DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcr and c5

DIOPT Version :9

Sequence 1:NP_524688.1 Gene:Mcr / 44071 FlyBaseID:FBgn0267488 Length:1760 Species:Drosophila melanogaster
Sequence 2:NP_001190988.1 Gene:c5 / 100485433 XenbaseID:XB-GENE-486371 Length:1688 Species:Xenopus tropicalis


Alignment Length:1748 Identity:401/1748 - (22%)
Similarity:691/1748 - (39%) Gaps:380/1748 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   128 REPTYFIVASRMVRPGLIYQV-----------SVSILQAQYP------ITVHASIACDGVQISGD 175
            :|.||.:...|..|.|.:..|           ::.|....||      .|.|..:         :
 Frog    21 QEKTYLVTGPREWRIGALETVVVQAFGQEGDLAIRINALSYPDKKTTYATQHLVL---------N 76

  Fly   176 SKDVKEGIPETLLMRIPPTSVTGSYKLRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTDKPL 240
            .::..:|:.:  ||..|....|.|....::..|...... ||..|.::..|.|:..:|:|||||.
 Frog    77 DQNNYQGLVK--LMIQPKDFPTYSSSDPMQFIYLQAQSN-AFNKEEQVPVSYRNGFLFIQTDKPF 138

  Fly   241 YMQGETVRFRTIPITTELKGFDNPVDVYMLDPNRHILKRWLSRQSNLGSVSL-EYKLSDQPTFGE 304
            |...::|:.|...:..|||.....|.:...|| ..:....:......|.:|. .:|:...|.||.
 Frog   139 YTPDQSVKIRVYSMDEELKPGRRKVVLTFKDP-EEVKVDSIEEDDLTGIISFPAFKIPANPKFGM 202

  Fly   305 WTIRVIAQGQ----QEESHFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNL 365
            |||.. |.|:    ...:.|.|:||...:|.|::.....|...|.|      ..||        :
 Frog   203 WTIEA-AYGKDFTTSGTAKFEVKEYVLPKFFVSIEPEKNFICYDKF------TEFT--------I 252

  Fly   366 TIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDG--AD 428
            |::|:.    ||...|.|.|..:               ||.               |.|||  ..
 Frog   253 TVRASY----YFKKLVDNAKVYI---------------RYG---------------LIQDGERTM 283

  Fly   429 LSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLR 493
            |.:.|..::.:..|..:||:.:..  |.:..|  ||.|..||:|                     
 Frog   284 LPKSIDLQSMFNGESIFQFNSQKA--VEELGY--SSLEEISGSY--------------------- 323

  Fly   494 ELELLVPNLANSEVLITATVGE-------------KFYDEIISGYSVARVYNSSLRVVFLGDSPQ 545
                         :.||.:|.|             ||   ::|.|:...|           .:|.
 Frog   324 -------------LYITVSVEESTGRTEESENVDVKF---VLSPYTFKLV-----------GTPL 361

  Fly   546 VFKPAMPFTTYLAVEYHD--GSPID--PNLLRQGLMEVSGFVESRNGGRRDWPAQRLPM-SQQSD 605
            ..||.:|:  |:.|:..|  ..|:.  |.:|...:::..|..|...||       ||.| |.:.|
 Frog   362 YVKPTLPY--YIKVQLRDTMDKPVGNIPLVLSGDMVKEDGTSEPLTGG-------RLRMSSDKRD 417

  Fly   606 GIWEVKIDIRNDLNLDDRPQARDFLNGVQNMRLQANFVDPRGERIQTELLLVSHYSPRNQHIKVT 670
            |.....::|.:|::      :.||.....:..|      |...:.....:.||:.|....::.:.
 Frog   418 GTGVFVLNIPSDIS------SLDFKITTDDGSL------PEDNQATVNHVAVSYQSLTKSYLYIN 470

  Fly   671 TSTEKPV--VGEYIIFHIRTN----FYLEEFNYLIMSKGVILVNDRETITEG--IKTIAVVLSSE 727
            .:.||.|  ||.::..|:..|    ..|..::||::|||.||........||  .:::.:.::|:
 Frog   471 WAREKEVLHVGSFLTIHLVPNSPYIAKLRHYSYLLISKGKILNFGTVQRVEGSDSQSLTLPITSD 535

