DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcr and zgc:171426

DIOPT Version :9

Sequence 1:	NP_524688.1	Gene:	Mcr / 44071	FlyBaseID:	FBgn0267488	Length:	1760	Species:	Drosophila melanogaster
Sequence 2:	XP_017210396.1	Gene:	zgc:171426 / 100137103	ZFINID:	ZDB-GENE-080212-2	Length:	1466	Species:	Danio rerio

Alignment Length:	1770	Identity:	378/1770 - (21%)
Similarity:	633/1770 - (35%)	Gaps:	474/1770 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 NNQNFGQTNPSDRPPYRTDSGSYNDIAGQDDYNKRVGGGYQDNEEPSLTRGKSSYNIKATFLESL 125
            :::.|...|||...|.....||               |.:.....|||....|...:.|:.|:..
Zfish    25 SSELFYVDNPSQTGPVTDGRGS---------------GPFFMVTFPSLIESGSDAKLCASLLKPK 74

  Fly   126 HSREPTYFIVASRMVRPGLIYQVSVSILQAQYPITVHASIACDGVQISGDSKDVKEGIPETLLMR 190
            .....|..:|..:.:...|:.|.|...|        |........|::|||...
Zfish    75 DRFTMTISLVDEKNIETRLVRQASQRKL--------HRCFKFQAPQVNGDSVQT----------- 120

  Fly   191 IPPTSVTGSYKLRVEGFYQNVFGGLAF--LNETRLDFSQRSMTIFVQTDKPLYMQGETVRFRTIP 253
                       :||      |..|.:|  ..|:::.|.......|:|||||||..|:||.||.:.
Zfish   121 -----------VRV------VVQGRSFKMTEESKVMFRSYLPLTFIQTDKPLYNPGQTVYFRVLT 168

  Fly   254 ITTELKGFDNPVD-----VYMLDPNRHI-LKRWLSRQSNLGSVSLEYKLSDQPTFGEWTIRVIAQ 312
            ::.:.:    |.|     |.:::.|.:| :.:|.:..|....:.|.:.|:.:...|.:|::....
Zfish   169 MSDKFE----PQDQLYSLVVVVEDNNNIRINQWTNVSSTNWILELSHTLNAEARVGTYTLKAYIG 229

  Fly   313 GQQEESHFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYF 377
            .:.....|.|::|...:|::.|..|..:...|..:.......:|.|.||.|.:.:
Zfish   230 DRVISKRFNVKKYVLPKFDLTVNTPQKYSVADVGLKVEACGKYTYGQPVPGQVFV---------- 284

  Fly   378 SNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRNQYVVE 442
              :|..::....|.|...:...||....|:
Zfish   285 --EVCRQRRPYIRDPKVTSVCLNETTWMND----------------------------------- 312

  Fly   443 RHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEV 507
                                      :|.....|....:|:..|             .|...:..
Zfish   313 --------------------------TGCASLVLSTSTFFSTNF-------------KNSLQNSF 338

  Fly   508 LITATVGEKFYDEIISGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSPIDPNLL 572
            ::...|.|:....::|..|...:.....:|.|: |.|:.              |..||.::
Zfish   339 VVNVNVTEEGTGVVMSKSSTVSITFEVGKVTFV-DLPKF--------------YDYGSTVN---- 384

  Fly   573 RQGLMEVSGFVESRNGG------------RRDWPAQRL-PMSQQSDGIWEVKIDIRN--DLNL-- 620
              |.:.||.|     ||            |..||.:.| .::....|..:..::..|  ..||
Zfish   385 --GKISVSDF-----GGNAISNKVVYLLDRGQWPNKVLFNVTTDESGFADFSLNTTNFPKANLIL 442

  Fly   621 --DDRPQA-RD-----FLNGVQNMRL-QANFVDPRGERIQTELLLVSHYSPRNQHIKVTTSTEKP 676
              ...||. ||     |....|.::| ||...|   ....::|.:||...|      :...|..|
Zfish   443 VASATPQTYRDSSSPYFATDYQVVQLSQAAAPD---NPTYSDLSIVSLQQP------LKCGTTYP 498

