Protein Alignment Mcr and a2m2h

DIOPT Version :10

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: XP_001923676.3
• Gene: a2m2h / 100006895
• ZFINID: ZDB-GENE-250409-2
• Length: 1442
• Species: Danio rerio
• Alignment Length: 1711
• Identity: 355/1711 - (20%)
• Similarity: 629/1711 - (36%)
• Gaps: 464/1711 - (27%)

  Fly   130 PTYFIVASRMVRPGLIYQVSVSILQAQYPITVHASIACDGVQISGDSKDVKEGIPETLLM----- 189
            |::.::...::..|...::..|:|.....:.::..:              .:|...|||:
Zfish    29 PSFMVMFPIVIESGSEAKLCASLLNPNESLVMNIYL--------------NDGNQSTLLLQEKAE 79

  Fly   190 ---------RIPPTSVTGSYKLRVEGFYQNVFGGLAF--LNETRLDFSQRSMTIFVQTDKPLYMQ 243
                     :.|........|::||      ..|.:|  ..|.::.|.......|:|||||:|:.
Zfish    80 QEFHRCFNFKAPLAKAETVQKIKVE------LQGKSFEMTEERKVMFKSYDPLTFIQTDKPIYIP 138

  Fly   244 GETVRFRTIPITTELKGFDNPV-DVYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFGEWTI 307
            |:||.||.:.:.......|... .|.:.|...:.:.:|.:..|....:...|:|:.:...|.:.:
Zfish   139 GQTVNFRIVTLDKNFAPLDQQYSSVVLEDSQDNRIGQWTNVSSTRWILQRSYELNPECREGTYKL 203

  Fly   308 RVIAQGQQEESH-FTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATI 371
            :... |:.|..| |.|::|...:|||.|..|......:..:...|.|.:|.|.||.|...:|...
Zfish   204 KTFI-GEMEVLHYFKVKKYVLPKFEVTVKKPNKVSVDEEELSIEVCAKYTYGQPVPGKSWVKVCR 267

  Fly   372 RPIGYFSNQVLNEKYRLGRSPL---EQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDI 433
            ..:.||..:..|        ||   |.|.:.......:|        :.|...|.....:..:|.
Zfish   268 NSVPYFHTKDFN--------PLCSEETTEITKTGCAIHN--------FGVSVFLNSTLKERLKDS 316

  Fly   434 LYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELL 498
            |:....|.|                                        .||          |:
Zfish   317 LHVEAVVTE----------------------------------------EGT----------EI- 330

  Fly   499 VPNLANSE-VLITATVGEKFYDEIISGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYLAVEYH 562
              .:|.|| |.:|..:|:....::.:.|....|....:::....|:|...|     ..||
Zfish   331 --TMAKSESVPLTYEIGKVKVIDLPNTYEHGSVIEGKIKLFDFKDAPIPNK-----EVYL----- 383

  Fly   563 DGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQ-RLPMSQQSDGIWEVKIDI----RNDLNLDD 622
                                :|..|     |.:: .|.::..|||:....::.    :.|::|
Zfish   384 --------------------LEGEN-----WSSKLLLNLTTDSDGLASFSLNTSSLSKKDISL-- 421

  Fly   623 RPQARDFLNGVQNMRLQANFVDPRGERIQTELLLVSHYSPRNQHIKV--TTSTEKPVVGEYIIFH 685
                      :.|:     :.|.|..:.:|     .::|...:.:|:  |.:...|...:.||.:
Zfish   422 ----------IANV-----YPDTRFRQYKT-----PYFSRDKKTVKLFQTATPYSPTFSKLIIEN 466

  Fly   686 IR------------TNFY-----LEEFN----YLIMSKGVIL--------VNDRETITEGIKTIA 721
            |.            ..:|     :|:||    |:::|||||:        |.....:..|..:..
Zfish   467 IEQPIKCGTEITATVKYYFVGETVEDFNTDIVYIVLSKGVIVHHGYEKVEVKSSNGVASGTMSFE 531

  Fly   722 VVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYINNRKARTGEKVEVAIFGEPG 786
            :.:.:::|||..|:.:.:.....::|.|.:..:.....|..::..:..||..|||..:.:..:||
Zfish   532 LSVGADVAPVVRILAYCVLPSENIIAASKSLDIEKCFGNKVSLQFSPAKAVPGEKNTLQLSAQPG 596

  Fly   787 SYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQTNGTYKHIWYSHEGNPDELVYFPASS--- 848
            |..|||.:|.:...:::|..|...||.:.:                     |.:.||:|.|:
Zfish   597 SLCGLSAVDQSVLILESGKRLDADKIFSLL---------------------PFQYVYYPYSAEDE 640

  Fly   849 ---FGVDANRTFEYSGLIVFTDGYVPRRQD-----TCNRTLGFGECLSGRCYRLEKQCDGLFDCD 905
               ..|...|:       |.||......:.     ..|..:...||||.|.
Zfish   641 QPCLPVRPRRS-------VLTDNVYNSLKSVGLKMASNLAVRVPECLSFRG-------------- 684

  Fly   906 DGTDEINCHARNDTELLNYRKYRFNRVLRH--------------------------YENVWLWKD 944
                            |.|.::| :.|:.|                          :...|:|..
Zfish   685 ----------------LTYHRFR-DIVMYHTSGRVGLGSSIESSTFDNSAVTIRTIFPETWIWDL 732

