Protein Alignment Mcr and LOC100006895

DIOPT Version :9

• Sequence 1: NP_524688.1
• Gene: Mcr / 44071
• FlyBaseID: FBgn0267488
• Length: 1760
• Species: Drosophila melanogaster
• Sequence 2: XP_001923676.2
• Gene: LOC100006895 / 100006895
• -ID: -
• Length: 1449
• Species: Danio rerio
• Alignment Length: 1711
• Identity: 355/1711 - (20%)
• Similarity: 629/1711 - (36%)
• Gaps: 464/1711 - (27%)

  Fly   130 PTYFIVASRMVRPGLIYQVSVSILQAQYPITVHASIACDGVQISGDSKDVKEGIPETLLM----- 189
            |::.::...::..|...::..|:|.....:.::..:              .:|...|||:
Zfish    36 PSFMVMFPIVIESGSEAKLCASLLNPNESLVMNIYL--------------NDGNQSTLLLQEKAE 86

  Fly   190 ---------RIPPTSVTGSYKLRVEGFYQNVFGGLAF--LNETRLDFSQRSMTIFVQTDKPLYMQ 243
                     :.|........|::||      ..|.:|  ..|.::.|.......|:|||||:|:.
Zfish    87 QEFHRCFNFKAPLAKAETVQKIKVE------LQGKSFEMTEERKVMFKSYDPLTFIQTDKPIYIP 145

  Fly   244 GETVRFRTIPITTELKGFDNPV-DVYMLDPNRHILKRWLSRQSNLGSVSLEYKLSDQPTFGEWTI 307
            |:||.||.:.:.......|... .|.:.|...:.:.:|.:..|....:...|:|:.:...|.:.:
Zfish   146 GQTVNFRIVTLDKNFAPLDQQYSSVVLEDSQDNRIGQWTNVSSTRWILQRSYELNPECREGTYKL 210

  Fly   308 RVIAQGQQEESH-FTVEEYYQTRFEVNVTMPAYFFTTDPFIYGRVMANFTSGLPVRGNLTIKATI 371
            :... |:.|..| |.|::|...:|||.|..|......:..:...|.|.:|.|.||.|...:|...
Zfish   211 KTFI-GEMEVLHYFKVKKYVLPKFEVTVKKPNKVSVDEEELSIEVCAKYTYGQPVPGKSWVKVCR 274

  Fly   372 RPIGYFSNQVLNEKYRLGRSPL---EQTNLYNERWRYNNPNQNPQVQYNVPGQLPQDGADLSQDI 433
            ..:.||..:..|        ||   |.|.:.......:|        :.|...|.....:..:|.
Zfish   275 NSVPYFHTKDFN--------PLCSEETTEITKTGCAIHN--------FGVSVFLNSTLKERLKDS 323

  Fly   434 LYRNQYVVERHYQFDEEWPFWVRKPEYQDSSYEAWSGTYRKTLPYLRYFNGTFDFKWPLRELELL 498
            |:....|.|                                        .||          |:
Zfish   324 LHVEAVVTE----------------------------------------EGT----------EI- 337

  Fly   499 VPNLANSE-VLITATVGEKFYDEIISGYSVARVYNSSLRVVFLGDSPQVFKPAMPFTTYLAVEYH 562
              .:|.|| |.:|..:|:....::.:.|....|....:::....|:|...|     ..||
Zfish   338 --TMAKSESVPLTYEIGKVKVIDLPNTYEHGSVIEGKIKLFDFKDAPIPNK-----EVYL----- 390

  Fly   563 DGSPIDPNLLRQGLMEVSGFVESRNGGRRDWPAQ-RLPMSQQSDGIWEVKIDI----RNDLNLDD 622
                                :|..|     |.:: .|.::..|||:....::.    :.|::|
Zfish   391 --------------------LEGEN-----WSSKLLLNLTTDSDGLASFSLNTSSLSKKDISL-- 428

  Fly   623 RPQARDFLNGVQNMRLQANFVDPRGERIQTELLLVSHYSPRNQHIKV--TTSTEKPVVGEYIIFH 685
                      :.|:     :.|.|..:.:|     .::|...:.:|:  |.:...|...:.||.:
Zfish   429 ----------IANV-----YPDTRFRQYKT-----PYFSRDKKTVKLFQTATPYSPTFSKLIIEN 473