  Fly   677 VVGEYIIFHIRTNFYLEEFNYLIMSKGVILVN--------DRETITEGIKTIAVVLSSEMAPVAT 733
            |..:| .|...|..|..:..|::||:|||:::        ..:|:|:|..:..:.:.:.||||..
Zfish   499 VTVKY-TFVGETGDYSADIIYMVMSRGVIVLHGFKTVQAFGSDTLTKGTVSFDLSVLAGMAPVVQ 562

  Fly   734 IVVWKINQQGQVVADSLTFPVNGISRNNFTVYINNRKARTGEKVEVAIFGEPGSYVGLSGIDSAF 798
            |:|:.:.....||..|.:|.......|..::..:...|..||...:.:..:.||..|||.||.:.
Zfish   563 ILVFSVLPSQTVVTGSASFDTEKCFSNQVSLQFSPATAVPGEGSILTVSAQAGSLCGLSAIDQSV 627

  Fly   799 YTMQAGNELTYAKI-----ITKMSNFD---EQTNGTYKHIWYSHEGNPDELVYFPASSFGVD-AN 854
            ..||:|..|:...:     :..:.::.   |...|..|              :.|..:...| |.
Zfish   628 LIMQSGGRLSAEAMFGLLPVRALHDYPPGVEDQQGCLK--------------FRPLRAVPTDQAY 678

  Fly   855 RTFEYSGLIVFTDGYVPRRQDTCNRTLG-------------FGE-------------CLSGRCYR 893
            .||:..|:.:.|:..|  |:..|....|             |.|             .|:.|
Zfish   679 NTFKGVGIKIATNLLV--REPPCLTYRGQNYYSSFQGGVSPFSETGFAMVENIAAPAVLAAR--- 738

  Fly   894 LEKQCDGLFDCDDGTDEINCHARNDTELLNYRKYRFNRVLRHYENVWLWKDVNIGPHGRYIFNVE 958
                    ...|..:..::...|.                 .:...|:|:..|:|..|.....:.
Zfish   739 --------VGGDSSSSAVDVTIRT-----------------FFPETWIWQLANVGDSGSTSVPLT 778

  Fly   959 VPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITP 1023
            |||....|...||.:| |.|||:....| ....||||:.:.:|.:..:||...::.|||||:...
Zfish   779 VPDTITTWDTEAFCLS-SSGFGLAPPVL-LTAFQPFFLELTLPYSIIRGEFFELKATVFNYLSQC 841

  Fly  1024 IEAIVVLHDSPDYKFVHVEEDGIVRSYNPRTSFGEHQFFIYLEAQGTTVVYVPVVPQRLGNVDVT 1088
            |:..|....|.::....:.:|   .||.             |.|.|.......:....||.::||
Zfish   842 IKVQVTPTPSSNFTLKSLNDD---HSYT-------------LSANGRKTFKWDLSASVLGTLNVT 890

  Fly  1089 L-------------HVATLLGT---DTITRTLHVESDGLPQYRHQSVLLDLSNRAYVLEYMHVNV 1137
            :             .:.|:..:   |.:||:|.|.::|:.:...:|.|  |..:..:|. .:|.:
Zfish   891 VSAEASPSQELCDNDIVTVPSSGRIDVVTRSLLVLAEGVKRTFTRSWL--LCPKGSMLS-ENVKI 952

  Fly  1138 TQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNASSLLSLPMESGEQNAFSFAANLYT 1202
            |....|        :.||.:..:||:||::|....    |.::||.:|...||||....|.|:||
Zfish   953 TFPANI--------IKGSARCSVSVIGDIMGRSLR----NLANLLQMPYGCGEQNMIILAPNIYT 1005