  Fly   945 VNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQ 1009
            ..:|..|.....|.|||....|...||.:| |.|.|:...| :....||||:.:.:|.:..:||.
Zfish   733 AEVGDSGSTEVPVTVPDTITTWETEAFCLS-STGLGLAPPA-QLTVFQPFFLELSLPYSIIRGEI 795

  Fly  1010 VGIRVTVFNYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSY------NPRTSF---------GEH 1059
            ..::.|||||:...|...|....|.||......:|    .|      |.|.:|         |..
Zfish   796 FELKATVFNYLSKCIMVKVSPAPSSDYTLKASSDD----QYSSCLCANGRQTFKWILTPSVLGVV 856

  Fly  1060 QFFIYLEAQGTTVV---YVPVVPQRLGNVDVTLHVATLLGTDTITRTLHVESDGLPQYRHQSVLL 1121
            ...:..||:.:..|   .:..||:| |.:|:            :||:|.|:::|:.:....|.||
Zfish   857 NVTVSAEAEASQTVCDNEIVSVPER-GRIDI------------VTRSLLVQAEGIEKTETNSWLL 908

  Fly  1122 -----DLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNASSL 1181
                 .||.          ||..|  :|..|    :.||.|:.:||:||::|....    |...|
Zfish   909 CPKGDSLSE----------NVDLT--VPKDV----IEGSAKSSVSVIGDILGRALQ----NLHGL 953

  Fly  1182 LSLPMESGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRS 1246
            |.:|...||||....:.|:|.:.|:....|....:.:.|...:..||||||::...||::|.|
Zfish   954 LRMPYGCGEQNMAVLSPNIYILQYLENTKQLTSAIREKASSFLKSGYQRQLNYKHFDGAYSTF-- 1016

  Fly  1247 DWNNSDSSVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPDRK 1311
              ...|.:.|||::.||.|.:|     :.:.:||..||:....||:..:...|.|.:...|.:.:
Zfish  1017 --GYGDGNTWLTAFVLRSFGKA-----QKYTFIDPQIIQSAKDWLISRRDSDGCFIQQGRLFNNR 1074

  Fly  1312 MNRTNFDKNITLTSHV---LITLAT-VKDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDV 1372
            | :.....|:|:|:::   |:.|.| |.|...|.|    |:..|::....:|         .:..
Zfish  1075 M-KGGVTDNVTMTAYITASLLELETPVTDPVVTKG----LSCLRSVIEDVKN---------TYTT 1125

  Fly  1373 AITAYALQLC-NSPIAEEVFAILRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDS 1436
            |:.||...|. ::...:::|:.|...|.:.|..::|.......                  :..|
Zfish  1126 ALLAYTFSLARDTNTRQQLFSKLEDLAISDGPLVHWSQSASAD------------------DSAS 1172

  Fly  1437 LNIETTAYALLVYVARREF------FVDPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSR 1495
            |::|.::|.||..:.....      |.:.||.||..|:...||::|||||..||:||..|..:..
Zfish  1173 LDVEISSYVLLAVLTADSLTTADLGFANRIVSWLVKQQNAYGGFSSTQDTVVALQALSLYATKVF 1237

  Fly  1496 LREVSSLTVEIEASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNV 1560
            ..:.|| ||.::::   |.:....::..|....|..::.:..|...::.||:....:||...||:
Zfish  1238 SSDGSS-TVTVQSA---GDSHHFDVNQDNKLLYQEKQLANVPGKYSIEVKGSACVSVQMAQFYNI 1298

  Fly  1561 DIEKFQTKPPVPAFGLHTKAIFHGRNQSHISYVACQNWINQN-----------ESERSGMAVLDV 1614
                   ..|..|..|...|...|         .|:....||           ...|:.|.::|:
Zfish  1299 -------PTPTEAKTLSIDAEVEG---------DCKKTFGQNLMLNVTVTYDGPQNRTNMVIVDI 1347

  Fly  1615 AIPTGYWIQQQKLDTYVLSNRVRNLRRARYL------------ERKIVFYFDYLDHEDICVNFTI 1667
            .:.:|:     ..||.:|..:.::.....:.            :..:|:..:.|..:.:.:...:
Zfish  1348 KLLSGF-----TADTSMLKTQRQSFDSLDFFGHAPVERIDSKDDHVLVYLEEVLKEDPVNLQIGL 1407

  Fly  1668 ERWYPVANMSRYLPVRIYDYY 1688
            .:...|.|:...: :::||||
Zfish  1408 NQIIQVKNLKPAV-IKVYDYY 1427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	YfaS	<226..1575	CDD:441940	318/1461 (22%)
		A2M_BRD	667..801	CDD:462235	37/164 (23%)
		A2M	939..1030	CDD:459711	30/90 (33%)
		TED_complement	1160..1490	CDD:462227	91/340 (27%)
		A2M_recep	1605..1699	CDD:462226	15/96 (16%)
a2m2h	XP_001923676.3	YfaS	<128..1393	CDD:441940	332/1555 (21%)
		A2M_2	946..1232	CDD:239227	86/330 (26%)