  Fly   728 MAPVATIVVWKI---NQQGQVVADSLTFPVNGISRNNFTVYINNRKA--RTGEKVEVAIFGEPGS 787
            |.|...::|:.|   :...::||||:...|.....|:.||.::.|:.  :.|:|..:.:.|...|
 Frog   536 MVPSVRLLVYYIVTGDATAELVADSIWLDVVESCVNHQTVELSTRETTLKPGQKFNLKVSGPSKS 600

  Fly   788 YVGLSGIDSAFYTM----QAGNELTYAKIITKMSNFDEQTNGTYKHIWYSHEGNPDELVYFPASS 848
            .|.||.:|:|.|.:    |...|..:.||       :|...|.                   .:.
 Frog   601 LVALSAVDTAIYDVGKRFQRPLETVFRKI-------EESDLGC-------------------GAG 639

  Fly   849 FGVDANRTFEYSGLIVFTDGYVPRRQD---TCN------RTLGFGE-----------------CL 887
            .|.:....|..:||...|:..:...|.   .||      |:..|.|                 |.
 Frog   640 AGQNNADVFRLAGLTFLTNANIQASQKYALKCNEVLRPKRSFNFKEEINKKARVYKDRNIRKCCY 704

  Fly   888 SG-RCYRLEKQCD-GLF--------DCDDGTDEINCHARN-----DTELLN------YRKYRFN- 930
            .| :|:..|..|. |:.        .|.|...:....|::     |.|:.:      |.:...| 
 Frog   705 DGVKCFLEENDCTAGISRVSKRYGKSCTDTFQDCCFFAKSLKEKMDAEIQDVGMGRMYIRTVLNI 769

  Fly   931 ---RVLRHYENVWLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQ 992
               ::..::...|||::..:...|....:|.:||....|.:...|:| .||..:.:: .:....:
 Frog   770 DEPQIRSYFPESWLWEEYLLDDRGEKTLSVTLPDSLTTWEIQGVSMS-DKGLCVADR-FKVTAYK 832

  Fly   993 PFFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSYNPRTSFG 1057
            .:|::|::|.:..:|||:.|:|.||||....::..|::.          .|..|.:.....|..|
 Frog   833 DYFLDVQLPYSVVRGEQIQIKVVVFNYRNNNVKGCVLMS----------AEKEICKFSETSTRKG 887

  Fly  1058 EHQFFIY-LEAQGTTVVYVPVVPQRLGNVDVTLHVATLLGTDTITRTLHVESDGLPQYRHQSVLL 1121
            ..:.|.: |.|...|.....::|..:|...:|..::....:|.:.:||.|..:|:.:.|:....|
 Frog   888 LKECFSHTLSASSLTPFTFTILPLEVGLHPLTFTLSASGSSDIVKKTLRVVPEGIKKERNAGFTL 952

  Fly  1122 DLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARI-SVVGDVVGPIFPTMPVNASS---LL 1182
            |......|       ..:..:|.|::....|..|..:|| |:.|:::|.:..|: |.:..   |:
 Frog   953 DPQGIRGV-------ARRRQDISYKIHANIVPKSKVSRILSISGNILGEVINTV-VKSEGLQYLI 1009

  Fly  1183 SLPMESGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAF-------YHMNIGYQRQLSFMRPDGS 1240
            |||..|.|..........|...|:. .::|...|..|..       ..|..|....|||...|.|
 Frog  1010 SLPKASAETELMRVVPIFYVYHYLE-TSKRWDLLGTNILAAQIEMQRKMREGVNSILSFRGSDYS 1073

  Fly  1241 FSLFRSDWNNSDSSVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLL-QHQTPQGSFFEV 1304
            :|:    |.....|.|||::.|::|.|.     |.:::::...:..::.||: |.|...|||.:.
 Frog  1074 YSI----WKEGKPSAWLTAFALKIFGEI-----EKYVYVNKMSVCNSISWLIDQCQLRDGSFIDR 1129

