Protein Alignment Mcr and c3

DIOPT Version :10

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: XP_031755344.1
• Gene: c3 / 100216255
• XenbaseID: XB-GENE-486274
• Length: 1658
• Species: Xenopus tropicalis
• Alignment Length: 1759
• Identity: 373/1759 - (21%)
• Similarity: 677/1759 - (38%)
• Gaps: 455/1759 - (25%)

  Fly    96 VGGGYQDNE----EPSLTRGKSSYNIKATFLESLHSREPTYFIVASRMVRPGLIYQVSVSILQAQ 156
            |.|.|...:    .|:|.|.:|               |.|..|.|.     |......|.|:..:
 Frog    14 VSGSYAQPQCSLITPNLLRAES---------------EETIIIDAQ-----GQNAAFEVEIIIHE 58

  Fly   157 YPITVHASIACDGVQISGDSKDVKEGIPETLLMRIPPTSVTGSYKLRVEGFYQNVFGGLAFLNET 221
            :| ....::|...|.::.|:|.:     .|..::||...|... |...:..|.::...:..|.:.
 Frog    59 FP-QKKLNLASAKVTLNSDNKFL-----GTATVKIPSADVPKD-KQNKQYVYVSLKSNVCALEKV 116

  Fly   222 RLDFSQRSMTIFVQTDKPLYMQGETVRFRTIPITTELKGFDNPVDVYMLDPNRHILKR-WLSRQS 285
            .: .|..|..||:||||.:|..|.||.:|...:..:::.....:.:..:.|:..|:|| .:.:.|
 Frog   117 VM-LSYHSGYIFLQTDKTIYTPGSTVLYRIYSMNYKMQPISKTLIIEFVTPDGVIVKRDSILQDS 180

  Fly   286 NLGSVSLEYKLSDQPTFGEWTIRVIAQGQQEESH---FTVEEYYQTRFEVNVTMPAYFFTTDPFI 347
            ..|.:||.:||.:..:.|.|||....:...::::   |.|:||.....|:.:.....||..|...
 Frog   181 KSGIISLSHKLPELLSLGVWTISAKYEDTPQQNYTTNFEVKEYVLPSMEIILKPDTNFFYADANS 245

  Fly   348 YG-RVMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQN 411
            :| .:.|.:..|..|.|...:...||                                      .
 Frog   246 FGVDIHAQYLYGKHVDGYAFVLFGIR--------------------------------------K 272

  Fly   412 PQVQYNVPGQLPQ----DG---ADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWS 469
            ..|:..:|..|.:    ||   |:|.::.|
 Frog   273 DNVKKGIPESLTRVRIDDGEGRAELKREDL----------------------------------- 302

  Fly   470 GTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEVLITATVGEKFYDEIISGYSVARVYNSS 534
                     ::||         .::.::|...|..:..::|.|..:....||    ....:..:.
 Frog   303 ---------VKYF---------AKQEDMLQYCLYVTVSVVTETGSDMVEAEI----ECINIVTTP 345

  Fly   535 LRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLP 599
            .:::|...| :.|||.|||...:.|...||||    ..|..:....|.:|.
 Frog   346 YKILFTRTS-KYFKPGMPFDMMVYVTNPDGSP----ARRITVAAEPGNIEG-------------- 391

  Fly   600 MSQQSDGIWEVKIDIRNDLNLDDRPQARDFLNGVQNMRLQANFVDP--RGERIQTELLLVSHYSP 662
             :.|:||...:.::.|.|:   ||            :.:.....||  ...|..|..:..:.|.|
 Frog   392 -TTQADGTTRLTMNTRPDI---DR------------LHITVKTKDPVLPAARQATATMTATAYRP 440

  Fly   663 RNQ-----HIKVTTSTEKPVVGEYIIFHIR-----TNFYLEEFNYLIMSKGVILVNDRETITEG- 716
            ...     ||.:..|..||.....:.|:||     ....:::|.|||||:|.|:...|:....|
 Frog   441 SKAQGNYLHISIAGSEIKPGENIPVNFNIRNTDAGVQNLIQQFTYLIMSRGRIVKVGRQARQPGQ 505