  Fly   686 IR------------TNFY-----LEEFN----YLIMSKGVIL--------VNDRETITEGIKTIA 721
            |.            ..:|     :|:||    |:::|||||:        |.....:..|..:..
Zfish   474 IEQPIKCGTEITATVKYYFVGETVEDFNTDIVYIVLSKGVIVHHGYEKVEVKSSNGVASGTMSFE 538

  Fly   722 VVLSSEMAPVATIVVWKINQQGQVVADSLTFPVNGISRNNFTVYINNRKARTGEKVEVAIFGEPG 786
            :.:.:::|||..|:.:.:.....::|.|.:..:.....|..::..:..||..|||..:.:..:||
Zfish   539 LSVGADVAPVVRILAYCVLPSENIIAASKSLDIEKCFGNKVSLQFSPAKAVPGEKNTLQLSAQPG 603

  Fly   787 SYVGLSGIDSAFYTMQAGNELTYAKIITKMSNFDEQTNGTYKHIWYSHEGNPDELVYFPASS--- 848
            |..|||.:|.:...:::|..|...||.:.:                     |.:.||:|.|:
Zfish   604 SLCGLSAVDQSVLILESGKRLDADKIFSLL---------------------PFQYVYYPYSAEDE 647

  Fly   849 ---FGVDANRTFEYSGLIVFTDGYVPRRQD-----TCNRTLGFGECLSGRCYRLEKQCDGLFDCD 905
               ..|...|:       |.||......:.     ..|..:...||||.|.
Zfish   648 QPCLPVRPRRS-------VLTDNVYNSLKSVGLKMASNLAVRVPECLSFRG-------------- 691

  Fly   906 DGTDEINCHARNDTELLNYRKYRFNRVLRH--------------------------YENVWLWKD 944
                            |.|.::| :.|:.|                          :...|:|..
Zfish   692 ----------------LTYHRFR-DIVMYHTSGRVGLGSSIESSTFDNSAVTIRTIFPETWIWDL 739

  Fly   945 VNIGPHGRYIFNVEVPDRPAYWMVSAFSVSPSKGFGMMNKALEYVGVQPFFINVEMPEACRQGEQ 1009
            ..:|..|.....|.|||....|...||.:| |.|.|:...| :....||||:.:.:|.:..:||.
Zfish   740 AEVGDSGSTEVPVTVPDTITTWETEAFCLS-STGLGLAPPA-QLTVFQPFFLELSLPYSIIRGEI 802

  Fly  1010 VGIRVTVFNYMITPIEAIVVLHDSPDYKFVHVEEDGIVRSY------NPRTSF---------GEH 1059
            ..::.|||||:...|...|....|.||......:|    .|      |.|.:|         |..
Zfish   803 FELKATVFNYLSKCIMVKVSPAPSSDYTLKASSDD----QYSSCLCANGRQTFKWILTPSVLGVV 863

  Fly  1060 QFFIYLEAQGTTVV---YVPVVPQRLGNVDVTLHVATLLGTDTITRTLHVESDGLPQYRHQSVLL 1121
            ...:..||:.:..|   .:..||:| |.:|:            :||:|.|:::|:.:....|.||
Zfish   864 NVTVSAEAEASQTVCDNEIVSVPER-GRIDI------------VTRSLLVQAEGIEKTETNSWLL 915

  Fly  1122 -----DLSNRAYVLEYMHVNVTQTPEIPYQVDRYFVYGSNKARISVVGDVVGPIFPTMPVNASSL 1181
                 .||.          ||..|  :|..|    :.||.|:.:||:||::|....    |...|
Zfish   916 CPKGDSLSE----------NVDLT--VPKDV----IEGSAKSSVSVIGDILGRALQ----NLHGL 960

  Fly  1182 LSLPMESGEQNAFSFAANLYTIMYMRLINQRNKTLEKNAFYHMNIGYQRQLSFMRPDGSFSLFRS 1246
            |.:|...||||....:.|:|.:.|:....|....:.:.|...:..||||||::...||::|.|
Zfish   961 LRMPYGCGEQNMAVLSPNIYILQYLENTKQLTSAIREKASSFLKSGYQRQLNYKHFDGAYSTF-- 1023