  Fly  1305 TWLPDRKMNRT----NFDKNITLTSHVLITLATVKDISGTLGSRVALATQRALAYIERNMDFLRH 1365
            :.....|:..|    :.::::.||:.|.|.:.  |.........|..|.:||..|:..|   :|.
 Frog  1130 SGYQPGKLQGTIPSESEERSLYLTAFVFIGIQ--KSFHMCPLEEVNAAMRRAEEYLSNN---IRK 1189

  Fly  1366 QAQPFDVAITAYALQLCNSPIA--EEVFAILRRQARTI--GDF---MYWGNQEIPQPPRKLENQK 1423
            ....|.:||..|||...:..:|  ..|...|.|:|..|  ||.   .||      :...|..|  
 Frog  1190 AKSTFTLAIAGYALASWDGTLASVRYVKGALEREAYVIESGDLPIVRYW------KDSLKKVN-- 1246

  Fly  1424 WFSLPRLPYEYDSLNIETTAYALLVY--VARREFFVDPIVRWLNSQRLNDGGWASTQDTSAALKA 1486
                |..|....:..:||||||||:|  :|::::: :|:||||..|:...||:.|||||:.||:|
 Frog  1247 ----PTAPGAESARMVETTAYALLMYLKLAQKDYY-NPVVRWLKEQQRYGGGFYSTQDTAIALEA 1306

  Fly  1487 LVEYTVRSRLREVSSLTVEIEASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAI 1551
            |.|.::..: :...::.|::.....|........:.::..:.:.:.:|:........|.|    |
 Frog  1307 LTEVSIVDK-KLTLNMAVQVSYKKSGDFKNYRLTETSSFTRPEEVPLPEDLIVSTPTANG----I 1366

  Fly  1552 LQMHVQ--YNVDIEKFQTKPPVPAFGLHTK-----------AIFHGRNQSHISYVACQNW-INQN 1602
            ..:|||  ||:      ..||......|.|           :||.......|...||..: ...:
 Frog  1367 ATVHVQTVYNI------ISPPQEKCQFHLKIGKKLNWKPRQSIFDSDKSGAIPIEACARYKAPDD 1425

  Fly  1603 ESERSGMAVLDVAIPTGYWIQQQKLDTYVLSNRVRNLRRARYLE-RKIVFYFDYLDHED-ICVNF 1665
            :...||.||:::.:.||..:.:.:|:.  |:.||.....|..:| .|:..:||.:..:: |||..
 Frog  1426 DPYISGSAVMEITMVTGLVVDESELEE--LAQRVDQFVTAYDIEDGKVNLHFDGIPSDEYICVTL 1488

  Fly  1666 TIERWYPVANMSRYLPVRIYDYYAPERFNESIFDALPTY-LLNICE----VCGSSQCP 1718
            .....:.|:.:|..: .|:|:::||:....::|:.|.:. |:|:|.    .|..:.||
 Frog  1489 LAWEQFKVSMLSPGV-FRVYEFHAPDEECTTLFNPLASQDLVNVCTGNQCKCIQATCP 1545

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
McrNP_524688.1 A2M_N 232..332 CDD:280081 31/104 (30%)
A2M_N_2 669..799 CDD:285005 40/142 (28%)
LDLa 886..913 CDD:238060 8/36 (22%)
A2M 940..1030 CDD:278630 25/89 (28%)
ISOPREN_C2_like 1177..1490 CDD:298658 96/336 (29%)
A2M_comp 1226..1492 CDD:284982 85/279 (30%)
A2M_recep 1607..1695 CDD:284981 24/89 (27%)
c5NP_001190988.1 A2M_N 130..223 CDD:280081 27/94 (29%)
A2M_N_2 474..613 CDD:285005 40/138 (29%)
ANATO 686..752 CDD:294031 10/65 (15%)
A2M 781..870 CDD:278630 25/90 (28%)
complement_C3_C4_C5 1001..1309 CDD:239226 96/335 (29%)
A2M_comp 1059..1312 CDD:284982 85/279 (30%)
A2M_recep 1430..1518 CDD:284981 24/90 (27%)
NTR_like 1532..1688 CDD:295338 4/14 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 51 1.000 Domainoid score I11365
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
33.010

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