Protein Alignment Mcr and a2m2c

DIOPT Version :10

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: NP_001410202.1
• Gene: a2m2c / 100006993
• ZFINID: ZDB-GENE-030131-1342
• Length: 1417
• Species: Danio rerio
• Alignment Length: 1582
• Identity: 325/1582 - (20%)
• Similarity: 590/1582 - (37%)
• Gaps: 372/1582 - (23%)

  Fly   201 KLRVEGFYQNVFGGLAF--LNETRLDFSQRSMTIFVQTDKPLYMQGETVRFRTIPITTELKGFDN 263
            |::||      ..|.:|  ..|.::.|.......|:|.|||.|:.|:||.||.:.:....:..|.
Zfish   100 KIKVE------LQGESFNMTEERKVMFKSYHPLTFIQMDKPFYIAGQTVNFRVVTMDKSFRPLDQ 158

  Fly   264 PVDVYML-DPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFGEWTIRVIAQGQQEESH-FTVEEYY 326
            .....:| |...:.:.:|.:..|....:...|.|:.:...|.:.::... |::..|| |.|::|.
Zfish   159 QYSAVVLEDSQDNRIGQWTNVSSTRWILQRSYDLNPEAREGTYKVKAFI-GERMISHDFDVKKYV 222

  Fly   327 QTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATIRPIGYFSNQVLNEKYRLGRS 391
            ..:|.|.|..|......|.|:...|...:|.|.||.|..::|...:.:...|...:.|.     :
Zfish   223 LPKFGVFVISPNPVSIDDEFMVIEVCGKYTYGKPVLGKSSVKVCRKTLDTHSPLCVKES-----T 282

  Fly   392 PLEQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDILYRNQYVVERHYQFDEEWPFWVR 456
            .:.:|...|.                               .|..:.:....|:|.
Zfish   283 EISKTGCANH-------------------------------TLALSVFFYPTHHQL--------- 307

  Fly   457 KPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELLVPNLANSEVLITATVGEKFYDEI 521
               ..|...||                       .:.|.|..:....::.:.:|..:|:..:.::
Zfish   308 ---LNDLHIEA-----------------------TITEEETEITMTQSNTISLTYEIGKVTFTDL 346

  Fly   522 ISGYSVARVYNSSLRVV-FLGDSPQVFKPAMPFT-TYLAVEYHDGSPIDPNLLRQGLMEVSGFVE 584
            ...|....|....:::. |.|       .|:|.. .|:...|
Zfish   347 PKTYEYGSVIEGKVKLARFRG-------TAVPGKHIYILENY----------------------- 381

  Fly   585 SRNGGRRDWPAQ-RLPMSQQSDGIWEVKID----IRNDLNL--DDRPQARDFLNGVQNMRLQANF 642
                   .||.: .|.::..|:|:....::    :::|:||  ...|..|.:..       ::.:
Zfish   382 -------SWPPKVLLNLTTDSNGLANFSLNTLRFVKSDINLMASAYPGYRSYFQ-------KSPY 432

  Fly   643 VDPRGERIQTELLLVSHYSPRNQHIKVTTSTEKPV-VGEYIIFHIRTNFYLEE---FN----YLI 699
            .:...:.:|......:.|:|....: :..:.|:|: .|..|...::..|..|.   ||    |::
Zfish   433 FNTDEKTVQFFPKPAASYTPTFSEL-IIENIEQPLKCGTEITATVKYYFVKETVKIFNADIVYMV 496

  Fly   700 MSKGVIL--------VNDRETITEGIKTIAVVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNG 756
            :|:|||:        |.....:..|..:..:.:.:::||:..|:.:.:.....:...|..|.|..
Zfish   497 LSRGVIIHHGYEKVEVKSSNAVASGTMSFKLSVGADVAPLVQILAYCVLPSENIAIHSENFHVEK 561

  Fly   757 ISRNNFTVYINNRKARTGEKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKIITKM----- 816
            ..:|..::..:..||..|||..:.:..:|||..|||.:|.:...:::|..|...||...:
Zfish   562 CLKNKVSLQFSPAKAVPGEKNTLQLSAQPGSLCGLSAVDQSVLMLESGKRLDADKIFNLLPVKYG 626

  Fly   817 SNFDEQTNGTYKHIWYSHEGNPDELVYFPASSFGVDANRTFEYS---GLIVFTDGYVPRRQDTCN 878
            |.:....              |||...|  ....|.....|:.|   ||.:.|:..|.....||.
Zfish   627 SGYPSSL--------------PDEKECF--YMMAVPIENIFKSSKRIGLKMATNLAVRSGTSTCE 675

  Fly   879 RTLGFGECLSGRCYRLEKQCDGLFDCDDGTDEINCHARNDTELLNYRKYRFNRV------LRHY- 936
            .                                            |:|:.|..:      :.|:
Zfish   676 M--------------------------------------------YKKFMFRDIGLAEDSVPHWT 696

  Fly   937 ---ENV-------WLWKDVNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGV 991
               |||       |||:.:.|...|.....|.|||....|...||.:| |.|.|:...| :....
Zfish   697 LFEENVRSVFPKTWLWQLIEISDSGSAEVPVTVPDTITSWETEAFCLS-STGLGLAPPA-QLTVF 759

  Fly   992 QPFFINVEMPEACRQGEQVGIRVTVFNYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSYNPRTSF 1056
            ||||:.:.:|.:..:||...::.|||||:...|...|....|.||......:|
Zfish   760 QPFFLELSLPYSIIRGEMFELKATVFNYLSKCIMVKVSPAPSSDYTLKASSDD------------ 812

