DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcr and c3a.4

DIOPT Version :9

Sequence 1:NP_524688.1 Gene:Mcr / 44071 FlyBaseID:FBgn0267488 Length:1760 Species:Drosophila melanogaster
Sequence 2:XP_002660623.3 Gene:c3a.4 / 100331428 ZFINID:ZDB-GENE-140822-3 Length:1642 Species:Danio rerio


Alignment Length:1760 Identity:380/1760 - (21%)
Similarity:672/1760 - (38%) Gaps:446/1760 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   129 EPTYFIVASRMVRPGLIYQVSVSILQ-AQYPITVHASIACDGVQISGDSKDVK---------EGI 183
            :|.|.:.|...::.|...:|.|.... |...:.|..|:.    :...|.::|.         :..
Zfish    22 QPLYILSAPNKLKLGSAERVFVEAQDYAGASLNVRISVR----RFKDDQREVASTSVTLTAGKNF 82

  Fly   184 PETLLMRIPPTSVTGSYKLRVEGFYQNVFGGLAFLNETRLDFSQRSMTIFVQTDKPLYMQGETVR 248
            .|.:.:.:|..|.|.....:.....|..|.......:..:.|  :|..|.:||||.:|....||.
Zfish    83 QELVEIEVPSNSFTFDKSAQQYAVLQAQFPNKLLQKQILVTF--QSGHIVLQTDKTIYTPDSTVH 145

  Fly   249 FRTIPITTEL-KGFDNPVDVYMLDPNRHILKRWLSRQSNL-----GSVSLEYKLSDQPTFGEWTI 307
            :|...::..: :.|.:.|.|.:|.|:      .:|.:|..     |.||..:.::|..:.|.|.:
Zfish   146 YRVFSLSPGMTRPFQSGVRVEILTPD------GISLESKSVFPDGGVVSGTFGITDPASPGLWKL 204

  Fly   308 RVIAQGQQEE---SHFTVEEYYQTRFEVNVT-MPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIK 368
            ....:...::   |.|.|:||....|||::: ..|:|:..|..:...:.|.:..|..|.|:    
Zfish   205 VAWHKNSPQKNFTSEFEVKEYVLPSFEVSLSPHKAFFYVNDDSLLVDIHAKYLFGETVNGH---- 265

  Fly   369 ATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQ----DGADL 429
                  |:....|:.|                           .:.:.::||.|.:    ||:..
Zfish   266 ------GFVVFGVVTE---------------------------DKGKISIPGSLQRVQIWDGSGT 297

  Fly   430 SQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRE 494
            :|  |.:.|.:                                 :|.|.:|              
Zfish   298 AQ--LTKRQIL---------------------------------QTFPEIR-------------- 313

  Fly   495 LELLVPNLANSEVLITATVGEKFYDEIISGYSVARVYNSSLRVV------FLGDSPQVFKPAMPF 553
             :|:..:|..|..|:|.           ||..:...:...:.:|      :...:||.|||.|||
Zfish   314 -QLVGKSLYISVSLLTE-----------SGSEMVEAHKKGIHIVTSPYTIYFKRTPQFFKPGMPF 366

  Fly   554 TTYLAVEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLPMSQQSDGIWEVKIDIRNDL 618
            ...:.|...|.:|. .|:.          ||...||        :....:::||.:|.|:..   
Zfish   367 DVSVYVTNPDETPA-KNVK----------VEVNPGG--------VSGQTKANGIAKVTINTP--- 409

  Fly   619 NLDDRPQARDFLNGVQNMRLQANFVDPR-GERIQTELLLVSH-YSP----RNQ-HIKVTTSTEKP 676
                        .|...:.:.|...||: ..|.|.|..:.:| |.|    ||. ||.:..:..: 
Zfish   410 ------------GGSSTLEITARTSDPQLTSRQQAEKKMTAHAYVPKGGSRNYLHIGIDAAELR- 461

  Fly   677 VVGEYIIFHIRTNFYL--------EEFNYLIMSKGVILVNDR-----ETITEGIKTIAVVLSSEM 728
             :|:    .::.|..|        ::|.|:|:|:|.|:..:|     :|:.    ::::.::.:|
Zfish   462 -IGD----SMKVNLNLGQSPGVRDQDFTYMILSRGQIVQANRFKRRGQTLV----SLSLPVTKDM 517

