DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mcr and a2ml

DIOPT Version :9

Sequence 1:	NP_524688.1	Gene:	Mcr / 44071	FlyBaseID:	FBgn0267488	Length:	1760	Species:	Drosophila melanogaster
Sequence 2:	XP_001345541.6	Gene:	a2ml / 100006972	ZFINID:	ZDB-GENE-090212-1	Length:	1449	Species:	Danio rerio

Alignment Length:	1691	Identity:	358/1691 - (21%)
Similarity:	631/1691 - (37%)	Gaps:	428/1691 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 EPTYFIVASRMVRPGLIYQVSVSILQAQYPITVHASIACDGVQISGDSKDVKEGIPETLLM---- 189
            ||::.:....::..|...::..|:|:....:.::..:.              .|...|||:
Zfish    35 EPSFMVTFPAVIESGSEAKLCASLLKPNESLVMNIYLV--------------HGNQSTLLLQENA 85

  Fly   190 ----------RIPPTSVTGSYKLRVEGFYQNVFGGLAF--LNETRLDFSQRSMTIFVQTDKPLYM 242
                      :.|........|::||      ..|.:|  ..|.::.|.......|:|||||:||
Zfish    86 EQEFHRCFNFKAPLAEAESVQKIKVE------LQGESFKMTEERKVMFKSYDPLTFIQTDKPIYM 144

  Fly   243 QGETVRFRTIPITTELKGFDNPVDVYML-DPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFGEWT 306
            .|:.|.||.:.:.|.....|....:.:| |...:.:.:|.:..|....:...|:|:.:...|.:.
Zfish   145 PGQIVNFRVVTMDTNFAPVDQQYSIIVLEDSQDNRIGQWTNVSSTRWILQRSYELNPECREGAYK 209

  Fly   307 IRVIAQGQQEESH-FTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKAT 370
            ::... |::...| |.|::|...:|||.:..|......:..:...|.|.:|.|.||.|...:|..
Zfish   210 LKAFI-GERMILHDFQVKKYVLPKFEVTLKKPKTVSVVEEELLIEVCAKYTYGQPVPGKSWVKVC 273

  Fly   371 IRPIGY--FSNQVLNEK----------YRLGRSPLEQTNLYNERWRYNNPNQNPQVQYNVPGQLP 423
            ..|:.|  |....|.|.          :..|.|.:..:.|.|          |.:...:|...:.
Zfish   274 RDPLPYIFFFPLCLGETLEITKTGCAIHNFGLSMILNSTLKN----------NLKDSLHVEAVVT 328

  Fly   424 QDGADLSQDILYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGT---YRKTLPYLRYFNG- 484
            ::|.::::                        .|.|....:||....|   ..||..:.....|
Zfish   329 EEGTEITR------------------------TKSESVHLTYEIGKATLIDLPKTYEHGSVIKGK 369

  Fly   485 --TFDFK---WPLRELELLVPNLANSEVLI---------------TATVGEKFYDEIISGYSVAR 529
              .||||   .|.:|:.||.....:|::|:               |:::.:|....|.|.|...|
Zfish   370 IKLFDFKDAPIPNKEVYLLEGENWSSKLLLNLTTDSDGLASFSLNTSSLSKKDISLIASVYPDTR 434

  Fly   530 VYNSSLRVVFLGD--SPQVFKPAMPFTTYLAVEYHDGSPIDPNLLRQGLMEVSGFVESRNGGRRD 592
            .|... ...|..|  :.|:|:.|   |.|           .|.|
Zfish   435 YYGYK-TPYFSTDKKTVQLFQIA---TAY-----------SPTL--------------------- 463

  Fly   593 WPAQRLPMSQQSDGIWEVKIDIRNDLNLDDRPQARDFLNGVQNMRLQANFVDPRGERIQTELLLV 657
                                                                       :||::.
Zfish   464 -----------------------------------------------------------SELIIE 469

  Fly   658 SHYSPRNQHIKVTTSTEKPVVGEYIIFHIRTNFYLEEFN----YLIMSKGVILVNDRET------ 712
            ....|.....::|.:.:...|||.:          |:|:    |:::|:|||:.:..|.
Zfish   470 DIEQPIKCGTEITATVKYYFVGETV----------EDFSTDIVYMVLSRGVIVHHGFEKVEVKSS 524

  Fly   713 ---ITEGIKTIAVVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYINNRKARTG 774
               :..|..:..:.:.:::.||..|:.:.:.....|:|.:.|........|..::..:..||..|
Zfish   525 SNGVASGTMSFKLSVGADLTPVVQILAYCVLPSENVIAANKTLDTEKCFGNKVSLQFSPAKAVPG 589

  Fly   775 EKVEVAIFGEPGSYVGLSGIDSAFYTMQAGNELTYAKI-----ITKMSNFDEQTNGTYKHIWYSH 834
            ||..:.:..:|||..|||.:|.:...:::|..|...||     :..:|::.           ||.
Zfish   590 EKNTLQLSAQPGSLCGLSAVDQSVLILESGKRLEADKIFNLLPVHSVSDYP-----------YSV 643

  Fly   835 EGNPDELVYFPASSFGVD-ANRTFEYSGLIVFTDGYVPRRQDTCNRTLGFGECLSGR-------- 890
            |.....|...|..|...| ...|.:..||.:.|           |..:...|||..:
Zfish   644 EDGQACLYVRPRRSLLTDNTYETLKSVGLKMAT-----------NLAVRVPECLLYKGLAYHKNF 697

