Protein Alignment Mcr and cd109

DIOPT Version :9

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: XP_031758448.1
• Gene: cd109 / 100486953
• XenbaseID: XB-GENE-954886
• Length: 1433
• Species: Xenopus tropicalis
• Alignment Length: 1675
• Identity: 405/1675 - (24%)
• Similarity: 694/1675 - (41%)
• Gaps: 334/1675 - (19%)

  Fly   130 PTYFIVASRMVRPGLIYQVSVSILQAQYP-ITVHASIACD-GVQISGDSKDVKEGIPETLLMRIP 192
            |.:.|.:...:|||:...:.:.:||...| :.|.|.:..| ...:.|:|...:.|....:|.::|
 Frog    27 PIFLITSPMDIRPGVNLTLGIEMLQESPPLVKVVAQLQKDEHTLLEGESFFKRGGFGTLVLPQLP 91

  Fly   193 PTSVTGSYKLRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTDKPLYMQGETVRFRTIPITTE 257
            ..||.|.|:|.|:|:.:.   .|.|.|:|.|:|..:..::|::|:...|..|:.|:.|.:..:..
 Frog    92 LNSVNGKYELNVKGYSEE---NLIFFNKTSLEFKSKGFSVFIETNSVFYKPGQEVKIRILAFSFH 153

  Fly   258 LKGFDNPVDVYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFGEWTIRVIAQGQQEESHFTV 322
            :|.:.:.||:|:|||..:::::||..:..||.||....|||.|..|:|||:|....|.....|||
 Frog   154 MKPYKSTVDIYILDPQGNLIEQWLEEEMELGVVSQSLYLSDNPPLGDWTIKVKLHQQLHYQTFTV 218

  Fly   323 EEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNEKYR 387
            .|....||||.:....|....:|.:.|.|.|.:|.|:||:|.|::.
 Frog   219 MEQVLPRFEVLLNTTLYHSIKNPHLEGTVTAKYTYGMPVKGKLSVM------------------- 264

  Fly   388 LGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRNQYVVERHYQFDEEWP 452
                 |...::|.::                        .::::|.:
 Frog   265 -----LSHNSIYKKK------------------------TNITKDFV------------------ 282

  Fly   453 FWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEVLITATVG-EK 516
                                         .||...|.:...||:.|:.|.......:|..|. :.
 Frog   283 -----------------------------INGCARFSFSNVELKELMKNADYGSNKVTGPVDIDV 318

  Fly   517 FYDEIISG---------YSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSPIDPNLL 572
            ...|.::|         :.:.:.||    :.|| |.|.|.||.:.||..|.:..:||..:... .
 Frog   319 NVKESLTGITQNVTTSVFVIDKEYN----IEFL-DHPTVLKPMLNFTIRLQIVRYDGRKLTAE-E 377

  Fly   573 RQGLMEVSGFVESRNGGRRDWPAQ-RLPMSQQSDGIWEVKID----IRNDLNLDDRPQARDFLNG 632
            |...:.|: ..::|....||...: ....::..|.:..:::.    .:|.:...:.|...|
 Frog   378 RDNEVAVT-VTQTRRFNFRDNSVELNATENESEDNVEMIQLTRYTVPKNGIICIEIPLLAD---- 437

  Fly   633 VQNMRLQANFVDPRGERIQTELLLVSHYSPRN-QHIKVTTSTEKPVVGEYIIFHIRTNFYLEEFN 696
            :.::.::|.|:|.:......:|     :|..| .:|::..:.:...||......:..:|.|::.:
 Frog   438 IMHLYIKAEFLDAKNNLFINDL-----FSSLNGTYIQIKKADQDLKVGIPYTLSVDGSFPLKDIS 497

  Fly   697 YLIMSKGVILVNDRETITEGIKTIAVVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNGISRNN 761
            ||::|||.|:...:    ...|.|.:...:...|...::|:.:...|.|..|.....|..|..|.
 Frog   498 YLVVSKGQIVAGGK----GNPKNITLNPENTWTPEVCLIVYHVANDGTVTNDVTAVSVQPIFENK 558

  Fly   762 FTVYINNRKARTGEKVEVAI-FGEPGSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQTNG 825
            ..:..|..:||..:.|.:.: ..||.|.|.||.||.....:....|::.|.::.::.::
 Frog   559 VYISWNTTQARPADMVSLNVNVAEPNSLVVLSVIDKRVKLLGDRQEISTANVLKELKSY------ 617

  Fly   826 TYKHIWYSHEGNPDELVYFPASSFGV--DAN--------RTFEYSGLIVFTDGYVPRRQDTCNRT 880
            :..||  .|..||.|:  |...:.||  |||        ..|| ||..:...|.:|
 Frog   618 STSHI--QHYTNPSEV--FEMCNIGVMTDANIEVHDHFDILFE-SGFDIPVQGALP--------- 668

  Fly   881 LGFGECLSGRCYRLEKQCDGLFDCDDGTDEINCHARNDTELLNYRKYRFNRVLRHYENVWLWKDV 945
            :.||.                                            .|:...:...|:||.:
 Frog   669 VNFGS--------------------------------------------PRIRSLFPETWIWKHL 689

  Fly   946 NIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQV 1010
            ..|.......:::|||....|:.||:.:|.:.||||:....:....||||:::.:|....:|||.
 Frog   690 KTGSTTHMTLDLKVPDVITTWITSAYVISENFGFGMLAPPEQLEAFQPFFLSLNLPSYVIRGEQF 754