  Fly   729 APVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYINN--RKARTGEKVEVAIFGEPGSYVGL 791
            .|....|.:......:||:||:...|......:..|.:::  .....||:.|:.|.|:||:.|||
Zfish   518 VPSFRFVAYYHVGSSEVVSDSVWVDVKDTCMGSLKVEVHDPVEVYEPGEEFELRITGDPGAKVGL 582

  Fly   792 SGIDSAFYTMQAGNELTYAKIITKMSNFDEQ-TNGTYKHIWYSHEGNPDELVYFPASSFG----- 850
            ..:|...|.:...:.:|.:||...:.:.|.. |.|:.|:   |.:...|..:.|.:||.|     
Zfish   583 VAVDKGVYVLNNKHRITQSKIWDVVESHDTGCTAGSGKN---SMQVFSDAGLLFESSSAGGTSVR 644

  Fly   851 ------------------VDANRTF--EYSGLIVFTDGYVPRRQDTCNRTLGFGECLSGRC-YRL 894
                              |:.::|.  :||||          .::.|...|...:.|...| ||.
Zfish   645 TNSECPSSSRRRKRRETLVNLHKTLLDKYSGL----------ARECCVDGLKALDVLDFSCEYRS 699

  Fly   895 E-----KQC-DGLFDC---------DDGTDEINCHARNDTELLNYRKYRFNRVLRHYENVWLWKD 944
            .     |:| |...||         :...:||......|.|.:|.... .:|.|  :...|||::
Zfish   700 SFILDGKECRDAFLDCCNRLTSHREEPAEEEIFLGRSEDEEFVNSDDI-VSRTL--FPESWLWEE 761

  Fly   945 VNIGPH---GRYIFNVEVP-------DRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVE 999
            |.: |.   .|......:|       |....|.::|.|:|.:.|..:.: ..|.:..:.|||:::
Zfish   762 VML-PKCLGNRQCQTTTLPKDGLWLKDSITTWEITAISLSNTHGICVAD-VHEMIVAKNFFIDLK 824

  Fly  1000 MPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSYNPRTSFGEHQFFIY 1064
            :|.:..:.||:.|:..:.|.....::..|.|.::.|.             .:|.::.|.:...:.
Zfish   825 IPYSAVRNEQIEIKAIIHNLYSKAVKVRVELKETKDI-------------CSPASNKGRYAVTVT 876

  Fly  1065 LEAQGTTVVYVPVVPQRLGNVDVTLHVATL-LGTDTITRTLHVESDGLPQYRHQSVLLDLSNRAY 1128
            :.::.:..|...:||..||...:.:..|.. .|.|.:.:.|.|.|:|        ||..:|..  
Zfish   877 VASKSSYSVPFVIVPLALGRHAIEVKAAASGRGNDGVKKDLLVVSEG--------VLTKISEN-- 931

  Fly  1129 VLEY--------------MHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNAS 1179
             |::              .|:...|.|..|           :...:..:||.:     |:.:..:
Zfish   932 -LQFNPFKKGDEDVQVIRSHILKDQAPNTP-----------SSTYVQAIGDTI-----TITIEKA 979

  Fly  1180 -------SLLSLPMESGEQNAFSFAANLYTIMYMRLINQRNKT---LEKNAFYHMNIGYQRQLSF 1234
                   ||:..|...||||.......:....|:...||.:..   |.:.|..::..||.::|::
Zfish   980 ISGAAMGSLIIQPGGCGEQNMMGLTMPVIATHYLDKTNQWHTVRAGLRQTATEYIRKGYNQELAY 1044

  Fly  1235 MRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLLQH-QTPQ 1298
            .:.||||:.    |.|..||.|||:|..:||..||     :.|.||..:|...:|||:.: |.|.
Zfish  1045 RKSDGSFAA----WINRPSSTWLTAYVAKVFAMAS-----DIIHIDQNVICSALRWLIMNRQLPN 1100