  Fly  1247 DWNNSDSSVWLTSYCLRVFQEASFYEWENFIWIDATIIEKNMRWLLQHQTPQGSFFEVTWLPDRK 1311
              ...|.:.|||::.||.|.:|     :.:.:||..||:....||:..:...|.|.:...|.:.:
Zfish  1024 --GYGDGNTWLTAFVLRSFGKA-----QKYTFIDPQIIQSAKDWLISRRDSDGCFIQQGRLFNNR 1081

  Fly  1312 MNRTNFDKNITLTSHV---LITLAT-VKDISGTLGSRVALATQRALAYIERNMDFLRHQAQPFDV 1372
            | :.....|:|:|:::   |:.|.| |.|...|.|    |:..|::....:|         .:..
Zfish  1082 M-KGGVTDNVTMTAYITASLLELETPVTDPVVTKG----LSCLRSVIEDVKN---------TYTT 1132

  Fly  1373 AITAYALQLC-NSPIAEEVFAILRRQARTIGDFMYWGNQEIPQPPRKLENQKWFSLPRLPYEYDS 1436
            |:.||...|. ::...:::|:.|...|.:.|..::|.......                  :..|
Zfish  1133 ALLAYTFSLARDTNTRQQLFSKLEDLAISDGPLVHWSQSASAD------------------DSAS 1179

  Fly  1437 LNIETTAYALLVYVARREF------FVDPIVRWLNSQRLNDGGWASTQDTSAALKALVEYTVRSR 1495
            |::|.::|.||..:.....      |.:.||.||..|:...||::|||||..||:||..|..:..
Zfish  1180 LDVEISSYVLLAVLTADSLTTADLGFANRIVSWLVKQQNAYGGFSSTQDTVVALQALSLYATKVF 1244

  Fly  1496 LREVSSLTVEIEASSQGGKTQTLYIDDTNLAKLQSIEIPDAWGTIKVQAKGAGYAILQMHVQYNV 1560
            ..:.|| ||.::::   |.:....::..|....|..::.:..|...::.||:....:||...||:
Zfish  1245 SSDGSS-TVTVQSA---GDSHHFDVNQDNKLLYQEKQLANVPGKYSIEVKGSACVSVQMAQFYNI 1305

  Fly  1561 DIEKFQTKPPVPAFGLHTKAIFHGRNQSHISYVACQNWINQN-----------ESERSGMAVLDV 1614
                   ..|..|..|...|...|         .|:....||           ...|:.|.::|:
Zfish  1306 -------PTPTEAKTLSIDAEVEG---------DCKKTFGQNLMLNVTVTYDGPQNRTNMVIVDI 1354

  Fly  1615 AIPTGYWIQQQKLDTYVLSNRVRNLRRARYL------------ERKIVFYFDYLDHEDICVNFTI 1667
            .:.:|:     ..||.:|..:.::.....:.            :..:|:..:.|..:.:.:...:
Zfish  1355 KLLSGF-----TADTSMLKTQRQSFDSLDFFGHAPVERIDSKDDHVLVYLEEVLKEDPVNLQIGL 1414

  Fly  1668 ERWYPVANMSRYLPVRIYDYY 1688
            .:...|.|:...: :::||||
Zfish  1415 NQIIQVKNLKPAV-IKVYDYY 1434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mcr	NP_524688.1	A2M_N	232..332	CDD:280081	27/101 (27%)
		A2M_N_2	669..799	CDD:285005	36/160 (23%)
		LDLa	886..913	CDD:238060	4/26 (15%)
		A2M	940..1030	CDD:278630	30/89 (34%)
		ISOPREN_C2_like	1177..1490	CDD:298658	86/323 (27%)
		A2M_comp	1226..1492	CDD:284982	74/276 (27%)
		A2M_recep	1607..1695	CDD:284981	14/94 (15%)
LOC100006895	XP_001923676.2	A2M_N	134..225	CDD:280081	24/91 (26%)
		A2M_N_2	471..616	CDD:285005	33/144 (23%)
		A2M	734..822	CDD:278630	29/89 (33%)
		A2M_2	953..1239	CDD:239227	86/330 (26%)
		A2M_comp	1005..1241	CDD:284982	74/276 (27%)
		A2M_recep	1347..1444	CDD:284981	14/94 (15%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177369at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010