DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mcr and c4a

DIOPT Version :9

Sequence 1:NP_524688.1 Gene:Mcr / 44071 FlyBaseID:FBgn0267488 Length:1760 Species:Drosophila melanogaster
Sequence 2:NP_001107156.1 Gene:c4a / 100135012 XenbaseID:XB-GENE-478881 Length:1683 Species:Xenopus tropicalis


Alignment Length:1785 Identity:374/1785 - (20%)
Similarity:684/1785 - (38%) Gaps:459/1785 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   127 SREPTYFIVASRMVRPGLIYQVSVSILQAQYP---------ITVHASIACDGVQIS----GDSKD 178
            :::|.:.:||.|::..|:...|.:   |.::|         |.|..|:.   .|:|    .:.|.
 Frog    21 AQQPNFLVVAPRILHVGVKEVVGI---QFEWPQGSSPPAGDIKVELSLR---NQLSMIDCSEEKR 79

  Fly   179 V--KEGIPETLLMRIPPTS---VTGSYKLRVEGFY------QNVFGGLAFLNETRLDFSQRSMTI 232
            |  .:|...|:|..:..||   .|.....|.:..|      .::||....:....:.: ||.. :
 Frog    80 VLLNKGNGYTILADLMLTSQRLTTCKLNERRDDRYVQLVVKSDIFGKQPKVVSIPVAY-QRGY-L 142

  Fly   233 FVQTDKPLYMQGETVRFRTIPITTELKGFDNPVDVYMLDPNRHILKR--WLSRQSNLGSVSLE-Y 294
            |:||||.:|...|.|..|...:...|:..:..|.:.:.:.....:::  .:|:    |||..| .
 Frog   143 FIQTDKSIYTPKEAVHIRLFTLDHVLRPTEELVTLSVFNAQGFQVRKVEMISK----GSVVAENL 203

  Fly   295 KLSDQPTFGEWTIRVIAQGQQE---ESHFTVEEYYQTRFEVNV--TMPAYFFTTDPFIYGRVMAN 354
            ::.|..|.|.|.|....:...|   .:.|.|:.|....|||.:  .:|.:..|.|.|.: ||.|.
 Frog   204 RIPDISTPGVWKISARYRDAPETNFTAEFEVKPYVLPNFEVKIIPEVPYFLMTKDSFTF-RVEAR 267

  Fly   355 FTSGLPVRGNLTIKATIRPIGYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVP 419
            :..|..|.|...::..|        ...|.|..:.|...:||.|.:|         |..:...: 
 Frog   268 YVYGENVAGVAYVRVGI--------TAQNGKRYMLRGLEKQTTLGDE---------NTAITIKM- 314

  Fly   420 GQLPQDGADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNG 484
                   ||:.:.|                          .||                      
 Frog   315 -------ADIKEKI--------------------------QQD---------------------- 324

  Fly   485 TFDFKWPLRELELLVPNLANSEVLITATVGEKFYDEIISGYSVARVYNSSLRVVFLGDSPQVFKP 549
                          :.||..:.:.|.|:|.||....:......:..:.||...:.|..:.:.|.|
 Frog   325 --------------MGNLLGASLYIAASVIEKASGVLEEKELTSVKFVSSPYKLDLSRTKRYFIP 375

  Fly   550 AMPFTTYLAVEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQRLPMSQQSDGIWEVKIDI 614
            ..|....:.|...||||         .:.||                 :.:|:.:..::|.|   
 Frog   376 GAPAQIVVEVSLIDGSP---------AVGVS-----------------VSLSKSNVQLFEFK--- 411

  Fly   615 RNDLNLDDRPQARDFLNGVQN-----MRLQANFVDPRGERIQTE-LLLVSHYSPRNQHIKVTTST 673
                 .||:......:|...|     :.::|| .|...|   || :.|:.:.|..|.::.:....
 Frog   412 -----TDDKGVVTFHVNTASNEKKCDITVKAN-ADSGSE---TERITLLPYTSKANSYLYINVPN 467

  Fly   674 EKPVVGEYIIFHIR----TNFYLEEFNYLIMSKGVILVN---DRETITEGIKTIAVVLSSEMAPV 731
            :....|..:...::    .|..:.:..|::::||.:|..   .|..:.|    :::.::|.|.|.
 Frog   468 QVLNPGSSVKVSLKAIISNNQNVGKIYYMVLNKGQLLSMASIQRAEVNE----MSIAVTSTMIPS 528