  Fly  1299 GSFFEVTWLPDRKM--NRTNFDKNITLTSHVLITLATVKDISGTLGSRVALATQRALAYIERNMD 1361
            |.|.|...:...:|  |....:...::|:.|.|.|...:.......|.:..:..:|:||::..:.
Zfish  1101 GVFRENAPVIHGEMTGNVQGSNSEASMTAFVTIALQEGRSRCNGQVSSLDSSIYKAIAYLKSQLQ 1165

  Fly  1362 FLRHQAQPFDVAITAYALQLCNSPIAEEVFAILRRQ---ARTIGDFMYWGNQEIPQPPRKLENQK 1423
            .|   ..|:.||:.:|||...||         |.:|   ::...|..:|     |.|..      
Zfish  1166 GL---INPYAVAMASYALANANS---------LNKQVLMSKASADKSHW-----PVPGS------ 1207

  Fly  1424 WFSLPRLPYEYDSLNIETTAYALLVYVARREF-FVDPIVRWLNSQRLNDGGWASTQDTSAALKAL 1487
                       .|..:|.::||||..|...:: ...|||.|||:||..:||:.:||.|....:|:
Zfish  1208 -----------SSFTLEASSYALLALVKLHDYQNTAPIVNWLNNQRQYNGGYGTTQATIMVFQAV 1261

  Fly  1488 VEYTVRSRLREVSSLTVEIEASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAIL 1552
            .||.:.:  :.:..|.:|:....:|.:.........|....|:.:||...| |.:.|||.|.|.:
Zfish  1262 AEYRIHA--KNIKQLDLELSIRVEGVRPTVFTFSKNNDHLSQTAKIPSNKG-ITISAKGFGEASV 1323

  Fly  1553 QMHVQY------------NVDIEKFQTKPPVPAFGLHTKAIFHGRNQSHISYVACQNWINQNESE 1605
            .:..:|            |.::|.        .|....:..:.|..:   ||....|....:...
Zfish  1324 TVVTEYYAKPKESSSTCKNFELEL--------TFEKDNEVRYQGATE---SYKLTINTRYLSADR 1377

  Fly  1606 RSGMAVLDVAIPTGYWIQQQKLDTYVLS----NRVRNLRRARYLERK--IVFYFDYLDH--EDIC 1662
            .:.|::|||::.||:.:.:.  |...||    ..::.....:.|..:  ::.|.|.:.|  :| .
Zfish  1378 DATMSILDVSLLTGFVVDEN--DLKALSTGRDKLIQKFEMNKQLSERGSLIIYLDKISHTRKD-R 1439

  Fly  1663 VNFTIERWYPVANMSRYLP--VRIYDYYAPERFNESIFDALPTY----LLNIC--EVCGSSQC-- 1717
            |.|.:.|   :.|.....|  |.:|:||:.|  |..:....||.    |..||  :||   ||  
Zfish  1440 VAFRLHR---IMNGGFLQPAGVTVYEYYSIE--NRCVKFYHPTRKEGGLQKICKNDVC---QCAE 1496

  Fly  1718 PYCSI 1722
            ..||:
Zfish  1497 DNCSL 1501

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
McrNP_524688.1 A2M_N 232..332 CDD:280081 28/108 (26%)
A2M_N_2 669..799 CDD:285005 31/144 (22%)
LDLa 886..913 CDD:238060 11/42 (26%)
A2M 940..1030 CDD:278630 23/99 (23%)
ISOPREN_C2_like 1177..1490 CDD:298658 89/329 (27%)
A2M_comp 1226..1492 CDD:284982 79/272 (29%)
A2M_recep 1607..1695 CDD:284981 24/97 (25%)
c3a.4XP_002660623.3 A2M_N 131..222 CDD:280081 23/96 (24%)
A2M_N_2 453..591 CDD:285005 32/147 (22%)
ANATO 668..734 CDD:237984 18/75 (24%)
A2M 756..855 CDD:278630 23/100 (23%)
complement_C3_C4_C5 981..1264 CDD:239226 89/325 (27%)
A2M_comp 1036..1264 CDD:284982 77/270 (29%)
A2M_recep 1379..1474 CDD:284981 25/102 (25%)
NTR_like 1494..1641 CDD:295338 3/8 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2373
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
ZFIN 00.000 Not matched by this tool.
54.870

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