  Fly   717 -IKTIAVVLSSEMAPVATIVVWKINQQG---QVVADSLTFPVNGISRNNFTVYINNRKAR----- 772
             ..|:::.::..:.|...||.:.|...|   .||:|||.  |:.:.....|:.:...|.|
 Frog   506 PFVTMSLSVTEALIPSFRIVAYYIVSSGGARDVVSDSLW--VDVVDECMGTLSVTGDKDRDNAIQ 568

  Fly   773 -TGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQTNGTYKHIWYSHE- 835
             .|..:::.:..:..|||||..:|...|.:.           :|..|       |.|.:|.|.|
 Frog   569 TPGSPMKLKLRADHKSYVGLVAVDKGVYVLN-----------SKFKN-------TQKKVWDSVEK 615

  Fly   836 ---------GNPDELVYFPA-----SSFGVDANRTFEYS-------------GLIVFTDGYVPRR 873
                     |...|.|:..|     :|||.:..:..|..             .:|....|.....
 Frog   616 SDIGCTPGSGANSEGVFSDAGLALQTSFGTNTAQRSEAHCPAPAQRRKRSSVAIIEIKAGKASEY 680

  Fly   874 QDTCNRTL--GFGECLSGR-C-----YRLE-KQC-DGLFDC----------------------DD 906
            :|...:..  |..|.|.|. |     |.|: |:| |...||                      .|
 Frog   681 KDKAKKCCLDGMQENLMGHTCERRARYILDGKECVDAFVDCCKYYEKKREAERLSKDEDTLGRSD 745

  Fly   907 GTDEINCHARNDTELLNYRKYRFNRVLRHYENVWLWK--------DVNIGPHGRYIFNVEVPDRP 963
            ..||...    |:::::..:         :...|.||        |.| |...:.: ||.:.|..
 Frog   746 EDDEYML----DSDIVSRTE---------FPESWFWKVEQMVEKADAN-GISTKTL-NVFLKDSI 795

  Fly   964 AYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIV 1028
            ..|.|.|.|:|.:||. .:.:..|...::.|||::::|.:..:.|||.||..::||....|:..|
 Frog   796 TTWEVLAVSLSETKGL-CVAQPYEIKVMKDFFIDLKLPYSVVRNEQVEIRAILYNYRNDRIKVRV 859

  Fly  1029 VLHDSPDYKFVHVEEDGIVRSYNPRTSFGEHQFFIYLEAQGTTVVYVPVVPQRLG--NVDVTLHV 1091
            .|..:|::          .....|:..:.:.   :::.|..:|.|.:.:||..||  :::|...|
 Frog   860 ELTHNPEF----------CSLATPKKKYRQE---VWIGALSSTAVPMVIVPLTLGQHDIEVKASV 911

  Fly  1092 ATLLGTDTITRTLHVESDGLPQYRH-QSVLL--DLSNRAYVLE-----YMHVNVTQTPEIPYQVD 1148
            |.....|.:.:.|.|..:|:...:. ::|:|  |:..:..|.|     ....||....:|...:.
 Frog   912 AGSFANDGVRKKLKVVPEGMRIAQDVKTVILEPDVKGKDGVQEEEIKALNPKNVVPRTDIDTTIT 976

  Fly  1149 RYFVYGSNKARISVVGDVVGPIFPTMPVNASSLLSLPMESGEQNAFSFAANLYTIMYM------- 1206
            ......|.....::.|:           |.:.|:.:|...||||..|...::....|:
 Frog   977 LQGTPISQMVEDAIDGN-----------NMNHLIVVPAGCGEQNMISTTPSVIATRYLDYSGQWE 1030

  Fly  1207 RL-INQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQEASF 1270
            |: :|:|.:.|:     ::..||.:|:::.:||.|::.    |.:..:|.|||.|..:||..|
 Frog  1031 RIGVNRREQALK-----NIKQGYAQQMTYRKPDNSYAA----WKDRPASTWLTGYVAKVFGMA-- 1084

