYGQGVPGKIS--------GKLCR 267

  Fly   380 QVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQ-VQYNVPGQLPQDG-----ADLSQDILYRNQ 438
            |                  |:..:..||.|:||: :..::.||:..||     .||||
 Frog   268 Q------------------YSSYYPGNNCNRNPEGICSHITGQMSSDGNFSQNIDLSQ------- 307

  Fly   439 YVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPN-- 501
                  :|.|.                    |.:...|                 .|::.|..
 Frog   308 ------FQLDR--------------------GGFSMNL-----------------NLDVTVTEEG 329

  Fly   502 -----LANSEVLITATVGEKFYDEIISGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYLAVEY 561
                 ..:..:.:|:.|.:..:|            |..:|        ..:||.:|:...:.:..
 Frog   330 TGVQVKESRSISVTSQVAQVTFD------------NEVMR--------PFYKPGIPYPVSMTLVN 374

  Fly   562 HDGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLPMSQQSDGIWEV--------KIDIR-ND 617
            ..|.||....:.   :.|:|     |.      .|.|...|.....:|:        ::||: |.
 Frog   375 SIGKPIKNEKIE---LLVAG-----NS------VQNLTTDQSGKATYEIDTSKYEQTQLDIQANY 425

  Fly   618 LNLDDRPQARDFLNGVQNMRLQA-NFVDPRGERIQTELLLVSHYSPRN-------QHIKVTTSTE 674
            .|.:....:...:....|....| .|....|..:|..       :|:.       |.:||..|..
 Frog   426 KNTETCADSNWVVPSYSNAYYSAGRFYSRTGSYVQMN-------APKQELSCGKVQSMKVHYSLS 483

  Fly   675 KPVVGEYIIFHIRTNFYLEEFNYLIMSKGVILVNDRETI-----TEGIKTIAVVLSSEMAPVATI 734
            |..:||.:   ...:||     :|:|||..|:.:...::     ..|..:..:.:|||:||.|.:
 Frog   484 KEGLGEKV---NTVSFY-----HLVMSKVKIVDSGSHSVDVSKSRRGSFSFDIPVSSELAPGANV 540

  Fly   735 VVWKINQQGQVVADSLTFPVNGISRNNFTVYINNRKARTGEKVEVAIFGEPGSYVGLSGIDSAFY 799
            ||:.: ...:|:.:::...|.....|..::..:..:...|..|::.:..:|.|..||..:||:..
 Frog   541 VVYSL-LDSEVIEETIHLNVENCFENQVSLSFSEAEGMPGSNVKLKLKADPKSMCGLKIVDSSTL 604

  Fly   800 TMQAGNELTYAKIITKMSNFDEQTNGTYKHIWYSHEG------NPDE------LVYFPASSFGVD 852
            .:....:||...|...:...  ..||.|.. .|:.|.      :|::      |.|.|.|..|..
 Frog   605 LLSQNGQLTPEVIYNALRYL--SLNGYYVG-QYNVEPPAPPCIDPNQRVMMNGLFYQPVSFPGEG 666

  Fly   853 -ANRTFEYSGLIVFTDGYVPRRQDTCNRTL-GFGECL-------SGRCYRLEKQCDGLFDCDDGT 908
             ....|:..|||..|:..: .:.:.|.:.: |.|..:       .|...|.....||:     |.
 Frog   667 YTYNDFKSIGLIFVTNVSL-HKPEVCGQNVWGGGRPVFLNAARPMGMAERFTFMADGM-----GA 725

  Fly   909 DEINCHARNDTELLNYRKYRFNRVLRHYENVWLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSV 973
            ..::.......|.:  ||:        :..||.:....:...|......:|||....|..|.|.:
 Frog   726 AGVSSAKAAPVETV--RKF--------FPEVWKFDFATVDNTGALTVTEKVPDTITQWQGSMFCM 780

  Fly   974 SPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDSPDY-K 1037
            |..||.|:...........|||:.|.:|.:..:||.:.:...|.||:...::....:..|.|| .
 Frog   781 SEEKGIGLTKYPSNLTSYLPFFLEVSLPYSFVRGETLVLTAVVANYLDKYVKVEATMKPSADYTA 845

  Fly  1038 FVHVEEDGIVRSYNPRTSFGEHQFFIYLEAQGTTVVYVPVVPQRLGNVDVTL-----HV-ATLLG 1096
            .:...|.....|...|.||..:                 |..:.||.:..|:     |: |:..|
 Frog   846 TLQQGEQNTCLSPRQRASFSWN-----------------VNAKSLGAITFTMTAKTTHIGASCKG 893

  Fly  1097 ---------TDTITRTLHVESDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQTPEIPYQVDRYFV 1152
                     :||:.::..||::|:.:....|.|:.:.....|:.   :|:|..|.:        |
 Frog   894 PSDNSQSPRSDTVIQSTIVEAEGIEKEITYSNLVCVEGTKSVIP---INITPPPNM--------V 947

