DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcr and zgc:165518

DIOPT Version :9

Sequence 1:	NP_524688.1	Gene:	Mcr / 44071	FlyBaseID:	FBgn0267488	Length:	1760	Species:	Drosophila melanogaster
Sequence 2:	NP_001093623.2	Gene:	zgc:165518 / 100101650	ZFINID:	ZDB-GENE-070720-15	Length:	1455	Species:	Danio rerio

Alignment Length:	1686	Identity:	362/1686 - (21%)
Similarity:	633/1686 - (37%)	Gaps:	393/1686 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 PTYFIVASRMVRPGLIYQVSVSILQAQYPITVHASIACDGVQISGDSKDVKEGIPET-------- 186
            |.:.:....::..|...::.||:|:....:|:..|:.       .|.|...:.:.:|
Zfish    47 PLFMVAFPSLIESGSDAKLCVSLLKHTGSLTITISLV-------DDQKTETQLVRQTSRRKLHQC 104

  Fly   187 LLMRIPPTSVTGSYKLRVEGFYQNVFGGLAF--LNETRLDFSQRSMTIFVQTDKPLYMQGETVRF 249
            ...:.|..:......:||      |..|.:|  ..|:::.|.......|:|||||||..|:.|..
Zfish   105 FTFQAPLVNGDSVQTVRV------VVQGPSFKMTEESKVMFRSYLPLTFIQTDKPLYNPGQKVNI 163

  Fly   250 RTIPITTELKGFDNPVDVYMLDPNRHI-LKRWLSRQSNLGSVS----LEYKLSDQPTFGEWTIRV 309
            |.:.::.:....:....:.:|:....| :::|    :|:.|::    |.:.|:.:...|.:|::.
Zfish   164 RVVTMSDQFVPQEQMYSLVVLEDLHGIRIRQW----ANVSSINWILELSHVLNPEAQTGTYTLKA 224

  Fly   310 IAQGQQEESHFTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPI 374
            ....:.....|.|::|...:|:|.|..|..:...|..:.....|.:|.|.||.|.:.::...:|.
Zfish   225 YIGDRILSQSFDVKQYVLPKFDVTVNAPQTYSVADVGLKVEACAKYTYGQPVPGQVVVEVCRQPF 289

  Fly   375 GYFSNQVLNEKYRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRNQY 439
            .|.                                |:|:|          ....||:.....|
Zfish   290 IYI--------------------------------QDPKV----------TSVCLSKSTKTNN-- 310

  Fly   440 VVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLAN 504
                                         :|....||....:| ||        .||    |...
Zfish   311 -----------------------------TGCASLTLTTSSFF-GT--------SLE----NSLQ 333

  Fly   505 SEVLITATVGEKFYDEIISGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYLAVEYHDGSPIDP 569
            :..::...|.|:....:||..:...:.....:|.|: |.|:.:.........::|...:|:||:.
Zfish   334 NSFVVNVNVTEEGTGVVISKSNTVSITFEVGKVTFV-DLPKFYDYGSTLNGKISVSDFNGNPINS 397

  Fly   570 NLLRQGLMEVSGFVESRNGGRRDWPAQRL-PMSQQSDGIWEVKIDI----RNDLNL--DDRPQAR 627
            ..:.  :::.|           .||.:.| .::...:|:....:|.    :.||||  ...||
Zfish   398 KAVY--VLDSS-----------TWPNKLLFNLTTNKNGLAMFSLDTTAFPKADLNLVASATPQ-- 447

  Fly   628 DFLNGVQNMRLQANFVDPRGERIQTELLLVSHY------SPRNQHIKVTTSTEKPV--------- 677
                         ::.........|:..||..:      :|....:.:.| .|:|:
Zfish   448 -------------SYFSYNSPYFTTDTRLVQLFQTAAPDNPSFSDLSIVT-LEQPLKCGNTYPVT 498

  Fly   678 -----VGEYIIFHIRTNFYLEEFNYLIMSKGVILVND--------RETITEGIKTIAVVLSSEMA 729
                 |||       |..|..:..|::||||||:::.        .:|||.|..:..:.:.:.||
Zfish   499 VKYSFVGE-------TGDYSADIIYMVMSKGVIILHGFKTVQALAFDTITSGTVSFDLSILANMA 556

  Fly   730 PVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYINNRKARTGEKVEVAIFGEPGSYVGLSGI 794
            |:..|:.:.:.....|||.|.:|.......|..::..:...|..||...:.:..:.||..|||.|
Zfish   557 PMVQILAFCVLPSQTVVAGSASFDTEKCFSNQVSLQFSPASAVPGEGSVLTVSAQAGSLCGLSAI 621

  Fly   795 DSAFYTMQAGNELTYAKI--ITKMSNFDEQTNGTYKHIWYSHEGNPDELVYFPASSFGVD-ANRT 856
            |.:...:|:|..||...:  :..:.:..:...|.        |...|.|...|..:...| |..|
Zfish   622 DQSVLILQSGGRLTAEAVFGLLPVQSLYDYPPGV--------EDQQDCLQVRPRRAVPTDQAYNT 678

  Fly   857 FEYSGLIVFTDGYVPRRQDTC--NRTLGFGECLSGRCYRLEKQ-----CDGLFDCDDGTDEINCH 914
            |:..|:.:.|:  :|.|:..|  .|.|.|        ||..::     .|.:........||...
Zfish   679 FKGVGIKMATN--LPVREPECLTYRRLNF--------YRNFRRPMLFAMDKVLAAPAAVSEIAGS 733

  Fly   915 ARNDTELLNYRKYRFNRVLRHYENVWLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGF 979
            .......:..|.:        :...|:|:...:|..|.....:.|||....|...||.:| |.||
Zfish   734 PSGSPVDVTIRTF--------FPETWIWQLTPVGDSGSTSVALTVPDTITTWKTEAFCLS-SNGF 789