  Fly  1057 GEHQFFIYLEAQGTTVVYVPVVPQRLGNVDVTLHVATLLG----------------TDTITRTLH 1105
               |:...|.|.|.......:.|..:|.|:||:.......                .||:||:|.
Zfish   813 ---QYSSCLCANGRKTFKWILTPSVIGVVNVTVRAEAEASQTVCDNEIVSVPERGRIDTVTRSLL 874

  Fly  1106 VESDGLPQYRHQSVLLDLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPI 1170
            |:::|:.:.:..|.||.....: :||          ||...:.:..:.||..:.:||:||:||
Zfish   875 VQAEGIKKAKTNSWLLCPKGDS-LLE----------EIDLTLPKDMIEGSVTSSVSVIGDIVG-- 926

  Fly  1171 FPTMPVNASSLLSLP------MESGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAFYHMNIGYQ 1229
                    .||..|.      ..||.||....:.::|.:.|:....|....:.:.|...:..|||
Zfish   927 --------RSLKKLHRTLWRIYRSGNQNIAILSPSIYILQYLENTKQLTSAIREKASSFLKSGYQ 983

  Fly  1230 RQLSFMRPDGSFSLFRSDWNNSDSSVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLLQH 1294
            |||.:...:|::|.|    .|...:.|||::.|:     ||.:.:.:|:||..||:...:||:..
Zfish   984 RQLKYRHRNGAYSTF----GNGKGNAWLTAFVLK-----SFVKAQKYIYIDPQIIKSAKKWLIGT 1039

  Fly  1295 QTPQGSFFEVTWLPDRKMNRTNFDKNITLTSHVLITLATVKDISGTLGSRVALATQRALAYIERN 1359
            |.|:|.|.:...|.:.:: :.....::|:|:::..:|             :.|.|......|.:.
Zfish  1040 QDPEGCFIQHGRLFNNRL-KGGVSDHVTMTAYITASL-------------LELETSVTDPVIIKG 1090

  Fly  1360 MDFLRHQAQ----PFDVAITAYALQLC-NSPIAEEVFAILRRQARTIGDFMYWGNQEIPQPPRKL 1419
            :..||...:    .:..|:.||...|. ::...:::|..|...|.:.|..::|.......
Zfish  1091 LSCLRSVIKDVKNTYTTALLAYTFSLARDTNTRQQLFNKLEDLAISDGPLVHWSQSASAD----- 1150

  Fly  1420 ENQKWFSLPRLPYEYDSLNIETTAYALLVYVARREF------FVDPIVRWLNSQRLNDGGWASTQ 1478
                         :.|||::|.::|.||..:.....      |.:.||.||..|:...||::|||
Zfish  1151 -------------DSDSLDVEISSYVLLAVLTADSLTTADLGFANRIVSWLVKQQNAYGGFSSTQ 1202

  Fly  1479 DTSAALKALVEYTVRSRLREVSSLTVEIEASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIKVQ 1543
            ||..||:||..|..:....:.|| ||.::::   |.:....::..|....|..::.:..|..|::
Zfish  1203 DTVVALQALSLYATKVFSSDGSS-TVTVQSA---GDSHYFNVNQDNKLVYQEKQLANVPGKYKIE 1263

  Fly  1544 AKGAGYAILQMHVQYNVDIEKFQTKPPVPAFGLHTKAIFHGRNQSHISYVACQNWIN-QNESERS 1607
            .||:....:||...||:     .|...|....:..| |.....::..:.:..:..:| ....|.:
Zfish  1264 VKGSACVSVQMAQFYNI-----LTPKEVKTLSIDVK-IEGDCKKTFGNKLLLEFTVNYDGPHETT 1322

  Fly  1608 GMAVLDVAIPTGYWIQQQKLDTYVLSNR----VRNLRRARYLERKIVFYFDYLDHEDICVNFTIE 1668
            .|.::||.:.:|:...    ||.:..:.    |..:.:..|.:..::.|...:. :...||:.|:
Zfish  1323 NMLIVDVKLLSGFTAD----DTTMFGSSSGFYVPLVEQVDYKDDHVIVYLKEVP-KHFPVNYQIQ 1382

  Fly  1669 RWYPVANMSRYLP--VRIYDYY 1688
             ...|.::....|  :::||||
Zfish  1383 -MKQVLHVMNLKPAVIKVYDYY 1403

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	YfaS	<226..1575	CDD:441940	296/1433 (21%)
		A2M_BRD	667..801	CDD:462235	34/149 (23%)
		A2M	939..1030	CDD:459711	32/97 (33%)
		TED_complement	1160..1490	CDD:462227	86/346 (25%)
		A2M_recep	1605..1699	CDD:462226	19/90 (21%)
a2m2c	NP_001410202.1	MG2	128..218	CDD:426464	23/90 (26%)
		MG3	220..299	CDD:465509	19/114 (17%)
		MG4	341..>411	CDD:465507	13/106 (12%)
		A2M_BRD	457..606	CDD:462235	34/149 (23%)
		A2M	709..797	CDD:459711	30/89 (34%)
		SVA	<754..849	CDD:398804	28/110 (25%)
		A2M_2	940..1214	CDD:239227	77/314 (25%)
		A2M_recep	1320..1413	CDD:462226	19/90 (21%)