  Fly  1153 YGSNKARISVVGDVVGPIFPTMPVNASSLLSLPMESGEQNAFSFAANLYTIMYMRLINQRNKTLE 1217
            ..|.:..::|:||::|....    |..||:.:|...||||..........:.|:....|..|.::
 Frog   948 ADSAQGSVTVIGDLLGHAVN----NPDSLIQMPTGCGEQNLVKLMPIPAVLAYLNCSGQLTKEMQ 1008

  Fly  1218 KNAFYHMNIGYQRQLSFMRPDGSFSLF-RSDWNNSDSSVWLTSYCLRVFQEASFYEWENFIWIDA 1281
            ..|...|..||.|||.:.|.||:||.| :||   .:.|.|||:.....|:....|     ..:|.
 Frog  1009 DKAVQFMQTGYIRQLGYKRWDGTFSAFGQSD---HEGSSWLTALIFHTFELIKPY-----TLVDP 1065

  Fly  1282 TIIEKNMRWLLQHQTPQGSFFEVTWLPDRKMNRTNFDKNITLTSHVLITL-ATVKDISGTL--GS 1343
            |:..:.:..|.:.|.|:...|:.|........:...|..|:.|.:|...| .|....:.||  |:
 Frog  1066 TVQNQALLALQRMQDPKTGCFKATGTLFHSGLKGGADNEISFTGYVAAMLWNTPYPAAQTLLHGA 1130

  Fly  1344 RVAL--ATQRALAYIERNMDFLRHQAQPFDVAITAYALQLC-NSPIAEEVFAILRRQA-RTIGDF 1404
            ...|  |::|     |:::         :::.:..||..:. |......:.|.|:.:| ..:|.
 Frog  1131 FSCLDEASKR-----EQSL---------YNLVLMFYAFAVSGNMEKRNYILAQLKSKAIHKVGT- 1180

  Fly  1405 MYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALL-------------VYVARREFF 1456
            .:|   |.|..|:: |...:||.|.     .|...|.|.||||             .|:|:
 Frog  1181 THW---ERPDKPKE-ETSPFFSAPS-----PSAETEITGYALLGMTYGPAPSQDDKSYMAQ---- 1232

  Fly  1457 VDPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIEASSQGGKTQTLYID 1521
               |..|...|:.:.||:.||.||..||:||..|   |.|......|.:::.:|.........:.
 Frog  1233 ---IALWFAQQQNSQGGYRSTADTVVALRALARY---SCLIYKPGATNQVKVTSGNTVIANFNVQ 1291

  Fly  1522 DTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNVDIEKFQTKPPVPAFGLHTKAIFHGRN 1586
            ..|...:|...:|...|....:.:|.|..::|..|:|||.:.|     .|.||.|..::
 Frog  1292 PNNRLLVQRQPLPKVPGNYGFEVEGKGCCLVQCSVRYNVPVIK-----GVSAFSLSVQS------ 1345

  Fly  1587 QSHISYVACQNWI--------------NQNESERSGMAVLDVAIPTGYWIQQQKLDTYVLSNRVR 1637
                ...:|.|.:              |:|:   |.|||:...:.:||.::.|.|      .::|
 Frog  1346 ----DRKSCVNGVAYTIPIAMSVSYHGNRNQ---SNMAVIMAKLLSGYTVEYQSL------QQLR 1397

  Fly  1638 -NLRRARYLERKIVFYFDYLDHEDICVNFTIERWYPVANMSRYLPVRIYDYY 1688
             |:.:...::.::|.|.:.:..:.|.::.|:|....|.|..... |.::|||
 Frog  1398 QNVSKVEQMDNRLVIYLESVSSKPITLSVTLEMSNRVQNFQPQF-VYVFDYY 1448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	A2M_N	232..332	CDD:280081	30/114 (26%)
		A2M_N_2	669..799	CDD:285005	32/134 (24%)
		LDLa	886..913	CDD:238060	5/33 (15%)
		A2M	940..1030	CDD:278630	22/89 (25%)
		ISOPREN_C2_like	1177..1490	CDD:298658	89/333 (27%)
		A2M_comp	1226..1492	CDD:284982	77/286 (27%)
		A2M_recep	1607..1695	CDD:284981	21/83 (25%)
LOC100487426	XP_017945276.2	A2M_N	128..218	CDD:396416	25/95 (26%)
		MG3	220..312	CDD:407663	27/130 (21%)
		MG4	358..445	CDD:407661	18/100 (18%)
		A2M_N_2	459..606	CDD:400170	36/162 (22%)
		A2M	746..837	CDD:395153	23/90 (26%)
		ISOPREN_C2_like	965..1263	CDD:415487	89/340 (26%)
		A2M_recep	1373..1457	CDD:400149	21/83 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010