  Fly   732 ATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYINNRKARTGEKVEVAIFGEPGSYVGLSGIDS 796
            ..|:.:..: :.:::|:|:...|..:......::.|.:....||..::.:..|..:.|.||.:|:
 Frog   529 FRIIAFYYH-ESEIIANSVWVDVTDVCEGKLELHANKQIIEPGEAFKLEVRAEGKASVSLSAVDT 592

  Fly   797 AFYTMQAGNELTYAKIITKMSNFDEQTNGTYKHIWYSHEGNPDELVYFPASSFGVDANRTFEYSG 861
            |.|.:...|:||..|:...|:.:|         :..|..|..|.:      :...||...|    
 Frog   593 AVYILNPKNKLTPQKMFKAMNAYD---------LGCSPGGGKDFI------NVLTDAGLAF---- 638

  Fly   862 LIVFTDGYVPRRQDTC------NRTLGFGECLSGRCYRL-------------------------- 894
              |.:.||....:..|      .|.:.|......:.|..                          
 Frog   639 --VSSAGYSQINELGCRVHQRKKRAIDFQALTQQKAYSYPTTELQRCCQHGMMLPPRKMSRVCTQ 701

  Fly   895 ------EKQCDGLFDCDDGTDEINC--HARNDTELLNYRKYR---FNRVLRHYENV--------- 939
                  :..|.|:|        :.|  :|.|..:.:...|.:   |.|.    :||         
 Frog   702 RAARVPDTSCRGVF--------LACCEYAENLRKQMTLEKRKTQGFGRT----QNVDEFDEDFAD 754

  Fly   940 -------------WLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGV 991
                         |||:.|.: .:|....||.|||....|.:.|..:||.||| .:.:.|:....
 Frog   755 ESDIQMRSFFPESWLWRTVKV-YNGLISENVYVPDSITTWEIQAVGMSPEKGF-CIAEPLKVKVF 817

  Fly   992 QPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSYNPRTSF 1056
            :.|.|.:.:|.:.::.||:.:|..::||....:|..|.:..:.|.             .:|.:  
 Frog   818 KDFHIYLRVPYSVKRFEQMELRPILYNYNDKDLEVKVYMEQTEDI-------------CSPGS-- 867

  Fly  1057 GE---HQFFIYLEAQGTTVVYVPVVPQRLGNVDVT-LHVATLLGTDTITRTLHVESDGLPQYRHQ 1117
            ||   |...:.:.|.....|...|||....|..|: :.:||.|.:|.:.:::.:..:|      .
 Frog   868 GESKPHIKQVTVAANSALPVPFVVVPIGKSNPVVSVVALATSLVSDAVKKSMKIVKEG------A 926

  Fly  1118 SVLLDLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARISVV--GDVVGPIFPTM--PVNA 1178
            ||   |..::|:::            |..:.|..:....:...:::  ||....|..||  |:|.
 Frog   927 SV---LEEKSYIID------------PTDITRQSIDFEEELPSNIIPDGDFHSSIKVTMDSPMNT 976

  Fly  1179 ----------SSLLSLPMESGEQNAFSFAANLYTIMYM------RLI--NQRNKTLEKNAFYHMN 1225
                      |.|:.:|....||...|.:..:|.:.|:      .|:  :::::.||     :|.
 Frog   977 INNSLGADGISKLIRVPYGCAEQTMISTSPGVYALRYLDHTEKWNLLPPDRKDQGLE-----NMR 1036

  Fly  1226 IGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMRW 1290
            .||.|.|.|.:.|||:..    |.:..||.|||::.::|....     .|:|.::...|.:::.:
 Frog  1037 QGYLRILQFKKTDGSYGA----WVSRASSTWLTAFVVKVLSLC-----RNYIDVNVEDIRRSVHY 1092

  Fly  1291 LLQHQTPQGSFFEVTWLPDRKM--NRTNFDKNITLTSHVLITLATVKDISGTLGSRVALATQRAL 1353
            |...||.:|:|.|...:..:.|  ..:..|..:::|::|.:.|....|........|..:..:|:
 Frog  1093 LTTMQTDKGAFQEKLTVIHQDMLGGASTIDAEVSITAYVTVALYHSLDALSEDNVAVKSSISKAV 1157