  Fly   891 -CYRLEKQCDGLFDCDDGTDEINCHARNDTELLNYRKYRFNRVLRHYENVWLWKDVNIGPHGRYI 954
             .||......|:|  ..|...::....|...:         .:...:...|:|:...:|..|...
Zfish   698 VMYRQNAPAPGMF--AQGMAGVDGLVGNSPSV---------TIRTVFPETWIWELAEVGDSGSAE 751

  Fly   955 FNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQVGIRVTVFNY 1019
            ..|:|||....|...||.:| |.|.|:...| :....||||:.:.:|.:..:||...::.|||||
Zfish   752 VPVKVPDTITTWETEAFCLS-STGLGLAPPA-QLTVFQPFFLELSLPYSIIRGEIFELKATVFNY 814

  Fly  1020 MITPIEAIVVLHDSPDYKFVHVEEDGIVRSY------NPRTSF---------GEHQFFIYLEAQG 1069
            :...|...|....|.||......:|    .|      |.|.:|         |.....:..||:.
Zfish   815 LSKCIMVKVSPAPSSDYTLKASSDD----QYSSCLCANGRKTFKWILTPSVLGVVNVTVSAEAEA 875

  Fly  1070 TTVV---YVPVVPQRLGNVDVTLHVATLLGTDTITRTLHVESDGLPQYRHQSVLL-----DLSNR 1126
            :..|   .:..||:| |.:|:            :||:|.|:::|:.:....|.||     .||.:
Zfish   876 SQTVCDNEIVSVPER-GRIDI------------VTRSLLVQAEGIEKTETNSWLLCPKGDSLSEK 927

  Fly  1127 AYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNASSLLSLPMESGEQ 1191
                    |::|    :|..|    :.||.|:.:||:||::|....    |...||.:|...|||
Zfish   928 --------VDLT----LPKDV----IEGSAKSSVSVIGDILGRALQ----NLHGLLRMPYGCGEQ 972

  Fly  1192 NAFSFAANLYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRSDWNNSDSSVW 1256
            |....:.|:|.:.|:....|....:.:.|...:..||||||::...||::|.|    ...|.:.|
Zfish   973 NMAVLSPNIYILQYLENTKQLTSAIREKASSFLKSGYQRQLNYKHFDGAYSTF----GYGDGNTW 1033

  Fly  1257 LTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPDRKMNRTNFDKNI 1321
            ||::.||.|.:|     :.:.:||..||:....||:..:...|.|.:...|.:.:| :...:.|:
Zfish  1034 LTAFVLRSFGKA-----QKYTFIDPQIIQSAKDWLISRRDSDGCFIQQGRLFNNRM-KGGVNDNV 1092

  Fly  1322 TLTSHVLITLATVKDISGTLGSRVALATQRALAYIERNMDFLRHQAQ----PFDVAITAYALQLC 1382
            |:|:::..:|             :.|.|......|.:.:..||...:    .:..|:.||...|.
Zfish  1093 TMTAYITASL-------------LELETPVTDPVITKGLSCLRSVIEEVKNTYTTALLAYTFSLA 1144

  Fly  1383 -NSPIAEEVFAILRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDSLNIETTAYAL 1446
             ::...:::|..|...|.:.|..::|.......                  :..||::|.::|.|
Zfish  1145 RDTNTRQQLFNKLEDLAISDGPLVHWSQSASAD------------------DSASLDVEISSYVL 1191

  Fly  1447 LVYVARREF------FVDPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSRLREVSSLTVE 1505
            |..:.....      |.:.||.||..|:...||::|||||..||:||..|..:....:.|| ||.
Zfish  1192 LAVLTADSLTTADLGFANRIVSWLVKQQNAYGGFSSTQDTVVALQALSLYATKVFSSDGSS-TVT 1255

  Fly  1506 IEASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNVDIEKFQTKPP 1570
            ::::   |.:....::..|....|..::.:..|...::.||:....:|:...||:       ..|
Zfish  1256 VQSA---GDSHHFDVNQDNKLLYQEKQLANVPGKYSIEVKGSACVSVQIAQFYNI-------PTP 1310

  Fly  1571 VPAFGLHTKAIFHGRNQSHISYVACQNWI------NQNESERSGMAVLDVAIPTGYWIQQQKL-- 1627
            ..|..|...|...|..::     ..||:|      .....|::.||::|:.:.:|:......|
Zfish  1311 TEAKTLSIDAKIEGDCEA-----LGQNFIFDFTVKYDGPEEKTNMAIVDIKLLSGFTADTSALGT 1370

  Fly  1628 --DTYV-LSNRVRNLRRARYLERKIVFYFDYLDHEDICVNFTIE--RWYPVANMSRYLPVRIYDY 1687
              .||| |..||.:      .:..::.|...:. :::.:|:.|:  :..||.|:...: |::|||
Zfish  1371 SSGTYVSLVERVDS------KDDHVIVYLKEIP-KNVAMNYQIQMKQVLPVKNLKPAV-VKVYDY 1427

  Fly  1688 Y 1688
            |
Zfish  1428 Y 1428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	A2M_N	232..332	CDD:280081	27/101 (27%)
		A2M_N_2	669..799	CDD:285005	32/142 (23%)
		LDLa	886..913	CDD:238060	7/35 (20%)
		A2M	940..1030	CDD:278630	30/89 (34%)
		ISOPREN_C2_like	1177..1490	CDD:298658	82/323 (25%)
		A2M_comp	1226..1492	CDD:284982	70/276 (25%)
		A2M_recep	1607..1695	CDD:284981	22/89 (25%)
a2ml	XP_001345541.6	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11188
eggNOG	1	0.900	-	-		E1_COG2373
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820