  Fly   980 GMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDSPDYKFVHVEED 1044
            |:...|| ....||||:.:.:|.:..:||...::.|||||:...|:..|....|.::....:::.
Zfish   790 GLAPPAL-LTAFQPFFLELTLPYSIIRGEVFELKATVFNYLSQCIKVQVTPTPSSNFTLNSLDQS 853

  Fly  1045 GIVRSYNPRTSF---------GEHQFFIYLEAQ------GTTVVYVPVVPQRLGNVDVTLHVATL 1094
            ......|.|.:|         |.....|..:|.      |..||   .||.| |.:|:
Zfish   854 SSTLVANGRKTFKWALTASVIGTVNVTISAQANPSQELCGNRVV---TVPSR-GRIDI------- 907

  Fly  1095 LGTDTITRTLHVESDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKAR 1159
                 :||:|.|.::|:.:...:|.|  |..:..:|. ..|.:|    .|..|    :.||.:..
Zfish   908 -----VTRSLLVLAEGVKRTFTRSWL--LCPKGSMLS-EDVRIT----FPKNV----IQGSARCS 956

  Fly  1160 ISVVGDVVGPIFPTMPVNASSLLSLPMESGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAFYHM 1224
            :||:||::|....    |.::||.:|...||||......|:|.:.|:::..|....::..|..::
Zfish   957 VSVIGDIMGRALK----NLANLLQMPYGCGEQNMIILGPNIYILRYLKVTAQLTPAIQDTAMTYL 1017

  Fly  1225 NIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMR 1289
            ..|||.||::...|||||.|..|    :|:.|||::.:|.|..|     .:|.:||..:::....
Zfish  1018 QSGYQGQLNYRHSDGSFSTFGYD----ESNTWLTAFVMRTFGLA-----RSFTYIDPNVLQSAKD 1073

  Fly  1290 WLLQHQTPQGSFFEVTWLPDRKMNRTNFDKNITLTSHVLITLATV----------------KDIS 1338
            ||:..|...|.|.:...|....| |.....|:|:|.:::..|..:                :.:.
Zfish  1074 WLISKQGSNGCFVQQGTLYHNDM-RGGVGDNVTMTGYIVAALLEIGVPVTDPVITKALSFLRPLV 1137

  Fly  1339 GTLGSRVALATQRALAYIERNMDFLRHQAQPFDVA-ITAYALQLCNSPIAEEVFAILRRQARTIG 1402
            |.||:....|   .|||             .|.:| .|:...||.||         ||..|.:.|
Zfish  1138 GNLGNTYVTA---LLAY-------------TFSLAGETSTRAQLLNS---------LRNTAISEG 1177

  Fly  1403 DFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYALLVYVARREF------FVDPIV 1461
            ..::|....                     ..|:|.:|.:||.||..:..:..      :.:.||
Zfish  1178 TTLHWSQTT---------------------SGDTLAVEISAYVLLAVLNVQPVTTATLGYANRIV 1221

  Fly  1462 RWLNSQRLNDGGWASTQDTSAALKALVEYT--VRSRLREVSSLTVEIEASSQGGKTQTLYIDDTN 1524
            .||.:|:...||:.|||||..||:|:..|.  |.|   ...|.||.:::|...|......:...|
Zfish  1222 NWLVAQQNPYGGFTSTQDTVVALQAMALYASLVFS---SGGSSTVTVQSSVPAGDVYNFAVTPNN 1283

  Fly  1525 LAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNVDIEKFQTKPPVPAFGLHTKAIFHGRNQSH 1589
            ....|...:.:..||..|.|.|:....:|:...||:      ..|.|.|..|...|...|..::.
Zfish  1284 RLLYQESPLNNFPGTYSVVASGSTCVSVQVACFYNI------PTPVVVAKTLSVVAKVTGNCKAS 1342

  Fly  1590 ---------ISYVACQNWINQNESERSGMAVLDVAIPTGYWIQQQKLDTYVLS---NRVRNLRRA 1642
                     :.|...:...|        |.::|:.:.:|:     ..||.:|.   |....::|.
Zfish  1343 PVNLMLTFTVKYTGPKPTTN--------MLLVDIKVLSGF-----TADTSLLGSPPNFSPLVQRV 1394

  Fly  1643 RYLERKIVFYFDYLDHEDICVNFTIERWYPVANMSRYLP--VRIYDYYAPERFNESIFDAL 1701
            .....:::.|...:. :.:.|.::|:....|| :....|  :.:||||......|:.:.::
Zfish  1395 DTEGDRVLVYLQEVP-KGVPVTYSIQLTQTVA-VKNLKPAVINVYDYYQRSESFETTYTSV 1453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	A2M_N	232..332	CDD:280081	24/104 (23%)
		A2M_N_2	669..799	CDD:285005	39/151 (26%)
		LDLa	886..913	CDD:238060	5/31 (16%)
		A2M	940..1030	CDD:278630	31/89 (35%)
		ISOPREN_C2_like	1177..1490	CDD:298658	88/335 (26%)
		A2M_comp	1226..1492	CDD:284982	76/290 (26%)
		A2M_recep	1607..1695	CDD:284981	18/92 (20%)
zgc:165518	NP_001093623.2	A2M_N	146..237	CDD:280081	21/94 (22%)
		A2M_N_2	482..626	CDD:285005	39/151 (26%)
		A2M	750..838	CDD:278630	30/89 (34%)
		A2M_2	967..1250	CDD:239227	88/342 (26%)
		A2M_comp	1019..1251	CDD:284982	75/287 (26%)
		A2M_recep	1361..1450	CDD:284981	20/103 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11188
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820