  Fly  1354 AYIERNMDFLRHQAQPFDVAITAYALQLC--NSPIAEEVFAILRRQARTIGDFMYWGNQEIPQPP 1416
            .|:...:|.::|   |:.:|:|.|||.|.  :|.:.:.....|..||:  ||            |
 Frog  1158 DYLRTKLDIVKH---PYSLALTTYALTLTSKDSILKDNANNKLMSQAQ--GD------------P 1205

  Fly  1417 RKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVAR---REFFVDPIVRWLNSQRLNDGGWASTQ 1478
            .|.|  .:|..|.     .:|.:|||:|.||:.:.|   |:  .:.:..||:.|:...||:.|||
 Frog  1206 NKKE--LYFGPPG-----TALAVETTSYVLLITLLRGNIRD--AEKMYTWLSEQQNYGGGFRSTQ 1261

  Fly  1479 DTSAALKALVEYTVRSRLREVSSLTVEIEA-SSQGGKTQTLYIDDTNLAKLQSIEIPDAWGT--- 1539
            ||..||:||.||.:|:..::.::|.:|:.: ..|..:...|..:|:...:|:|:      ||   
 Frog  1262 DTVMALEALSEYWIRTFKQDDNTLEIEVNSLEKQHSQKFRLRKEDSLQEELRSM------GTKFN 1320

  Fly  1540 IKVQAKGAG-------YAILQMH----VQYNVDI--------------------EKFQTKP--PV 1571
            :||..||.|       |.|:||.    .:..:|:                    |:...:|  |:
 Frog  1321 VKVSGKGKGILTVMRMYNIIQMQNTSCTELGMDVTVTDASVDAGPDDQDDYDYDEEMADEPRDPI 1385

  Fly  1572 PAFGLHTKA----IFHGRNQSHISYVACQNWINQNESERSGMAVLDVAIPTGYWIQQQKLDTY-- 1630
            ....|..::    .|....:..:.|..|. |...::...||||::|:.:.:|.   |..:|..  
 Frog  1386 VWHDLRHRSRREVTFAKEKEVKLLYEVCL-WKKSSKVHLSGMAIVDITMLSGI---QPVIDDLKK 1446

  Fly  1631 VLSNRVRNLRRARYLERKIVFYFDYLDHEDICVNFTIERWYPVANMSRYLPVRIYDYYAPERFNE 1695
            :..:..:.:....|...:::.|||.:.....||.|...:...|:.:.....| :||:|.| ....
 Frog  1447 LAESSEQYISHYEYQPGRLLLYFDKVPDTRDCVTFEAVQTVKVSVLQPASAV-LYDFYEP-NIKC 1509

  Fly  1696 SIF---DALPTYLLNIC--EVCGSSQ--CP 1718
            ::|   .:.|.::..:|  :||..::  ||
 Frog  1510 TVFYGAPSKPNFVSTLCSGDVCQCAEGLCP 1539

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
McrNP_524688.1 A2M_N 232..332 CDD:280081 26/105 (25%)
A2M_N_2 669..799 CDD:285005 24/136 (18%)
LDLa 886..913 CDD:238060 4/58 (7%)
A2M 940..1030 CDD:278630 28/89 (31%)
ISOPREN_C2_like 1177..1490 CDD:298658 89/337 (26%)
A2M_comp 1226..1492 CDD:284982 78/272 (29%)
A2M_recep 1607..1695 CDD:284981 21/89 (24%)
c4aNP_001107156.1 MG1 23..131 CDD:375333 25/113 (22%)
A2M_N 142..234 CDD:376626 23/95 (24%)
MG3 237..>291 CDD:375334 16/62 (26%)
MG4 364..>436 CDD:375332 18/105 (17%)
A2M_N_2 461..597 CDD:377903 25/140 (18%)
ANATO 668..732 CDD:237984 7/71 (10%)
A2M 767..856 CDD:365945 28/90 (31%)
complement_C3_C4_C5 983..1273 CDD:239226 88/329 (27%)
A2M_recep 1424..1513 CDD:369460 21/93 (23%)
NTR_like 1531..1681 CDD:382999 3/9 (33%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 51 1.000 Domainoid score I11365
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D177369at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR11412
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
33.110

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