  Fly  1203 IMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQE 1267
            :.|::...|....::..|..::..|||.:|::...|||||.|..|.:|:    |||::.:|.|..
Zfish  1006 LRYLKETAQLTPAIQDTATSYLQSGYQGELNYRHRDGSFSTFGYDASNT----WLTAFVMRTFGL 1066

  Fly  1268 ASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPDRKMNRTNFDKNITLTSHVLITLA 1332
            |     .:|.:||..:::....||:..|...|.|.:...|....| :...|.|:|:|.:::.:|.
Zfish  1067 A-----RSFTYIDPNVLKGAKDWLIGTQGSDGCFVQQGTLYHNDM-KGGVDDNVTMTGYIVASLL 1125

  Fly  1333 TV----------------KDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDVA-ITAYALQ 1380
            .:                :.:.|.||:....|   .|||             .|.:| .|....|
Zfish  1126 EIGVPVTDPVITKALSFLRPLVGNLGNTYVTA---LLAY-------------TFSLAGETRTRAQ 1174

  Fly  1381 LCNSPIAEEVFAILRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYA 1445
            |.||         ||..|.:.|..::|....                     ..|:|.:|.:||.
Zfish  1175 LLNS---------LRNTAISEGTTLHWSQTS---------------------SGDTLAVEISAYV 1209

  Fly  1446 LLVYVARREF------FVDPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTV 1504
            ||..:..:..      :.:.||.||.:|:...||:.|||||..||:||..|..:. .....|..|
Zfish  1210 LLAVLTLQPVTTANLGYANRIVNWLVAQQNPYGGFTSTQDTVVALQALALYAAQV-FSPGGSSKV 1273

  Fly  1505 EIEASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNVDIEKFQTKP 1569
            .:::|...|......:...|....|...:.:..||..|.|.|:.....|:...||:      ..|
Zfish  1274 TVQSSVPTGDVFHFAVTPNNRLLYQESPLKNFPGTYSVAATGSACVSAQVACFYNI------PTP 1332

  Fly  1570 PVPAFGLHTKAIFHGRNQSHISYVA-----CQNW-IN---------QNESERSGMAVLDVAIPTG 1619
            ||             |....:|..|     ||.. :|         ......:.|.::|:.:.:|
Zfish  1333 PV-------------RFSKTLSVGAKVTGDCQAVPVNLMLTFTVRYTGPKPTTNMVLVDIKLLSG 1384

  Fly  1620 YWIQQQKLDTYVLS---NRVRNLRRARYLERKIVFYFDYLDHEDICVNFTIERWYPVANMSRYLP 1681
            :     ..||.:|.   |....::|.......::.|...:. :.:.|.|:|:....|| :....|
Zfish  1385 F-----TADTSLLGSPPNFTPFVQRVDAEGDHVLVYLQEVP-KGVPVTFSIQLTQAVA-VKNLKP 1442

  Fly  1682 --VRIYDYY-APERF 1693
              :.||||| ..:||
Zfish  1443 AVINIYDYYQRSDRF 1457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	A2M_N	232..332	CDD:280081	28/105 (27%)
		A2M_N_2	669..799	CDD:285005	37/137 (27%)
		LDLa	886..913	CDD:238060	3/26 (12%)
		A2M	940..1030	CDD:278630	31/89 (35%)
		ISOPREN_C2_like	1177..1490	CDD:298658	90/335 (27%)
		A2M_comp	1226..1492	CDD:284982	76/288 (26%)
		A2M_recep	1607..1695	CDD:284981	22/93 (24%)
zgc:171426	XP_017210396.1	A2M_N	147..239	CDD:280081	25/95 (26%)
		YfaS	<148..>1086	CDD:225248	247/1149 (21%)
		A2M_N_2	484..628	CDD:285005	40/150 (27%)
		A2M	759..847	CDD:278630	30/89 (34%)
		A2M_2	977..1252	CDD:239227	86/334 (26%)
		A2M_comp	1029..1252	CDD:284982	71/278 (26%)
		A2M_recep	1372..1461	CDD:284981	22/93 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920