  Fly  1011 GIRVTVFNYMITPIEAIVVLHDSPDYK----FVHVEEDGIVRSYNPRTSFGEHQFFIYLEAQGTT 1071
            .:.|.||||:....|..|.|..|..::    ||:..|.               |..:.:.:|...
 Frog   755 VLEVIVFNYLQKETEVSVTLEKSDAFEIQLAFVNASES---------------QQSVSVPSQEGK 804

  Fly  1072 VVYVPVVPQRLGNVDVTLHVATLLGTDTITRTLHVESDGLPQYRHQSVLLDLSNRAYVLEYMHVN 1136
            :|:.|:.|..||.:.:|:...:.|.:|.:|:.|.|:::|:.|...|::||||...........:|
 Frog   805 IVFFPIKPIHLGEIPITVKAISALASDAVTQKLQVKAEGVQQSHSQTLLLDLMGNKPKSISQTLN 869

  Fly  1137 VTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNASSLLSLPMESGEQNAFSFAANLY 1201
            .|..|::        |.||.||.|:||||.:|....::    .||:.:|...||||...||.|::
 Frog   870 FTFPPDV--------VSGSEKAFITVVGDHLGLSIRSI----KSLIQMPYGCGEQNMIRFAPNIF 922

  Fly  1202 TIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSD--SSVWLTSYCLRV 1264
            .:.|:....|.|:.:.......:..||||||.:.|.|||||.|    .|.|  .|.||:::.|:.
 Frog   923 IMEYLSRTKQLNEDVAHKLISFIKNGYQRQLVYQREDGSFSAF----GNKDPFGSTWLSAFVLQC 983

  Fly  1265 FQEASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPDR---KMNRTNFDKNITLTSH 1326
            |.:|     ..||.:|..::...:.|||:||...|.|    |.|..   ...:......||||::
 Frog   984 FLKA-----RPFILVDPVVLHNTLTWLLKHQRKNGEF----WEPGTVIYSQIQGGHHSAITLTAY 1039

  Fly  1327 VLITLATVKDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDVAITAYALQLCNSPIAEEVF 1391
            ::..|.....:..:  |:||.||.    |:|..||.:  .:..:.:::..|||.|.....|.|..
 Frog  1040 IMAALIEYPGLKNS--SQVAAATD----YLESQMDEI--ISDNYTLSLVTYALSLVGRSKATEGL 1096

  Fly  1392 AILRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVARREFF 1456
            .:|..:|...|...:|.:.              .|..:.|.   |.:|..:|||||.||.:....
 Frog  1097 DLLNMRAEQEGQLRFWRSS--------------ISSCQHPC---STDIVISAYALLSYVVQNRIA 1144

  Fly  1457 VD-PIVRWLNSQRLNDGGWASTQDTSAALKALVE----YTVRSRLREVSSLTVEIEASSQGGKTQ 1516
            .. .:::||:.||.:.||::|||||..||:|:..    ||:.   :::.::||:   |.....|.
 Frog  1145 EGMAVMKWLSQQRSHLGGFSSTQDTIIALQAMSSFASVYTIN---KQILAITVD---SHPLNSTA 1203

  Fly  1517 TLYIDDTNLAKLQSIEIP-DAWGTIKVQAKGAGYAILQMHVQYNVDIEKFQTKPPVP-------- 1572
            |..||..|...||:.::. .....:.|.|:|.|:||||.|..||:       |..||
 Frog  1204 TFQIDSNNRILLQTKQLAVQQQMNLTVHAEGTGFAILQFHTIYNL-------KNSVPGRYKSISS 1261

  Fly  1573 --AFGLHTKAIFHGRNQSHISYVACQNWINQNESERSGMAVLDVAIPTGYWIQQQKLDTYVLSNR 1635
              ||.|....:.:..|.:.:|...|...|.::.|.::||.::.|.:.:|:.:..:.:....
 Frog  1262 QDAFDLGITVLDNKDNLNVVSLNICTRSIPRDGSTQTGMVLMQVDLLSGFSLVPEGIPMKY---- 1322

  Fly  1636 VRNLRRARYLERKIVFYFDYLDHEDICVNFTIERWYPVANMSRYLPVRIYDYYAP-----ERFNE 1695
              .:::..|.|.||..|.|.|:..::|:|....|.:.|....... |.:.|||.|     ..:|.
 Frog  1323 --PIKKVDYNEGKINIYLDSLNQTEVCINIPATRDFKVGYTQEAF-VYVIDYYDPGQRAIRSYNS 1384

  Fly  1696 SIFDALPTYLLNICEVCGSSQCPYCSIYNMGWRASMSMSLLFFSVFIYLL 1745
            .:...     ::.|..| :..|..|...|...|...::.:.:  :||.||
 Frog  1385 EVMQQ-----VSPCSFC-NDDCNQCITGNHALRTEQTLFINY--LFIILL 1426

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	A2M_N	232..332	CDD:280081	35/99 (35%)
		A2M_N_2	669..799	CDD:285005	32/130 (25%)
		LDLa	886..913	CDD:238060	0/26 (0%)
		A2M	940..1030	CDD:278630	30/89 (34%)
		ISOPREN_C2_like	1177..1490	CDD:298658	95/322 (30%)
		A2M_comp	1226..1492	CDD:284982	83/275 (30%)
		A2M_recep	1607..1695	CDD:284981	20/92 (22%)
cd109	XP_031758448.1	YfaS	57..1155	CDD:225248	320/1344 (24%)
		A2M	683..774	CDD:395153	30/90 (33%)
		A2M_2	895..1179	CDD:239227	95/325 (29%)
		A2M_recep	1298..1382	CDD:400149	20/90 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I9665
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010