  Fly  1271 YEWENFIWIDATIIEKNMRWL-LQHQTPQGSFFEVTWLPDRKM----NRTNFDKNITLTSHVLIT 1330
               :.|:.|:|.::...::|| |:.|.|.|.|:|...:..::|    .....:.:.:||:.::|.
 Frog  1085 ---QEFVDIEANVLCGAIKWLILERQKPDGLFYENAPVIHQEMVGGITTGAAEADSSLTAFIVIA 1146

  Fly  1331 LATVKDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDVAITAYALQLCNS-PIAEEVFAIL 1394
            :...:.......:.:.::..:|.:|:......||   :|:.:|||:|||.|... |..:::.::
 Frog  1147 MLECQRTCNEHVNNLQVSIDKATSYLTGQYPGLR---KPYSIAITSYALALAGKLPNTKKLMSV- 1207

  Fly  1395 RRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVARREFFVDP 1459
                 :||| .:|     .:|.::.                 :::|.|:||||..:..:|:  .|
 Frog  1208 -----SIGD-THW-----EEPGKRF-----------------ISLEMTSYALLTLLKMKEY--GP 1242

  Fly  1460 ---IVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVEIE---ASSQGGKTQTL 1518
               ||||||.||.....:.|||.|....:||.:|  ::.:..::.|.:::.   ...|...|..:
 Frog  1243 TGGIVRWLNEQRYYGAVYGSTQATIVMFQALAQY--QTDVPGLNELNLDVSLHLPERQQPLTYRI 1305

  Fly  1519 YIDDTNLAKLQSIEIPDAWGTIKVQAKGAG--------YAIL--------QMHVQYNVDIEKFQT 1567
            .:|:..||:.....:...: .:|.:.||.|        :|:|        ...:...|..||...
 Frog  1306 NLDNALLARSAETRLNQDF-VVKAKGKGQGTIRVVTVYHALLTEKERKCSNFELSVKVKEEKIAR 1369

  Fly  1568 KPPVPAFGLHTKAIFHGRNQSHISYVACQNWINQNESERSGMAVLDVAIPTGYWIQQQKLDTYVL 1632
            :|             .|. :|.:|..||..::.::::.   |:::|:::.||:     ..||..|
 Frog  1370 RP-------------EGA-RSTVSIEACARYLGKDDAT---MSIIDISMMTGF-----SPDTESL 1412

  Fly  1633 SNRVRNLRR--ARYLERK-------IVFYFDYLDH-EDICVNFTIERWYPVANMSRYLPVRIYDY 1687
            ...::.:.:  ::|...|       ::.|.|.:.: |:.||.|...:::.| ...:...|.:|||
 Frog  1413 DRLMKGVDKYISKYEVNKGANEKGTLILYLDKISNTEEECVKFYAHQYFEV-GFIQPASVTVYDY 1476

  Fly  1688 YAPE 1691
            |.||
 Frog  1477 YTPE 1480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	YfaS	<226..1575	CDD:441940	319/1497 (21%)
		A2M_BRD	667..801	CDD:462235	40/149 (27%)
		A2M	939..1030	CDD:459711	30/98 (31%)
		TED_complement	1160..1490	CDD:462227	84/346 (24%)
		A2M_recep	1605..1699	CDD:462226	23/97 (24%)
c3	XP_031755344.1	MG1	20..120	CDD:465508	23/127 (18%)
		MG2	125..220	CDD:426464	26/94 (28%)
		MG3	222..306	CDD:465509	21/165 (13%)
		MG4	348..424	CDD:465507	25/110 (23%)
		A2M_BRD	448..598	CDD:462235	41/151 (27%)
		ANATO	676..733	CDD:237984	13/56 (23%)
		A2M	765..861	CDD:459711	30/98 (31%)
		complement_C3_C4_C5	991..1276	CDD:239226	84/343 (24%)
		A2M_recep	1391..1488	CDD:462226	23/99 (23%)
		NTR_complement_C3	1507..1656	CDD:239638